Genes for normal sleep and sleep disorders.

Abstract:

:Sleep and wakefulness are complex behaviors that are influenced by many genetic and environmental factors, which are beginning to be discovered. The contribution of genetic components to sleep disorders is also increasingly recognized as important. Point mutations in the prion protein, period 2, and the prepro-hypocretin/orexin gene have been found as the cause of a few sleep disorders but the possibility that other gene defects may contribute to the pathophysiology of major sleep disorders is worth in-depth investigations. However, single gene disorders are rare and most common disorders are complex in terms of their genetic susceptibility, environmental effects, gene-gene, and gene-environment interactions. We review here the current progress in the genetics of normal and pathological sleep.

journal_name

Ann Med

journal_title

Annals of medicine

authors

Tafti M,Maret S,Dauvilliers Y

doi

10.1080/07853890500372047

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

580-9

issue

8

eissn

0785-3890

issn

1365-2060

pii

H715455442646728

journal_volume

37

pub_type

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