Abstract:
:Follicle-stimulating hormone (FSH) has been considered essential for normal ovarian follicular development and spermatogenesis. Although this concept remains valid, the recent reports of defects in genes encoding FSH and its receptor (FSHR) have altered the concepts, particularly with regard to the role of FSH in spermatogenesis. Complete FSH resistance caused by a mutation of the FSHR gene has demonstrated that normal FSH action is an absolute requirement for female fertility, but spermatogenesis and male fertility are possible without FSH action. Thus, while normal ovarian function is critically dependent on normal FSH action, male fertility is relatively independent of this hormone. The finding contradicts the potential of inhibition of FSH secretion or action as a means of male contraception.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Tapanainen JS,Aittomäki K,Huhtaniemi ITdoi
10.3109/07853899708999345subject
Has Abstractpub_date
1997-08-01 00:00:00pages
265-6issue
4eissn
0785-3890issn
1365-2060journal_volume
29pub_type
社论abstract::Abstract The limits of traditional anticoagulants, such as heparin and warfarin, have prompted the search for new agents for prophylaxis and treatment of arterial and venous thromboembolism, including factor Xa and thrombin inhibitors. These agents can be given orally, and their most significant advantage is that no l...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2010.539250
更新日期:2011-03-01 00:00:00
abstract::The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96.6% of patients and 93.9% of controls with a metabolic ratio of debrisoquine less than 12.6 were classified as extensive metabolizers of debrisoquine (P = NS). The distribution of f...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899009147261
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:The association between otitis media and vestibular symptoms has been hypothesized in the past. Thus, in this study, we aimed to critically analyze (based in a systematic review of the literature) whether patients who have otitis media are at greater risk of developing vestibular impairment or not. METHODS:...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2018.1470665
更新日期:2018-08-01 00:00:00
abstract::Hemostasis is traditionally defined as a physiological response to blood vessel injury and bleeding, which entails a co-ordinated process involving the blood vessel, platelets, and blood clotting proteins (i.e. coagulation factors). Hemostasis can be divided into primary and secondary components. The former rapidly in...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2011.576698
更新日期:2012-08-01 00:00:00
abstract::Serum trace element concentrations, parameters of iron metabolism and serum protein concentrations were investigated in thirteen adult recipients of bone-marrow transplants receiving total parenteral nutrition. Six of the patients died during the four weeks follow-up. Serum zinc concentrations were initially low but i...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899209164145
更新日期:1992-02-01 00:00:00
abstract::Clinical know-how and skills as well as up-to-date scientific evidence are cornerstones for providing effective treatment for patients. However, in order to improve the effectiveness of treatment in ordinary practice, also appropriate documentation of care at the health care units and benchmarking based on this docume...
journal_title:Annals of medicine
pub_type: 社论
doi:10.3109/07853890.2011.653394
更新日期:2013-03-01 00:00:00
abstract::Atherosclerosis, the leading cause of death in developed countries, is characterized by chronic inflammation in the artery wall. It has been appreciated for decades that this disease is linked to hypercholesterolemia and the accumulation of macrophages in the artery wall, yet the exact mechanisms underlying this infla...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890510007304
更新日期:2005-01-01 00:00:00
abstract::Erythropoietin (EPO) is of special interest in the perinatal period in the mother and fetus. On the one hand, thanks to the recent development of highly sensitive radio-immunoassays and the ability to monitor endogenous EPO production, we can now study the physiological aspects of maternal and fetal erythropoiesis and...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the e...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890.2020.1770849
更新日期:2020-08-01 00:00:00
abstract::Endothelial health is a key factor in normal cardiovascular homeostasis, and recent studies have revealed several important functions of the vascular endothelium that protect against atherothrombosis. These include control over arterial tone, coagulation, fibrinolysis, and vascular growth. Consequently, endothelial dy...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890008995931
更新日期:2000-07-01 00:00:00
abstract::Caveolae are vesicular organelles (50-100-nm in diameter) that are particularly abundant in cells of the cardiovascular system, including endothelial cells, smooth muscle cells, macrophages, cardiac myocytes and fibroblasts. In these cell types, caveolae function both in protein trafficking and signal transduction, as...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890410018899
更新日期:2004-01-01 00:00:00
abstract::Atherosclerosis is an inflammatory disease of the vessel wall, characterized by the accumulation of leukocytes, especially macrophages and T-cells. Chemokines are small heparin-binding polypeptides, whose main function is to attract cells to the areas of developing inflammation. They function by ligating G-protein cou...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890310019961
更新日期:2004-01-01 00:00:00
abstract::The phenomenon of treatment-resistant depression (TRD), described as the occurrence of an inadequate response after an adequate treatment with antidepressant agents (in terms of dose, duration, and adherence), is very common in clinical practice. It has been broadly defined in the context of unipolar major depression,...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2011.583675
更新日期:2011-11-01 00:00:00
abstract::The processes of glycation and oxidation play a significant role in the acceleration of atherosclerosis in diabetes mellitus. Glycation is thought not only to increase the susceptibility of low-density lipoprotein (LDL) to oxidation but also to enhance the propensity of vessel wall structural proteins to bind extravas...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899608999092
更新日期:1996-08-01 00:00:00
abstract::Cardiac rhythm during sleep was analysed in 168 healthy men aged 19 to 30 (mean 21.8) years using continuous nocturnal ECG recordings. Thirty five of the subjects were endurance athletes; 99 were recorded at home and 69 at a garrison during military service. The number of short term (less than one min) accelerations o...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899109148037
更新日期:1991-04-01 00:00:00
abstract::Several lines of evidence suggest that abnormal brain serotonin metabolism may occur in early onset, type 2 alcoholism in men. Low cerebrospinal fluid 5-hydroxy-indoleacetic acid concentration has been found to be associated with a history of paternal alcoholism, and abnormal oral glucose tolerance tests (tendency to ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899009147915
更新日期:1990-01-01 00:00:00
abstract::Despite the monumental success of childhood prophylactic vaccination, there is no similar program designed to provide protection as we age against adult onset diseases like breast cancer. Instead, the predominant focus of current cancer vaccine strategy is to vaccinate after the tumors become established. This strateg...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2011.565065
更新日期:2011-08-01 00:00:00
abstract::In adults, the high-density lipoprotein cholesterol (HDL-C) level is higher among physically active subjects. However, the association of physical activity and HDL-C is less well studied in adolescents and young adults. Furthermore, it is not known whether the effect of physical activity on HDL-C levels is independent...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899609033128
更新日期:1996-06-01 00:00:00
abstract::There are few relevant animal models for neurodegenerative diseases to be used for human drug development. Most current drugs for neurodegenerative diseases act through different neurotransmitter systems. Positron emission tomography (PET) is a unique tool in the study of neurodegenerative diseases as it enables quant...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899908998803
更新日期:1999-12-01 00:00:00
abstract::Aim: This meta-analysis study aimed to compare the efficacy and safety of TEVAR versus OCSR for TBAD patients.Methods: We systematically searched PubMed, EmBase, and the Cochrane library to identify studies compared the effectiveness of TEVAR and OCSR in TBAD patients from the inception up to July 2019. The summary re...
journal_title:Annals of medicine
pub_type: 杂志文章,meta分析
doi:10.1080/07853890.2019.1679874
更新日期:2019-01-01 00:00:00
abstract::The goals of this chapter are to provide a brief review of the biology of the protein C pathway and some of the features of the pathway that make it uniquely positioned to control microvascular coagulation and control the acute inflammatory response. Activated protein C works as an antithrombotic agent by inactivating...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/078538902321117823
更新日期:2002-01-01 00:00:00
abstract::Exposures of human populations to pesticides and industrial pollutants, and to synthetic chemicals present in foods, beverages, and plastics, have raised concern that these substances can interfere with endogenous sex hormone function. Interference with sex hormone action can, in turn, result in a variety of developme...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890108995952
更新日期:2001-09-01 00:00:00
abstract::Troglitazone is a novel once-daily oral antidiabetic agent for the treatment of type 2 diabetes patients. Here, we report the overall dose response characteristics of troglitazone, with respect to effects on metabolic control, using a pharmacodynamic model. Data from week 12 from two previously reported double-blind, ...
journal_title:Annals of medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/07853899808999405
更新日期:1998-04-01 00:00:00
abstract::Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with an increased risk of ischemic stroke (IS) and systemic embolism (SE). Stroke prevention is a key element for the overall management of AF patients. The non-vitamin K antagonist oral anticoagulants (NOACs), such as dabigatran, rivaroxaban,...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890.2018.1460489
更新日期:2018-06-01 00:00:00
abstract::Certain bacterial infections have been demonstrated to be causative of reactive arthritis. The most common bacterial trigger of reactive arthritis is Chlamydia trachomatis. Chlamydia pneumoniae is another known cause, albeit far less frequently. Although Chlamydia-induced reactive arthritis will often spontaneously re...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2011.606830
更新日期:2012-12-01 00:00:00
abstract::Atherosclerosis is a multifactorial pathological process. In recent years, the immune factors associated with its initiation and progression have been investigated intensively. Several autoantigens and their respective autoantibodies have been suggested as factors in atherogenesis. This manuscript provides a review of...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-01 00:00:00
abstract::Low back pain as a research topic has been treated in this symposium, as in other contexts, as though it were an illness. It is, however, a complaint - and as such, even, potentially not a genuine one. Appreciation of the true character of back pain is essential for the proper orientation and setting of priorities for...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853898909149228
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Eastern-born male Finns, irrespective of their place of residence, have high mortality from coronary heart disease (CHD), and half of such deaths are sudden. AIM:To study whether eastern birthplace alone or combined with life-style factors predicts risk for prehospital sudden cardiac death (SCD) in the new ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890802258753
更新日期:2009-01-01 00:00:00
abstract:AIM:To evaluate dyslipidemia as predictor of myocardial infarction (MI) in subjects with or without chronic kidney disease (CKD). METHODS:In 142,394 middle-aged Swedes referred for laboratory evaluation, glomerular filtration rates (GFR) were estimated using the Modification of Diet in Renal Disease study equation. CK...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2010.532153
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Multiple lines of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, pr...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890701278795
更新日期:2007-01-01 00:00:00