Abstract:
:In the Netherlands there are about 9700 explicit requests for euthanasia or physician-assisted suicide (EAS) each year, of which approximately 3600 are granted. Other countries have criticized the Dutch policy concerning EAS. It has been suggested that palliative care in the Netherlands is not adequate and that euthanasia is often requested by patients with depression. In addition, this criticism is partly based on the firm stance that 'human life has an absolute value and a human being has under no circumstances the right of self-determination over his or her own life'. Many aspects of EAS are currently the focus of attention in the literature. In this review the following aspects of EAS are discussed: ethics, judicial questions, the relationship between depression and euthanasia, and the impact of EAS on members of the family. Also, the current situation concerning EAS in the Netherlands is summarized and described. Despite the fact that EAS have been widely discussed in the literature, the association between depression and the number of requests for EAS remains to be discovered. It is also not yet known what the effects of EAS are on members of the family, and whether unnatural death causes a higher incidence of complicated grief.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Swarte NB,Heintz APdoi
10.3109/07853899908998793subject
Has Abstractpub_date
1999-12-01 00:00:00pages
364-71issue
6eissn
0785-3890issn
1365-2060journal_volume
31pub_type
杂志文章,评审abstract::Study of the growth and development of cartilage and bone has been difficult because the structure of the tissues makes biological experiments hard to conduct. Recent advances in molecular biology have offered new possibilities for studying these processes. Many cartilage and bone specific cDNAs have been cloned and c...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899109148050
更新日期:1991-08-01 00:00:00
abstract::Lyme borreliosis is endemic in the Aland Islands. Exposure of the inhabitants to bites of the tick Ixodes ricinus is heavy. The purpose of this study was to describe symptoms and signs of patients with late Lyme borreliosis in this area, and to correlate the findings with the epidemiological setting. The first 100 con...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899309147296
更新日期:1993-08-01 00:00:00
abstract::Abstract A host of clinical scenarios can be depicted in hereditary autoinflammatory diseases, and the cardiovascular system can also be involved especially in familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, and tumour necrosis factor receptor-associated periodic syndrome (TRAPS), caused by m...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2010.547212
更新日期:2011-08-01 00:00:00
abstract::Sudden arrhythmic death is the most common mode of death in Western countries. An increased understanding of the pathophysiology and trigger mechanisms of life-threatening ventricular tachyarrhythmias in patients with structural heart disease can provide a logical basis for improved therapeutic strategies in the preve...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899708999355
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:H+/K+-ATPase is the target autoantigen in autoimmune gastritis (AIG), an organ-specific autoimmune disease with a strong hereditary component. AIM:To detect possible polymorphisms in H+/K+-ATPase alpha- and beta-subunits in AIG patients. METHODS:Blood samples from 12 Finnish AIG patients were sequenced for...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890600673260
更新日期:2006-01-01 00:00:00
abstract::The recent identification of mutations in the RET proto-oncogene that are associated with multiple endocrine neoplasia type 2 (MEN 2) syndromes has allowed therapeutic intervention in affected individuals on the basis of direct genetic testing. The principal endocrine neoplasm that occurs in patients with the MEN 2 sy...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899608999099
更新日期:1996-10-01 00:00:00
abstract::Hypertension is a major cardiovascular risk factor with a multifactorial pathogenesis, including genetic and environmental factors. In addition to hypothesis-driven strategies, unbiased approaches such as genomics, proteomics, and metabolomics are useful tools to help unravel the pathophysiology of hypertension and as...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2012.660494
更新日期:2012-06-01 00:00:00
abstract::High-dose chemotherapy followed by transplantation of autologous hematopoietic progenitor cells has a proven track record of safety and efficacy in hematological malignancies and select solid tumors. The near-universal use of peripheral blood stem cells as source for autografts, routine growth factor support, and anti...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890.2014.952662
更新日期:2014-12-01 00:00:00
abstract::Neuropeptides and their receptors are produced and expressed by neuroendocrine tissues and function as neurotransmitters and/or mediators of well-defined hormonal activities in specific tissues and cells. However, neuropeptides and their receptors are also found in the immune system, and various neuropeptides are invo...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-01 00:00:00
abstract::This paper reviews current diagnostic techniques for Helicobacter pylori infection and critically questions their value under different diagnostic circumstances. As long as we do not have general treatment recommendations for H. pylori infection, endoscopy is still the basis for primary diagnosis because it assesses t...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890109002063
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Mortality from coronary heart disease (CHD) has been constantly higher in eastern late settlement regions compared to western early settlements in Finland, unrelated to classical risk factors. In line with this, eastern birthplace was an age-dependent predictor of severe coronary atherosclerosis and pre-hosp...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2012.727021
更新日期:2013-05-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, are therapeutic groups widely used for the treatment of pain, inflammation and fever. There is growing experimental and clinical evidence indicating NSAIDs and COX-2 inhibitors also have anti-cancer activity. Epidemiologi...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890310017053
更新日期:2003-01-01 00:00:00
abstract::This paper describes the responses of peripheral and central visceral nociceptive systems to acute injury and discusses these observations in relation to the concept of 'pre-emptive analgesia'. Visceral nociceptors are known to respond to injury but are also known to become sensitized to non-noxious stimuli during the...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899509031965
更新日期:1995-04-01 00:00:00
abstract::The processes of glycation and oxidation play a significant role in the acceleration of atherosclerosis in diabetes mellitus. Glycation is thought not only to increase the susceptibility of low-density lipoprotein (LDL) to oxidation but also to enhance the propensity of vessel wall structural proteins to bind extravas...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899608999092
更新日期:1996-08-01 00:00:00
abstract::Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.1080/07853890.2018.1490025
更新日期:2018-08-01 00:00:00
abstract::Aim: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during the last decade. Methods: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for aortic stenosis from 2008 to 2017. Results: The annua...
journal_title:Annals of medicine
pub_type: 临床试验,杂志文章
doi:10.1080/07853890.2019.1614657
更新日期:2019-01-01 00:00:00
abstract::The effect of different clinical conditions on urinary dolichols was studied in 219 hospital patients and in 24 pregnant women. Significantly increased urinary dolichol levels were found in patients with severe bacterial infections (mean +/- SEM, 37.5 +/- 8.0 micrograms/mmol creatinine, P less than 0.001), in patients...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853898909149176
更新日期:1989-02-01 00:00:00
abstract::On theoretical grounds, an apo E receptor defect should be manifested by the accumulation of lipoprotein remnants that are normally cleared by this receptor and cannot be processed by the normal apo B, E receptor (LDL-receptor). Furthermore, the defect should not be selective for a specific apo E phenotype since none ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899109148042
更新日期:1991-04-01 00:00:00
abstract::The mucosal surfaces are the first portals of entry for most infectious agents, among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms. Unspecific responses include the production of virus-induced ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890109002074
更新日期:2001-04-01 00:00:00
abstract::The WHO Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) Project was initiated in the early 1980s with the main objective of assessing the extent to which trends in coronary heart disease and cerebrovascular disease are related to changes in known risk factors, daily living habits...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899409147329
更新日期:1994-02-01 00:00:00
abstract::Visceral obesity is associated with metabolic abnormalities that increase the risk of type 2 diabetes and coronary heart disease. Obese patients with a substantial accumulation of visceral adipose tissue are characterized by higher insulinaemic and glycaemic responses during an oral glucose challenge as well as by a d...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890108995963
更新日期:2001-11-01 00:00:00
abstract::A comprehensive study of coronary heart disease (CHD) risk factors and their determinants in children and adolescents in Finland was initiated in the late 1970's. The main cross-sectional study was undertaken in 1980, with 3596 subjects aged from 3 to 18 years participating. The first follow-up study was carried out i...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853898909149938
更新日期:1989-06-01 00:00:00
abstract::Twenty-three randomly selected plasma samples from apparently healthy, middle aged men were analysed for coenzyme Q10 (CoQ10), alpha-tocopherol (AT) and free cholesterol (FC) in: 1) whole plasma, 2) the HDL lipoprotein fraction after LDL precipitation (VLDL + LDL). CoQ10, AT and FC in plasma averaged 0.69 +/- .11, 6.7...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899109148098
更新日期:1991-12-01 00:00:00
abstract::The causes of colorectal cancer are complex and in most cases obscure, making primary prevention impossible at present. Secondary prevention by finding and treating early asymptomatic cancers may possibly reduce mortality from this very common cancer. Results from conventional treatment have changed little during rece...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899109148076
更新日期:1991-10-01 00:00:00
abstract::Susceptibility to insulin-dependent diabetes mellitus (IDDM) correlates with the absence of aspartic acid in position 57 of the DQB1 and/or the presence of arginine in position 52 of the DQA1. It has been postulated that transcomplementation between the DQ alpha and beta chains of the two haplotypes could create new m...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853899209167007
更新日期:1992-12-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease caused by mutations in sarcomeric proteins. It is characterized by left ventricular hypertrophy in the absence of an increased external load, and myofibrillar disarray. While hypertrophy is a common cardiac response to injury, disarray is the pathologi...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:1998-08-01 00:00:00
abstract::More than 50 different pharmacological and mechanical interventions have been tested to date for prevention of vascular restenosis without success. Intracoronary radiotherapy is the first one showing promise of significantly attenuating neointimal proliferation, causing positive vascular remodelling and thus inhibitin...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890009002033
更新日期:2000-12-01 00:00:00
abstract:AIM:To evaluate if pulse pressure (PP) is a risk predictor for atrial fibrillation (AF) in a longitudinal study of 60-year-old men and women from Stockholm (n = 4,232), free from AF at baseline, with primary end-point incident AF. METHODS:AF diagnoses were obtained from the national hospital discharge register. The es...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890.2015.1100321
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:There is an unmet need for a straightforward and cost-effective assessment of multiple lipoprotein risk factors for vascular diseases. AIMS:1) To study the relation of various lipoprotein lipid and apolipoprotein (apo) measures on the Friedewald inputs, i.e. plasma triglycerides (TG), cholesterol (TC), and ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890902893392
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Obese youths may be susceptible to develop the metabolic syndrome (MS) later in life. AIM:To study childhood predictors of MS in adulthood. METHOD:Prospective cohort study including 2,195 subjects, aged 3-18 years at base-line in 1980, who were re-examined in 1983, 1986, and 2001. RESULTS:In adults (aged ...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890802307709
更新日期:2008-01-01 00:00:00