Birthplace predicts risk for prehospital sudden cardiac death in middle-aged men who migrated to metropolitan area: The Helsinki Sudden Death Study.

abstract：:After the sequencing of the human genome has been completed, non-invasive imaging studies are needed to assess the function of new genes in living organisms. The evaluation of genetically manipulated animals or new designed biomolecules will require a thorough understanding of physiology, biochemistry and pharmacology...

journal_title：Annals of medicine

authors： Haberkorn U,Altmann A

更新日期：2003-01-01 00:00:00

abstract：:Neuropeptides and their receptors are produced and expressed by neuroendocrine tissues and function as neurotransmitters and/or mediators of well-defined hormonal activities in specific tissues and cells. However, neuropeptides and their receptors are also found in the immune system, and various neuropeptides are invo...

journal_title：Annals of medicine

authors： van Hagen PM,Hofland LJ,ten Bokum AM,Lichtenauer-Kaligis EG,Kwekkeboom DJ,Ferone D,Lamberts SW

更新日期：1999-10-01 00:00:00

abstract：:With the last two decades, the importance of genetic factors in the aetiology of major mental illness has been firmly re-established and psychiatric research has now firmly embraced the era of molecular genetics. Despite a number of false starts in the study of schizophrenia and affective disorder, there have been suc...

journal_title：Annals of medicine

authors： O'Donovan MC,Owen MJ

更新日期：1992-06-01 00:00:00

abstract：:Alcoholism is a complex disorder involving both genetic and environmental factors and interactions between them. Localizing and characterizing the genetic influences on susceptibility to alcohol dependence may provide new insights into pathology and new avenues for treatment and prevention. However, because of the com...

journal_title：Annals of medicine

authors： Almasy L

更新日期：2003-01-01 00:00:00

abstract：:In the aetiological diagnosis of pulmonary infections in patients affected by haematological malignancies we evaluated the utility of bronchoalveolar lavage (BAL). One hundred and twenty-seven BAL were performed in 119 patients. In our series, we identified the agent of pneumonia in 53.5% of episodes with the best res...

journal_title：Annals of medicine

authors： Pagano L,Pagliari G,Basso A,Marra R,Sica S,Frigieri L,Morace G,Ardito F,Leone G

更新日期：1997-12-01 00:00:00

abstract：:Both genetic and environmental factors contribute to the development of rheumatoid arthritis (RA). A long-term latent process often precedes the onset of arthritis. Hence, the ultimate causes of RA cannot be clarified by studying only the inflamed joints. Longitudinal studies focusing on risk factors are crucial in ap...

journal_title：Annals of medicine

authors： Aho K,Heliövaara M

更新日期：2004-01-01 00:00:00

abstract：:A number of biochemical markers in maternal serum have been proposed for first trimester screening for Down's syndrome. The most promising four are pregnancy associated plasma protein A (PAPP-A), the free beta sub-unit of human chorionic gonadotrophin (hCG) (free beta glycoprotein sub-unit), unconjugated oestriol (uE3...

journal_title：Annals of medicine

authors： Wald NJ,Kennard A,Smith D

更新日期：1994-02-01 00:00:00

abstract：:Bone fractures affecting elderly people are a true public health burden, because they represent one of the most important causes of long-standing pain, functional impairment, disability, and death among this population. Compromised bone strength (osteoporosis) and falling, alone, or more frequently in combination, are...

journal_title：Annals of medicine

authors： Kannus P,Uusi-Rasi K,Palvanen M,Parkkari J

更新日期：2005-01-01 00:00:00

abstract：:Exposures of human populations to pesticides and industrial pollutants, and to synthetic chemicals present in foods, beverages, and plastics, have raised concern that these substances can interfere with endogenous sex hormone function. Interference with sex hormone action can, in turn, result in a variety of developme...

journal_title：Annals of medicine

authors： Akingbemi BT,Hardy MP

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The association between otitis media and vestibular symptoms has been hypothesized in the past. Thus, in this study, we aimed to critically analyze (based in a systematic review of the literature) whether patients who have otitis media are at greater risk of developing vestibular impairment or not. METHODS:...

journal_title：Annals of medicine

authors： Monsanto RDC,Kasemodel ALP,Tomaz A,Paparella MM,Penido NO

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Teriparatide is a potent anabolic agent for severe osteoporosis. OBJECTIVES:A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. METHODS:The patient population comprises 119 os...

journal_title：Annals of medicine

authors： Koski AM,Löyttyniemi E,Väänänen H,Laine H,Niskanen L,Nevalainen PI,Korpi-Hyövälti E,Välimäki MJ

更新日期：2013-05-01 00:00:00

abstract：:Health professionals provide care with some purpose in mind. It is reasonable to assume that they are therefore interested in observing and measuring health outcomes. In the recent past, it has become fashionable to describe health outcomes in terms of their impact on 'quality of life', a widely used term that is usua...

journal_title：Annals of medicine

authors： Kind P

更新日期：2001-07-01 00:00:00

abstract：:Regular presence and persistence of specific serum antibodies in Helicobacter pylori infection gives an excellent tool for diagnostic work. Eradication of the infection leads to gradual disappearance of the gastritis and decrease of specific serum antibodies. The fall of IgG and IgA antibody titres can be followed wit...

journal_title：Annals of medicine

authors： Kosunen TU

更新日期：1995-10-01 00:00:00

abstract：:We evaluated the reliability hospital discharge register data in the assessment of acute myocardial infarction trends. In the FINMONICA study areas, trends in age standarized attack rates for the years 1983-90 were calculated independently from two sources: the nationwide Finnish hospital discharge register and the FI...

journal_title：Annals of medicine

authors： Mähönen M,Miettinen H,Pyörälä K,Molarius A,Salomaa V,Kuulasmaa K

更新日期：1995-10-01 00:00:00

abstract：:The phenomenon of treatment-resistant depression (TRD), described as the occurrence of an inadequate response after an adequate treatment with antidepressant agents (in terms of dose, duration, and adherence), is very common in clinical practice. It has been broadly defined in the context of unipolar major depression,...

journal_title：Annals of medicine

authors： Vieta E,Colom F

更新日期：2011-11-01 00:00:00

abstract：:Geneticists have been predicting that advances in their discipline will revolutionize the understanding of human disease and behavior. While there has been considerable progress in disorders showing simple, Mendelian patterns of inheritance, expectations have yet to be fulfilled for disorders and traits showing comple...

journal_title：Annals of medicine

authors： van den Bree MB,Owen MJ

更新日期：2003-01-01 00:00:00

abstract：:Radiosurgery is an increasingly popular method for treating a variety of intracranial tumours. A great deal of treatment data has been accumulated suggesting that radiosurgery may be the treatment of choice for small acoustic schwannomas. Moreover, radiosurgery promises excellent tumour control and minimal risk in the...

journal_title：Annals of medicine

authors： Friedman WA,Foote KD

更新日期：2000-02-01 00:00:00

abstract：:The aetiology of insulin-dependent diabetes (IDDM) involves genetic predisposition, a major component of which has been mapped in the HLA complex, near to or identical with genes encoding class II molecules. In Caucasian populations IDDM is strongly associated with the serologically defined HLA-DR3 and DR4 antigens, w...

journal_title：Annals of medicine

authors： Deschamps I,Beressi JP,Khalil I,Robert JJ,Hors J

更新日期：1991-10-01 00:00:00

abstract：:The thoracolumbar junctional region (T10-L1) of the spine is a transitional zone, where more than half of the thoracic and lumbar fractures occur. In this presentation the origin of the pathoanatomical changes in the thoracolumbar junctional region of the spine is discussed in view of the previous studies. These studi...

journal_title：Annals of medicine

authors： Malmivaara AO

更新日期：1989-10-01 00:00:00

abstract：:The majority of patients with low back pain offer no objective clinical findings on which to make a diagnosis on the basis of physical examination. Therefore a diagnostic categorization of complaint based on duration and location is proposed. The justification for this organization is the assumption that the majority ...

journal_title：Annals of medicine

authors： Mooney V

更新日期：1989-10-01 00:00:00

abstract：:The understanding and treatment of schizophrenia have been greatly hampered by uncertainty about etiological factors and controversy about diagnostic boundaries. Adoption studies have helped clarify both of these problems. First, the adoptees study method, the index offspring of adopting-away schizophrenic biological ...

journal_title：Annals of medicine

authors： Tienari PJ,Wynne LC

更新日期：1994-08-01 00:00:00

abstract：AIM:To evaluate if pulse pressure (PP) is a risk predictor for atrial fibrillation (AF) in a longitudinal study of 60-year-old men and women from Stockholm (n = 4,232), free from AF at baseline, with primary end-point incident AF. METHODS:AF diagnoses were obtained from the national hospital discharge register. The es...

journal_title：Annals of medicine

authors： Miedel C,Leander K,de Faire U,Gigante B

更新日期：2015-01-01 00:00:00

abstract：:The Cardiovascular Risk in Young Finns Study is a collaborative effort of all university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country. The main cross-se...

journal_title：Annals of medicine

authors： Akerblom HK,Viikari J,Raitakari OT,Uhari M

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...

journal_title：Annals of medicine

authors： Oksanen AM,Lemmelä SM,Järvelä IE,Rautelin HI

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Commercial nucleic acid amplification tests, designed for the detection of Mycobacterium tuberculosis DNA/RNA in respiratory samples, are often applied also in nonrespiratory specimens in order to verify the diagnosis of extrapulmonary tuberculosis. AIM. To evaluate the value of the Abbott LCx Mycobacterium ...

journal_title：Annals of medicine

authors： Rantakokko-Jalava K,Marjamäki M,Marttila H,Mäkelä L,Valtonen V,Viljanen MK

更新日期：2001-02-01 00:00:00

abstract：:Prolyl 4-hydroxylases (P4Hs) have central roles in the synthesis of collagens and the regulation of oxygen homeostasis. The 4-hydroxyproline residues generated by the endoplasmic reticulum (ER) luminal collagen P4Hs (C-P4Hs) are essential for the stability of the collagen triple helix. Vertebrate C-P4Hs are alpha2beta...

journal_title：Annals of medicine

authors： Myllyharju J

更新日期：2008-01-01 00:00:00

abstract：:The concentration of nitric oxide (NO) in exhaled air is increased in patients with asthma, suggesting that measuring fractional exhaled NO concentration (FE(NO)) may be used to monitor asthmatic airway inflammation. However, increased FE(NO) is not specific for asthma, as other inflammatory lung diseases may also inc...

journal_title：Annals of medicine

authors： Lehtimäki L,Turjanmaa V,Kankaanranta H,Saarelainen S,Hahtola P,Moilanen E

更新日期：2000-09-01 00:00:00

abstract：:Hereditary tyrosinaemia type I is the most common of the diseases caused by defects in tyrosine metabolism. The underlying genetic defect is a mutation in the gene for fumarylacetate hydrolase (FAH), and more than 30 different mutations in this gene have been identified. The main clinical consequences of this defect i...

journal_title：Annals of medicine

authors： Pitkänen ST,Salo MK,Heikinheimo M

更新日期：2000-11-01 00:00:00

abstract：:Among the approximately 7,000 cytogenetically abnormal childhood and adult B- and T-lineage acute lymphoblastic leukemias (ALL) published to date, numerous recurring chromosomal aberrations and abnormality patterns have been identified, and it has been clearly shown that the cytogenetic features often correlate closel...

journal_title：Annals of medicine

authors： Johansson B,Mertens F,Mitelman F

更新日期：2004-01-01 00:00:00

abstract：:Autoantibodies directed to intracellular antigens can be detected in many systemic rheumatic diseases. In this review, we discuss the clinical significance of antinuclear antibodies (ANA) associated with systemic lupus erythematosus (SLE), Slögren's syndrome, scleroderma and polymyositis/dermatomyositis, the immunogen...

journal_title：Annals of medicine

authors： Hietarinta M,Lassila O

更新日期：1996-08-01 00:00:00