Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and reality.

abstract：:The pathophysiology of psychotic and other symptoms in schizophrenia remains a mystery despite decades of research. Even though it has been suspected for many years that autoimmune mechanisms may play a role in the pathophysiology of schizophrenia, firm evidence for this hypothesis has been lacking. Our studies, over ...

journal_title：Annals of medicine

authors： Ganguli R,Brar JS,Chengappa KN,Yang ZW,Nimgaonkar VL,Rabin BS

更新日期：1993-10-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal...

journal_title：Annals of medicine

authors： Marafini I,Monteleone G

更新日期：2018-08-01 00:00:00

abstract：:Abdominal obesity in man is an integrated part of the Metabolic Syndrome, and is associated with a complex neuroendocrine disturbance. Its consequences for the metabolism of the periphery seems to be insulin resistance caused by a combination of a relative hypercortisolaemia and a relative deficiency of sex steroid ho...

journal_title：Annals of medicine

authors： Björntorp P

更新日期：1992-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is a genetically complex disorder associated with multiple genetic defects either mutational or of susceptibility. Current AD genetics does not explain in full the etiopathogenesis of AD, suggesting that environmental factors and/or epigenetic phenomena may also contribute to AD pathology and ...

journal_title：Annals of medicine

authors： Cacabelos R

更新日期：2002-01-01 00:00:00

abstract：:Apolipoprotein (apo) A-IV is involved in the metabolism of triglyceride-rich lipoproteins and high-density lipoproteins and may thus play an important role in lipid metabolism, although the precise physiological function of apo A-IV is unknown. Structural and functional alterations of apolipoproteins, caused by a vari...

journal_title：Annals of medicine

authors： Tenkanen H,Ehnholm C

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Heart rate (HR), heart rate variability (HRV), and inflammation are all associated with cardiovascular morbidity and mortality. The aim of this study was to assess potential interrelationships between these parameters in a young and healthy population. METHODS:Healthy individuals aged 25-41 years were inclu...

journal_title：Annals of medicine

authors： Aeschbacher S,Schoen T,Dörig L,Kreuzmann R,Neuhauser C,Schmidt-Trucksäss A,Probst-Hensch NM,Risch M,Risch L,Conen D

更新日期：2017-02-01 00:00:00

abstract：:Caveolae are vesicular organelles (50-100-nm in diameter) that are particularly abundant in cells of the cardiovascular system, including endothelial cells, smooth muscle cells, macrophages, cardiac myocytes and fibroblasts. In these cell types, caveolae function both in protein trafficking and signal transduction, as...

journal_title：Annals of medicine

authors： Williams TM,Lisanti MP

更新日期：2004-01-01 00:00:00

abstract：:Although food habits arc not stable and unchanging during a person's lifetime, a base for healthy food habits can be created in early childhood. Children's food habits can be assumed to be influenced by their parents' food habits and choices. The aim of this article is to review factors influencing food choice in chil...

journal_title：Annals of medicine

authors： Hursti UK

更新日期：1999-01-01 00:00:00

abstract：:The causes of colorectal cancer are complex and in most cases obscure, making primary prevention impossible at present. Secondary prevention by finding and treating early asymptomatic cancers may possibly reduce mortality from this very common cancer. Results from conventional treatment have changed little during rece...

journal_title：Annals of medicine

authors： Kronborg O

更新日期：1991-10-01 00:00:00

abstract：:The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) can be related to abnormalities in the metabolism and disposition of sex hormones and/or bile acids, determined by a genetic predisposition interacting with environmental factors. The total amount of oestrogens and progesterone circulating in the blood or...

journal_title：Annals of medicine

authors： Reyes H,Sjövall J

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVES:To appraise effective predictors for COVID-19 mortality in a retrospective cohort study. METHODS:A total of 1270 COVID-19 patients, including 984 admitted in Sino French New City Branch (training and internal validation sets randomly split at 7:3 ratio) and 286 admitted in Optical Valley Branch (external va...

journal_title：Annals of medicine

authors： Guan X,Zhang B,Fu M,Li M,Yuan X,Zhu Y,Peng J,Guo H,Lu Y

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The expression of disintegrin and metalloprotease ADAM-9, ADAM-15, and ADAM-17 has been associated with cell-cell, cell-platelet, and cell-matrix interactions and inflammation. They are possibly implicated in the pathophysiology of atherosclerosis. METHODS AND RESULTS:Whole-genome expression array ...

journal_title：Annals of medicine

authors： Oksala N,Levula M,Airla N,Pelto-Huikko M,Ortiz RM,Järvinen O,Salenius JP,Ozsait B,Komurcu-Bayrak E,Erginel-Unaltuna N,Huovila AP,Kytömäki L,Soini JT,Kähönen M,Karhunen PJ,Laaksonen R,Lehtimäki T

更新日期：2009-01-01 00:00:00

abstract：:The question 'what is a pathogen?' derives from pathogen-centered views of microbial pathogenesis that invoke microbial characteristics to explain virulence. However, virulence cannot be an independent microbial variable since it is only expressed in a susceptible host. Hence, the question 'what is a pathogen?' cannot...

journal_title：Annals of medicine

authors： Casadevall A,Pirofski LA

更新日期：2002-01-01 00:00:00

abstract：:Transvaginal ultrasonic monitoring of the lower uterine segment was performed in 15 pregnancies in which the mother had previously had three or more caesarean sections. The typical findings were thinning of the myometrium, asymmetric isthmal structures and ventral ballooning of the isthmus. An image of the other of th...

journal_title：Annals of medicine

authors： Kirkinen P

更新日期：1990-04-01 00:00:00

abstract：:Aim: This meta-analysis study aimed to compare the efficacy and safety of TEVAR versus OCSR for TBAD patients.Methods: We systematically searched PubMed, EmBase, and the Cochrane library to identify studies compared the effectiveness of TEVAR and OCSR in TBAD patients from the inception up to July 2019. The summary re...

journal_title：Annals of medicine

authors： Liu J,Xia J,Yan G,Zhang Y,Ge J,Cao L

更新日期：2019-01-01 00:00:00

abstract：:Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the ...

journal_title：Annals of medicine

authors： Svanborg C,Bergsten G,Fischer H,Frendéus B,Godaly G,Gustafsson E,Hang L,Hedlund M,Karpman D,Lundstedt AC,Samuelsson M,Samuelsson P,Svensson M,Wullt B

更新日期：2001-12-01 00:00:00

abstract：:On theoretical grounds, an apo E receptor defect should be manifested by the accumulation of lipoprotein remnants that are normally cleared by this receptor and cannot be processed by the normal apo B, E receptor (LDL-receptor). Furthermore, the defect should not be selective for a specific apo E phenotype since none ...

journal_title：Annals of medicine

authors： Davignon J,Dallongeville J,Roederer G,Roy M,Fruchart JC,Kessling AM,Bouthillier D,Lussier-Cacan S

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE AND METHODS:The impact of the rs9939609 FTO variant on cardiovascular events was investigated in the 19-year follow-up of subjects recruited to the OPERA study. RESULTS:A total of 212 cardiovascular disease (CVD) and 152 coronary heart disease (CHD) events or deaths occurred during follow-up. The logistic re...

journal_title：Annals of medicine

authors： Äijälä M,Ronkainen J,Huusko T,Malo E,Savolainen ER,Savolainen MJ,Salonurmi T,Bloigu R,Kesäniemi YA,Ukkola O

更新日期：2015-01-01 00:00:00

abstract：:In order to assess the effectiveness of lifestyle interventions in reducing cardiovascular disease risk factors, morbidity and mortality among working-age adults, we undertook a systematic review of randomized controlled trials of various lifestyle interventions (diet, exercise, smoking cessation, alcohol intake reduc...

journal_title：Annals of medicine

authors： Ketola E,Sipilä R,Mäkelä M

更新日期：2000-05-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is phenotypically and genotypically a heterogeneous disease. Since 1989, four chromosomal loci have been identified for HCM and the genes residing on three of these have been identified as beta-myosin heavy chain (beta-MHC), cardiac troponin-T and alpha-tropomyosin. These genes code f...

journal_title：Annals of medicine

authors： Durand JB,Abchee AB,Roberts R

更新日期：1995-06-01 00:00:00

abstract：:Atrial fibrillation is a common cardiac arrhythmia with rapid and irregular atrial activity. Instead of uniformly contracting as one chamber, the atrial compartment fibrillates. Several studies have demonstrated that this arrhythmia contributes substantially to cardiac morbidity and mortality. The purpose of this revi...

journal_title：Annals of medicine

authors： Miyazaki S,Shah AJ,Scherr D,Haïssaguerre M

更新日期：2011-01-01 00:00:00

abstract：:One of the major discoveries in modern genetics is the phenomenon of genomic, or parental, imprinting. The parent-of-origin effects seen after transmission of an imprinted gene from parents to their children do not follow the genetic rules postulated by Gregor Mendel. This has obvious consequences for genetic counsell...

journal_title：Annals of medicine

authors： Mannens M,Alders M

更新日期：1999-02-01 00:00:00

abstract：:BACKGROUND. Non-steroidal anti-inflammatory drugs are associated with poor upper gastrointestinal (UGI) tolerability and increased ulcer risk, but patient adherence to gastroprotective co-therapy is frequently inadequate. A fixed-dose combination of enteric-coated naproxen 500 mg and immediate-release esomeprazole mag...

journal_title：Annals of medicine

authors： Cryer BL,Sostek MB,Fort JG,Svensson O,Hwang C,Hochberg MC

更新日期：2011-12-01 00:00:00

abstract：:Visceral obesity is associated with metabolic abnormalities that increase the risk of type 2 diabetes and coronary heart disease. Obese patients with a substantial accumulation of visceral adipose tissue are characterized by higher insulinaemic and glycaemic responses during an oral glucose challenge as well as by a d...

journal_title：Annals of medicine

authors： Després JP

更新日期：2001-11-01 00:00:00

abstract：:Type 2 diabetes (T2D) and obesity are recognized as conditions of growing biomedical importance to societies worldwide. Despite this, lack of understanding concerning the processes which normally serve to maintain weight and to regulate glucose concentrations, and ignorance about the mechanisms by which these homeosta...

journal_title：Annals of medicine

authors： Jafar-Mohammadi B,McCarthy MI

更新日期：2008-01-01 00:00:00

abstract：:This paper describes the responses of peripheral and central visceral nociceptive systems to acute injury and discusses these observations in relation to the concept of 'pre-emptive analgesia'. Visceral nociceptors are known to respond to injury but are also known to become sensitized to non-noxious stimuli during the...

journal_title：Annals of medicine

authors： Cervero F

更新日期：1995-04-01 00:00:00

abstract：:Naltrexone is the first safe and effective pharmaceutical adjunct for use in the treatment of alcohol abuse. Theoretically it could be effective also as a means for terminating methadone maintenance and in the treatment of other forms of substance abuse. Two general types of protocols have been used with naltrexone. O...

journal_title：Annals of medicine

authors： Sinclair JD

更新日期：1998-08-01 00:00:00

abstract：:The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96.6% of patients and 93.9% of controls with a metabolic ratio of debrisoquine less than 12.6 were classified as extensive metabolizers of debrisoquine (P = NS). The distribution of f...

journal_title：Annals of medicine

authors： Benítez J,Ladero JM,Fernández-Gundín MJ,Llerena A,Cobaleda J,Martínez C,Muñoz JJ,Vargas E,Prados J,González-Rozas F

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Mortality from coronary heart disease (CHD) has been constantly higher in eastern late settlement regions compared to western early settlements in Finland, unrelated to classical risk factors. In line with this, eastern birthplace was an age-dependent predictor of severe coronary atherosclerosis and pre-hosp...

journal_title：Annals of medicine

authors： Tyynelä P,Goebeler S,Ilveskoski E,Mikkelsson J,Perola M,Lehtimäki T,Karhunen PJ

更新日期：2013-05-01 00:00:00

abstract：:The question why low-density lipoprotein (LDL) stranded in the subendothelium of arteries should acquire the proinflammatory properties that initiate and sustain atherogenesis has puzzled researchers for decades. The most popular concept contends that oxidative processes are crucial because oxidized LDL (ox-LDL) produ...

journal_title：Annals of medicine

authors： Bhakdi S

更新日期：1998-12-01 00:00:00