Abstract：
AIM:The aim of the study was to compare the kinetic analysis of 18F-labeled choline (FCH) uptake with static analysis and clinicopathological parameters in patients with newly diagnosed prostate cancer (PC). MATERIALS AND METHODS:Sixty-one patients were included. PSA was performed few days before FCH PET/CT. Gleason scoring (GS) was collected from systematic sextant biopsies. FCH PET/CT consisted in a dual phase: early pelvic list-mode acquisition (from 0 to10 min post-injection) and late whole-body acquisition (60 min post-injection). PC volume of interest was drawn using an adaptative thresholding (40% of the maximal uptake) on the late acquisition and projected onto an early static frame of 10 min and each of the 20 reconstructed frames of 30 s. Kinetic analysis was performed using an imaging-derived plasma input function. Early kinetic parameter (K1 as influx) and static parameters (early SUVmean, late SUVmean, and retention index) were extracted and compared to clinicopathological parameters. RESULTS:K1 was significantly, but moderately correlated with early SUVmean (r = 0.57, p < 0.001) and late SUVmean (r = 0.43, p < 0.001). K1, early SUVmean, and late SUVmean were moderately correlated with PSA level (respectively, r = 0.36, p = 0.004; r = 0.67, p < 0.001; r = 0.51, p < 0.001). Concerning GS, K1 was higher for patients with GS ≥ 4 + 3 than for patients with GS < 4 + 3 (median value 0.409 vs 0.272 min- 1, p < 0.001). No significant difference was observed for static parameters. CONCLUSIONS:FCH influx index K1 seems to be related to GS and could be a non-invasive tool to gain further information concerning tumor aggressiveness.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Palard-Novello X,Blin AL,Bourhis D,Garin E,Salaün PY,Devillers A,Querellou S,Bourguet P,Le Jeune F,Saint-Jalmes Hdoi
10.1007/s12149-018-1246-zsubject
Has Abstractpub_date
2018-05-01 00:00:00pages
281-287issue
4eissn
0914-7187issn
1864-6433pii
10.1007/s12149-018-1246-zjournal_volume
32pub_type
杂志文章abstract：OBJECTIVE:Enhanced washout of 99mTc-tetrofosmin (TF) has been reported in patients with hypertrophic cardiomyopathy (HCM). Here, using quantitative dual-autoradiography, the relationship between TF retention abnormality and metabolism depicted by 125I-BMIPP uptake was investigated quantitatively in a hamster model of c...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02985000
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVE:Chemobrain is a recently proposed pathological entity. 18F-FDG PET/CT can show objective abnormalities to explain brain disorders caused by chemotherapy, although no study has investigated these phenomena in children to date. The main objective of the present study was to examine quantitatively the effects of...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-019-01363-8
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:The tumor-to-normal tissue (T/N) boron ratio is determined in a patient prior to boron neutron capture therapy (BNCT) using 4-borono-2-18F-fluoro-L-phenylalanine (18F-FBPA) positron emission tomography (PET). The T/N ratio is used as a reference parameter to calculate BNCT dose and to evaluate treatment effec...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-019-01415-z
更新日期：2020-01-01 00:00:00
abstract：:The Logan plot is a widely used algorithm for the quantitative analysis of neuroreceptors using PET because it is easy to use and simple to implement. The Logan plot is also suitable for receptor imaging because its algorithm is fast. However, use of the Logan plot, and interpretation of the formed receptor images sho...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章,评审
doi：10.1007/BF03033993
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:Iodine-123-labeled N-isopropyl-4-iodoamphetamine (IMP) is used as a tracer for the measurement of cerebral blood flow (CBF) by single-photon emission computed tomography (SPECT). Two IMP products, IMP(A) (Nihon Medi-Physics Co., Ltd.) and IMP(B) (FUJIFILM RI Pharma Co., Ltd.), produced by different radiopharm...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-009-0242-8
更新日期：2009-06-01 00:00:00
abstract：:Nerve growth factor (NGF) exerts various actions on neuronal and non-neuronal tissues and has potential therapeutic utility, but difficulties in using the whole protein have stimulated interest in small NGF fragments. We radioiodinated a small cyclic peptide derived from NGF using the Bolton-Hunter method [125I-C(92-9...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03026817
更新日期：2006-10-01 00:00:00
abstract：:We report a functional neuroimaging study of a 43-year-old woman with Nasu-Hakola disease (NHD). Regional cerebral blood flow (rCBF) images were measured with technetium-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT). rCBF was decreased in the bilateral frontal lobes and thalamus. This f...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02984623
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the usefulness of a breath-holding (BH) (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography ((18)F-FDG-PET) technique for PET/computed tomography (CT) scanning of pulmonary lesions near the diaphragm, where image quality is influenced by respiratory motion. METHODS:In a basic study, sim...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-008-0206-4
更新日期：2009-01-01 00:00:00
abstract：:A case of Plummer's disease that spontaneously progressed to hypothyroidism is presented. A 49-year-old female visited our hospital because of a 3 kg decrease in body weight during the previous month and a painless nodule in the right anterior area of her neck. A diagnosis of Plummer's disease was made based on the re...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03164940
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVES:We compared the diagnostic value of fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) with that of computed tomography (CT) following radiofrequency ablation (RFA) of inoperable recurrent or metastatic cancers in the lung. METHODS:Twelve patients (9 males and 3 females; 5 had recurrent l...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF02985623
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the left ventricular (LV) functional parameters calculated using quantitative electrocardiography (ECG)-gated myocardial perfusion single photon emission computed tomography (QGS). In addition to LV systolic parameters, diastolic parameters were compared with those by ult...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF02985571
更新日期：2005-09-01 00:00:00
abstract：:The aim of this study was to evaluate the washout rate of Tc-99m tetrofosmin in asymmetric septal hypertrophy (ASH). As Tc-99m tetrofosmin accumulation and retention depend on sarcolemmal and/or mitochondrial function, the presence or absence of abnormalities in the washout rate of Tc-99m tetrofosmin could provide inf...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF02986332
更新日期：2005-02-01 00:00:00
abstract：UNLABELLED:To determine the utility of the myocardial tracer Tc-99m-tetrofosmin in the examination of patients with left bundle branch block (LBBB) and to investigate Tc-99m-tetrofosmin uptake and retention in the myocardium, early and delayed Tc-99m-tetrofosmin SPECT was performed in 10 patients having LBBB without co...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF03164914
更新日期：1998-10-01 00:00:00
abstract：:F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging is a useful modality in the detection of various tumors, including colon cancer and gastric cancer. We evaluated a patient with duodenal cancer with multiple metastases including brain metastases using FDG-PET imaging. It revealed multiple tumor up...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02984475
更新日期：2004-06-01 00:00:00
abstract：:Cerebral perfusion single photon emission computed tomography (SPECT) has been used to confirm the localization of the epileptic focus and the evaluation of seizure. Recently, diffusion-weighted MR imaging (DWI) has been recognized for evaluation of seizure activity. We describe a case of transient seizure activity de...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02987844
更新日期：2001-06-01 00:00:00
abstract：UNLABELLED:We studied the causative mechanism of ampulla (Takotsubo) cardiomyopathy. METHODS:We examined 7 patients with ampulla cardiomyopathy by means of coronary angiography, two-dimensional echocardiography and 99Tc-tetrofosmin myocardial SPECT at the time of emergency admission (acute phase), at 3 to 5 days after...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02988242
更新日期：2001-08-01 00:00:00
abstract：PURPOSE:Nitrate administration has been proposed to enhance the detection of myocardial viability when performing myocardial perfusion imaging. In this study, we aimed to compare Tl-201 exercise-rest-reinjection protocol with rest isosorbide dinitrate (ISDN)-Tc99m MIBI study in the same population examined for the myoc...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s12149-009-0256-2
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:The Response Evaluation Criteria In Solid Tumors (RECIST) is the most used radiological method for evaluating response after peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumors. This method may give too positive estimates of response in slow growing tumors as it allows a substa...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-018-1316-2
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to investigate the outcomes and prognostic factors of high-dose 131I-metaiodobenzylguanidine (131I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan. METHODS:We retrospectively analyzed 20 patients with refractory or relapsed high-risk NBL who underwe...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-020-01460-z
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:Because thickening of the gallbladder wall is observed not only in patients with gallbladder cancer but also in those with benign diseases such as chronic cholecystitis and gallbladder adenomyosis, it is difficult to distinguish between benign and malignant gallbladder wall thickening by conventional techniqu...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/BF02984683
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVE:Exact classifying between malignant and benign tumors in the parotid gland is important because the cancer has relatively poor prognosis. There have been several studies that F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) can differentiate between malignant and benign parotid gland tumors. H...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-016-1068-9
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:CBF, OEF and CMRO(2) provide us important clinical indices and are used for assessing ischemic degree in cerebrovascular disorders. These quantitative images can be measured by PET using (15)O-labelled tracers such as C(15)O, C(15)O(2) and (15)O(2). To reduce the time of scan, one possibility is to omit the u...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-010-0438-y
更新日期：2011-04-01 00:00:00
abstract：OBJECTIVE:Because of the urinary excretion of fluorine-18 fluorodeoxyglucose ((18)F-FDG), FDG-PET or PET/CT is thought of little value in patients with bladder cancer. The purpose of our study was to investigate the value of (18)F-FDG PET/CT with additional pelvic images in detection of recurrent bladder cancers. METH...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-012-0614-3
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:Bone-seeking radiopharmaceuticals have the main role in the treatment of painful bone metastases. The aim of this study was to dosimetrically compare radiopharmaceuticals in use for bone pain palliation therapy and bone scan. METHODS:The MCNPX code was used to simulate the radiation transport in a vertebral ...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-019-01329-w
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:A complication after spinal fusion surgery is pseudarthrosis, but its radiological diagnosis is of limited value. (18)F-fluoride PET with its ability to assess bone metabolism activity could be of value. The goal of this study was to assess the clinical feasibility of calculating the static standardized uptak...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-015-1008-0
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:We examined the cardiac function of patients who underwent Tc-99m sestamibi quantitative gated myocardial single photon emission computed tomography with 16-framing data acquisition between January 1, 2004 and March 31, 2006 for an evaluation of suspected or known heart disease in our hospital. METHODS:In 19...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-007-0032-0
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:Studies have suggested that ischemia-induced diastolic dysfunction persists longer than systolic dysfunction. We examined whether global left ventricular (LV) diastolic function during stress testing assessed by 16-frame gated myocardial perfusion single-photon emission computed tomography (SPECT) is useful a...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-008-0174-8
更新日期：2008-10-01 00:00:00
abstract：:Bone scintigraphy is often performed to assess the response to systemic therapy of bone metastasis from prostate cancer. We examined the changes in bone scintigraphic findings and the agreement with AIP, AcP, or other tumor markers measured in the follow-up of patients with known bone metastasis after hormonal therapy...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF03165024
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:The aim of the study was to compare widely used ordered subset expectation maximisation (OSEM) algorithm with a new Bayesian penalised likelihood (BPL) Q.Clear algorithm in 18F-PSMA-1007 PET/CT. METHODS:We retrospectively assessed 25 18F-PSMA-1007 PET/CT scans with both OSEM and Q.Clear reconstructions avai...
journal_title：Annals of nuclear medicine
pub_type： 杂志文章
doi：10.1007/s12149-019-01433-x
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:Single photon emission computed tomography (SPECT) images provide many details of the anatomical structure. Also about bone scintigraphy, there are many reports of the improvement of diagnosis by SPECT images. Although SPECT is useful, it requires much time. So to perform SPECT for all cases is difficult in t...
journal_title：Annals of nuclear medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF02985048
更新日期：2005-10-01 00:00:00
