Antibody titres in Helicobacter pylori infection: implications in the follow-up of antimicrobial therapy.

abstract：:Antisense oligonucleotides represent a novel class of potential drugs for highly selective blocking of genes. The basic concept of antisense strategy is simple: an antisense molecule recognizes a complementary mRNA (or DNA) by sequence-specific base pairing, and hence prevents translation (or transcription), resulting...

journal_title：Annals of medicine

authors： Lönnberg H,Vuorio E

更新日期：1996-12-01 00:00:00

abstract：:Erythropoietin (EPO) is of special interest in the perinatal period in the mother and fetus. On the one hand, thanks to the recent development of highly sensitive radio-immunoassays and the ability to monitor endogenous EPO production, we can now study the physiological aspects of maternal and fetal erythropoiesis and...

journal_title：Annals of medicine

authors： Huch R,Huch A

更新日期：1993-06-01 00:00:00

abstract：:The effect of different clinical conditions on urinary dolichols was studied in 219 hospital patients and in 24 pregnant women. Significantly increased urinary dolichol levels were found in patients with severe bacterial infections (mean +/- SEM, 37.5 +/- 8.0 micrograms/mmol creatinine, P less than 0.001), in patients...

journal_title：Annals of medicine

authors： Roine R,Humaloja K,Hämäläinen J,Nykänen I,Ylikahri R,Salaspuro M

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:The association between otitis media and vestibular symptoms has been hypothesized in the past. Thus, in this study, we aimed to critically analyze (based in a systematic review of the literature) whether patients who have otitis media are at greater risk of developing vestibular impairment or not. METHODS:...

journal_title：Annals of medicine

authors： Monsanto RDC,Kasemodel ALP,Tomaz A,Paparella MM,Penido NO

更新日期：2018-08-01 00:00:00

abstract：:Obesity in males is accompanied by a significant decrease in testosterone levels. This decrease is essentially a consequence of the decrease of the sex hormone binding hormone (SHBG) binding capacity, itself probably the consequence of the increased insulin levels. In moderate obesity, free testosterone levels are nor...

journal_title：Annals of medicine

authors： Vermeulen A

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND AIMS:A mild increase in liver enzyme levels is sometimes observed in patients with diabetic ketosis or ketoacidosis. The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ke...

journal_title：Annals of medicine

authors： Takaike H,Uchigata Y,Iwamoto Y,Imagawa A,Iwahashi H,Kanatsuka A,Kawasaki E,Kobayashi T,Shimada A,Shimizu I,Maruyama T,Hanafusa T,Makino H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Obese youths may be susceptible to develop the metabolic syndrome (MS) later in life. AIM:To study childhood predictors of MS in adulthood. METHOD:Prospective cohort study including 2,195 subjects, aged 3-18 years at base-line in 1980, who were re-examined in 1983, 1986, and 2001. RESULTS:In adults (aged ...

journal_title：Annals of medicine

authors： Mattsson N,Rönnemaa T,Juonala M,Viikari JS,Raitakari OT

更新日期：2008-01-01 00:00:00

abstract：AIM:To evaluate if pulse pressure (PP) is a risk predictor for atrial fibrillation (AF) in a longitudinal study of 60-year-old men and women from Stockholm (n = 4,232), free from AF at baseline, with primary end-point incident AF. METHODS:AF diagnoses were obtained from the national hospital discharge register. The es...

journal_title：Annals of medicine

authors： Miedel C,Leander K,de Faire U,Gigante B

更新日期：2015-01-01 00:00:00

abstract：:The circadian rhythms of night shift workers do not usually adjust to their unusual work and sleep schedules, reducing their quality of life and producing potentially dangerous health and safety problems. This paper reviews field studies of simulated night work in which shifted light-dark cycles were constructed with ...

journal_title：Annals of medicine

authors： Eastman CI,Martin SK

更新日期：1999-04-01 00:00:00

abstract：:Abdominal obesity in man is an integrated part of the Metabolic Syndrome, and is associated with a complex neuroendocrine disturbance. Its consequences for the metabolism of the periphery seems to be insulin resistance caused by a combination of a relative hypercortisolaemia and a relative deficiency of sex steroid ho...

journal_title：Annals of medicine

authors： Björntorp P

更新日期：1992-12-01 00:00:00

abstract：:The goals of this chapter are to provide a brief review of the biology of the protein C pathway and some of the features of the pathway that make it uniquely positioned to control microvascular coagulation and control the acute inflammatory response. Activated protein C works as an antithrombotic agent by inactivating...

journal_title：Annals of medicine

authors： Esmon CT

更新日期：2002-01-01 00:00:00

abstract：:The molecular circadian clock entrains biological rhythms to a 24-hour schedule. Aspects of cardiovascular physiology and, indeed, the incidence of myocardial infarction and stroke are also subject to diurnal variation. The use of rodent models of disrupted clock function has begun to elucidate the role of the molecul...

journal_title：Annals of medicine

authors： Curtis AM,Fitzgerald GA

更新日期：2006-01-01 00:00:00

abstract：:Despite intensive research in spondyloarthritis pathogenesis, some important questions still remain unanswered, particularly concerning enthesis new bone formation. Several evidences suggest that it prevalently occurs by endochondral ossification, however it remains to identify factors that can induce and influence it...

journal_title：Annals of medicine

authors： Neve A,Maruotti N,Corrado A,Cantatore FP

更新日期：2017-05-01 00:00:00

abstract：:When the optimal chemotherapy regimen for advanced ovarian cancer is discussed the following should be considered: the type and number of drugs, the dose of individual drugs and the number of cycles. Optimal chemotherapy should include a platinum compound, because platinum-based chemotherapy yields a superior response...

journal_title：Annals of medicine

authors： Bertelsen K

更新日期：1995-02-01 00:00:00

abstract：:Endothelial health is a key factor in normal cardiovascular homeostasis, and recent studies have revealed several important functions of the vascular endothelium that protect against atherothrombosis. These include control over arterial tone, coagulation, fibrinolysis, and vascular growth. Consequently, endothelial dy...

journal_title：Annals of medicine

authors： Raitakari OT,Celermajer DS

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...

journal_title：Annals of medicine

authors： Oksanen AM,Lemmelä SM,Järvelä IE,Rautelin HI

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in ant...

journal_title：Annals of medicine

authors： Bah A,Nuotio I,Grönberg T,Ylitalo A,Airaksinen KE,Hartikainen JE

更新日期：2017-05-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with an increased risk of ischemic stroke (IS) and systemic embolism (SE). Stroke prevention is a key element for the overall management of AF patients. The non-vitamin K antagonist oral anticoagulants (NOACs), such as dabigatran, rivaroxaban,...

journal_title：Annals of medicine

authors： Li YG,Pastori D,Lip GYH

更新日期：2018-06-01 00:00:00

abstract：:Large granular lymphocytic (LGL) leukemia is an incurable chronic disease, characterized by clonal expansion of cytotoxic T- or NK-cells in blood and bone marrow. Cytopenias (anemia, neutropenia) and autoimmune disorders such as rheumatoid arthritis are the most common clinical manifestations of LGL leukemia. Recently...

journal_title：Annals of medicine

authors： Rajala HL,Porkka K,Maciejewski JP,Loughran TP Jr,Mustjoki S

更新日期：2014-05-01 00:00:00

abstract：:This study examined the predictive validity of preadolescent Type A determinants for Type A dimensions in young adulthood (n = 375). Predictive variables, i.e. hyperactivity, aggression, social maladjustment and self-esteem were measured when the subjects were aged 12. Type A dimensions, i.e. hard-driving, competitive...

journal_title：Annals of medicine

authors： Keltikangas-Järvinen L,Räikkönen K,Keskivaara P,Pietikäinen M,Viikari J,Kaprio EA,Akerblom HK

更新日期：1991-02-01 00:00:00

abstract：:In the aetiological diagnosis of pulmonary infections in patients affected by haematological malignancies we evaluated the utility of bronchoalveolar lavage (BAL). One hundred and twenty-seven BAL were performed in 119 patients. In our series, we identified the agent of pneumonia in 53.5% of episodes with the best res...

journal_title：Annals of medicine

authors： Pagano L,Pagliari G,Basso A,Marra R,Sica S,Frigieri L,Morace G,Ardito F,Leone G

更新日期：1997-12-01 00:00:00

abstract：:Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocre...

journal_title：Annals of medicine

authors： Tafti M,Maret S,Dauvilliers Y

更新日期：2005-01-01 00:00:00

abstract：:Epidemiological and experimental studies indicate an inverse relationship between the risk of colon cancer development and intake of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). All NSAIDs are known inhibitors of cyclo-oxygenase, the enzyme responsible for converting arachidonic acid to prostagland...

journal_title：Annals of medicine

authors： Gustafson-Svärd C,Lilja I,Hallböök O,Sjödahl R

更新日期：1997-06-01 00:00:00

abstract：INTRODUCTION:Aiming at identifying biomarkers for hypertrophic cardiomyopathy (HCM), the serum proteome was explored through a two-dimensional gel-based proteomic approach (2D-DIGE) coupled with mass spectrometry and database interrogation. METHODS:Serum samples from 20 male HCM patients and their sex- and age-matched...

journal_title：Annals of medicine

authors： Orenes-Piñero E,Hernández-Romero D,de Torre C,Vilchez JA,Martínez M,Romero-Aniorte AI,Climent V,García-Honrubia A,Valdés M,Marín F

更新日期：2013-06-01 00:00:00

abstract：:Hereditary tyrosinaemia type I is the most common of the diseases caused by defects in tyrosine metabolism. The underlying genetic defect is a mutation in the gene for fumarylacetate hydrolase (FAH), and more than 30 different mutations in this gene have been identified. The main clinical consequences of this defect i...

journal_title：Annals of medicine

authors： Pitkänen ST,Salo MK,Heikinheimo M

更新日期：2000-11-01 00:00:00

abstract：:Bone fractures affecting elderly people are a true public health burden, because they represent one of the most important causes of long-standing pain, functional impairment, disability, and death among this population. Compromised bone strength (osteoporosis) and falling, alone, or more frequently in combination, are...

journal_title：Annals of medicine

authors： Kannus P,Uusi-Rasi K,Palvanen M,Parkkari J

更新日期：2005-01-01 00:00:00

abstract：:Clinical experience has indicated that the effects of RU 486 can be divided into dose-dependent and dose-independent effects. Examples of the dose-dependent effects include the antiglucocorticoid effects of RU 486, whereas pregnancy termination or dilatation of the cervix can be considered dose-independent with the va...

journal_title：Annals of medicine

authors： Heikinheimo O,Kekkonen R

更新日期：1993-02-01 00:00:00

abstract：:Regenerative medicine is a multidisciplinary field utilizing the potential of stem cells and the regenerative capability of the body to restore, maintain, or enhance tissue and organ functions. Stem cells are unspecialized cells that can self-renew but also differentiate into several somatic cells when subjected the a...

journal_title：Annals of medicine

authors： Kaivosoja E,Barreto G,Levón K,Virtanen S,Ainola M,Konttinen YT

更新日期：2012-11-01 00:00:00

abstract：:Copper is a trace element necessary for the normal function of several important enzymes but copper homeostasis is still poorly understood. In recent years remarkable progress has been made in this field following the isolation of the gene defective in Menkes disease. Menkes disease and occipital horn syndrome are X-l...

journal_title：Annals of medicine

authors： Tümer Z,Horn N

更新日期：1996-04-01 00:00:00

abstract：:Despite the monumental success of childhood prophylactic vaccination, there is no similar program designed to provide protection as we age against adult onset diseases like breast cancer. Instead, the predominant focus of current cancer vaccine strategy is to vaccinate after the tumors become established. This strateg...

journal_title：Annals of medicine

authors： Tuohy VK,Jaini R

更新日期：2011-08-01 00:00:00