Cardiovascular Risk in Young Finns Study: general outline and recent developments.


:The Cardiovascular Risk in Young Finns Study is a collaborative effort of all university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country. The main cross-sectional study carried out in 1980 included 3596 3-18-year-old subjects. Follow-up studies have been performed in 1983, 1986, 1989 and 1992; in the last of these studies the subjects were 15-30 years old. The findings in anthropometry, obesity and blood pressure have been rather similar to reports from other countries in Europe. However, serum cholesterol and low-density lipoprotein cholesterol concentrations were higher than in other countries, 4.83 mmol/L and 3.09 mmol/L, respectively in 1980. By 1992 a decrease of 8% took place, probably as a result of dietary changes. Apolipoprotein phenotypes E4E4 or E4E3 were relatively frequent (34%) in the sample. Tracking and clustering have also been studied. Serum insulin levels predicted the clustering of the typical risk factor profile associated with insulin resistance syndrome. The dietary polyunsaturated to saturated fat (P/S) ratio increased from 0.26 in 1980 to 0.39 in 1992, with no significant changes in the total energy derived from fat. 'Hard-driving' was found to be the psychological risk factor most consistently related to the CHD risk factor level.


Ann Med


Annals of medicine


Akerblom HK,Viikari J,Raitakari OT,Uhari M


Has Abstract


1999-04-01 00:00:00








31 Suppl 1


  • Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects.

    abstract:OBJECTIVE:Rapid weight loss with very-low-calorie diet (VLCD) is known to improve insulin sensitivity and decrease adipose tissue masses. The aim was to investigate the effects of VLCD on adipose tissue regional glucose uptake (rGU) and perfusion and their association with adipokines. RESEARCH DESIGN AND METHODS:Sixte...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Viljanen AP,Lautamäki R,Järvisalo M,Parkkola R,Huupponen R,Lehtimäki T,Rönnemaa T,Raitakari OT,Iozzo P,Nuutila P

    更新日期:2009-01-01 00:00:00

  • Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition.

    abstract::In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the e...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Wilhelmi de Toledo F,Grundler F,Sirtori CR,Ruscica M

    更新日期:2020-08-01 00:00:00

  • Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence.

    abstract:PURPOSE:Evidence on the association between depression, antidepressant use and venous thromboembolism (VTE) risk is conflicting. We conducted a systematic review and meta-analysis of published observational studies evaluating the associations of depression and antidepressant use with VTE risk. DESIGN:Eligible studies ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,meta分析


    authors: Kunutsor SK,Seidu S,Khunti K

    更新日期:2018-09-01 00:00:00

  • Optimal chemotherapy of ovarian cancer with an old regimen.

    abstract::When the optimal chemotherapy regimen for advanced ovarian cancer is discussed the following should be considered: the type and number of drugs, the dose of individual drugs and the number of cycles. Optimal chemotherapy should include a platinum compound, because platinum-based chemotherapy yields a superior response...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Bertelsen K

    更新日期:1995-02-01 00:00:00

  • Sleep and cardiac rhythm in healthy men.

    abstract::Cardiac rhythm during sleep was analysed in 168 healthy men aged 19 to 30 (mean 21.8) years using continuous nocturnal ECG recordings. Thirty five of the subjects were endurance athletes; 99 were recorded at home and 69 at a garrison during military service. The number of short term (less than one min) accelerations o...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Viitasalo M,Halonen L,Partinen M,Iivanainen M,Kala R,Eisalo A

    更新日期:1991-04-01 00:00:00

  • The fibromyalgia syndrome.

    abstract::The term fibromyalgia describes a complex syndrome characterized by pain amplification, musculoskeletal discomfort, and systemic symptoms. Although its existence has been controversial, nearly all rheumatologists now accept fibromyalgia as a distinct diagnostic entity. In fact, in the United States it is the third or ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Wallace DJ

    更新日期:1997-02-01 00:00:00

  • Drug development for neurodegenerative diseases: role of PET.

    abstract::There are few relevant animal models for neurodegenerative diseases to be used for human drug development. Most current drugs for neurodegenerative diseases act through different neurotransmitter systems. Positron emission tomography (PET) is a unique tool in the study of neurodegenerative diseases as it enables quant...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Rinne JO

    更新日期:1999-12-01 00:00:00

  • Assessment of endothelial (dys)function in atrial fibrillation.

    abstract::Atrial fibrillation (AF) is associated with an increased risk of mortality and morbidity from stroke and thromboembolism. Endothelial damage or dysfunction may contribute to this increased risk of thromboembolism via the mediation of a prothrombotic or hypercoagulable state. However, the precise pathophysiological mec...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Krishnamoorthy S,Lim SH,Lip GY

    更新日期:2009-01-01 00:00:00

  • Clinical significance of antinuclear antibodies in systemic rheumatic diseases.

    abstract::Autoantibodies directed to intracellular antigens can be detected in many systemic rheumatic diseases. In this review, we discuss the clinical significance of antinuclear antibodies (ANA) associated with systemic lupus erythematosus (SLE), Slögren's syndrome, scleroderma and polymyositis/dermatomyositis, the immunogen...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Hietarinta M,Lassila O

    更新日期:1996-08-01 00:00:00

  • Coenzyme Q10, alpha-tocopherol and free cholesterol in HDL and LDL fractions.

    abstract::Twenty-three randomly selected plasma samples from apparently healthy, middle aged men were analysed for coenzyme Q10 (CoQ10), alpha-tocopherol (AT) and free cholesterol (FC) in: 1) whole plasma, 2) the HDL lipoprotein fraction after LDL precipitation (VLDL + LDL). CoQ10, AT and FC in plasma averaged 0.69 +/- .11, 6.7...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Johansen K,Theorell H,Karlsson J,Diamant B,Folkers K

    更新日期:1991-12-01 00:00:00

  • What is a pathogen?

    abstract::The question 'what is a pathogen?' derives from pathogen-centered views of microbial pathogenesis that invoke microbial characteristics to explain virulence. However, virulence cannot be an independent microbial variable since it is only expressed in a susceptible host. Hence, the question 'what is a pathogen?' cannot...

    journal_title:Annals of medicine

    pub_type: 社论


    authors: Casadevall A,Pirofski LA

    更新日期:2002-01-01 00:00:00

  • Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.

    abstract::The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) can be related to abnormalities in the metabolism and disposition of sex hormones and/or bile acids, determined by a genetic predisposition interacting with environmental factors. The total amount of oestrogens and progesterone circulating in the blood or...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Reyes H,Sjövall J

    更新日期:2000-03-01 00:00:00

  • Cancer, stem cells, and oncolytic viruses.

    abstract::Cells with stem cell-like attributes, such as self-renewal and pluripotency, have been isolated from hematological malignancies and from several solid tumor types. Tumor-initiating cells, also referred to as cancer stem cells, are thought to be responsible for the initiation and growth of tumors. Like their normal cou...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Ribacka C,Pesonen S,Hemminki A

    更新日期:2008-01-01 00:00:00

  • Association between low-grade albuminuria and hearing impairment in a non-diabetic Korean population: The Korea National Health and Nutrition Examination Survey (2011-2013).

    abstract:INTRODUCTION:The objective of the present study was to examine the association between low-grade albuminuria and hearing impairment in the non-diabetic population. MATERIALS AND METHODS:Data from the Korean National Health and Nutrition Examination Survey 2011-2013 were used in the analyses. Participants were excluded...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Kang SH,Jung DJ,Choi EW,Park JW,Cho KH,Yoon KW,Do JY

    更新日期:2015-01-01 00:00:00

  • Benchmarking Controlled Trial--a novel concept covering all observational effectiveness studies.

    abstract::The Benchmarking Controlled Trial (BCT) is a novel concept which covers all observational studies aiming to assess effectiveness. BCTs provide evidence of the comparative effectiveness between health service providers, and of effectiveness due to particular features of the health and social care systems. BCTs compleme...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Malmivaara A

    更新日期:2015-06-01 00:00:00

  • Childhood predictors of the metabolic syndrome in adulthood. The Cardiovascular Risk in Young Finns Study.

    abstract:BACKGROUND:Obese youths may be susceptible to develop the metabolic syndrome (MS) later in life. AIM:To study childhood predictors of MS in adulthood. METHOD:Prospective cohort study including 2,195 subjects, aged 3-18 years at base-line in 1980, who were re-examined in 1983, 1986, and 2001. RESULTS:In adults (aged ...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Mattsson N,Rönnemaa T,Juonala M,Viikari JS,Raitakari OT

    更新日期:2008-01-01 00:00:00

  • Diagnosis and treatment of vulvodynia.

    abstract::Vulvodynia is a complex multifactorial and multidisciplinary clinical syndrome of unexplained vulvar pain, sexual dysfunction, and psychological disability. Because of the absence of abnormal physical findings among such patients, vulvodynia was long thought to be solely a psychosomatic syndrome. The incidence or prev...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Paavonen J

    更新日期:1995-04-01 00:00:00

  • Small cell carcinoma of the prostate presenting with Cushing Syndrome. A narrative review of an uncommon condition.

    abstract::Small cell carcinoma (SCC) of the prostate is an uncommon condition; there are very few cases in which presenting symptoms are consistent with Cushing Syndrome (CS). We report a new case in which CS triggers the suspicion of an SCC of the prostate and a review of the published cases of SCC of the prostate presenting w...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Rueda-Camino JA,Losada-Vila B,De Ancos-Aracil CL,Rodríguez-Lajusticia L,Tardío JC,Zapatero-Gaviria A

    更新日期:2016-01-01 00:00:00

  • Eating disorders: antecedents, evolution and course.

    abstract::Concepts of eating disorders have altered so that anorexia nervosa is now recognized as an important but uncommon syndrome within a spectrum of disordered eating. Behaviours used by dieters constitute the mild end of the eating disorder spectrum. Dieting in young women is for the most part a transient and benign activ...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Patton GC

    更新日期:1992-08-01 00:00:00

  • Undetermined stroke with an embolic pattern--a common phenotype with high early recurrence risk.

    abstract:INTRODUCTION:Undetermined strokes with an embolic pattern (USEP) represent a common phenotype. We assessed their frequency and compared USEP with cardioembolic stroke with a known source and non-cardioembolic stroke etiology. METHODS:Study patients were 540 consecutive ischemic stroke patients admitted to Helsinki Uni...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Putaala J,Nieminen T,Haapaniemi E,Meretoja A,Rantanen K,Heikkinen N,Kinnunen J,Strbian D,Mustanoja S,Curtze S,Pakarinen S,Lehto M,Tatlisumak T

    更新日期:2015-01-01 00:00:00

  • Medical research on a complaint: orientation and priorities.

    abstract::Low back pain as a research topic has been treated in this symposium, as in other contexts, as though it were an illness. It is, however, a complaint - and as such, even, potentially not a genuine one. Appreciation of the true character of back pain is essential for the proper orientation and setting of priorities for...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Miettinen OS,Caro JJ

    更新日期:1989-10-01 00:00:00

  • MicroRNA: potential biomarkers and therapeutic targets for allergic asthma?

    abstract::MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). However, alterations in their le...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Tay HL,Plank M,Collison A,Mattes J,Kumar RK,Foster PS

    更新日期:2014-12-01 00:00:00

  • Extensive phenotype data and machine learning in prediction of mortality in acute coronary syndrome - the MADDEC study.

    abstract::Objective: Investigation of the clinical potential of extensive phenotype data and machine learning (ML) in the prediction of mortality in acute coronary syndrome (ACS). Methods: The value of ML and extensive clinical data was analyzed in a retrospective registry study of 9066 consecutive ACS patients (January 2007 to...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Hernesniemi JA,Mahdiani S,Tynkkynen JA,Lyytikäinen LP,Mishra PP,Lehtimäki T,Eskola M,Nikus K,Antila K,Oksala N

    更新日期:2019-03-01 00:00:00

  • Carotid atherosclerosis in relation to systolic and diastolic blood pressure: Kuopio Ischaemic Heart Disease Risk Factor Study.

    abstract::We investigated the association of systolic and diastolic blood pressure and hypertension with two different manifestations of carotid atherosclerosis in a random population sample of 1165 Eastern Finnish men aged 42, 48, 54 or 60 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study. Carotid atheros...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Salonen R,Salonen JT

    更新日期:1991-02-01 00:00:00

  • Hereditary tyrosinaemia type I: from basics to progress in treatment.

    abstract::Hereditary tyrosinaemia type I is the most common of the diseases caused by defects in tyrosine metabolism. The underlying genetic defect is a mutation in the gene for fumarylacetate hydrolase (FAH), and more than 30 different mutations in this gene have been identified. The main clinical consequences of this defect i...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Pitkänen ST,Salo MK,Heikinheimo M

    更新日期:2000-11-01 00:00:00

  • Study and introduction of family planning methods in developing countries.

    abstract::Research in developing countries is essential for the evaluation of the safety, efficacy and acceptability of both new and already available contraceptives. Research conducted by scientists in developing countries has also played an essential role in the development of new contraceptives. The continuous delivery of pr...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Rivera R

    更新日期:1993-02-01 00:00:00

  • The Caveolin genes: from cell biology to medicine.

    abstract::Caveolae are vesicular organelles (50-100-nm in diameter) that are particularly abundant in cells of the cardiovascular system, including endothelial cells, smooth muscle cells, macrophages, cardiac myocytes and fibroblasts. In these cell types, caveolae function both in protein trafficking and signal transduction, as...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Williams TM,Lisanti MP

    更新日期:2004-01-01 00:00:00

  • Increased bronchial nitric oxide production in patients with asthma measured with a novel method of different exhalation flow rates.

    abstract::The concentration of nitric oxide (NO) in exhaled air is increased in patients with asthma, suggesting that measuring fractional exhaled NO concentration (FE(NO)) may be used to monitor asthmatic airway inflammation. However, increased FE(NO) is not specific for asthma, as other inflammatory lung diseases may also inc...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Lehtimäki L,Turjanmaa V,Kankaanranta H,Saarelainen S,Hahtola P,Moilanen E

    更新日期:2000-09-01 00:00:00

  • The role of genetic predisposition to type I (insulin-dependent) diabetes mellitus.

    abstract::The aetiology of insulin-dependent diabetes (IDDM) involves genetic predisposition, a major component of which has been mapped in the HLA complex, near to or identical with genes encoding class II molecules. In Caucasian populations IDDM is strongly associated with the serologically defined HLA-DR3 and DR4 antigens, w...

    journal_title:Annals of medicine

    pub_type: 杂志文章,评审


    authors: Deschamps I,Beressi JP,Khalil I,Robert JJ,Hors J

    更新日期:1991-10-01 00:00:00

  • Cardiovascular risk in young Finns, results from the second follow-up study.

    abstract::A comprehensive study of coronary heart disease (CHD) risk factors and their determinants in children and adolescents in Finland was initiated in the late 1970's. The main cross-sectional study was undertaken in 1980, with 3596 subjects aged from 3 to 18 years participating. The first follow-up study was carried out i...

    journal_title:Annals of medicine

    pub_type: 杂志文章


    authors: Akerblom HK,Viikari J,Räsänen L,Kuusela V,Uhari M,Lautala P

    更新日期:1989-06-01 00:00:00