The risk-map of Europe. WHO ERICA Research Group.

abstract：:Objective: Investigation of the clinical potential of extensive phenotype data and machine learning (ML) in the prediction of mortality in acute coronary syndrome (ACS). Methods: The value of ML and extensive clinical data was analyzed in a retrospective registry study of 9066 consecutive ACS patients (January 2007 to...

journal_title：Annals of medicine

authors： Hernesniemi JA,Mahdiani S,Tynkkynen JA,Lyytikäinen LP,Mishra PP,Lehtimäki T,Eskola M,Nikus K,Antila K,Oksala N

更新日期：2019-03-01 00:00:00

abstract：:Non-alcoholic fatty liver disease or NAFLD is a chronic liver condition characterized by hepatic steatosis and associated with insulin resistance and type 2 diabetes mellitus (T2DM). In many patients fat accumulation leads to steatohepatitis (NASH) with chronic necrosis, inflammation, and fibrosis, and eventually to t...

journal_title：Annals of medicine

authors： Ali R,Cusi K

更新日期：2009-01-01 00:00:00

abstract：:Mutations in cardiac voltage-gated K+ channels cause long-QT syndrome (LQTS) and sudden death. We have created a mouse with a long-QT phenotype by overexpression of truncated K+ channels in the heart and have investigated the phenotype of these mice. These mice have long-QT phenotype, and spontaneous and inducible arr...

journal_title：Annals of medicine

authors： Koren G

更新日期：2004-01-01 00:00:00

abstract：:With the last two decades, the importance of genetic factors in the aetiology of major mental illness has been firmly re-established and psychiatric research has now firmly embraced the era of molecular genetics. Despite a number of false starts in the study of schizophrenia and affective disorder, there have been suc...

journal_title：Annals of medicine

authors： O'Donovan MC,Owen MJ

更新日期：1992-06-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal...

journal_title：Annals of medicine

authors： Marafini I,Monteleone G

更新日期：2018-08-01 00:00:00

abstract：:A radioimmunoassay method for endothelin was developed. Antisera raised against endothelin 1 showed significant crossreaction with endothelin 2 and 3 (45 and 13%, respectively). Considerable endothelin immunoreactivity was shown to be present in the cerebrospinal fluid of patients with a subarachnoid hemorrhage, rangi...

journal_title：Annals of medicine

authors： Suzuki H,Sato S,Suzuki Y,Oka M,Tsuchiya T,Iino I,Yamanaka T,Ishihara N,Shimoda S

更新日期：1990-01-01 00:00:00

abstract：:Second primary cancers are a difficult problem in the upper aerodigestive tract and in several other organ sites. Among patients with early stage head and neck cancers, second primary tumours are a primary cause of death. It has been postulated that such second cancers represent new tumours developing from carcinogen-...

journal_title：Annals of medicine

authors： Carey TE

更新日期：1996-06-01 00:00:00

abstract：:Mixed connective tissue disease (MCTD) was first reported 25 years ago. This report provides an assessment of the course of juvenile (J) MCTD in 224 patients available in the literature until 1996, including our own 33 patients. Most patients improved and remissions were observed in 3-5% (up to 27%). Among the long-te...

journal_title：Annals of medicine

authors： Michels H

更新日期：1997-10-01 00:00:00

abstract：:Pulmonary arterial hypertension is a rapidly progressing disease characterized by an over- expression of endothelin. In addition to its potent pulmonary vasoconstrictor effects, endothelin has been shown to produce many of the aberrant changes, such as hypertrophy, fibrosis, inflammation, and neurohormonal activation ...

journal_title：Annals of medicine

authors： Clozel M

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Ambient air pollution is associated with adverse cardiovascular events. This meta-analysis aimed to investigate the short-term association between air pollution and cardiovascular effects on healthy volunteers. METHODS:We searched databases to identify randomized trials with controlled human exposures to ...

journal_title：Annals of medicine

authors： Vieira JL,Macedo FY,Benjo AM,Guimarães GV,Contreras JP,Bocchi EA

更新日期：2017-03-01 00:00:00

abstract：:This study examined the predictive validity of preadolescent Type A determinants for Type A dimensions in young adulthood (n = 375). Predictive variables, i.e. hyperactivity, aggression, social maladjustment and self-esteem were measured when the subjects were aged 12. Type A dimensions, i.e. hard-driving, competitive...

journal_title：Annals of medicine

authors： Keltikangas-Järvinen L,Räikkönen K,Keskivaara P,Pietikäinen M,Viikari J,Kaprio EA,Akerblom HK

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:We aimed to assess the prospective association of serum albumin with venous thromboembolism (VTE) risk and evaluate if the association is independent of or modified by inflammation, as measured by high sensitivity C-reactive protein (hsCRP). DESIGN:We analysed data of 2176 men aged 42-61 years free from VTE in...

journal_title：Annals of medicine

authors： Kunutsor SK,Seidu S,Katechia DT,Laukkanen JA

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The association between otitis media and vestibular symptoms has been hypothesized in the past. Thus, in this study, we aimed to critically analyze (based in a systematic review of the literature) whether patients who have otitis media are at greater risk of developing vestibular impairment or not. METHODS:...

journal_title：Annals of medicine

authors： Monsanto RDC,Kasemodel ALP,Tomaz A,Paparella MM,Penido NO

更新日期：2018-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a genetically complex disorder associated with multiple genetic defects either mutational or of susceptibility. Current AD genetics does not explain in full the etiopathogenesis of AD, suggesting that environmental factors and/or epigenetic phenomena may also contribute to AD pathology and ...

journal_title：Annals of medicine

authors： Cacabelos R

更新日期：2002-01-01 00:00:00

abstract：:Endothelial health is a key factor in normal cardiovascular homeostasis, and recent studies have revealed several important functions of the vascular endothelium that protect against atherothrombosis. These include control over arterial tone, coagulation, fibrinolysis, and vascular growth. Consequently, endothelial dy...

journal_title：Annals of medicine

authors： Raitakari OT,Celermajer DS

更新日期：2000-07-01 00:00:00

abstract：:Visceral obesity is associated with metabolic abnormalities that increase the risk of type 2 diabetes and coronary heart disease. Obese patients with a substantial accumulation of visceral adipose tissue are characterized by higher insulinaemic and glycaemic responses during an oral glucose challenge as well as by a d...

journal_title：Annals of medicine

authors： Després JP

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. METHODS:This is a retrospective mu...

journal_title：Annals of medicine

authors： Carrasco-Sánchez FJ,López-Carmona MD,Martínez-Marcos FJ,Pérez-Belmonte LM,Hidalgo-Jiménez A,Buonaiuto V,Suárez Fernández C,Freire Castro SJ,Luordo D,Pesqueira Fontan PM,Blázquez Encinar JC,Magallanes Gamboa JO,de la Peña Fernánde

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:To appraise effective predictors for COVID-19 mortality in a retrospective cohort study. METHODS:A total of 1270 COVID-19 patients, including 984 admitted in Sino French New City Branch (training and internal validation sets randomly split at 7:3 ratio) and 286 admitted in Optical Valley Branch (external va...

journal_title：Annals of medicine

authors： Guan X,Zhang B,Fu M,Li M,Yuan X,Zhu Y,Peng J,Guo H,Lu Y

更新日期：2021-12-01 00:00:00

abstract：:Adding to the difficulty of interpreting the human genome sequence and annotating protein sequence databases is the observation that a single protein can 'moonlight' or perform multiple, apparently unrelated, functions. This review summarizes examples of moonlighting proteins in cellular activities and biochemical pat...

journal_title：Annals of medicine

authors： Jeffery CJ

更新日期：2003-01-01 00:00:00

abstract：:Twenty-three randomly selected plasma samples from apparently healthy, middle aged men were analysed for coenzyme Q10 (CoQ10), alpha-tocopherol (AT) and free cholesterol (FC) in: 1) whole plasma, 2) the HDL lipoprotein fraction after LDL precipitation (VLDL + LDL). CoQ10, AT and FC in plasma averaged 0.69 +/- .11, 6.7...

journal_title：Annals of medicine

authors： Johansen K,Theorell H,Karlsson J,Diamant B,Folkers K

更新日期：1991-12-01 00:00:00

abstract：:The overall incidence of osteomyelitis following primary knee arthroplasty is 1-2%. Major risk factors are large prostheses, rheumatoid arthritis, postoperative wound-healing complications, skin infections, and prior deep infections. The major infecting organism is Staphylococcus aureus. Healing of the infection is to...

journal_title：Annals of medicine

authors： Bengtson S

更新日期：1993-12-01 00:00:00

abstract：INTRODUCTION:Obesity has reached epidemic proportions worldwide. Maternal obesity has consequences for the offspring's later health. Only few studies have focused upon the long-term consequences of maternal obesity on the offspring's later health. METHODS:A total of 13,345 men and women born in Helsinki during 1934-44...

journal_title：Annals of medicine

authors： Eriksson JG,Sandboge S,Salonen MK,Kajantie E,Osmond C

更新日期：2014-09-01 00:00:00

abstract：:A number of biochemical markers in maternal serum have been proposed for first trimester screening for Down's syndrome. The most promising four are pregnancy associated plasma protein A (PAPP-A), the free beta sub-unit of human chorionic gonadotrophin (hCG) (free beta glycoprotein sub-unit), unconjugated oestriol (uE3...

journal_title：Annals of medicine

authors： Wald NJ,Kennard A,Smith D

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Chlamydia pneumoniae infection has been associated with atherosclerosis by sero-epidemiological, histopathological and interventional studies, and animal experiments. We hypothesized that if chlamydial infection is causative of atherosclerosis, the occurrence of antibodies against C. pneumoniae should be ass...

journal_title：Annals of medicine

authors： Janatuinen T,Friberg J,Viljanen MK,Raitakari OT,Nuutila P,Vainionpää R,Oksi J,Peltonen R,Engblom E,Laine H,Knuuti J

更新日期：2002-01-01 00:00:00

abstract：:The associations between candidate gene polymorphisms and coronary heart disease (CHD) are complex as a consequence of pleiotropy, variation with age, selection due to the high lethality of the disease, and interactions with other genes and with environmental factors. Identification of the gene variants that contribut...

journal_title：Annals of medicine

authors： Cambien F

更新日期：1996-10-01 00:00:00

abstract：INTRODUCTION:As individuals age, the prevalence of neurocognitive and mental health disorders increases. Current biomedical treatments do not completely address the management of these conditions. Despite new pharmacological therapy the challenges of managing these diseases remain.There is increasing evidence that the ...

journal_title：Annals of medicine

authors： Halverson T,Alagiakrishnan K

更新日期：2020-12-01 00:00:00

abstract：:Despite striking extensions of lifespan, leading causes of death in most countries now constitute chronic, degenerative diseases which outpace the capacity of health systems. Cardiovascular disease is the most common cause of death in both developed and undeveloped countries. In America, nearly half of the adult popul...

journal_title：Annals of medicine

authors： Kones R,Rumana U

更新日期：2017-05-01 00:00:00

abstract：:Nitric oxide (NO), derived from the vascular endothelium and other cells of the cardiovascular system, has important roles in physiological regulation of blood flow and may have pathophysiological functions in cardiovascular disease. The mechanisms involved in NO-induced vasodilatation and cytotoxicity are briefly rev...

journal_title：Annals of medicine

authors： Dusting GJ,Macdonald PS

更新日期：1995-06-01 00:00:00

abstract：:A 33-year old man suddenly dropped dead during a military march. He had complained of non-specific thoracoabdominal symptoms, pain and fatigue for a year before his death. Autopsy showed coronary polyarteritis nodosa of the left main coronary artery. This patient seems to be only the second case with isolated polyarte...

journal_title：Annals of medicine

authors： Paul RA,Helle MJ,Tarssanen LT

更新日期：1990-06-01 00:00:00

abstract：:Despite intensive research in spondyloarthritis pathogenesis, some important questions still remain unanswered, particularly concerning enthesis new bone formation. Several evidences suggest that it prevalently occurs by endochondral ossification, however it remains to identify factors that can induce and influence it...

journal_title：Annals of medicine

authors： Neve A,Maruotti N,Corrado A,Cantatore FP

更新日期：2017-05-01 00:00:00