Liver transplantation restores low serum levels of very low density and high density lipoproteins in end-stage primary biliary cirrhosis.

abstract：:The Benchmarking Controlled Trial (BCT) is a novel concept which covers all observational studies aiming to assess effectiveness. BCTs provide evidence of the comparative effectiveness between health service providers, and of effectiveness due to particular features of the health and social care systems. BCTs compleme...

journal_title：Annals of medicine

authors： Malmivaara A

更新日期：2015-06-01 00:00:00

abstract：:Aim: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during the last decade. Methods: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for aortic stenosis from 2008 to 2017. Results: The annua...

journal_title：Annals of medicine

authors： Mäkikallio T,Jalava MP,Husso A,Virtanen M,Laakso T,Ahvenvaara T,Tauriainen T,Maaranen P,Kinnunen EM,Dahlbacka S,Jaakkola J,Airaksinen J,Anttila V,Savontaus M,Laine M,Juvonen T,Valtola A,Raivio P,Eskola M,Niemelä M,

更新日期：2019-01-01 00:00:00

abstract：:Vulvodynia is a complex multifactorial and multidisciplinary clinical syndrome of unexplained vulvar pain, sexual dysfunction, and psychological disability. Because of the absence of abnormal physical findings among such patients, vulvodynia was long thought to be solely a psychosomatic syndrome. The incidence or prev...

journal_title：Annals of medicine

authors： Paavonen J

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Teriparatide is a potent anabolic agent for severe osteoporosis. OBJECTIVES:A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. METHODS:The patient population comprises 119 os...

journal_title：Annals of medicine

authors： Koski AM,Löyttyniemi E,Väänänen H,Laine H,Niskanen L,Nevalainen PI,Korpi-Hyövälti E,Välimäki MJ

更新日期：2013-05-01 00:00:00

abstract：:Depression, among other mood disorders, represents one of the most common health problems worldwide, with steadily increasing incidence and major socio-economic consequences. However, since the knowledge about the underlying pathophysiological principles is still very scanty, depression and other mood disorders are cu...

journal_title：Annals of medicine

authors： Pollak DD,Rey CE,Monje FJ

更新日期：2010-05-06 00:00:00

abstract：:Potatoes (Solanum tuberosum) are an important food crop worldwide and contribute key nutrients to the diet, including vitamin C, potassium, and dietary fiber. Potatoes and potato components have been shown to have favorable impacts on several measures of cardiometabolic health in animals and humans, including lowering...

journal_title：Annals of medicine

authors： McGill CR,Kurilich AC,Davignon J

更新日期：2013-11-01 00:00:00

abstract：:Transvaginal ultrasonic monitoring of the lower uterine segment was performed in 15 pregnancies in which the mother had previously had three or more caesarean sections. The typical findings were thinning of the myometrium, asymmetric isthmal structures and ventral ballooning of the isthmus. An image of the other of th...

journal_title：Annals of medicine

authors： Kirkinen P

更新日期：1990-04-01 00:00:00

abstract：:This paper reviews current diagnostic techniques for Helicobacter pylori infection and critically questions their value under different diagnostic circumstances. As long as we do not have general treatment recommendations for H. pylori infection, endoscopy is still the basis for primary diagnosis because it assesses t...

journal_title：Annals of medicine

authors： Braden B,Caspary WF

更新日期：2001-03-01 00:00:00

abstract：:This review highlights recent progress in our understanding of the beneficial effects of hormone replacement therapy (HRT) in cardiovascular disease (CVD). The fact that HRT is increasingly advocated has raised concern about possible adverse effects weighed against the potential benefits of HRT regimens. Both favourab...

journal_title：Annals of medicine

authors： Taskinen MR

更新日期：1998-10-01 00:00:00

abstract：:Concepts of eating disorders have altered so that anorexia nervosa is now recognized as an important but uncommon syndrome within a spectrum of disordered eating. Behaviours used by dieters constitute the mild end of the eating disorder spectrum. Dieting in young women is for the most part a transient and benign activ...

journal_title：Annals of medicine

authors： Patton GC

更新日期：1992-08-01 00:00:00

abstract：:In order to assess the effectiveness of lifestyle interventions in reducing cardiovascular disease risk factors, morbidity and mortality among working-age adults, we undertook a systematic review of randomized controlled trials of various lifestyle interventions (diet, exercise, smoking cessation, alcohol intake reduc...

journal_title：Annals of medicine

authors： Ketola E,Sipilä R,Mäkelä M

更新日期：2000-05-01 00:00:00

abstract：:Among the approximately 7,000 cytogenetically abnormal childhood and adult B- and T-lineage acute lymphoblastic leukemias (ALL) published to date, numerous recurring chromosomal aberrations and abnormality patterns have been identified, and it has been clearly shown that the cytogenetic features often correlate closel...

journal_title：Annals of medicine

authors： Johansson B,Mertens F,Mitelman F

更新日期：2004-01-01 00:00:00

abstract：:Atherosclerosis, the leading cause of death in developed countries, is characterized by chronic inflammation in the artery wall. It has been appreciated for decades that this disease is linked to hypercholesterolemia and the accumulation of macrophages in the artery wall, yet the exact mechanisms underlying this infla...

journal_title：Annals of medicine

authors： Laberge MA,Moore KJ,Freeman MW

更新日期：2005-01-01 00:00:00

abstract：:The thoracolumbar junctional region (T10-L1) of the spine is a transitional zone, where more than half of the thoracic and lumbar fractures occur. In this presentation the origin of the pathoanatomical changes in the thoracolumbar junctional region of the spine is discussed in view of the previous studies. These studi...

journal_title：Annals of medicine

authors： Malmivaara AO

更新日期：1989-10-01 00:00:00

abstract：:Both genetic and environmental factors contribute to the development of rheumatoid arthritis (RA). A long-term latent process often precedes the onset of arthritis. Hence, the ultimate causes of RA cannot be clarified by studying only the inflamed joints. Longitudinal studies focusing on risk factors are crucial in ap...

journal_title：Annals of medicine

authors： Aho K,Heliövaara M

更新日期：2004-01-01 00:00:00

abstract：:High-dose chemotherapy followed by transplantation of autologous hematopoietic progenitor cells has a proven track record of safety and efficacy in hematological malignancies and select solid tumors. The near-universal use of peripheral blood stem cells as source for autografts, routine growth factor support, and anti...

journal_title：Annals of medicine

authors： Hamadani M

更新日期：2014-12-01 00:00:00

abstract：:Type 2 diabetes (T2D) and obesity are recognized as conditions of growing biomedical importance to societies worldwide. Despite this, lack of understanding concerning the processes which normally serve to maintain weight and to regulate glucose concentrations, and ignorance about the mechanisms by which these homeosta...

journal_title：Annals of medicine

authors： Jafar-Mohammadi B,McCarthy MI

更新日期：2008-01-01 00:00:00

abstract：:Pancreatic beta-cell dysfunction and insulin resistance are two interrelated defects in the pathophysiology of type 2 diabetes. Defects in peripheral insulin action precede the development of glucose intolerance, as the pancreas compensates for insulin resistance by increasing insulin production and secretion. This ma...

journal_title：Annals of medicine

authors： Sesti G

更新日期：2002-01-01 00:00:00

abstract：:Leukotriene-forming enzymes are expressed within atherosclerotic lesions and locally produced leukotrienes exert pro-inflammatory actions within the vascular wall by means of cell surface receptors of the BLT and CysLT receptor subtypes. The migration and accumulation of inflammatory cells that follow leukotriene rece...

journal_title：Annals of medicine

authors： Bäck M,Hansson GK

更新日期：2006-01-01 00:00:00

abstract：:Research in developing countries is essential for the evaluation of the safety, efficacy and acceptability of both new and already available contraceptives. Research conducted by scientists in developing countries has also played an essential role in the development of new contraceptives. The continuous delivery of pr...

journal_title：Annals of medicine

authors： Rivera R

更新日期：1993-02-01 00:00:00

abstract：:Despite the monumental success of childhood prophylactic vaccination, there is no similar program designed to provide protection as we age against adult onset diseases like breast cancer. Instead, the predominant focus of current cancer vaccine strategy is to vaccinate after the tumors become established. This strateg...

journal_title：Annals of medicine

authors： Tuohy VK,Jaini R

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE AND METHODS:The impact of the rs9939609 FTO variant on cardiovascular events was investigated in the 19-year follow-up of subjects recruited to the OPERA study. RESULTS:A total of 212 cardiovascular disease (CVD) and 152 coronary heart disease (CHD) events or deaths occurred during follow-up. The logistic re...

journal_title：Annals of medicine

authors： Äijälä M,Ronkainen J,Huusko T,Malo E,Savolainen ER,Savolainen MJ,Salonurmi T,Bloigu R,Kesäniemi YA,Ukkola O

更新日期：2015-01-01 00:00:00

abstract：:Obesity in males is accompanied by a significant decrease in testosterone levels. This decrease is essentially a consequence of the decrease of the sex hormone binding hormone (SHBG) binding capacity, itself probably the consequence of the increased insulin levels. In moderate obesity, free testosterone levels are nor...

journal_title：Annals of medicine

authors： Vermeulen A

更新日期：1996-02-01 00:00:00

abstract：:Scleroderma or systemic sclerosis (SSc) is a complex disease in which the vasculopathy and the activation of the immune system with production of inflammatory mediators lead to dysregulated fibroblast activation. The resulting excessive deposition of collagens and other extracellular matrix proteins ends in fibrosis a...

journal_title：Annals of medicine

authors： Chizzolini C

更新日期：2007-01-01 00:00:00

abstract：:Several lines of evidence suggest that abnormal brain serotonin metabolism may occur in early onset, type 2 alcoholism in men. Low cerebrospinal fluid 5-hydroxy-indoleacetic acid concentration has been found to be associated with a history of paternal alcoholism, and abnormal oral glucose tolerance tests (tendency to ...

journal_title：Annals of medicine

authors： Virkkunen M,Linnoila M

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP) is one of the most powerful determinants of cardiovascular risk in women. This risk may differ between post-menopausal women with and without vasomotor hot flushes, possibly indicating different vascular responses to hormone therapy (HT). Thus, we compared in a clinical trial the effect o...

journal_title：Annals of medicine

authors： Tuomikoski P,Haapalahti P,Sarna S,Ylikorkala O,Mikkola TS

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Undetermined strokes with an embolic pattern (USEP) represent a common phenotype. We assessed their frequency and compared USEP with cardioembolic stroke with a known source and non-cardioembolic stroke etiology. METHODS:Study patients were 540 consecutive ischemic stroke patients admitted to Helsinki Uni...

journal_title：Annals of medicine

authors： Putaala J,Nieminen T,Haapaniemi E,Meretoja A,Rantanen K,Heikkinen N,Kinnunen J,Strbian D,Mustanoja S,Curtze S,Pakarinen S,Lehto M,Tatlisumak T

更新日期：2015-01-01 00:00:00

abstract：AIM:To evaluate the effects of canrenone compared to placebo on blood pressure control, some non-conventional biomarkers in cardiovascular stratification, and on metalloproteinases in patients affected by metabolic syndrome. METHODS:A total of 156 Caucasian patients were treated with placebo or canrenone, 50 mg once a...

journal_title：Annals of medicine

authors： Derosa G,Romano D,Bianchi L,D'Angelo A,Maffioli P

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...

journal_title：Annals of medicine

authors： Oksanen AM,Lemmelä SM,Järvelä IE,Rautelin HI

更新日期：2006-01-01 00:00:00

abstract：:In adults, the high-density lipoprotein cholesterol (HDL-C) level is higher among physically active subjects. However, the association of physical activity and HDL-C is less well studied in adolescents and young adults. Furthermore, it is not known whether the effect of physical activity on HDL-C levels is independent...

journal_title：Annals of medicine

authors： Raitakari OT,Taimela S,Porkka KV,Viikari JS

更新日期：1996-06-01 00:00:00