Abstract：
PURPOSE:To evaluate the change in visual acuity and retinal appearance in patients after early initiation of intravitreal bevacizumab treatment for central retinal vein occlusion (CRVO). DESIGN:Retrospective, interventional case series. METHODS:Patients with CRVO of fewer than three months' duration receiving intravitreal bevacizumab as primary treatment were evaluated. Patients received an intravitreal 1.25 mg (0.05 ml) bevacizumab injection. Changes in visual acuity, central macular thickness, venous tortuosity and diameter, and optic disk edema were noted. RESULTS:Six eyes of five consecutive patients with CRVO treated with intravitreal bevacizumab injection were reviewed retrospectively. The patients did not have other ocular conditions that could have compromised visual acuity. The mean baseline visual acuity was 20/428 (logarithm of the minimum angle of resolution [logMAR] units, 1.33). The mean follow-up period was 12 months (range, seven to 15 months), and the number of bevacizumab injections ranged from four to 10. The patients showed a statistically significant decrease in optic nerve head swelling, venous tortuosity, and venous diameter, with the largest proportion of change occurring within one month of the first bevacizumab injection. The mean visual acuity at last follow-up was 20/53 (logMAR units, 0.42; P = .035, as compared with baseline). In no patient did collateral vessels at the optic nerve head develop. CONCLUSIONS:The patients experienced a dramatic improvement in the visual acuity and clinical fundus appearance, without collateral vessel formation. These findings are difficult to explain with current theories of the pathophysiologic features of CRVO. These findings also suggest early initiation of anti-vascular endothelial growth factor (VEGF) treatment should be studied in a larger trial for CRVO.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Ferrara DC,Koizumi H,Spaide RFdoi
10.1016/j.ajo.2007.07.038subject
Has Abstractpub_date
2007-12-01 00:00:00pages
864-71issue
6eissn
0002-9394issn
1879-1891pii
S0002-9394(07)00694-0journal_volume
144pub_type
杂志文章abstract：PURPOSE:To describe the incidence rates of visual loss and ocular complications in patients with retinal vasculitis (RV). DESIGN:Retrospective cohort study. METHODS:Clinical data were collected for 96 patients (175 eyes) diagnosed with RV from 2003 to 2013. Main outcome measures included rates of visual loss and ocul...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.05.007
更新日期：2017-07-01 00:00:00
abstract：PURPOSE:To reexamine the role of the vitreous gel in ocular health and disease based on recent information in the ophthalmic literature. DESIGN:Perspective. METHODS:Review, analysis, and discussion of the implications of selected pertinent literature. RESULTS:A new understanding of the vitreous gel is emerging, plac...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
abstract：PURPOSE:To determine the efficacy of internal limiting membrane (ILM) peeling during vitrectomy for rhegmatogenous retinal detachment (RRD) regarding post-vitrectomy epiretinal membrane (ERM) development and visual outcomes. DESIGN:Retrospective, interventional, comparative case series. METHODS:Setting: Institutional...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.08.015
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:To document a branch retinal vein obstruction secondary to a congenital arteriovenous communication. METHOD:Case report of a young patient with retinal arteriovenous communication. RESULTS:A 12-year-old girl had a grade 2 retinal arteriovenous communication in her right eye. She was asymptomatic and was subse...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00103-2
更新日期：1998-09-01 00:00:00
abstract：:We treated seven patients (all male, ranging in age from 11 to 31 years) with Schwartz syndrome, a combination of uveitis, high intraocular pressure, and retinal detachment with peripheral tears. The condition was resistant to corticosteroids but responded well to surgery. Puncture of the anterior chamber disclosed ma...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1986-06-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2005.11.003
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:To compare three phacoemulsification machines for measurement accuracy and postocclusion surge (POS) in human cadaver eyes. DESIGN:In vitro comparisons of machine accuracy and POS. METHODS:Tip vacuum and flow were compared with machine indicated vacuum and flow. All machines were placed in two human cadaver e...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.01.024
更新日期：2008-06-01 00:00:00
abstract：:I devised a small mirror for hemianopia that is mounted on a clip placed over the spectacle frames on the nasal side. The mirror is adjustable so that the peripheral retina is stimulated by any motion reflected in the mirror when the eye is gazing straight ahead. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90681-0
更新日期：1979-10-01 00:00:00
abstract：:Endoscopic intranasal dacryocystorhinostomy has been used as a primary treatment of lacrimal obstruction and for revision of conventional dacryocystorhinostomy. This study correlates dacryocystographic anatomy with the success of the endoscopic surgical technique. Eighteen patients with epiphora and nasolacrimal obstr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71524-7
更新日期：1992-02-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90057-x
更新日期：1981-05-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.09.026
更新日期：2006-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.09.025
更新日期：2019-01-01 00:00:00
abstract：:Although surgical excision, with or without adjunctive cryotherapy, is an accepted method of managing conjunctival squamous cell carcinoma, histologically verified tumor-free surgical margins cannot be assured by excision alone. We used a tissue conservation method, an adaptation of the Mohs' micrographic technique fo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73021-1
更新日期：1994-01-15 00:00:00
abstract：:We undertook an in vitro investigation of the role of the design of the eyedrop dispenser in bacterial contamination. The nozzle tips of pipette and squeeze bottles containing Fluress (pH 5.0) were inoculated with 10 microliter of an ocular isolate of Pseudomonas aeruginosa (5.5 X 10(5) bacteria/ml). Cultures of singl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90238-1
更新日期：1984-11-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.11.043
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:To evaluate changes in contrast sensitivity after surgery for macula-on rhegmatogenous retinal detachment (RRD). DESIGN:Prospective, interventional, consecutive, case-control study. METHODS:This study included 84 eyes of 84 patients with unilateral macula-on RRD undergoing primary scleral buckling or vitrecto...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.05.017
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:To use multiple imaging methods to investigate patients with type 2 idiopathic macular telangiectasia (IMT) at different disease severity stages so as to characterize and categorize disease progression through the full spectrum of disease phenotypes. DESIGN:Observational case series. METHODS:Twelve patients w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2009.04.030
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:To update the biomicroscopic classification and anatomic interpretations of the stages of development of age-related macular hole and provide explanations for the remarkable recovery of visual acuity that occurs in some patients after vitreous surgery. METHODS:Recent biomicroscopic observations of various stag...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72781-3
更新日期：1995-06-01 00:00:00
abstract：PURPOSE:To evaluate the significance of the surgical scar of external dacryocystorhinostomy (DCR) as assessed by the patients. DESIGN:Cross-sectional questionnaire-based study. METHODS:Two hundred ninety-seven external DCRs were performed in 263 patients at the private practices of consultants who were attached to th...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.04.039
更新日期：2005-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.08.034
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:To assess the prevalence of refractive error and vision impairment in school age children in the terai area of the Mechi zone in Eastern Nepal. METHODS:Random selection of village-based clusters was used to identify a sample of children 5 to 15 years of age. Children in the 25 selected clusters were enumerated...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2000-04-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2009.12.008
更新日期：2010-05-01 00:00:00
abstract：:In a postmortem study of 57 diabetic patients, 19 of 23 patients with blood glucose levels greater than 200 mg/100 ml in the 72-hour period before death showed the characteristic histologic findings of "lacy" vacuolation of the iris pigment epithelium as well as vacuolation of the renal tubules (Armanni-Ebstein nephro...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1975-05-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.10.005
更新日期：2007-01-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.01.049
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:To evaluate the impact of cataract surgery on subfoveal choroidal thickness and central retinal thickness in the elderly. DESIGN:Prospective observational case series. METHODS:This cohort study included 29 eyes of 29 patients with senile cataract, but no previous ocular surgery or other ocular abnormality. Al...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.05.016
更新日期：2014-09-01 00:00:00
abstract：:Four patients, two men 25 and 43 years old and two women 20 and 40 years old, had complete monocular temporal hemianopsias, suggesting that it may be a more common functional deficit than has been recognized. The initial symptoms were visual loss and headache, and eye pain also occurred. Correct diagnosis is possible ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90600-8
更新日期：1986-02-15 00:00:00
abstract：PURPOSE:To study the glistening formation in various hydrophobic-acrylic intraocular lens (IOL) models, and to evaluate the effect of glistenings on light scattering in these IOLs. DESIGN:Laboratory investigation. METHODS:The susceptibility of the hydrophobic-acrylic material to develop glistenings was evaluated in 6...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.08.032
更新日期：2018-12-01 00:00:00
abstract：:Because determination of the differential light threshold of a visual field is a psychophysiologic test, the results can be subject to variation. This scatter measured during a single examination is usually called the short-term fluctuation. Increases of the short-term fluctuation were thought to occur primarily in ab...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90667-3
更新日期：1989-04-15 00:00:00
abstract：PURPOSE:To investigate the fundus autofluorescence (FAF) imaging findings in patients with serous and drusenoid pigment epithelial detachment (PED) associated with age-related macular degeneration (AMD). DESIGN:Observational case series. METHODS:Fourteen eyes of 13 consecutive patients with serous (n = 10) and drusen...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.07.037
更新日期：2005-12-01 00:00:00
