Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes?

abstract：:Obesity in males is accompanied by a significant decrease in testosterone levels. This decrease is essentially a consequence of the decrease of the sex hormone binding hormone (SHBG) binding capacity, itself probably the consequence of the increased insulin levels. In moderate obesity, free testosterone levels are nor...

journal_title：Annals of medicine

authors： Vermeulen A

更新日期：1996-02-01 00:00:00

abstract：:Visceral obesity is associated with metabolic abnormalities that increase the risk of type 2 diabetes and coronary heart disease. Obese patients with a substantial accumulation of visceral adipose tissue are characterized by higher insulinaemic and glycaemic responses during an oral glucose challenge as well as by a d...

journal_title：Annals of medicine

authors： Després JP

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people. PATIENTS AND METHODS:Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. RESULTS:A total of 375 ...

journal_title：Annals of medicine

authors： González Silva Y,Abad Manteca L,de la Red Gallego H,Álvarez Muñoz M,Rodríguez Carbajo M,Murcia Casado T,Ausín Pérez L,Abadía Otero J,Pérez-Castrillón JL

更新日期：2018-09-01 00:00:00

abstract：:Mitochondria provide cells with most of the energy in the form of adenosine triphosphate (ATP). Mitochondria are complex organelles encoded both by nuclear and mtDNA. Only a few mitochondrial components are encoded by mtDNA, most of the mt-proteins are nuclear DNA encoded. Remarkably, the majority of the known mutatio...

journal_title：Annals of medicine

authors： Maassen JA,Janssen GM,'t Hart LM

更新日期：2005-01-01 00:00:00

abstract：:The circadian clock generates oscillations in physiology and behavior, known as circadian rhythms. Links between the circadian clock genes Periods, Bmal1, and Cryptochromes and aging and cancer are emerging. Circadian clock gene expression is changed in human pathologies, and transgenic mice with mutations in clock ge...

journal_title：Annals of medicine

authors： Khapre RV,Samsa WE,Kondratov RV

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Inflammation is an important contributor to the development of chronic diseases. We examined whether a healthy Nordic diet, also called the Baltic Sea diet, associates with lower concentrations of inflammatory markers. METHODS:We used two independent cross-sectional studies: the DILGOM study including Fin...

journal_title：Annals of medicine

authors： Kanerva N,Loo BM,Eriksson JG,Leiviskä J,Kaartinen NE,Jula A,Männistö S

更新日期：2014-03-01 00:00:00

abstract：:Non-alcoholic fatty liver disease or NAFLD is a chronic liver condition characterized by hepatic steatosis and associated with insulin resistance and type 2 diabetes mellitus (T2DM). In many patients fat accumulation leads to steatohepatitis (NASH) with chronic necrosis, inflammation, and fibrosis, and eventually to t...

journal_title：Annals of medicine

authors： Ali R,Cusi K

更新日期：2009-01-01 00:00:00

abstract：:Antisense oligonucleotides represent a novel class of potential drugs for highly selective blocking of genes. The basic concept of antisense strategy is simple: an antisense molecule recognizes a complementary mRNA (or DNA) by sequence-specific base pairing, and hence prevents translation (or transcription), resulting...

journal_title：Annals of medicine

authors： Lönnberg H,Vuorio E

更新日期：1996-12-01 00:00:00

abstract：:More than 50 different pharmacological and mechanical interventions have been tested to date for prevention of vascular restenosis without success. Intracoronary radiotherapy is the first one showing promise of significantly attenuating neointimal proliferation, causing positive vascular remodelling and thus inhibitin...

journal_title：Annals of medicine

authors： Kaluza GL,Ali NM,Raizner AE

更新日期：2000-12-01 00:00:00

abstract：INTRODUCTION:The objective of the present study was to examine the association between low-grade albuminuria and hearing impairment in the non-diabetic population. MATERIALS AND METHODS:Data from the Korean National Health and Nutrition Examination Survey 2011-2013 were used in the analyses. Participants were excluded...

journal_title：Annals of medicine

authors： Kang SH,Jung DJ,Choi EW,Park JW,Cho KH,Yoon KW,Do JY

更新日期：2015-01-01 00:00:00

abstract：:Second primary cancers are a difficult problem in the upper aerodigestive tract and in several other organ sites. Among patients with early stage head and neck cancers, second primary tumours are a primary cause of death. It has been postulated that such second cancers represent new tumours developing from carcinogen-...

journal_title：Annals of medicine

authors： Carey TE

更新日期：1996-06-01 00:00:00

abstract：:The understanding and treatment of schizophrenia have been greatly hampered by uncertainty about etiological factors and controversy about diagnostic boundaries. Adoption studies have helped clarify both of these problems. First, the adoptees study method, the index offspring of adopting-away schizophrenic biological ...

journal_title：Annals of medicine

authors： Tienari PJ,Wynne LC

更新日期：1994-08-01 00:00:00

abstract：:Copper is a trace element necessary for the normal function of several important enzymes but copper homeostasis is still poorly understood. In recent years remarkable progress has been made in this field following the isolation of the gene defective in Menkes disease. Menkes disease and occipital horn syndrome are X-l...

journal_title：Annals of medicine

authors： Tümer Z,Horn N

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in ant...

journal_title：Annals of medicine

authors： Bah A,Nuotio I,Grönberg T,Ylitalo A,Airaksinen KE,Hartikainen JE

更新日期：2017-05-01 00:00:00

abstract：:Mutations in cardiac voltage-gated K+ channels cause long-QT syndrome (LQTS) and sudden death. We have created a mouse with a long-QT phenotype by overexpression of truncated K+ channels in the heart and have investigated the phenotype of these mice. These mice have long-QT phenotype, and spontaneous and inducible arr...

journal_title：Annals of medicine

authors： Koren G

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Several studies have suggested that the occurrence of severe hypoglycemia during sleep may be more dangerous for cardiac arrhythmia than that in the day-time. METHODS:We performed a retrospective study between January 2006 and March 2012 to assess electrocardiograms during severe hypoglycemia in patients wi...

journal_title：Annals of medicine

authors： Tsujimoto T,Yamamoto-Honda R,Kajio H,Kishimoto M,Noto H,Hachiya R,Kimura A,Kakei M,Noda M

更新日期：2015-05-01 00:00:00

abstract：:A radioimmunoassay method for endothelin was developed. Antisera raised against endothelin 1 showed significant crossreaction with endothelin 2 and 3 (45 and 13%, respectively). Considerable endothelin immunoreactivity was shown to be present in the cerebrospinal fluid of patients with a subarachnoid hemorrhage, rangi...

journal_title：Annals of medicine

authors： Suzuki H,Sato S,Suzuki Y,Oka M,Tsuchiya T,Iino I,Yamanaka T,Ishihara N,Shimoda S

更新日期：1990-01-01 00:00:00

abstract：:The concentration of nitric oxide (NO) in exhaled air is increased in patients with asthma, suggesting that measuring fractional exhaled NO concentration (FE(NO)) may be used to monitor asthmatic airway inflammation. However, increased FE(NO) is not specific for asthma, as other inflammatory lung diseases may also inc...

journal_title：Annals of medicine

authors： Lehtimäki L,Turjanmaa V,Kankaanranta H,Saarelainen S,Hahtola P,Moilanen E

更新日期：2000-09-01 00:00:00

abstract：:The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96.6% of patients and 93.9% of controls with a metabolic ratio of debrisoquine less than 12.6 were classified as extensive metabolizers of debrisoquine (P = NS). The distribution of f...

journal_title：Annals of medicine

authors： Benítez J,Ladero JM,Fernández-Gundín MJ,Llerena A,Cobaleda J,Martínez C,Muñoz JJ,Vargas E,Prados J,González-Rozas F

更新日期：1990-06-01 00:00:00

abstract：:Abstract A host of clinical scenarios can be depicted in hereditary autoinflammatory diseases, and the cardiovascular system can also be involved especially in familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, and tumour necrosis factor receptor-associated periodic syndrome (TRAPS), caused by m...

journal_title：Annals of medicine

authors： Rigante D,Cantarini L,Imazio M,Lucherini OM,Sacco E,Galeazzi M,Brizi MG,Brucato A

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Heart rate (HR), heart rate variability (HRV), and inflammation are all associated with cardiovascular morbidity and mortality. The aim of this study was to assess potential interrelationships between these parameters in a young and healthy population. METHODS:Healthy individuals aged 25-41 years were inclu...

journal_title：Annals of medicine

authors： Aeschbacher S,Schoen T,Dörig L,Kreuzmann R,Neuhauser C,Schmidt-Trucksäss A,Probst-Hensch NM,Risch M,Risch L,Conen D

更新日期：2017-02-01 00:00:00

abstract：:Clinical know-how and skills as well as up-to-date scientific evidence are cornerstones for providing effective treatment for patients. However, in order to improve the effectiveness of treatment in ordinary practice, also appropriate documentation of care at the health care units and benchmarking based on this docume...

journal_title：Annals of medicine

authors： Malmivaara A

更新日期：2013-03-01 00:00:00

abstract：:Vaccines are considered to be one of the greatest public health achievements of the last century. Depending on the biology of the infection, the disease to be prevented, and the targeted population, a vaccine may require the induction of different adaptive immune mechanisms to be effective. Understanding the basic con...

journal_title：Annals of medicine

authors： Vetter V,Denizer G,Friedland LR,Krishnan J,Shapiro M

更新日期：2018-03-01 00:00:00

abstract：:Heart failure syndrome results from compensatory mechanisms that operate to restore - back to normal - the systemic perfusion pressure. Sympathetic overactivity plays a pivotal role in heart failure; norepinephrine contributes to maintenance of the systemic blood pressure and increasing preload. Cardiac norepinephrine...

journal_title：Annals of medicine

authors： Nammas W,Koistinen J,Paana T,Karjalainen PP

更新日期：2017-08-01 00:00:00

abstract：:The causes of colorectal cancer are complex and in most cases obscure, making primary prevention impossible at present. Secondary prevention by finding and treating early asymptomatic cancers may possibly reduce mortality from this very common cancer. Results from conventional treatment have changed little during rece...

journal_title：Annals of medicine

authors： Kronborg O

更新日期：1991-10-01 00:00:00

abstract：:Regular presence and persistence of specific serum antibodies in Helicobacter pylori infection gives an excellent tool for diagnostic work. Eradication of the infection leads to gradual disappearance of the gastritis and decrease of specific serum antibodies. The fall of IgG and IgA antibody titres can be followed wit...

journal_title：Annals of medicine

authors： Kosunen TU

更新日期：1995-10-01 00:00:00

abstract：:Clinical experience has indicated that the effects of RU 486 can be divided into dose-dependent and dose-independent effects. Examples of the dose-dependent effects include the antiglucocorticoid effects of RU 486, whereas pregnancy termination or dilatation of the cervix can be considered dose-independent with the va...

journal_title：Annals of medicine

authors： Heikinheimo O,Kekkonen R

更新日期：1993-02-01 00:00:00

abstract：:Endothelial health is a key factor in normal cardiovascular homeostasis, and recent studies have revealed several important functions of the vascular endothelium that protect against atherothrombosis. These include control over arterial tone, coagulation, fibrinolysis, and vascular growth. Consequently, endothelial dy...

journal_title：Annals of medicine

authors： Raitakari OT,Celermajer DS

更新日期：2000-07-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) has been considered essential for normal ovarian follicular development and spermatogenesis. Although this concept remains valid, the recent reports of defects in genes encoding FSH and its receptor (FSHR) have altered the concepts, particularly with regard to the role of FSH in sper...

journal_title：Annals of medicine

authors： Tapanainen JS,Aittomäki K,Huhtaniemi IT

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:We aimed to assess the prospective association of serum albumin with venous thromboembolism (VTE) risk and evaluate if the association is independent of or modified by inflammation, as measured by high sensitivity C-reactive protein (hsCRP). DESIGN:We analysed data of 2176 men aged 42-61 years free from VTE in...

journal_title：Annals of medicine

authors： Kunutsor SK,Seidu S,Katechia DT,Laukkanen JA

更新日期：2018-05-01 00:00:00