Abstract:
BACKGROUND AIMS:A mild increase in liver enzyme levels is sometimes observed in patients with diabetic ketosis or ketoacidosis. The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ketosis or ketoacidosis. METHODS:We analyzed data on the liver transaminase levels of 108 patients over 18 years of age with newly diagnosed type 1 diabetes complicated by ketosis or ketoacidosis. The data were collated from a nationwide survey on fulminant type 1 diabetes and retrospective medical records. RESULTS:Thirty-two (60.4%) out of the 53 patients suffering from fulminant type 1 diabetes were detected with transient elevation of liver transaminase (TELT) levels during the first month after initiation of insulin therapy; in the case of acute-onset type 1 diabetes, such an observation was noted in 16 (29.1%) out of 55 patients. Fatty liver was diagnosed in 20% of the patients, and 65% of these patients exhibited TELT. The dosage of insulin injected in these patients was significantly high. CONCLUSIONS:High blood glucose and fatty liver may influence the elevation of liver transaminase levels during the treatment of new-onset type 1 diabetes.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Takaike H,Uchigata Y,Iwamoto Y,Imagawa A,Iwahashi H,Kanatsuka A,Kawasaki E,Kobayashi T,Shimada A,Shimizu I,Maruyama T,Hanafusa T,Makino Hdoi
10.1080/07853890802032711subject
Has Abstractpub_date
2008-01-01 00:00:00pages
395-400issue
5eissn
0785-3890issn
1365-2060pii
792070280journal_volume
40pub_type
杂志文章abstract:BACKGROUND:There is an unmet need for a straightforward and cost-effective assessment of multiple lipoprotein risk factors for vascular diseases. AIMS:1) To study the relation of various lipoprotein lipid and apolipoprotein (apo) measures on the Friedewald inputs, i.e. plasma triglycerides (TG), cholesterol (TC), and ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890902893392
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journal_title:Annals of medicine
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journal_title:Annals of medicine
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journal_title:Annals of medicine
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Annals of medicine
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abstract::Autism is a complex neurodevelopmental disorder characterized by impairment in social interaction accompanied by a delay or lack of language, restricted interests, stereotyped behavior, and repetitive movement. Genetic predisposition to autism is evident from family and twin studies, and heritability in idiopathic aut...
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journal_title:Annals of medicine
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journal_title:Annals of medicine
pub_type: 杂志文章,评审
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journal_title:Annals of medicine
pub_type: 杂志文章,多中心研究
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更新日期:2001-02-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, are therapeutic groups widely used for the treatment of pain, inflammation and fever. There is growing experimental and clinical evidence indicating NSAIDs and COX-2 inhibitors also have anti-cancer activity. Epidemiologi...
journal_title:Annals of medicine
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journal_title:Annals of medicine
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journal_title:Annals of medicine
pub_type: 社论
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