Abstract：
:Subretinal neovascularization was demonstrated in a subhuman primate eye (Macaca speciosa) one year after the internal carotid injection of yeast-phase Histoplasma capsulatum. In this animal model of ocular histoplasmosis, initial injection of viable H. capsulatum results in the development of self-limiting acute multifocal choroiditis. Acute lesions resolve within six months, forming chorioretinal scars that are clinically similar to human histo spots. Detailed ultrastructural study of a peripapillary scar 30 months after the injection showed the presence of subretinal neovascularization located between Bruch's membrane and degenerated retinal inner segments. These vessels appeared to be continuous, had tight junctional complexes, and a well-developed basal lamina with occasional pericytes. Failure of fluorescein angiography to demonstrate the presence of this neovascular net may be explained by the presence of tight junctions within the subretinal capillaries.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Jester JV,Smith REdoi
10.1016/0002-9394(85)90790-1subject
Has Abstractpub_date
1985-08-15 00:00:00pages
252-8issue
2eissn
0002-9394issn
1879-1891pii
0002-9394(85)90790-1journal_volume
100pub_type
杂志文章abstract：:A 6-year-old boy with a visual acuity of 6/30 (20/100) in each eye had a diffuse corneal epithelial disruption that was most severe in the interpalpebral area. Corneal anesthesia was demonstrated with the Cochet-Bonnet aesthesiometer. Artificial tears, lubricant ointments, and taping of the eyelids were unsuccessful i...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77729-3
更新日期：1978-03-01 00:00:00
abstract：PURPOSE:To reexamine the role of the vitreous gel in ocular health and disease based on recent information in the ophthalmic literature. DESIGN:Perspective. METHODS:Review, analysis, and discussion of the implications of selected pertinent literature. RESULTS:A new understanding of the vitreous gel is emerging, plac...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2009.07.036
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:To examine the influence of corneal allograft rejection on the survival of penetrating corneal transplantation, to review the status of conventional therapies to improve graft survival, and to consider prospects for alternative approaches to reduce the impact of rejection. DESIGN:Perspective, including prospec...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2005.07.024
更新日期：2005-12-01 00:00:00
abstract：PURPOSE:To report a case of conjunctival-corneal intraepithelial neoplasia (CCIN) in an elderly African American patient treated with topical mitomycin C and the subsequent complication of limbal stem cell deficiency. DESIGN:Interventional case report. METHODS:A 92-year-old African American woman was diagnosed with C...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.10.048
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:To describe the clinical characteristics and course of optic disk edema (ODE) associated with isolated sudden-onset anterior uveitis. DESIGN:Interventional, noncomparative retrospective case series. METHODS:Review of patients with sudden-onset anterior uveitis and concomitant ODE seen in an academic uveitis r...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.03.062
更新日期：2005-10-01 00:00:00
abstract：PURPOSE:To describe a modified technique of haptic externalization during repositioning of dislocated posterior chamber lens implants, which facilitates placement of scleral fixation sutures around the haptic for implant stabilization. METHODS:We describe a technique of repositioning a dislocated posterior chamber imp...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00650-4
更新日期：2001-01-01 00:00:00
abstract：PURPOSE:To report a case of recurrent bleeding after photodynamic therapy (PDT) in an eye with polypoidal choroidal vasculopathy (PCV). DESIGN:Interventional case report. METHODS:A 73-year-old man was treated in the left eye for PCV with PDT. RESULTS:Two weeks after PDT, his left eye showed extensive subretinal hemo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.12.002
更新日期：2006-05-01 00:00:00
abstract：PURPOSE:To evaluate whether cost, insurance prior authorization, pregnancy considerations, and subspecialty practice lead to changes in therapeutic decisions among uveitis and retina specialists in the treatment of intermediate and posterior uveitis. DESIGN:Prospective cross-sectional study. METHODS:A total of 934 uv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.10.015
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:To determine risk factors for poor visual acuity outcomes in patients with endogenous Klebsiella pneumoniae endophthalmitis. DESIGN:Retrospective case-control study. METHODS:We reviewed all consecutive patients diagnosed with endogenous Klebsiella pneumoniae endophthalmitis over 20 years. Data collected inclu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.08.036
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:To evaluate the possible toxicity of indocyanine green (ICG) dye in macular hole surgery by comparing functional results after successful surgeries performed with and without staining. DESIGN:Prospective observational case series. METHODS:In a study conducted at our department, 30 eyes of 29 patients with idi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.05.054
更新日期：2006-11-01 00:00:00
abstract：PURPOSE:To report a modified transposition procedure of the vertical recti for severely limited abduction of the globe caused by sixth nerve palsy and to compare this with the Hummelsheim transposition procedure. METHODS:Retrospective study of 13 eyes of 12 patients that had Hummelsheim transposition procedure and 19 ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00805-9
更新日期：2001-03-01 00:00:00
abstract：PURPOSE:Macular imaging with optical coherence tomography (OCT) measures the most critical retinal ganglion cells (RGCs) in the human eye. The goal of this perspective is to review the challenges to detection of glaucoma progression with macular OCT imaging and propose ways to enhance its performance. DESIGN:Perspecti...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.09.026
更新日期：2020-09-18 00:00:00
abstract：:A patient who used contact lenses and had a history of blunt trauma developed vaccinia keratouveitis after accidental ocular autoinoculation from a recent vaccination site. Corneal and conjunctival cultures were taken for bacteria, fungi, Acanthamoeba, and viruses. Viral-like cytopathic effects became evident in tissu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70008-x
更新日期：1994-04-15 00:00:00
abstract：PURPOSE:To determine the safety of pars plana vitrectomy in eyes containing a treated posterior uveal melanoma. DESIGN:Interventional case series. METHODS:Retrospective case series of patients with posterior uveal melanoma who underwent pars plana vitrectomy. Complications, vitreous cytology, local tumor control, and...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00244-7
更新日期：2003-09-01 00:00:00
abstract：PURPOSE:To report a case of bilateral periopticoscleral hemorrhages associated with traumatic child abuse. METHODS:Postmortem gross examination and histopathologic studies of both eyes and the optic nerves of a 6-month-old infant who died from subdural hematoma. RESULTS:Gross examination and histopathologic step sect...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00392-4
更新日期：1999-04-01 00:00:00
abstract：PURPOSE:The Drusen Laser Study evaluated macular laser to prevent choroidal neovascularization (CNV) and vision loss in high-risk age-related maculopathy (ARM). DESIGN:Prospective, interventional, randomized, controlled clinical trial in five hospital centers. METHODS:Patients in the unilateral group had neovascular ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2005.08.019
更新日期：2006-02-01 00:00:00
abstract：:Cell loss and regeneration were investigated and compared in the retinal microvasculature of age- and sex-matched normal and streptozotocin diabetic rats. Selective pericyte loss in the diabetic rat was characterized by changes in the pericyte to endothelial cell ratio in retinal capillaries isolated for microscopy by...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74982-7
更新日期：1985-07-15 00:00:00
abstract：PURPOSE:The purpose of this study was to compare the perioperative parameters of quadrant, sextant, and grid lens fragmentation patterns in femtosecond laser-assisted cataract surgery (FLACS). DESIGN:Prospective randomized clinical trial. METHODS:Setting: Eye Center of the Second Affiliated Hospital, School of Medici...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2019.12.017
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:To evaluate the change in visual acuity and retinal appearance in patients after early initiation of intravitreal bevacizumab treatment for central retinal vein occlusion (CRVO). DESIGN:Retrospective, interventional case series. METHODS:Patients with CRVO of fewer than three months' duration receiving intravi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.07.038
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:To study the clinicopathologic features of an untreated macular hole in the right eye and a macular hole in the left eye treated by vitrectomy, application of transforming growth factor-beta 2, and gas tamponade. METHODS:The patient, a 73-year-old man with bilateral macular holes, was studied clinically before...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70382-4
更新日期：1996-12-01 00:00:00
abstract：PURPOSE:To determine the ciliary body thickness and other biometric findings in eyes with narrow angles. METHODS:Eighteen otherwise normal eyes with narrow angles in 18 Japanese patients and 18 normal control eyes with open angles in 18 age-matched and sex-matched Japanese patients were studied. A-scan ultrasonography...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00353-0
更新日期：2000-03-01 00:00:00
abstract：:The medical records of 13 patients with primary malignant lesions of the lacrimal gland revealed adenoid cystic carcinoma as the most common malignant tumor. The histologic cell type, neural invasion, and bony destruction were correlated with localized control and ultimate survival. Surgical removal of the lacrimal gl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90455-9
更新日期：1975-01-01 00:00:00
abstract：PURPOSE:To evaluate total plasma homocysteine (tHcy) levels in patients diagnosed with primary open-angle glaucoma (POAG) and normal subjects. DESIGN:Case-control study. METHODS:This study involved 55 POAG patients, 16 patients with secondary open-angle glaucoma or angle-closure glaucoma (non-POAG group), and 39 cont...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.09.041
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:To compare the ultrastructural features of excised tissue removed during surgery for idiopathic macular holes with the preoperative stage of the macular hole. METHODS:Twelve consecutive patients with a unilateral idiopathic macular hole underwent vitrectomy with surgical removal of the internal limiting membra...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71965-8
更新日期：1996-07-01 00:00:00
abstract：:Two siblings had atrophic maculopathy associated with hereditary ataxia clinically defined as an olivopontocerebellar degeneration. The macular changes were suggestive of an early bull's-eye maculopathy in one case and of a late atrophic stage of bull's-eye maculopathy in the other. This suggests that concentric annul...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75125-6
更新日期：1980-11-01 00:00:00
abstract：PURPOSE:To compare polymerase chain reaction (PCR) results to presumptive clinical diagnosis in patients with vitritis. DESIGN:Retrospective review of PCR laboratory records from vitreous samples. METHODS:Fifty consecutive laboratory records of vitreous samples sent for PCR testing were reviewed. Three reviewers with...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.10.011
更新日期：2006-03-01 00:00:00
abstract：:Topical ketoconazole (2% ointment three times per day for three weeks) markedly reduced the severity of keratitis produced with Candida albicans inoculation in the right eyes of 20 rabbits. Clinical scores of affected eyes were significantly lower in the treated eyes than in the controls, which consisted of the 20 ino...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90084-x
更新日期：1986-10-15 00:00:00
abstract：:We conducted a prospective randomized clinical trial on the use of 2% hydroxypropyl methylcellulose and 1% sodium hyaluronate in the anterior chamber during anterior capsulotomy and nuclear expression in extracapsular cataract extraction with posterior chamber lens implantation in 70 patients. Both viscoelastic substa...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-9394(86)90399-5
更新日期：1986-12-15 00:00:00
abstract：:Total retinal detachment and neovascular glaucoma occurred after a penetrating injury to the left globe that left the eye blind and painful. A retrobulbar injection of alcohol and enucleation modified but did not relieve the orbital discomfort. At surgery, we discovered a neuroma with cartilaginous metaplasia involvin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75139-6
更新日期：1980-11-01 00:00:00
abstract：PURPOSE:To evaluate the ocular biometric parameters associated with intraocular pressure (IOP) reduction after phacoemulsification. DESIGN:Prospective, observational case series. METHODS:The study included 999 patients who had undergone uncomplicated phacoemulsification. IOP and ocular biometric parameters were check...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.02.003
更新日期：2013-07-01 00:00:00
