Abstract:
:Research in developing countries is essential for the evaluation of the safety, efficacy and acceptability of both new and already available contraceptives. Research conducted by scientists in developing countries has also played an essential role in the development of new contraceptives. The continuous delivery of progestin at a low dose, copper IUDs, contraceptive implants, monthly injectables and vaginal rings are examples of new methods developed with the input of research conducted largely in developing countries. When research in developing countries is funded or coordinated by international agencies, local scientists have to be involved not only in its implementation, but in the planning, analysis and dissemination of such research. The World Health Organization, the Population Council and Family Health International have played an important role in supporting collaborative studies for the development, introduction and evaluation of family planning methods in developing countries. :A key element of international support for family planning programs in developing countries is research in the development, evaluation, and introduction of family planning methods and services. These countries have the capacity to do high quality contraceptive research (from early preclinical research to phase III clinical trials). 3 international organizations are leaders in collaborating with researchers in developing countries to develop and support a network of clinical research centers in family planning. USAID assists 2 of these organizations because of its interest in family planning research: The Population Council and Family Health International. The Population Council's chief goal is the development and introduction of new contraceptive modalities. The Council developed Norplant, the sole new contraceptive approved by the US Food and Drug Administration in recent years. The International Committee for Contraceptive Research (ICCR) implements most of the Council's development program. ICCR consists of a group of research clinics and laboratories in Chile, the Dominican Republic, Finland, France, India, and the US. It is responsible for the development of 3 Copper-T IUDs and a levonorgestrel-releasing IUD. Family Health International conducts evaluation of family planning programs, epidemiological research in reproductive health, and clinical trials. WHO's Special Programme of Research, Development and Research Training in Human Reproduction is the other major player in family planning research in developing countries, specifically, assessment of contraceptive safety and efficacy, development of new contraceptives, and infertility. WHO and the Rockefeller Foundation have established a South to South collaboration in research to promote cooperation between developing countries. National and international agencies need to further develop and maintain these various international efforts.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Rivera Rdoi
10.3109/07853899309147858subject
Has Abstractpub_date
1993-02-01 00:00:00pages
57-60issue
1eissn
0785-3890issn
1365-2060journal_volume
25pub_type
杂志文章abstract:BACKGROUND:Obese youths may be susceptible to develop the metabolic syndrome (MS) later in life. AIM:To study childhood predictors of MS in adulthood. METHOD:Prospective cohort study including 2,195 subjects, aged 3-18 years at base-line in 1980, who were re-examined in 1983, 1986, and 2001. RESULTS:In adults (aged ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890802307709
更新日期:2008-01-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, are therapeutic groups widely used for the treatment of pain, inflammation and fever. There is growing experimental and clinical evidence indicating NSAIDs and COX-2 inhibitors also have anti-cancer activity. Epidemiologi...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890310017053
更新日期:2003-01-01 00:00:00
abstract::In humans, microbial colonization of the intestine begins just after birth. However, development of the normal flora is a gradual process, which is initially determined by factors such as composition of the maternal gut microflora, environment and possibly also by genetic aspects. A number of variables, such as the de...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899908995892
更新日期:1999-08-01 00:00:00
abstract::There are few relevant animal models for neurodegenerative diseases to be used for human drug development. Most current drugs for neurodegenerative diseases act through different neurotransmitter systems. Positron emission tomography (PET) is a unique tool in the study of neurodegenerative diseases as it enables quant...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899908998803
更新日期:1999-12-01 00:00:00
abstract:AIM:To evaluate if pulse pressure (PP) is a risk predictor for atrial fibrillation (AF) in a longitudinal study of 60-year-old men and women from Stockholm (n = 4,232), free from AF at baseline, with primary end-point incident AF. METHODS:AF diagnoses were obtained from the national hospital discharge register. The es...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1100321
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Teriparatide is a potent anabolic agent for severe osteoporosis. OBJECTIVES:A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. METHODS:The patient population comprises 119 os...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2012.742560
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890600673260
更新日期:2006-01-01 00:00:00
abstract::Visceral obesity is associated with metabolic abnormalities that increase the risk of type 2 diabetes and coronary heart disease. Obese patients with a substantial accumulation of visceral adipose tissue are characterized by higher insulinaemic and glycaemic responses during an oral glucose challenge as well as by a d...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890108995963
更新日期:2001-11-01 00:00:00
abstract::Mitochondria provide cells with most of the energy in the form of adenosine triphosphate (ATP). Mitochondria are complex organelles encoded both by nuclear and mtDNA. Only a few mitochondrial components are encoded by mtDNA, most of the mt-proteins are nuclear DNA encoded. Remarkably, the majority of the known mutatio...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890510007188
更新日期:2005-01-01 00:00:00
abstract::Hereditary nonpolyposis colorectal cancer (HNPCC) represents the most common form of genetic predisposition to colon cancer. Even in kindreds with several affected members it is, however, difficult to rule out chance clustering and other nonhereditary factors since colon cancer is so common in the general population. ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899409147893
更新日期:1994-06-01 00:00:00
abstract::Dementia of the Alzheimer type (AD) is clinically characterized by a progressive deterioration of intellect, memory, judgment, and abstract thinking. It is incurable, and causal therapy is not yet available. For the development of therapeutic drugs, valid animal models are needed that mimic the pathophysiological chan...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899809002606
更新日期:1998-12-01 00:00:00
abstract::Cardiac arrhythmias cause more than 300,000 sudden deaths each year in the USA alone. Long QT syndrome (LQT) is a cardiac disorder that causes sudden death from ventricular tachyarrhythmias, specifically torsade de pointes. Four LQT genes have been identified: KVLQT1 (LQT1) on chromosome 11p15.5, HERG (LQT2) on chromo...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899808999385
更新日期:1998-02-01 00:00:00
abstract::We evaluated the reliability hospital discharge register data in the assessment of acute myocardial infarction trends. In the FINMONICA study areas, trends in age standarized attack rates for the years 1983-90 were calculated independently from two sources: the nationwide Finnish hospital discharge register and the FI...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899509002467
更新日期:1995-10-01 00:00:00
abstract::This is a brief overview of the cytokine network within juvenile chronic arthritis, introducing the concept of the production of T-helper 1 (TH-1) or TH2-cell differentiation as a result of cytokine production, as well as the concept of the balance between pro- and anti-inflammatory cytokines. The balance of TH1 and T...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899709113701
更新日期:1997-04-01 00:00:00
abstract:INTRODUCTION:Inflammation is an important contributor to the development of chronic diseases. We examined whether a healthy Nordic diet, also called the Baltic Sea diet, associates with lower concentrations of inflammatory markers. METHODS:We used two independent cross-sectional studies: the DILGOM study including Fin...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2013.870020
更新日期:2014-03-01 00:00:00
abstract:IMPORTANCE:There is limited information about the durability of glycaemic control when different oral glucose-lowering therapies (GLTs) are used as add-on treatments to metformin (MET) in patients with type 2 diabetes mellitus (T2DM). OBJECTIVE:To compare time to treatment failure between different classes of oral GLT...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2016.1157263
更新日期:2016-01-01 00:00:00
abstract::In Europe around 1970 there were only a few small and often poorly known epidemiological studies on risk factors and the incidence of coronary heart disease. In order to enhance the utilization of the information contained in them, the Medical Clinic in Heidelberg offered uniform data analysis to qualifying contributi...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853898909149931
更新日期:1989-06-01 00:00:00
abstract::About 40 years ago Friedenstein described stromal cells in the bone marrow that were spindle shaped and proliferate to form colonies. These cells attach to plastic and are able to differentiate under defined in vitro conditions into multiple cell types present in many different tissues, e.g. osteoblasts, chondroblasts...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890500371957
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Heart rate (HR), heart rate variability (HRV), and inflammation are all associated with cardiovascular morbidity and mortality. The aim of this study was to assess potential interrelationships between these parameters in a young and healthy population. METHODS:Healthy individuals aged 25-41 years were inclu...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2016.1226512
更新日期:2017-02-01 00:00:00
abstract::Prolyl 4-hydroxylases (P4Hs) have central roles in the synthesis of collagens and the regulation of oxygen homeostasis. The 4-hydroxyproline residues generated by the endoplasmic reticulum (ER) luminal collagen P4Hs (C-P4Hs) are essential for the stability of the collagen triple helix. Vertebrate C-P4Hs are alpha2beta...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890801986594
更新日期:2008-01-01 00:00:00
abstract::The WHO Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) Project was initiated in the early 1980s with the main objective of assessing the extent to which trends in coronary heart disease and cerebrovascular disease are related to changes in known risk factors, daily living habits...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899409147329
更新日期:1994-02-01 00:00:00
abstract::Congruence of evidence from all medical research methodologies has established the major causal influences in cardiovascular disease. Causation thus established, epidemiological observations are the best available evidence on which to base estimates of the potential of preventive strategies. From population comparison...
journal_title:Annals of medicine
pub_type: 临床试验,杂志文章,评审
doi:10.3109/07853898909149926
更新日期:1989-06-01 00:00:00
abstract::Molecular oxygen (O2)is a basic requirement for cellular growth and viability and many aspects of anatomy and physiology are dedicated to achieving reliable distribution. Recent work has identified a specific sensing and response system, centred around a transcription complex called Hypoxia-inducible Factor 1 (HIF-1),...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/0785389031000458233
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AIMS:A mild increase in liver enzyme levels is sometimes observed in patients with diabetic ketosis or ketoacidosis. The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ke...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890802032711
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Prospective data on development of venous obstruction after electrode implantation are limited. We performed a prospective study on 150 patients undergoing first pacemaker implantation. METHODS:Venographies at base-line and 6 months postimplantation in all patients, 50 patients included into a long...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890802498961
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people. PATIENTS AND METHODS:Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. RESULTS:A total of 375 ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2018.1505052
更新日期:2018-09-01 00:00:00
abstract::Radiosurgery is an increasingly popular method for treating a variety of intracranial tumours. A great deal of treatment data has been accumulated suggesting that radiosurgery may be the treatment of choice for small acoustic schwannomas. Moreover, radiosurgery promises excellent tumour control and minimal risk in the...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890008995912
更新日期:2000-02-01 00:00:00
abstract::Scleroderma or systemic sclerosis (SSc) is a complex disease in which the vasculopathy and the activation of the immune system with production of inflammatory mediators lead to dysregulated fibroblast activation. The resulting excessive deposition of collagens and other extracellular matrix proteins ends in fibrosis a...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890601098152
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Multiple lines of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, pr...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890701278795
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS:To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890903022801
更新日期:2009-01-01 00:00:00