Abstract:
:Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocretin/orexin gene have been found as the cause of a few sleep disorders but the possibility that other gene defects may contribute to the pathophysiology of major sleep disorders is worth in-depth investigations. However, single gene disorders are rare and most common disorders are complex in terms of their genetic susceptibility, environmental effects, gene-gene, and gene-environment interactions. We review here the current progress in the genetics of normal and pathological sleep.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Tafti M,Maret S,Dauvilliers Ydoi
10.1080/07853890500372047subject
Has Abstractpub_date
2005-01-01 00:00:00pages
580-9issue
8eissn
0785-3890issn
1365-2060pii
H715455442646728journal_volume
37pub_type
杂志文章,评审abstract::The effect of different clinical conditions on urinary dolichols was studied in 219 hospital patients and in 24 pregnant women. Significantly increased urinary dolichol levels were found in patients with severe bacterial infections (mean +/- SEM, 37.5 +/- 8.0 micrograms/mmol creatinine, P less than 0.001), in patients...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853898909149176
更新日期:1989-02-01 00:00:00
abstract::Concepts of eating disorders have altered so that anorexia nervosa is now recognized as an important but uncommon syndrome within a spectrum of disordered eating. Behaviours used by dieters constitute the mild end of the eating disorder spectrum. Dieting in young women is for the most part a transient and benign activ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899209149955
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Both depression and the metabolic syndrome are frequently found among patients with type 1 diabetes, but their potential association has not yet been investigated. In this paper the relationship between depression and the metabolic syndrome among patients with type 1 diabetes was evaluated. METHODS:A total ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2010.503660
更新日期:2010-10-01 00:00:00
abstract::Transvaginal ultrasonic monitoring of the lower uterine segment was performed in 15 pregnancies in which the mother had previously had three or more caesarean sections. The typical findings were thinning of the myometrium, asymmetric isthmal structures and ventral ballooning of the isthmus. An image of the other of th...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899009147256
更新日期:1990-04-01 00:00:00
abstract::Hemostasis is traditionally defined as a physiological response to blood vessel injury and bleeding, which entails a co-ordinated process involving the blood vessel, platelets, and blood clotting proteins (i.e. coagulation factors). Hemostasis can be divided into primary and secondary components. The former rapidly in...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2011.576698
更新日期:2012-08-01 00:00:00
abstract::Research in developing countries is essential for the evaluation of the safety, efficacy and acceptability of both new and already available contraceptives. Research conducted by scientists in developing countries has also played an essential role in the development of new contraceptives. The continuous delivery of pr...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899309147858
更新日期:1993-02-01 00:00:00
abstract::Pancreatic beta-cell dysfunction and insulin resistance are two interrelated defects in the pathophysiology of type 2 diabetes. Defects in peripheral insulin action precede the development of glucose intolerance, as the pancreas compensates for insulin resistance by increasing insulin production and secretion. This ma...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/078538902321012397
更新日期:2002-01-01 00:00:00
abstract::Certain bacterial infections have been demonstrated to be causative of reactive arthritis. The most common bacterial trigger of reactive arthritis is Chlamydia trachomatis. Chlamydia pneumoniae is another known cause, albeit far less frequently. Although Chlamydia-induced reactive arthritis will often spontaneously re...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2011.606830
更新日期:2012-12-01 00:00:00
abstract::Insulin resistance in humans is not always accompanied by obesity, since severe insulin resistance also characterizes patients lacking subcutaneous fat such as those with HAART- (highly-active antiretroviral therapy)-associated lipodystrophy. Both obese and lipodystrophic patients, however, have an increase in the amo...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890510037383
更新日期:2005-01-01 00:00:00
abstract::On theoretical grounds, an apo E receptor defect should be manifested by the accumulation of lipoprotein remnants that are normally cleared by this receptor and cannot be processed by the normal apo B, E receptor (LDL-receptor). Furthermore, the defect should not be selective for a specific apo E phenotype since none ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899109148042
更新日期:1991-04-01 00:00:00
abstract::Aim: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during the last decade. Methods: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for aortic stenosis from 2008 to 2017. Results: The annua...
journal_title:Annals of medicine
pub_type: 临床试验,杂志文章
doi:10.1080/07853890.2019.1614657
更新日期:2019-01-01 00:00:00
abstract::In order to assess the effectiveness of lifestyle interventions in reducing cardiovascular disease risk factors, morbidity and mortality among working-age adults, we undertook a systematic review of randomized controlled trials of various lifestyle interventions (diet, exercise, smoking cessation, alcohol intake reduc...
journal_title:Annals of medicine
pub_type: 杂志文章,meta分析
doi:10.3109/07853890009011767
更新日期:2000-05-01 00:00:00
abstract::Dementia of the Alzheimer type (AD) is clinically characterized by a progressive deterioration of intellect, memory, judgment, and abstract thinking. It is incurable, and causal therapy is not yet available. For the development of therapeutic drugs, valid animal models are needed that mimic the pathophysiological chan...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899809002606
更新日期:1998-12-01 00:00:00
abstract::This study examined the predictive validity of preadolescent Type A determinants for Type A dimensions in young adulthood (n = 375). Predictive variables, i.e. hyperactivity, aggression, social maladjustment and self-esteem were measured when the subjects were aged 12. Type A dimensions, i.e. hard-driving, competitive...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899109147935
更新日期:1991-02-01 00:00:00
abstract::Susceptibility to insulin-dependent diabetes mellitus (IDDM) correlates with the absence of aspartic acid in position 57 of the DQB1 and/or the presence of arginine in position 52 of the DQA1. It has been postulated that transcomplementation between the DQ alpha and beta chains of the two haplotypes could create new m...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899209167007
更新日期:1992-12-01 00:00:00
abstract::The Human Genome Project (HGP), as the primary sequencing of the human genome, lasted more than one decade to be completed using the traditional Sanger's method. At present, next-generation sequencing (NGS) technology could provide the genome sequence data in hours. NGS has also decreased the expense of sequencing; th...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890.2017.1392595
更新日期:2018-03-01 00:00:00
abstract:AIM:Previous studies have shown that both triglyceride glucose (TyG) and haemoglobin glycation indexes (HGI) are predictors of cardiovascular risk. However, the prognostic value of TyG index and HGI in patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD) is not determined. METHODS:We ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2018.1523549
更新日期:2018-11-01 00:00:00
abstract::There are few relevant animal models for neurodegenerative diseases to be used for human drug development. Most current drugs for neurodegenerative diseases act through different neurotransmitter systems. Positron emission tomography (PET) is a unique tool in the study of neurodegenerative diseases as it enables quant...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899908998803
更新日期:1999-12-01 00:00:00
abstract:AIM:To evaluate the effects of canrenone compared to placebo on blood pressure control, some non-conventional biomarkers in cardiovascular stratification, and on metalloproteinases in patients affected by metabolic syndrome. METHODS:A total of 156 Caucasian patients were treated with placebo or canrenone, 50 mg once a...
journal_title:Annals of medicine
pub_type: 杂志文章,随机对照试验
doi:10.3109/07853890.2014.969303
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS:To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890903022801
更新日期:2009-01-01 00:00:00
abstract::Despite the monumental success of childhood prophylactic vaccination, there is no similar program designed to provide protection as we age against adult onset diseases like breast cancer. Instead, the predominant focus of current cancer vaccine strategy is to vaccinate after the tumors become established. This strateg...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2011.565065
更新日期:2011-08-01 00:00:00
abstract::A 33-year old man suddenly dropped dead during a military march. He had complained of non-specific thoracoabdominal symptoms, pain and fatigue for a year before his death. Autopsy showed coronary polyarteritis nodosa of the left main coronary artery. This patient seems to be only the second case with isolated polyarte...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899009147262
更新日期:1990-06-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, are therapeutic groups widely used for the treatment of pain, inflammation and fever. There is growing experimental and clinical evidence indicating NSAIDs and COX-2 inhibitors also have anti-cancer activity. Epidemiologi...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890310017053
更新日期:2003-01-01 00:00:00
abstract::Human anxiety disorders represent one of the most common mental illnesses. They are complex diseases with both genetic and environmental factors affecting their predisposition. Since the basic neuronal mechanisms are shared across mammalian species, the same set of genes may regulate critical aspects of anxiety in hum...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890701747096
更新日期:2008-01-01 00:00:00
abstract::Introduction: The use of dipeptidyl peptidase-4 inhibitors in hospitalized patients is an area of active research. We aimed to compare the efficacy and the safety of the basal-bolus insulin regimen versus linagliptin-basal insulin in non-critically ill non-cardiac surgery patients in a real-world setting. Methods: We ...
journal_title:Annals of medicine
pub_type: 杂志文章,多中心研究
doi:10.1080/07853890.2019.1613672
更新日期:2019-01-01 00:00:00
abstract::Large granular lymphocytic (LGL) leukemia is an incurable chronic disease, characterized by clonal expansion of cytotoxic T- or NK-cells in blood and bone marrow. Cytopenias (anemia, neutropenia) and autoimmune disorders such as rheumatoid arthritis are the most common clinical manifestations of LGL leukemia. Recently...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2014.882105
更新日期:2014-05-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease caused by mutations in sarcomeric proteins. It is characterized by left ventricular hypertrophy in the absence of an increased external load, and myofibrillar disarray. While hypertrophy is a common cardiac response to injury, disarray is the pathologi...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:1998-08-01 00:00:00
abstract::The purpose of this study was to test the applicability of exercise echocardiography in the diagnosis of coronary artery disease. The results were compared to findings of coronary angiography. 118 patients, 100 males and 18 females, who were all referred to coronary angiography for suspected ischaemic heart disease, u...
journal_title:Annals of medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07853899608999078
更新日期:1996-02-01 00:00:00
abstract::This meta-analysis examined the effect of probiotics on the reduction of lipid components and coexisting risk factors associated with cardiovascular disease. All randomized controlled trials published in English on PubMed and Scopus from 2000 to 2014 were systematically searched. Using the PEDro scale to assess the qu...
journal_title:Annals of medicine
pub_type: 杂志文章,meta分析,评审
doi:10.3109/07853890.2015.1071872
更新日期:2015-01-01 00:00:00
abstract::Study of the growth and development of cartilage and bone has been difficult because the structure of the tissues makes biological experiments hard to conduct. Recent advances in molecular biology have offered new possibilities for studying these processes. Many cartilage and bone specific cDNAs have been cloned and c...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899109148050
更新日期:1991-08-01 00:00:00