Abstract：
OBJECTIVE:To design, build, and evaluate an animal PET scanner, which can be used with non-human primates under conscious condition, incorporating flat-panel position-sensitive photomultiplier tubes (PS-PMTs). METHODS:The system contains 30 detector modules, each having two PS-PMTs and 16×18 lutetium–yttrium oxyortho-silicate scintillation crystal arrays. The system has 17,280 crystals (480 per ring) arranged in 36 rings, with a diameter of 508 mm and axial extent of 108 mm. The gantry tilt mechanism enables PET studies to be performed on a monkey in the sitting position. Data can be acquired in either the 2D or 3D mode, with the slice collimators being retracted in the 3D mode. RESULTS:At the center of the field-of-view, radial resolution is 2.7 mm full width at half maximum (FWHM) and tangential resolution is 2.4 mm FWHM, while axial resolution is 2.5 mm FWHM for direct slices and 2.7 mm FWHM for cross slices. Scatter fraction, count rate capability, and sensitivity were evaluated using a cylindrical phantom 10 cm in diameter. The noise equivalent count rate in the 3D mode is equivalent to that in the 2D mode at a three times higher radioactivity level. Total system sensitivity is 1.3 kcps/(kBq/mL) in 2D mode and 7.4 kcps/(kBq/mL) in the 3D mode. Animal studies with a monkey were performed to evaluate the imaging capabilities of the scanner. CONCLUSION:The new PET scanner will be a useful research tool with non-human primates for pre-clinical drug development.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Okamoto T,Ote K,Sakai K,Noda A,Shimizu K,Masuda K,Ohmura T,Watanabe Mdoi
10.1007/s12149-013-0772-ysubject
Has Abstractpub_date
2014-01-01 00:00:00pages
74-80issue
1eissn
0914-7187issn
1864-6433journal_volume
28pub_type
杂志文章abstract：AIM:To assess the predictive and prognostic value of textural parameters in locally advanced breast cancer (LABC) obtained by 18F-FDG PET/CT. METHODS:Prospective study including 68 patients with LABC, neoadjuvant chemotherapy (NC) indication and a baseline 18F-FDG PET/CT. Breast specimens were grouped into molecular p...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-018-1253-0
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determine...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-014-0917-7
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:To determine the optimal accumulation time for three-dimensional positron emission tomography (3D-PET) with (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) to detect the brain uptake pattern typical of Alzheimer's disease (AD). METHODS:Patients with mild AD or amnestic mild cognitive impairment (MCI) and normal...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s12149-013-0704-x
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:We examined the diagnostic value of brain perfusion single-photon emission computed tomography (SPECT) using voxel-based statistical analysis with CT-based attenuation correction (CT-AC) by comparing it to that with Chang's AC in mild cognitive impairment (MCI) patients and attempted to locate brain areas tha...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-020-01477-4
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:The utility of 18F-FDG PET/CT in the assessment of thyroid nodules is unclear as there are several conflicting reports on the usefulness of SUV as an indicator to distinguish benign from malignant thyroid lesions. This study incorporated an additional parameter, namely dual time point imaging, to determine the ...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s12149-010-0357-y
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess I-131 biokinetics in thyroid cancer and remnant tissue in patients with differentiated thyroid cancer using whole-body scan (WBS) and SPECT images acquired after I-131 therapy. The influence of thyroid stimulating hormone (TSH) stimulation method on the kinetics was also ev...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-017-1188-x
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:An artificial neural network (ANN) has been applied to detect myocardial perfusion defects and ischemia. The present study compares the diagnostic accuracy of a more recent ANN version (1.1) with the initial version 1.0. METHODS:We examined 106 patients (age, 77 ± 10 years) with coronary angiographic findings,...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s12149-018-1247-y
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:Variable uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has been noticed in positron emission tomography (PET) studies of gastric carcinoma patients, with low uptake occurring especially in some particular histological subtypes and early carcinomas. But this phenomenon has not been adequately explained. The ...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02984657
更新日期：2006-11-01 00:00:00
abstract：:16alpha-[(18)F]Fluoro-17beta-estradiol (FES) is an estrogen receptor (ER) ligand used for the detection of ER-positive malignant tumors such as breast cancer. We recently reported the feasibility of combined FES-and 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) scans for the differential d...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-007-0075-2
更新日期：2008-01-01 00:00:00
abstract：:This investigation was conducted to determine the ability of 201Tl brain SPECT with respect to preoperative prediction of lesional aggressiveness of meningioma. Fifty-nine lesions in 42 patients were examined. Early (15 min) and late (3 h) SPECT were obtained. Early uptake ratio (ER; lesion to normal brain average cou...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF03006435
更新日期：2003-09-01 00:00:00
abstract：:We reported two Tc-99m(V) DMSA scintigrams in patients with idiopathic synovial chondromatosis which affected the metacarpo-phalangeal joint and shoulder joint. Tc-99m(V) DMSA accumulated markedly and diffusely in the tumor. Tc-99m(V) DMSA scintigraphy would be valuable for deciding the optimal site for biopsy. ...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03165044
更新日期：1995-08-01 00:00:00
abstract：AIM:The aim of the study was to compare the kinetic analysis of 18F-labeled choline (FCH) uptake with static analysis and clinicopathological parameters in patients with newly diagnosed prostate cancer (PC). MATERIALS AND METHODS:Sixty-one patients were included. PSA was performed few days before FCH PET/CT. Gleason s...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-018-1246-z
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:The tumor-to-normal tissue (T/N) boron ratio is determined in a patient prior to boron neutron capture therapy (BNCT) using 4-borono-2-18F-fluoro-L-phenylalanine (18F-FBPA) positron emission tomography (PET). The T/N ratio is used as a reference parameter to calculate BNCT dose and to evaluate treatment effec...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-019-01415-z
更新日期：2020-01-01 00:00:00
abstract：:HIV infection results in profound alterations of immunologic function that render the patient severely immunocompromised, and susceptible to malignancies and opportunistic infections. Three AIDS-defining malignancies include Kaposi's sarcoma (KS), non-Hodgkin's lymphoma (NHL) and invasive cervical cancer. In AIDS pati...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章,评审
doi：10.1007/s12149-011-0506-y
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Exact classifying between malignant and benign tumors in the parotid gland is important because the cancer has relatively poor prognosis. There have been several studies that F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) can differentiate between malignant and benign parotid gland tumors. H...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-016-1068-9
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. METHODS:Forty-seve...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s12149-007-0179-8
更新日期：2008-11-01 00:00:00
abstract：:Tuberculosis peritonitis is a rare manifestation of extrapulmonary tuberculosis. The results of gallium-67 scintigraphy of three patients with tuberculosis peritonitis were reviewed to assess its usefulness in the diagnosis of this condition. Tuberculosis peritonitis was associated with diffuse or focal abdominal loca...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03164860
更新日期：1999-06-01 00:00:00
abstract：:We present an interesting case with a central mediastinal pheochromocytoma showing intense F-18 fluorodeoxyglucose (FDG) uptake in tumor and systemic brown adipose tissue (BAT) mimicking metastases. The findings of hypertension and high plasma catecholamine concentration suggested the presence of pheochromocytoma. Med...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-007-0096-x
更新日期：2008-04-01 00:00:00
abstract：:A 48-year-old male patient was admitted to our hospital with dyspnea accompanied by orthopnea. Chest x-rays showed a cardiothoracic ratio of 68% and pulmonary congestion. He was diagnosed with dilated cardiomyopathy. Beta-Blocker (carvedilol) therapy was initiated on Day 22 of the disease using a small initial dose. H...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02984613
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:Lutetium oxyorthosilicate (LSO) contains natural radioactivity that emits beta particles and three gamma photons simultaneously. These beta particles and gamma photons increase the single and random rates in a positron emission tomography (PET) system while a beta particle and gamma photon produced in the sam...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03027389
更新日期：2005-04-01 00:00:00
abstract：:Scintigraphy with 99mTc-diethylenetriaminepentaacetate with galactosyl human serum albumin (99mTc-GSA) and per-rectal portal scintigraphy are useful for evaluating hepatic functional reserve and portal circulation, respectively. We did the procedures simultaneously in some patients to examine the relationship between ...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03164899
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVE:A positron emission tomography (PET) scanner using a silicon photomultiplier (SiPM PET) in place of a photomultiplier tube significantly improves the spatial and time resolution. It may also improve the evaluation of smaller lesions compared to conventional (non-SiPM) PET scanners. We compared the maximum sta...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-020-01489-0
更新日期：2020-09-01 00:00:00
abstract：:18F-fluorodeoxyglucose positron emission tomography (F-18 FDG-PET) plays an important role in differentiating benign from malignant tumors. However, some false-positive findings, such as tuberculosis, may occur. We report a case referred for F-18 FDG whole-body PET computed tomography (PET/CT) scan owing to an elevate...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-008-0139-y
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVES:Nowadays, the number of primary studies on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been increasing rapidly. Thus, we updated meta-analysis to evaluate the test performance of FDG PET/CT for nodal staging in non-small cell lung cancer (NSCLC) including the most r...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s12149-015-0958-6
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:This study investigated the prognostic value of preoperative breast-specific gamma imaging (BSGI) uptake measured by a semi-quantitative method in invasive ductal carcinoma (IDC). METHODS:One hundred and sixty-two women with IDC who underwent preoperative BSGI were retrospectively enrolled. The tumor-to-nor...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-015-0977-3
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:(11)C-Methionine positron emission tomography (MET-PET) has been used to distinguish brain tumor recurrence from radiation necrosis. Because the spatial resolution of conventional PET scanners is low, partial volume effect (PVE) may decrease the detectability of small tumor recurrence. The aim of this study i...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-010-0450-2
更新日期：2011-04-01 00:00:00
abstract：:Positron emission tomography (PET) using pyruvate-1-11C was carried out to investigate the in vivo metabolism of pyruvate in the brains of patients with mitochondrial encephalomyopathy and Leigh's disease. Two epileptic patients were studied as control subjects. Radioactivity was eliminated from the brain tissue of th...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03164593
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND:The aim of the study was to compare widely used ordered subset expectation maximisation (OSEM) algorithm with a new Bayesian penalised likelihood (BPL) Q.Clear algorithm in 18F-PSMA-1007 PET/CT. METHODS:We retrospectively assessed 25 18F-PSMA-1007 PET/CT scans with both OSEM and Q.Clear reconstructions avai...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-019-01433-x
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:In mCRPC patients treated with 223Ra, a major issue is the validation of reliable prognostic and predictive biomarkers to maximize clinical benefit and minimize toxicities and costs. Bearing in mind how changes in tALP did not meet statistical requirements as surrogate marker for survival, aim of this single-...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-017-1228-6
更新日期：2018-02-01 00:00:00
abstract：:Physiological functions (e.g., cerebral blood flow, glucose metabolism, and neuroreceptor binding) can be investigated as parameters estimated by kinetic modeling using dynamic positron emission tomography (PET) images. Imaging of these physiological parameters, called parametric imaging, can locate the regional distr...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章,评审
doi：10.1007/s12149-007-0044-9
更新日期：2007-09-01 00:00:00
