Molecular basis for apo A-IV polymorphisms.

abstract：:A radioimmunoassay method for endothelin was developed. Antisera raised against endothelin 1 showed significant crossreaction with endothelin 2 and 3 (45 and 13%, respectively). Considerable endothelin immunoreactivity was shown to be present in the cerebrospinal fluid of patients with a subarachnoid hemorrhage, rangi...

journal_title：Annals of medicine

authors： Suzuki H,Sato S,Suzuki Y,Oka M,Tsuchiya T,Iino I,Yamanaka T,Ishihara N,Shimoda S

更新日期：1990-01-01 00:00:00

abstract：:The effect of different clinical conditions on urinary dolichols was studied in 219 hospital patients and in 24 pregnant women. Significantly increased urinary dolichol levels were found in patients with severe bacterial infections (mean +/- SEM, 37.5 +/- 8.0 micrograms/mmol creatinine, P less than 0.001), in patients...

journal_title：Annals of medicine

authors： Roine R,Humaloja K,Hämäläinen J,Nykänen I,Ylikahri R,Salaspuro M

更新日期：1989-02-01 00:00:00

abstract：:The calcium-sensing receptor is a G protein-coupled receptor that has a key role in extracellular calcium homeostasis, regulating the secretion of parathyroid hormone and the reabsorption of urinary calcium appropriate to the prevailing calcaemic environment. Molecular abnormalities of the calcium-sensing receptor are...

journal_title：Annals of medicine

authors： Pearce SH

更新日期：2002-01-01 00:00:00

abstract：:About 40 years ago Friedenstein described stromal cells in the bone marrow that were spindle shaped and proliferate to form colonies. These cells attach to plastic and are able to differentiate under defined in vitro conditions into multiple cell types present in many different tissues, e.g. osteoblasts, chondroblasts...

journal_title：Annals of medicine

authors： Väänänen HK

更新日期：2005-01-01 00:00:00

abstract：:Atherosclerosis, the leading cause of death in developed countries, is characterized by chronic inflammation in the artery wall. It has been appreciated for decades that this disease is linked to hypercholesterolemia and the accumulation of macrophages in the artery wall, yet the exact mechanisms underlying this infla...

journal_title：Annals of medicine

authors： Laberge MA,Moore KJ,Freeman MW

更新日期：2005-01-01 00:00:00

abstract：:Low back pain as a research topic has been treated in this symposium, as in other contexts, as though it were an illness. It is, however, a complaint - and as such, even, potentially not a genuine one. Appreciation of the true character of back pain is essential for the proper orientation and setting of priorities for...

journal_title：Annals of medicine

authors： Miettinen OS,Caro JJ

更新日期：1989-10-01 00:00:00

abstract：:Human anxiety disorders represent one of the most common mental illnesses. They are complex diseases with both genetic and environmental factors affecting their predisposition. Since the basic neuronal mechanisms are shared across mammalian species, the same set of genes may regulate critical aspects of anxiety in hum...

journal_title：Annals of medicine

authors： Hovatta I,Barlow C

更新日期：2008-01-01 00:00:00

abstract：:Small cell carcinoma (SCC) of the prostate is an uncommon condition; there are very few cases in which presenting symptoms are consistent with Cushing Syndrome (CS). We report a new case in which CS triggers the suspicion of an SCC of the prostate and a review of the published cases of SCC of the prostate presenting w...

journal_title：Annals of medicine

authors： Rueda-Camino JA,Losada-Vila B,De Ancos-Aracil CL,Rodríguez-Lajusticia L,Tardío JC,Zapatero-Gaviria A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Eastern-born male Finns, irrespective of their place of residence, have high mortality from coronary heart disease (CHD), and half of such deaths are sudden. AIM:To study whether eastern birthplace alone or combined with life-style factors predicts risk for prehospital sudden cardiac death (SCD) in the new ...

journal_title：Annals of medicine

authors： Tyynela P,Goebeler S,Ilveskoski E,Mikkelsson J,Perola M,Loytonen M,Karhunen PJ

更新日期：2009-01-01 00:00:00

abstract：:A new form of acute hepatic porphyria with double genetic defect--deficiency of porphobilinogen deaminase and coproporphyrinogen oxidase--is described. Among 17 studied family members this double enzymatic deficiency was found in five individuals, deficiency of porphobilinogen deaminase in four, and deficiency of copr...

journal_title：Annals of medicine

authors： Gregor A,Kostrzewska E,Tarczynska-Nosal S,Stachurska H

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in ant...

journal_title：Annals of medicine

authors： Bah A,Nuotio I,Grönberg T,Ylitalo A,Airaksinen KE,Hartikainen JE

更新日期：2017-05-01 00:00:00

abstract：:Type 2 diabetes (T2D) and obesity are recognized as conditions of growing biomedical importance to societies worldwide. Despite this, lack of understanding concerning the processes which normally serve to maintain weight and to regulate glucose concentrations, and ignorance about the mechanisms by which these homeosta...

journal_title：Annals of medicine

authors： Jafar-Mohammadi B,McCarthy MI

更新日期：2008-01-01 00:00:00

abstract：:Copper is a trace element necessary for the normal function of several important enzymes but copper homeostasis is still poorly understood. In recent years remarkable progress has been made in this field following the isolation of the gene defective in Menkes disease. Menkes disease and occipital horn syndrome are X-l...

journal_title：Annals of medicine

authors： Tümer Z,Horn N

更新日期：1996-04-01 00:00:00

abstract：:Despite striking extensions of lifespan, leading causes of death in most countries now constitute chronic, degenerative diseases which outpace the capacity of health systems. Cardiovascular disease is the most common cause of death in both developed and undeveloped countries. In America, nearly half of the adult popul...

journal_title：Annals of medicine

authors： Kones R,Rumana U

更新日期：2017-05-01 00:00:00

abstract：:The term 'prion diseases' refers to a group of neurodegenerative disorders thought to be caused by prions, pathogenic agents with novel modes of replication and transmission. Prion diseases are characterized by long incubation periods ranging from months to years and are invariably fatal once clinical symptoms have ap...

journal_title：Annals of medicine

authors： Haltia M

更新日期：2000-10-01 00:00:00

abstract：:There are few relevant animal models for neurodegenerative diseases to be used for human drug development. Most current drugs for neurodegenerative diseases act through different neurotransmitter systems. Positron emission tomography (PET) is a unique tool in the study of neurodegenerative diseases as it enables quant...

journal_title：Annals of medicine

authors： Rinne JO

更新日期：1999-12-01 00:00:00

abstract：AIM:As the capability of human mesenchymal stem cells (hMSC) to engraft, differentiate and improve myocardial function cannot be studied in humans, exploration was performed in a xenomodel. METHODS:The rats were divided into three groups depending on the type of rats used (Rowett nude (RNU) or Fischer rats +/- immunos...

journal_title：Annals of medicine

authors： Grinnemo KH,Månsson-Broberg A,Leblanc K,Corbascio M,Wärdell E,Siddiqui AJ,Hao X,Sylvén C,Dellgren G

更新日期：2006-01-01 00:00:00

abstract：:Pulmonary arterial hypertension is a rapidly progressing disease characterized by an over- expression of endothelin. In addition to its potent pulmonary vasoconstrictor effects, endothelin has been shown to produce many of the aberrant changes, such as hypertrophy, fibrosis, inflammation, and neurohormonal activation ...

journal_title：Annals of medicine

authors： Clozel M

更新日期：2003-01-01 00:00:00

abstract：:Second primary cancers are a difficult problem in the upper aerodigestive tract and in several other organ sites. Among patients with early stage head and neck cancers, second primary tumours are a primary cause of death. It has been postulated that such second cancers represent new tumours developing from carcinogen-...

journal_title：Annals of medicine

authors： Carey TE

更新日期：1996-06-01 00:00:00

abstract：:Visceral obesity is associated with metabolic abnormalities that increase the risk of type 2 diabetes and coronary heart disease. Obese patients with a substantial accumulation of visceral adipose tissue are characterized by higher insulinaemic and glycaemic responses during an oral glucose challenge as well as by a d...

journal_title：Annals of medicine

authors： Després JP

更新日期：2001-11-01 00:00:00

abstract：:The aetiology of insulin-dependent diabetes (IDDM) involves genetic predisposition, a major component of which has been mapped in the HLA complex, near to or identical with genes encoding class II molecules. In Caucasian populations IDDM is strongly associated with the serologically defined HLA-DR3 and DR4 antigens, w...

journal_title：Annals of medicine

authors： Deschamps I,Beressi JP,Khalil I,Robert JJ,Hors J

更新日期：1991-10-01 00:00:00

abstract：:Hemostasis is traditionally defined as a physiological response to blood vessel injury and bleeding, which entails a co-ordinated process involving the blood vessel, platelets, and blood clotting proteins (i.e. coagulation factors). Hemostasis can be divided into primary and secondary components. The former rapidly in...

journal_title：Annals of medicine

authors： Lippi G,Franchini M,Montagnana M,Favaloro EJ

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:To appraise effective predictors for COVID-19 mortality in a retrospective cohort study. METHODS:A total of 1270 COVID-19 patients, including 984 admitted in Sino French New City Branch (training and internal validation sets randomly split at 7:3 ratio) and 286 admitted in Optical Valley Branch (external va...

journal_title：Annals of medicine

authors： Guan X,Zhang B,Fu M,Li M,Yuan X,Zhu Y,Peng J,Guo H,Lu Y

更新日期：2021-12-01 00:00:00

abstract：:The thoracolumbar junctional region (T10-L1) of the spine is a transitional zone, where more than half of the thoracic and lumbar fractures occur. In this presentation the origin of the pathoanatomical changes in the thoracolumbar junctional region of the spine is discussed in view of the previous studies. These studi...

journal_title：Annals of medicine

authors： Malmivaara AO

更新日期：1989-10-01 00:00:00

abstract：:In adults, the high-density lipoprotein cholesterol (HDL-C) level is higher among physically active subjects. However, the association of physical activity and HDL-C is less well studied in adolescents and young adults. Furthermore, it is not known whether the effect of physical activity on HDL-C levels is independent...

journal_title：Annals of medicine

authors： Raitakari OT,Taimela S,Porkka KV,Viikari JS

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Different soluble molecules involved in inflammation, endothelial damage, or hemostasis are recognized as potential cardiovascular risk markers. Studies to assess the role of these markers in the atherosclerotic process by evaluating their relationship to carotid intima-media thickness (C-IMT) tend to provid...

journal_title：Annals of medicine

authors： Baldassarre D,De Jong A,Amato M,Werba JP,Castelnuovo S,Frigerio B,Veglia F,Tremoli E,Sirtori CR

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP) is one of the most powerful determinants of cardiovascular risk in women. This risk may differ between post-menopausal women with and without vasomotor hot flushes, possibly indicating different vascular responses to hormone therapy (HT). Thus, we compared in a clinical trial the effect o...

journal_title：Annals of medicine

authors： Tuomikoski P,Haapalahti P,Sarna S,Ylikorkala O,Mikkola TS

更新日期：2010-07-01 00:00:00

abstract：:During recent decades an increasing number of case reports have pointed at a relation between atrophic gastritis type A and gastric carcinoid. This relation has now been quantitatively documented in endoscopic screening studies. Among patients with pernicious anaemia the prevalence of gastric carcinoid was 2-9%. Many ...

journal_title：Annals of medicine

authors： Borch K

更新日期：1989-08-01 00:00:00

abstract：:It is established beyond doubt that free radicals in tissues and cells can damage DNA, proteins, carbohydrates and lipids. These potentially deleterious reactions are at least partly controlled by antioxidants capable of scavenging free radicals. It is widely believed that a proper balance between free radicals and an...

journal_title：Annals of medicine

authors： Rautalahti M,Huttunen J

更新日期：1994-12-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal...

journal_title：Annals of medicine

authors： Marafini I,Monteleone G

更新日期：2018-08-01 00:00:00