Abstract：
:In rat models of absence epilepsy, epileptic spike-wave discharges appeared in EEG spontaneously, and the incidence of epileptic activity increases with age. Spike-wave discharges and sleep spindles are known to share common thalamo-cortical mechanism, suggesting that absence seizures might affect some intrinsic properties of sleep spindles. This paper examines time-frequency EEG characteristics of anterior sleep spindles in non-epileptic Wistar and epileptic WAG/Rij rats at the age of 7 and 9 months. Considering non-stationary features of sleep spindles, EEG analysis was performed using Morlet-based continuous wavelet transform. It was found, first, that the average frequency of sleep spindles in non-epileptic Wistar rats was higher than in WAG/Rij (13.2 vs 11.2 Hz). Second, the instantaneous frequency ascended during a spindle event in Wistar rats, but it was constant in WAG/Rij. Third, in WAG/Rij rats, the number and duration of epileptic discharges increased in a period between 7 and 9 months of age, but duration and mean value of intra-spindle frequency did not change. In general, age-dependent aggravation of absence seizures in WAG/Rij rats did not affect EEG properties of sleep spindles; it was suggested that pro-epileptic changes in thalamo-cortical network in WAG/Rij rats might prevent dynamic changes of sleep spindles that were detected in Wistar.
journal_name
Brain Resjournal_title
Brain researchauthors
Sitnikova E,Hramov AE,Grubov V,Koronovsky AAdoi
10.1016/j.brainres.2013.11.001subject
Has Abstractpub_date
2014-01-16 00:00:00pages
290-9eissn
0006-8993issn
1872-6240pii
S0006-8993(13)01496-0journal_volume
1543pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitiona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.07.039
更新日期：2014-09-25 00:00:00
abstract：:The effect of lead as a neurotoxic agent has been associated with alterations in calcium metabolism. On this line, the present study shows that lead alters the characteristics of [3H]nitrendipine ([ 3H]NDP) binding to rat striatal membranes. In vitro, lead shares the action of calcium in enhancing [3H]NDP binding alth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91202-2
更新日期：1984-11-19 00:00:00
abstract：:The aim of the present study was to develop a model culture system for the study of factors controlling regeneration of axons from injured adult mammalian central nervous system. We show, for the first that retinal ganglion cells (RGC) dissociated from adult rat retina, regrow processes in vitro over long distances un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90204-0
更新日期：1988-07-01 00:00:00
abstract：:To test the hypothesis that enkephalins, substance P, bradykinin and angiotensin II could act as neurohumoral modulators of hypothalamic function, these peptides (0.01-20 microgram) were injected into the general circulation of anesthetized rats, and changes in hypothalamo-neurohypophysial activity were determined by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90214-6
更新日期：1981-09-07 00:00:00
abstract：:Sleep-related changes-including modification in sensory processing-that influence brain and body functions, occur during both slow wave and paradoxical sleep. Our aim was to investigate how cortical auditory neurons behave during the sleep/waking cycle, and to study cell firing patterns in relation to the processing o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01194-9
更新日期：1999-01-23 00:00:00
abstract：:Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90621-7
更新日期：1977-04-15 00:00:00
abstract：:Immunohistochemical and neuronal tracing methods were used in cats to determine which type of postganglionic sympathetic neuron is innervated by preganglionic neurons which contain corticotrophin releasing factor-like immunoreactivity (CRF-LI). Preganglionic neurons with CRF-LI have their cell bodies at two restricted...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90399-t
更新日期：1992-12-25 00:00:00
abstract：:We previously found that the dopamine D3 receptor can be split at the third cytoplasmic loop into two fragments (D3trunk and D3tail), and that the mixture of the two fragments retains the binding and functional activity of the wild type receptor. The dopamine D3 receptor gene gives rise to several inactive receptor sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03360-2
更新日期：2003-10-17 00:00:00
abstract：BACKGROUND:Toll-like receptor 4 (TLR4) is an important mediator of the innate immune response. It significantly contributes to neuroinflammation and may be involved in ischemic tolerance. It is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.005
更新日期：2011-04-12 00:00:00
abstract：:The purpose of this study was to identify the CNS cellular constituent immunoreactive for specific P2X7 receptor antiserum in the kainate-induced seizure and non-seizure rat brain. Analysis of P2X7 immunocytochemistry (ICC) revealed small immunoreactive cells with processes showing distinct morphological changes as se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.040
更新日期：2006-05-17 00:00:00
abstract：:The transcription factor cAMP responsive element binding protein (CREB) is important in regulating immediate-early genes and some late-effector genes involved in neuroplasticity in response to peripheral injury and stressful insults. Partial nerve injury elicited neuropathic pain is accompanied by increased phosphoryl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03348-1
更新日期：2003-10-24 00:00:00
abstract：:Certain developmental abnormalities have been associated with environmental exposure to lead and our previous studies have indicated that the endogenous opioid system is disrupted by this metal. In connection with this we report the ontogeny of proenkephalin products in the rat striatum determined by combined HPLC and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90070-7
更新日期：1985-09-01 00:00:00
abstract：:Previous studies have indicated that central sensitization is a state of increased excitability of nociceptive neurons in the spinal dorsal horn following peripheral tissue injury and/or inflammation and astrocytes play an important role in the central sensitization. The current study investigated the role of amino ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.018
更新日期：2012-04-17 00:00:00
abstract：:Corticotropin-releasing factor (CRF) in the brain plays an important role in regulations of physiological and behavioral processes, yet CRF distribution in tree shrew brain has not been thoroughly and systematically reported. Here we examined the distribution of CRF immunoreactivity in the brain of tree shrews (Tupaia...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.06.004
更新日期：2015-08-27 00:00:00
abstract：:In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy fr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90819-x
更新日期：1986-04-16 00:00:00
abstract：:Binge-like ethanol treatment of septal neurons blunts GABAAR-mediated miniature postsynaptic currents (mPSCs), suggesting it arrests synaptic development. Ethanol may disrupt postsynaptic maturation by blunting feedback signaling through immature GABAARs. Here, the impact of ethanol on the sensitivity of mPSCs to zolp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.023
更新日期：2006-05-17 00:00:00
abstract：:Recent neurocognitive studies of visual word recognition provide information about neuronal networks correlated with processes involved in lexical access and their time course (e.g., [Holcomb, Ph.J., Grainger J. and O'Rourke, T. (2002). An Electrophysiological Study of the Effects of Orthographic Neighborhood Size on ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.078
更新日期：2006-02-16 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a devastating stroke often modelled in rats. Isoflurane anesthetic, commonly used in preclinical research, affects general physiology (e.g., blood pressure) and electrophysiology (e.g., burst suppression) in many ways. These physiological changes may detract from the clinical relevanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146593
更新日期：2020-02-01 00:00:00
abstract：:Cerebral accumulation of amyloid beta protein (Abeta) is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Insulin degrading enzyme (IDE) is involved in Abeta degradation, therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for AD. In Chinese Han ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.034
更新日期：2009-01-16 00:00:00
abstract：:Molecular mechanism underlying ischemic stroke remains poorly understood. We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.03.001
更新日期：2018-05-15 00:00:00
abstract：:The deposition of amyloid beta-peptide (Abeta) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Beta-site APP cleaving enzyme (BACE) is the rate-limiting enzyme in the Abeta formation. BACE mutations/polymorphisms may be associated with AD. We searched the BACE coding region mutations/polymorphism...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03849-0
更新日期：2003-01-24 00:00:00
abstract：:Cell death was due to activation of the receptor responsive to N-methyl-D-aspartate (NMDA). Even during a 30-min incubation, glutamate toxicity was unaffected by 5 microM CNQX and was greater than 90% blocked by 160 nM MK-801, a specific antagonist of the NMDA receptor. The extent of toxicity was dependent on the age ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91244-u
更新日期：1991-09-27 00:00:00
abstract：:Because brainstem auditory evoked potentials (BAEPs) are frequently recorded in anesthetized animals and humans, it is important to become familiar with the effects on the BAEP of drugs used during anesthesia, including pre-anesthetics. The dose-dependent and stimulus intensity-dependent effects on the BAEP of a pre-a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90221-1
更新日期：1988-07-26 00:00:00
abstract：:The present study attempts to elucidate the possible role of adenosine 3',5'-monophosphate (cAMP) and prostaglandin E2 (PGE2) in the function of the neural luteinizing hormone-releasing hormone (LH-RH) apparatus. To this end, in vitro LH-RH release from superfused hypothalamic fragments and cAMP production by hypothal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90162-9
更新日期：1986-10-29 00:00:00
abstract：:Hereditary Cystatin C Amyloid Angiopathy (HCCAA) is a rare genetic disease in Icelandic families caused by a mutation in the cystatin C gene, CST3. HCCAA is classified as a cerebral amyloid angiopathy and mutant cystatin C forms amyloid deposits in cerebral arteries resulting in fatal haemorrhagic strokes in young adu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.08.029
更新日期：2013-10-16 00:00:00
abstract：:Abnormal development of the neocortex is often associated with cognitive deficits and epilepsy. Rodent models are widely used to study normal and abnormal cortical development and have revealed the roles of many important genetic and environmental factors. Interestingly, several inbred mouse strains commonly used in b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.026
更新日期：2011-05-19 00:00:00
abstract：:Rats were anesthetized with a continuous infusion of pentobarbital. First we showed that electroacupuncture (EA) suppressed the tail flick nociceptive reflex. Naltrexone (a long acting opiate antagonist) was given either intravenously or intrathecally to attempt to block this EA effect. The naltrexone prevented this E...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90027-3
更新日期：1988-06-14 00:00:00
abstract：:The distributions of neurotensin and opiate receptors within the dorsal horn of the rat spinal cord were studied with quantitative autoradiographic techniques and compared with the immunohistochemical localizations of neurotensin and methionine-enkephalin-like immunoreactivity in this region. High densities of both ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90395-4
更新日期：1981-12-28 00:00:00
abstract：:In anaesthetized, spontaneously breathing cats and dogs, extracellular recordings were made of the spontaneous activities of 28 single neurones with cardiac rhythm. It was confirmed by histological examination that the neurones were situated in the mediodorsal portion of the nucleus of the solitary tract. Different di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90049-x
更新日期：1977-09-09 00:00:00
abstract：:For the purpose of obtaining chemical information about the physiological role of N-acetylaspartylglutamate (NAAG), the release of endogenous NAAG from and the uptake of [3H]NAAG by Guinea pig cerebellar slices were investigated in comparison with L-aspartate (Asp) and L-glutamate (Glu). Although endogenous NAAG was f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90544-1
更新日期：1989-03-13 00:00:00
