Comparison of exercise-rest-reinjection Tl-201 imaging and rest sublingual isosorbide dinitrate Tc-99m MIBI imaging for the assessment of myocardial viability.

Abstract:

PURPOSE:Nitrate administration has been proposed to enhance the detection of myocardial viability when performing myocardial perfusion imaging. In this study, we aimed to compare Tl-201 exercise-rest-reinjection protocol with rest isosorbide dinitrate (ISDN)-Tc99m MIBI study in the same population examined for the myocardial viability. METHODS:Twenty-six patients with coronary artery disease who had fixed segmental defects on exercise-rest-Tl-201 imaging were studied. All of them underwent Tl-201 reinjection study. Within 1 week of Tl-201 imaging, rest-Tc99m MIBI imaging was performed after sublingual 5 mg ISDN administration (2-day protocol). For each study, tomograms were divided into 20 segments based on three short-axis slices, one vertical long-axis representing the totality of the left ventricle and regional tracer uptake was quantitatively analyzed. Regional tracer uptake was evaluated in 20 myocardial segments for all patients. Viability was defined as presence of tracer uptake >/=50% of peak activity on each study. A total 520 myocardial segments were assessed by semi quantitative analysis. RESULT:On the baseline rest Tl-201 studies, 211 segments of the 520 segments that were analyzed had <50% of peak activity. Of these segments, 42 (20%) showed reversibility after reinjection Tl-201 imaging and 55 segments (27%) described as viable on the rest ISDN-Tc99m MIBI imaging. There was 89% concordance between the ISDN-Tc99m MIBI study and Tl-201 reinjection study regarding viable myocardial segments. Of the 23 segments with discordant results, 18 were irreversible on Tl-201 reinjection study, but showed >/=50% uptake on ISDN-Tc99m MIBI. CONCLUSION:Observation of good agreement between Tl-201 reinjection and ISDN-Tc99m MIBI study studies led us to suggest the use of ISDN enhanced imaging in the evaluation of myocardial viability.

journal_name

Ann Nucl Med

authors

Günel SE,Akgun A

doi

10.1007/s12149-009-0256-2

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

451-7

issue

5

eissn

0914-7187

issn

1864-6433

journal_volume

23

pub_type

临床试验,杂志文章
  • Evaluation of treatment effects in brain abscess with positron emission tomography: comparison of fluorine-18-fluorodeoxyglucose and carbon-11-methionine.

    abstract::Positron emission tomography (PET) imaging is in common use preoperatively to clinically evaluate patients who present with central nervous system mass lesions. The usefulness of PET is also recognized as a method to detect intracranial tumorous lesions. A number of papers reportthat some inflammatory processes also s...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988258

    authors: Tsuyuguchi N,Sunada I,Ohata K,Takami T,Nishio A,Hara M,Kawabe J,Okamura T,Ochi H

    更新日期:2003-02-01 00:00:00

  • Assessment of cardiac function in patients with heart disease by quantitative gated myocardial perfusion SPECT.

    abstract:OBJECTIVE:We examined the cardiac function of patients who underwent Tc-99m sestamibi quantitative gated myocardial single photon emission computed tomography with 16-framing data acquisition between January 1, 2004 and March 31, 2006 for an evaluation of suspected or known heart disease in our hospital. METHODS:In 19...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0032-0

    authors: Nakae I,Matsuo S,Tsutamoto T,Matsumoto T,Mitsunami K,Horie M

    更新日期:2007-08-01 00:00:00

  • Introduction of the targeted alpha therapy (with Radium-223) into clinical practice in Japan: learnings and implementation.

    abstract::Radium-223 dichloride (Ra-223) is the first targeted alpha therapy approved for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone metastasis. Ra-223 improved overall survival in the international Phase III ALSYMPCA (ALpharadin in SYMPtomatic Prostate Cancer) study. Ra-223 was also de...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1317-1

    authors: Hosono M,Ikebuchi H,Nakamura Y,Yanagida S,Kinuya S

    更新日期:2019-03-01 00:00:00

  • Evaluation of a direct 4D reconstruction method using generalised linear least squares for estimating nonlinear micro-parametric maps.

    abstract:OBJECTIVE:Estimation of nonlinear micro-parameters is a computationally demanding and fairly challenging process, since it involves the use of rather slow iterative nonlinear fitting algorithms and it often results in very noisy voxel-wise parametric maps. Direct reconstruction algorithms can provide parametric maps wi...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0881-2

    authors: Angelis GI,Matthews JC,Kotasidis FA,Markiewicz PJ,Lionheart WR,Reader AJ

    更新日期:2014-11-01 00:00:00

  • A new method for apparent diffusion coefficient measurement using sequential (18)F-FDG PET and MRI: correlation with histological grade of invasive ductal carcinoma of the breast.

    abstract:OBJECTIVE:The aim of this study was to measure the apparent diffusion coefficient (ADC) value at the region with the highest FDG uptake using sequential (18)F-FDG PET and MRI, and to correlate it with the histological grade of invasive ductal carcinoma (IDC) of the breast. METHODS:A retrospective study was conducted o...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-013-0737-1

    authors: Byun BH,Noh WC,Lim I,Lee SS,Cho AR,Park JA,Kim KM,Kim HA,Kim EK,Kim BI,Choi CW,Lim SM

    更新日期:2013-10-01 00:00:00

  • Evaluation of pleural lesions after pleurodesis with OK-432 by fluorodeoxyglucose-positron emission tomography/CT.

    abstract:OBJECTIVE:This study aimed to determine changes in FDG-PET/CT after pleurodesis with OK-432 and to investigate differences in the changes between non-malignant and malignant lesions. METHODS:Study participants were 17 patients with a history of malignant chest disease who underwent FDG-PET/CT after pleurodesis using O...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01508-0

    authors: Nishimori M,Yoshimatsu R,Iwasa H,Miyatake K,Nitta N,Anayama T,Yamagami T

    更新日期:2020-10-01 00:00:00

  • Bremsstrahlung parameters of praseodymium-142 in different human tissues: a dosimetric perspective for (142)Pr radionuclide therapy.

    abstract:OBJECTIVE:Praseodymium-142 [T 1/2 = 19.12 h, [Formula: see text] = 2.162 MeV (96.3%), Eγ = 1575 keV (3.7%)] is one of the (141)Pr radioisotopes. Many studies have been attempted to assess the significance of usage (142)Pr in radionuclide therapy. In many studies, the dosimetric parameters of (142)Pr sources were calcul...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-012-0591-6

    authors: Bakht MK,Jabal-Ameli H,Ahmadi SJ,Sadeghi M,Sadjadi S,Tenreiro C

    更新日期:2012-06-01 00:00:00

  • Morphine-augmented cholescintigraphy enhances duodenogastric reflux.

    abstract::Morphine intervention in cholescintigraphy decreases imaging time to diagnose acute cholecystitis. Not infrequently we observe duodenogastric reflux during scintigraphy with and without morphine intervention. To evaluate occurrence of duodenogastric reflux related to morphine, we reviewed 55 patients who underwent cho...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03168405

    authors: Shih WJ,Lee JK,Magoun S,Wierzbinski B,Ryo UY

    更新日期:1995-11-01 00:00:00

  • Usefulness of cerebral blood flow (CBF) measurements to predict the functional outcome for rehabilitation in patients with cerebrovascular disease (CVD).

    abstract:PURPOSE:The objectives of this study were to (1) elucidate the relationship between the mean CBF in the whole brain (Av.mCBF) before rehabilitation of CVD patients and the BI score before and after rehabilitation, (2) determine whether the efficacy of rehabilitation can be predicted by measurement of the Av.mCBF, and (...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02990478

    authors: Tamamoto F,Sumi Y,Nakanishi A,Okayasu K,Maehara T,Katayama H

    更新日期:2000-02-01 00:00:00

  • Abnormal retention of 99mTc-TF in a hamster model of cardiomyopathy analyzed by 99mTc-TF and 125I-BMIPP autoradiography.

    abstract:OBJECTIVE:Enhanced washout of 99mTc-tetrofosmin (TF) has been reported in patients with hypertrophic cardiomyopathy (HCM). Here, using quantitative dual-autoradiography, the relationship between TF retention abnormality and metabolism depicted by 125I-BMIPP uptake was investigated quantitatively in a hamster model of c...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02985000

    authors: Thet-Thet-Lwin,Takeda T,Wu J,Tsuchiya Y,Itai Y

    更新日期:2004-05-01 00:00:00

  • Computer-aided diagnosis system for bone scintigrams from Japanese patients: importance of training database.

    abstract:AIM:Computer-aided diagnosis (CAD) software for bone scintigrams have recently been introduced as a clinical quality assurance tool. The purpose of this study was to compare the diagnostic accuracy of two CAD systems, one based on a European and one on a Japanese training database, in a group of bone scans from Japanes...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-012-0620-5

    authors: Horikoshi H,Kikuchi A,Onoguchi M,Sjöstrand K,Edenbrandt L

    更新日期:2012-10-01 00:00:00

  • An enhanced treatment effect can be expected from a higher serum thyroglobulin level after radioactive iodine therapy.

    abstract:OBJECTIVE:The aim of this study was to investigate if increased serum thyroglobulin (Tg) levels after radioactive iodine (RAI) showed more therapeutic effects in patients with differentiated thyroid cancer (DTC). METHODS:Data of 65 patients with DTC who underwent RAI from June 2014 to September 2016 were reviewed. Ser...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1313-5

    authors: Choi JH,Lim I,Lee I,Byun BH,Kim BI,Choi CW,Lim SM

    更新日期:2019-02-01 00:00:00

  • 99mTc(V)-DMSA and 67Ga-citrate images in a patient with recurrent extraabdominal fibromatosis.

    abstract::67Ga-citrate and 99mTc(V)-DMSA images were obtained in a patient with recurrent extraabdominal fibromatosis of the left calf. The 67Ga-citrate image showed abnormal uptake in the left calf lesion and right calf, which was considered due to probable myositis caused by overexertion. On the other hand, the 99mTc(V)-DMSA ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164850

    authors: Ohta H,Komibuchi T,Tomihara M,Watanabe H,Fujikawa S,Shintaku M

    更新日期:1998-08-01 00:00:00

  • Cerebral blood flow and metabolic abnormalities in Alzheimer's disease.

    abstract::In this review I summarize observations of PET and SPECT studies about cerebral blood flow and metabolic abnormalities in Alzheimer's disease. In very early AD flow or metabolism reduces first in the posterior cingulate gyrus and precuneus. This reduction may arise from functional deafferentation caused by primary neu...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/BF02988596

    authors: Matsuda H

    更新日期:2001-04-01 00:00:00

  • Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions.

    abstract:OBJECTIVE:(11)C-Methionine positron emission tomography (MET-PET) has been used to distinguish brain tumor recurrence from radiation necrosis. Because the spatial resolution of conventional PET scanners is low, partial volume effect (PVE) may decrease the detectability of small tumor recurrence. The aim of this study i...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-010-0450-2

    authors: Okamoto S,Shiga T,Hattori N,Kubo N,Takei T,Katoh N,Sawamura Y,Nishijima K,Kuge Y,Tamaki N

    更新日期:2011-04-01 00:00:00

  • Intravascular large B-cell lymphoma with diffuse FDG uptake in the lung by 18FDG-PET/CT without chest CT findings.

    abstract::We report a rare case of intravascular large B-cell lymphoma (IVLBCL) with diffuse fluorodeoxyglucose (FDG) uptake in the lung by (18)FDG-positron emission tomography/computed tomography (PET/CT). CT showed nodular shadow, whereas diffuse FDG uptake in PET/CT suggested IVLBCL in the lung. A random skin biopsy provided...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-012-0600-9

    authors: Yamashita H,Suzuki A,Takahashi Y,Kubota K,Kano T,Mimori A

    更新日期:2012-07-01 00:00:00

  • Tuberculosis peritonitis: gallium-67 scintigraphic appearance.

    abstract::Tuberculosis peritonitis is a rare manifestation of extrapulmonary tuberculosis. The results of gallium-67 scintigraphy of three patients with tuberculosis peritonitis were reviewed to assess its usefulness in the diagnosis of this condition. Tuberculosis peritonitis was associated with diffuse or focal abdominal loca...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164860

    authors: Sumi Y,Ozaki Y,Hasegawa H,Shindoh N,Katayama H,Tamamoto F

    更新日期:1999-06-01 00:00:00

  • A comparison of Tc-99m HMPAO brain SPECT images of young and aged normal individuals.

    abstract::The purpose of this study was to examine the normal distribution patterns of 99mTc-HMPAO (HMPAO) in young and aged normal individuals and to clarify differences between the distribution patterns of the two groups by means of an anatomical standardization technique. The tracer distribution was measured with HMPAO and S...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164922

    authors: Goto R,Kawashima R,Ito H,Koyama M,Sato K,Ono S,Yoshioka S,Fukuda H

    更新日期:1998-12-01 00:00:00

  • Assessment of liver function in chronic liver diseases and regional function of irradiated liver by means of 99mTc-galactosyl-human serum albumin liver scintigraphy and quantitative spectral analysis.

    abstract::Scintigraphy with 99mTc-diethylenetriamine pentaacetic acid galactosyl human serum albumin (99mTc-GSA) was performed on 102 patients, then the hepatic extraction fraction (HEF), the rate constant for liver uptake of the tracer from the blood (K1) and the hepatic blood flow index (HBFI) were determined by spectral anal...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988293

    authors: Fukui A,Murase K,Tsuda T,Fujii T,Ikezoe J

    更新日期:2000-12-01 00:00:00

  • Visual and semi-quantitative analyses of dual-phase breast-specific gamma imaging with Tc-99m-sestamibi in detecting primary breast cancer.

    abstract:OBJECTIVES:Breast cancer is the most common malignancy for females worldwide. This study was to evaluate the application of dual-phase breast-specific gamma imaging (BSGI) in detecting primary breast cancer. METHODS:Seventy-six patients with indeterminate breast lesions that underwent dual-phase BSGI enrolled in this ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-013-0776-7

    authors: Tan H,Jiang L,Gu Y,Xiu Y,Han L,Wu P,Zhang H,Shi H

    更新日期:2014-01-01 00:00:00

  • Study on the primary visual cortex of visually impaired subjects by means of 123I-IMP SPECT and MRI.

    abstract::We conducted a study of rCBF in the primary visual cortex of visually impaired subjects who have not been subjected to external stimulation for a long period, by means of 123I-IMP SPECT and MRI. The four subjects had lost their sight due to brain tumors (n = 2), glaucoma (n = 1) and trauma (n = 1). 123I-IMP SPECT show...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164976

    authors: Ishikawa N,Nishijo K,Satou M,Takeda T,Itai Y

    更新日期:1995-05-01 00:00:00

  • Surveillance study for creating the national clinical database related to ECG-gated myocardial perfusion SPECT of ischemic heart disease: J-ACCESS study design.

    abstract:BACKGROUND:ECG-gated myocardial perfusion SPECT is widely applied to diagnose ischemic heart disease, and such findings are useful to predict patient prognosis. However, Japan does not have a database that correlates SPECT image findings with the prognosis of patients who have ischemic heart disease. METHODS:A large-s...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/BF03027430

    authors: Kusuoka H,Nishimura S,Yamashina A,Nakajima K,Nishimura T

    更新日期:2006-04-01 00:00:00

  • Prognostic role of baseline 18F-FDG PET/CT metabolic parameters in mantle cell lymphoma.

    abstract:OBJECTIVE:Mantle cell lymphoma (MCL) is an aggressive lymphoma sub-type with poor prognosis and high 18F-FDG avidity at PET/CT; nowadays, no validated criteria for PET/CT in treatment response evaluation and prediction of outcome are present. The aim of study was to investigate whether the metabolic PET/CT features may...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-019-01354-9

    authors: Albano D,Bosio G,Bianchetti N,Pagani C,Re A,Tucci A,Giubbini R,Bertagna F

    更新日期:2019-07-01 00:00:00

  • Measurement of cerebral blood flow by the autoradiographic method with N-isopropyl-4-[I-123] iodoamphetamine: comparison of radiopharmaceuticals marketed by different companies in Japan.

    abstract:OBJECTIVE:Iodine-123-labeled N-isopropyl-4-iodoamphetamine (IMP) is used as a tracer for the measurement of cerebral blood flow (CBF) by single-photon emission computed tomography (SPECT). Two IMP products, IMP(A) (Nihon Medi-Physics Co., Ltd.) and IMP(B) (FUJIFILM RI Pharma Co., Ltd.), produced by different radiopharm...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-009-0242-8

    authors: Ogura T,Ito H,Hida K,Masuzuka T,Fukuda H,Hatazawa J

    更新日期:2009-06-01 00:00:00

  • Prognostic implications of 62Cu-diacetyl-bis (N4-methylthiosemicarbazone) PET/CT in patients with glioma.

    abstract:OBJECTIVE:The potential of positron emission tomography/computed tomography using 62Cu-diacetyl-bis (N4-methylthiosemicarbazone) (62Cu-ATSM PET/CT), which was originally developed as a hypoxic tracer, to predict therapeutic resistance and prognosis has been reported in various cancers. Our purpose was to investigate pr...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12149-018-1241-4

    authors: Toriihara A,Ohtake M,Tateishi K,Hino-Shishikura A,Yoneyama T,Kitazume Y,Inoue T,Kawahara N,Tateishi U

    更新日期:2018-05-01 00:00:00

  • Prospective evaluation of solitary thyroid nodule on 18F-FDG PET/CT and high-resolution ultrasonography.

    abstract:PURPOSE:The utility of 18F-FDG PET/CT in the assessment of thyroid nodules is unclear as there are several conflicting reports on the usefulness of SUV as an indicator to distinguish benign from malignant thyroid lesions. This study incorporated an additional parameter, namely dual time point imaging, to determine the ...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12149-010-0357-y

    authors: D'Souza MM,Marwaha RK,Sharma R,Jaimini A,Thomas S,Singh D,Jain M,Bhalla PJ,Tripathi M,Tiwari A,Mishra A,Mondal A,Tripathi RP

    更新日期:2010-06-01 00:00:00

  • Micronucleus evaluation for determining the chromosomal breakages after radionuclide synovectomy in patients with hemophilia.

    abstract:OBJECTIVE:To investigate the genotoxic effects of (90)Y and (186)Re in patients with hemophilia who were undergoing radionuclide synovectomy (RS) procedure in the last 3 years. METHODS:Nineteen patients were enrolled in the study. Most of the patients (n = 17) were hemophilia-A (mean age 20.6 ± 10.5 years) and 18 pati...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-011-0540-9

    authors: Kavakli K,Cogulu O,Karaca E,Durmaz B,Ozkinay F,Aydogdu S,Ozkilic H,Balkan C,Karapinar D,Ay Y

    更新日期:2012-01-01 00:00:00

  • Does lung perfusion scintigraphy continue to have a role in the clinical management of patients suspected of pulmonary embolism in the CT pulmonary angiography era?

    abstract:OBJECTIVE:Acute pulmonary embolism (PE) is a life-threatening disorder with high mortality. A prompt diagnosis and treatment is essential for reducing the mortality rate. The purpose of the study is to evaluate if lung perfusion scintigraphy (LPS) continues to have a role in the clinical management of patients suspecte...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1295-3

    authors: Koukouraki SI,Hatzidakis AA,Mitrouska I,Stathaki MI,Perisinakis K

    更新日期:2018-12-01 00:00:00

  • Performance assessment of the ALBIRA II pre-clinical SPECT S102 system for 99mTc imaging.

    abstract:OBJECTIVE:The performance characteristics of the SPECT sub-system S102 of the ALBIRA II PET/SPECT/CT are analyzed for the 80 mm field of view (FOV) to evaluate the potential in-vivo imaging in rats, based on measurements of the system response for the commonly used Technetium-99 m (99mTc) in small animal imaging. METH...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01547-7

    authors: Attarwala AA,Hardiansyah D,Romanó C,Jiménez-Franco LD,Roscher M,Wängler B,Glatting G

    更新日期:2021-01-01 00:00:00

  • Quantification evaluation of 99mTc-MDP concentration in the lumbar spine with SPECT/CT: compare with bone mineral density.

    abstract:BACKGROUND:Despite recent technological advances allowing for quantitative single-photon emission computed tomography (SPECT), quantitative SPECT has not been widely used in the clinical practice of osteoporosis. The aim of this study is to evaluate the feasibility of quantitative bone SPECT/CT for measuring lumbar sta...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-019-01425-x

    authors: Huang K,Feng Y,Liu D,Liang W,Li L

    更新日期:2020-02-01 00:00:00