Clinical significance of diastolic function as an indicator of myocardial ischemia assessed by 16-frame gated myocardial perfusion SPECT.


OBJECTIVE:Studies have suggested that ischemia-induced diastolic dysfunction persists longer than systolic dysfunction. We examined whether global left ventricular (LV) diastolic function during stress testing assessed by 16-frame gated myocardial perfusion single-photon emission computed tomography (SPECT) is useful as an indicator of myocardial ischemia. METHODS:Thirty-nine patients underwent 16-frame technetium-99m (Tc-99m) quantitative gated SPECT (QGS), including treadmill exercise testing for suspected ischemic heart disease. Diastolic parameters of the first-third filling fraction (1/3FF), and the peak filling rate (PFR) were calculated by a time-volume curve from the QGS data. RESULTS:The patients were divided into four groups, namely, IS, NL, DN, and DD, on the basis of tracer accumulation and the LV ejection fraction (LVEF) at rest. In the IS group (reversible tracer uptake reduction suggesting ischemia; n=11), LVEF, 1/3FF, and PFR after stress were significantly lower than those at rest, whereas in the NL group (normal perfusion; n=10) and DN group (fixed tracer uptake reduction with normal systolic function; EF>or=60% at rest; n=10), LVEF, 1/3FF, and PFR after stress did not differ from those at rest. However, in the DD group (fixed tracer uptake reduction with cardiac dysfunction; EF<60%, average 47.1%; n=8), LVEF, 1/3FF, and PFR were significantly altered after stress. CONCLUSIONS:Altered global LV diastolic function during stress assessed by 16-frame gated myocardial perfusion SPECT is useful for the detection of myocardial ischemia. However, similar findings are observed in patients with cardiac dysfunction but without detectable ischemia. Our findings do suggest that tests should be performed with caution to determine whether ischemia exists on the basis of altered global LV function after stress in patients with cardiac dysfunction.


Ann Nucl Med


Nakae I,Matsuo S,Matsumoto T,Mitsunami K,Horie M




Has Abstract


2008-10-01 00:00:00












  • Radioiodination and preclinical evaluation of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl)piperidine as a breast tumor imaging tracer in mouse.

    abstract:OBJECTIVE:4-Benzyl-1-(3-iodobenzylsulfonyl)piperidine, 4-B-IBSP, has shown high-binding affinity to both sigma (σ) receptors in our previous work. In current study, radiolabeling and preclinical evaluation of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl)piperidine, 4-B-[125I]IBSP, in human ductal breast carcinoma (T47D) cel...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Sadeghzadeh M,Alirezapour B,Charkhlooie GA,Baghery MK,Khorouti A

    更新日期:2017-05-01 00:00:00

  • Occult myofibroblastic sarcoma detected on FDG-PET performed for cancer screening.

    abstract::We present a rare case of occult low-grade myofibroblastic sarcoma (LGMFS) detected by marked 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) uptake on positron emission tomography (PET). A 46-year-old woman presented with abnormal FDG uptake in her back when FDG-PET was performed for cancer screening. The maximum stan...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Morii T,Mochizuki K,Sano H,Fujino T,Harasawa A,Satomi K

    更新日期:2008-11-01 00:00:00

  • Performance assessment of the ALBIRA II pre-clinical SPECT S102 system for 99mTc imaging.

    abstract:OBJECTIVE:The performance characteristics of the SPECT sub-system S102 of the ALBIRA II PET/SPECT/CT are analyzed for the 80 mm field of view (FOV) to evaluate the potential in-vivo imaging in rats, based on measurements of the system response for the commonly used Technetium-99 m (99mTc) in small animal imaging. METH...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Attarwala AA,Hardiansyah D,Romanó C,Jiménez-Franco LD,Roscher M,Wängler B,Glatting G

    更新日期:2021-01-01 00:00:00

  • Comparison between single photon emission computed tomography with computed tomography and planar scintigraphy in sentinel node biopsy in breast cancer patients.

    abstract:OBJECTIVE:Radio-guided sentinel node (SN) biopsy is a standard method used in the treatment of early breast cancer. Single photon emission computed tomography with computed tomography (SPECT/CT) has been commonly used for SN detection. SPECT/CT adds precise anatomical information of SN sites, and it is reported that mo...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Koizumi M,Koyama M

    更新日期:2019-03-01 00:00:00

  • Tc-99m RBC perfusion and blood-pool scintigraphy in the evaluation of vascular leiomyoma of the hand.

    abstract::A 62-year-old man with a soft, non-tender, movable mass 2.5 x 2.5-cm in diameter in the volar surface of the right index finger over the proximal phalanx underwent Tc-99m RBC perfusion and blood-pool scintigraphy to evaluate the vascular nature and extent of the mass. Highly increased activity on early and delayed blo...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Lim ST,Kim MW,Sohn MH

    更新日期:2002-06-01 00:00:00

  • The role of adrenocortical scintigraphy in the evaluation of unilateral incidentally discovered adrenal and juxtaadrenal masses.

    abstract::We reviewed the findings of adrenocortical scintigraphy with 131I-6-beta-iodomethyl-19-norcholesterol (NCL-6-131I) of 39 patients to clarify its role in the evaluation of unilateral adrenal or juxtaadrenal masses incidentally discovered by CT, ultrasonography or plain radiography. Twenty-seven benign adrenal masses sh...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Nakajo M,Nakabeppu Y,Yonekura R,Iwashita S,Goto T

    更新日期:1993-08-01 00:00:00

  • Assessment of cerebral hemodynamics before and after revascularization in patients with occlusive cerebrovascular disease by means of quantitative IMP-SPECT with double-injection protocol.

    abstract:UNLABELLED:The purpose of this study was to validate a double-injection (DI) method with N-isopropyl-[123I]p-iodoamphetamine (IMP) to measure regional cerebral blood flow (rCBF) twice in a single session of dynamic SPECT and to elucidate a possible role of this method to identify patients with occlusive disease of majo...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Ueno M,Nishizawa S,Toyoda H,Shimono T,Miyamoto S,Hashimoto N,Konishi J

    更新日期:2001-06-01 00:00:00

  • Detection of alveolar epithelial injury by 99mTC-DTPA radioaerosol inhalation lung scan following blunt chest trauma.

    abstract::DTPA clearance rate is a reliable index of alveolar epithelial permeability, and is a highly sensitive marker of pulmonary epithelial damage, even of mild degree. In this study, 99mTc-DTPA aerosol inhalation scintigraphy was used to assesss the pulmonary epithelial membrane permeability and to investigate the possible...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Okudan B,Han S,Baldemir M,Yildiz M

    更新日期:2004-10-01 00:00:00

  • The management of pyothorax-associated lymphoma using 18F-FDG PET/CT.

    abstract:OBJECTIVE:Pyothorax-associated lymphoma (PAL) is a rare form of lymphoma and its management on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined computed tomography (CT) has not been well reported. The purpose of this study was to evaluate the usefulness of FDG PET/CT in patients with PAL. MAT...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Ito K,Shida Y,Kubota K,Morooka M,Aruga T,Itami J,Matsuda H

    更新日期:2010-11-01 00:00:00

  • Update on nodal staging in non-small cell lung cancer with integrated positron emission tomography/computed tomography: a meta-analysis.

    abstract:OBJECTIVES:Nowadays, the number of primary studies on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been increasing rapidly. Thus, we updated meta-analysis to evaluate the test performance of FDG PET/CT for nodal staging in non-small cell lung cancer (NSCLC) including the most r...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,meta分析


    authors: Pak K,Park S,Cheon GJ,Kang KW,Kim IJ,Lee DS,Kim EE,Chung JK

    更新日期:2015-06-01 00:00:00

  • Measurement of cerebral blood flow by the autoradiographic method with N-isopropyl-4-[I-123] iodoamphetamine: comparison of radiopharmaceuticals marketed by different companies in Japan.

    abstract:OBJECTIVE:Iodine-123-labeled N-isopropyl-4-iodoamphetamine (IMP) is used as a tracer for the measurement of cerebral blood flow (CBF) by single-photon emission computed tomography (SPECT). Two IMP products, IMP(A) (Nihon Medi-Physics Co., Ltd.) and IMP(B) (FUJIFILM RI Pharma Co., Ltd.), produced by different radiopharm...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Ogura T,Ito H,Hida K,Masuzuka T,Fukuda H,Hatazawa J

    更新日期:2009-06-01 00:00:00

  • Morphine-augmented cholescintigraphy enhances duodenogastric reflux.

    abstract::Morphine intervention in cholescintigraphy decreases imaging time to diagnose acute cholecystitis. Not infrequently we observe duodenogastric reflux during scintigraphy with and without morphine intervention. To evaluate occurrence of duodenogastric reflux related to morphine, we reviewed 55 patients who underwent cho...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Shih WJ,Lee JK,Magoun S,Wierzbinski B,Ryo UY

    更新日期:1995-11-01 00:00:00

  • Demonstrations of AIDS-associated malignancies and infections at FDG PET-CT.

    abstract::HIV infection results in profound alterations of immunologic function that render the patient severely immunocompromised, and susceptible to malignancies and opportunistic infections. Three AIDS-defining malignancies include Kaposi's sarcoma (KS), non-Hodgkin's lymphoma (NHL) and invasive cervical cancer. In AIDS pati...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审


    authors: Liu Y

    更新日期:2011-10-01 00:00:00

  • Role of (64)CuCl 2 PET/CT in staging of prostate cancer.

    abstract:AIM:The presence of an elevated copper concentration in cancer cells may be potentially used to differentiate healthy from transformed cells. In this study, we aimed to look at the possible role of (64)CuCl2 PET/CT in staging of patients with prostate cancer (PC). METHODS:Seven patients affected by histologically conf...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Capasso E,Durzu S,Piras S,Zandieh S,Knoll P,Haug A,Hacker M,Meleddu C,Mirzaei S

    更新日期:2015-07-01 00:00:00

  • Unusual patterns of I-131 contamination.

    abstract::Whole body imaging with radioiodine can detect functioning metastases, which can often be effectively treated with appropriate amounts of radioiodine. Non-physiologic I-131 uptake detected on images is usually interpreted as suggesting functioning thyroid metastases. However, extra-thyroidal I-131 accumulation does no...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Ozguven M,Ilgan S,Arslan N,Karacalioglu AO,Yuksel D,Dundar S

    更新日期:2004-05-01 00:00:00

  • Phase I clinical trial of 99mTc-etarfolatide, an imaging agent for folate receptor in healthy Japanese adults.

    abstract:OBJECTIVE:Technetium etarfolatide ((99m)Tc-EF) is a radioactive diagnostic imaging agent that was developed to assess the expression of folate receptors in tumors. Administering folic acid prior to the administration of (99m)Tc-EF has been shown to improve SPECT images. Here, we conducted a phase I clinical trial to as...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Yamada Y,Nakatani H,Yanaihara H,Omote M

    更新日期:2015-11-01 00:00:00

  • High detection sensitivity and reliable morphological correlation of PET with a silicon photomultiplier for primary tongue squamous cell carcinoma.

    abstract:OBJECTIVE:A positron emission tomography (PET) scanner using a silicon photomultiplier (SiPM PET) in place of a photomultiplier tube significantly improves the spatial and time resolution. It may also improve the evaluation of smaller lesions compared to conventional (non-SiPM) PET scanners. We compared the maximum sta...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Kojima I,Takanami K,Ogawa T,Sakamoto M,Nagai H,Miyashita H,Iikubo M

    更新日期:2020-09-01 00:00:00

  • Evaluation of treatment effects in brain abscess with positron emission tomography: comparison of fluorine-18-fluorodeoxyglucose and carbon-11-methionine.

    abstract::Positron emission tomography (PET) imaging is in common use preoperatively to clinically evaluate patients who present with central nervous system mass lesions. The usefulness of PET is also recognized as a method to detect intracranial tumorous lesions. A number of papers reportthat some inflammatory processes also s...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Tsuyuguchi N,Sunada I,Ohata K,Takami T,Nishio A,Hara M,Kawabe J,Okamura T,Ochi H

    更新日期:2003-02-01 00:00:00

  • Optimization of Butterworth filter for brain SPECT imaging.

    abstract::A method has been described to optimize the cutoff frequency of the Butterworth filter for brain SPECT imaging. Since a computer simulation study has demonstrated that separation between an object signal and the random noise in projection images in a spatial-frequency domain is influenced by the total number of counts...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Minoshima S,Maruno H,Yui N,Togawa T,Kinoshita F,Kubota M,Berger KL,Uchida Y,Uno K,Arimizu N

    更新日期:1993-05-01 00:00:00

  • Assessment of Takotsubo (ampulla) cardiomyopathy using 99mTc-tetrofosmin myocardial SPECT--comparison with acute coronary syndrome.

    abstract:UNLABELLED:We assessed Takotsubo (ampulla) cardiomyopathy compared with acute coronary syndrome (ACS) using two-dimensional echocardiography and 99mTc-tetrofosmin myocardial SPECT. METHODS:We examined 10 patients with Takotsubo cardiomyopathy and 16 with ACS at the time of emergency admission (acute phase), at three t...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Ito K,Sugihara H,Katoh S,Azuma A,Nakagawa M

    更新日期:2003-04-01 00:00:00

  • Clinical need for both scintigraphy with technetium-99m GSA and per-rectal portal scintigraphy in some patients with chronic liver disease.

    abstract::Scintigraphy with 99mTc-diethylenetriaminepentaacetate with galactosyl human serum albumin (99mTc-GSA) and per-rectal portal scintigraphy are useful for evaluating hepatic functional reserve and portal circulation, respectively. We did the procedures simultaneously in some patients to examine the relationship between ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Shiomi S,Iwata Y,Sasaki N,Kurooka H,Tamori A,Habu D,Takeda T,Nishiguchi S,Kuroki T,Ochi H

    更新日期:1999-08-01 00:00:00

  • 18F-FDG PET/CT in visceral leishmaniasis: uptake patterns in the context of a multiannual outbreak in Northern Italy.

    abstract:OBJECTIVES:Visceral leishmaniasis (VL) is the most severe manifestation of the infection caused by the protozoan Leishmania, recently on increase in Italy and Spain. The aim of the study was to describe FDG uptake patterns in VL patients (pts) who underwent 18F-FDG PET/CT. METHODS:A retrospective monocentric study of ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Zanoni L,Varani S,Attard L,Morigi JJ,Vanino E,Ortalli M,Fonti C,Viale P,Re MC,Fanti S,Ambrosini V

    更新日期:2019-09-01 00:00:00

  • Animal studies on the reduction and/or dilution of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) activity in the urinary system.

    abstract::To evaluate two methods for decreasing and/or diluting the FDG activity in the urinary system, five rats were intraperitoneally given 1,000 micrograms/g of L-lysine 4 times, starting from 60 minutes before iv injection of FDG, and then at 30-minute intervals for 90 minutes. Five rats were used as controls. In a furose...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Kosuda S,Fisher S,Wahl RL

    更新日期:1997-08-01 00:00:00

  • Scintigraphic changes in bone metastasis from prostate cancer after hormonal therapy--comparison with tumor markers and bone X-ray.

    abstract::Bone scintigraphy is often performed to assess the response to systemic therapy of bone metastasis from prostate cancer. We examined the changes in bone scintigraphic findings and the agreement with AIP, AcP, or other tumor markers measured in the follow-up of patients with known bone metastasis after hormonal therapy...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Koizumi K,Uchiyama G,Komatsu H

    更新日期:1994-11-01 00:00:00

  • Assessment of the solid-state gamma camera to depict axillary sentinel lymph nodes in breast cancer patients.

    abstract:PURPOSE:The solid-state gamma camera is now commercially available offering the advantages of a compact and portable system, currently used mainly in the cardiac region. We evaluate the ability of the solid-state gamma camera to depict axillary sentinel lymph nodes (SLNs) in breast cancer patients. MATERIALS AND METHO...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Goto M,Okuyama C,Kubota T,Ushijima Y,Nishimura T

    更新日期:2005-10-01 00:00:00

  • Distinctive FDG and FES accumulation pattern of two tamoxifen-treated patients with endometrial hyperplasia.

    abstract::16alpha-[(18)F]Fluoro-17beta-estradiol (FES) is an estrogen receptor (ER) ligand used for the detection of ER-positive malignant tumors such as breast cancer. We recently reported the feasibility of combined FES-and 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) scans for the differential d...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Tsujikawa T,Okazawa H,Yoshida Y,Mori T,Kobayashi M,Tsuchida T,Fujibayashi Y

    更新日期:2008-01-01 00:00:00

  • Usefulness of 67Ga SPECT and integrated low-dose CT scanning (SPECT/CT) in the diagnosis of cardiac sarcoidosis.

    abstract:OBJECTIVE:We performed 67Gallium (Ga) single-photon emission computed tomography (SPECT) with integrated low-dose computed tomography (CT) for the interpretation of myocardial outline to investigate the value of co-registered fusion imaging using a hybrid system (SPECT/CT) in patients with cardiac sarcoidosis. METHODS...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Momose M,Kadoya M,Koshikawa M,Matsushita T,Yamada A

    更新日期:2007-12-01 00:00:00

  • Metallic artifacts caused by dental metal prostheses on PET images: a PET/CT phantom study using different PET/CT scanners.

    abstract:OBJECTIVE:The objective of this study was to investigate the effects of computed tomography (CT) artifacts caused by dental metal prostheses on positron emission tomography (PET) images. METHODS:A dental arch cast was fixed in a cylindrical water-bath phantom. A spherical phantom positioned in the vicinity of the dent...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Shimamoto H,Kakimoto N,Fujino K,Hamada S,Shimosegawa E,Murakami S,Furukawa S,Hatazawa J

    更新日期:2009-07-01 00:00:00

  • Cardiac involvement of progressive muscular dystrophy (Becker type, Limb-girdle type and Fukuyama type) evaluated by radionuclide method.

    abstract::Tl-201 SPECT and Tc-99m-Human serum albumin (HSA) multigated radionuclide ventriculography were performed on 11 patients with progressive muscular dystrophy (Becker type 2, Fukuyama type 2, Limb-girdle type 7) to evaluate myocardial involvement. Hypoperfusion was detected in 8 patients on Tl-201 SPECT. Decreases in bo...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Nagamachi S,Inoue K,Jinnouchi S,Hoshi H,Ono S,Ohnishi T,Futami S,Watanabe K,Hayashi T

    更新日期:1994-02-01 00:00:00

  • Distinct different intra-tumor distribution of FDG between early phase and late phase in mouse fibrosarcoma.

    abstract::An early image of intra-tumor distribution of 14C-labeled fluorodeoxy glucose (14C-FDG) was compared with a late image of 18F-labeled FDG (18F-FDG) using mouse fibrosarcoma. Heterogeneous intra-tumor distribution of 14C-FDG was observed 1 minute post injection of the tracer, whereas relatively homogeneous distribution...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Inoue O,Shukuri M,Hosoi R,Amitani M,Matsuura N,Hatazawa J,Takai N

    更新日期:2005-12-01 00:00:00