Surveillance study for creating the national clinical database related to ECG-gated myocardial perfusion SPECT of ischemic heart disease: J-ACCESS study design.


BACKGROUND:ECG-gated myocardial perfusion SPECT is widely applied to diagnose ischemic heart disease, and such findings are useful to predict patient prognosis. However, Japan does not have a database that correlates SPECT image findings with the prognosis of patients who have ischemic heart disease. METHODS:A large-scale clinical study involving 117 medical facilities throughout Japan was established to survey the clinical background and image findings of patients who have undergone ECG-gated stress perfusion SPECT. These patients were followed up for three years to investigate the occurrence of cardiac events. RESULTS:The 4,629 registered patients comprised 2,989 males (age 64.9 +/- 10.3 y, mean +/- SD) and 1,640 females (age 67.2 +/- 9.7 y). The most frequent complication was hypertension (54.5%), followed by hyperlipidemia (47.2%) and diabetes (29.4%). Percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) was conducted on 1,925 of the patients. SPECT examinations were ordered for further examination of chest pain (32.8%), periodic follow-up after coronary artery intervention (24.2%), screening for coronary artery disease (15.1%), follow-up of old myocardial infarction (14.9%), more detailed investigation of ECG or echocardiographic abnormalities (13.1%), etiological assessment of heart failure (1.6%), and further inspection for acute coronary syndrome (0.3%). The method of inducing stress was most often exercise loading at 68.8%, and infusion of either dipyridamole (14.6%) or adenosine triphosphate (ATP, 13.8%). The most frequently applied amount of 99mTc-tetrofosmin was an initial dose of 200 to 300 MBq combined with a second dose of 700 to 800 MBq (37.7%). The mean doses were 305 +/- 81 at the initial and 709 +/- 132 MBq at the second administration. A history of angina pectoris (41.2%) was the most frequent, followed by myocardial infarction (29.5%). CONCLUSIONS:During the two years of follow-up after registration, 46 of the 4,629 subjects have discontinued or dropped out, 134 have died, and 4,449 (97.8%) continue to undergo follow-up investigations. A complete report will be presented when the follow-up data for 3 years have been compiled and analyzed.


Ann Nucl Med


Kusuoka H,Nishimura S,Yamashina A,Nakajima K,Nishimura T




Has Abstract


2006-04-01 00:00:00












  • The usefulness of (18)F-FDG PET/MRI fusion image in diagnosing pancreatic tumor: comparison with (18)F-FDG PET/CT.

    abstract:PURPOSE:This study aimed at demonstrating the feasibility of retrospectively fused (18)F FDG-PET and MRI (PET/MRI fusion image) in diagnosing pancreatic tumor, in particular differentiating malignant tumor from benign lesions. In addition, we evaluated additional findings characterizing pancreatic lesions by FDG-PET/MR...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Nagamachi S,Nishii R,Wakamatsu H,Mizutani Y,Kiyohara S,Fujita S,Futami S,Sakae T,Furukoji E,Tamura S,Arita H,Chijiiwa K,Kawai K

    更新日期:2013-07-01 00:00:00

  • A case of inferior vena cava thrombosis and pulmonary embolism secondary to acute exacerbation of chronic pancreatitis: a rare finding in radionuclide venography.

    abstract::A rare case of inferior vena cava (IVC) thrombosis and pulmonary embolism secondary to acute exacerbation of chronic pancreatitis was reported. Radionuclide venography and lung perfusion scintigraphy were performed on a 46-year-old male with acute exacerbation of chronic pancreatitis who complained of mild swelling of...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Ohta H,Hachiya T

    更新日期:2002-04-01 00:00:00

  • Distinguishing benign from malignant gallbladder wall thickening using FDG-PET.

    abstract:OBJECTIVE:Because thickening of the gallbladder wall is observed not only in patients with gallbladder cancer but also in those with benign diseases such as chronic cholecystitis and gallbladder adenomyosis, it is difficult to distinguish between benign and malignant gallbladder wall thickening by conventional techniqu...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Oe A,Kawabe J,Torii K,Kawamura E,Higashiyama S,Kotani J,Hayashi T,Kurooka H,Tsumoto C,Kubo S,Shiomi S

    更新日期:2006-12-01 00:00:00

  • Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang's

    abstract:OBJECTIVE:We examined the diagnostic value of brain perfusion single-photon emission computed tomography (SPECT) using voxel-based statistical analysis with CT-based attenuation correction (CT-AC) by comparing it to that with Chang's AC in mild cognitive impairment (MCI) patients and attempted to locate brain areas tha...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Sohara K,Kiriyama T,Mizumura S,Ishiwata A,Yamazaki M,Kimura K,Kumita SI

    更新日期:2020-07-01 00:00:00

  • Usefulness of a breath-holding acquisition method in PET/CT for pulmonary lesions.

    abstract:OBJECTIVE:To evaluate the usefulness of a breath-holding (BH) (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography ((18)F-FDG-PET) technique for PET/computed tomography (CT) scanning of pulmonary lesions near the diaphragm, where image quality is influenced by respiratory motion. METHODS:In a basic study, sim...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Yamaguchi T,Ueda O,Hara H,Sakai H,Kida T,Suzuki K,Adachi S,Ishii K

    更新日期:2009-01-01 00:00:00

  • Tl-201 uptake and retention in a Warthin's tumor.

    abstract::We report scan findings of Tl-201 in a case of histologically proved Warthin's tumor. Dual isotopes acquisition was performed in a case of left parotid Warthin's tumor. Both early and delayed Tc-99m-pertechnetate (Tc-99m) images showed increased uptake at the tumor. Tl-201 scan also showed an increase of uptake on the...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Arbab AS,Koizumi K,Arai T,Toyama K,Araki T

    更新日期:1996-08-01 00:00:00

  • Ordered subset expectation maximisation vs Bayesian penalised likelihood reconstruction algorithm in 18F-PSMA-1007 PET/CT.

    abstract:BACKGROUND:The aim of the study was to compare widely used ordered subset expectation maximisation (OSEM) algorithm with a new Bayesian penalised likelihood (BPL) Q.Clear algorithm in 18F-PSMA-1007 PET/CT. METHODS:We retrospectively assessed 25 18F-PSMA-1007 PET/CT scans with both OSEM and Q.Clear reconstructions avai...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Witkowska-Patena E,Budzyńska A,Giżewska A,Dziuk M,Walęcka-Mazur A

    更新日期:2020-03-01 00:00:00

  • Comparison of exercise-rest-reinjection Tl-201 imaging and rest sublingual isosorbide dinitrate Tc-99m MIBI imaging for the assessment of myocardial viability.

    abstract:PURPOSE:Nitrate administration has been proposed to enhance the detection of myocardial viability when performing myocardial perfusion imaging. In this study, we aimed to compare Tl-201 exercise-rest-reinjection protocol with rest isosorbide dinitrate (ISDN)-Tc99m MIBI study in the same population examined for the myoc...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Günel SE,Akgun A

    更新日期:2009-07-01 00:00:00

  • Dilated cardiomyopathy relieved as a result of beta-blocker therapy: a case report--key points in assessment of prognosis based on MIBG myocardial scintigraphy and BNP levels.

    abstract::A 48-year-old male patient was admitted to our hospital with dyspnea accompanied by orthopnea. Chest x-rays showed a cardiothoracic ratio of 68% and pulmonary congestion. He was diagnosed with dilated cardiomyopathy. Beta-Blocker (carvedilol) therapy was initiated on Day 22 of the disease using a small initial dose. H...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Matsuo S,Nakae I,Masuda D,Matsumoto T,Horie M

    更新日期:2005-05-01 00:00:00

  • A comparative study of breast-specific gamma imaging with the conventional imaging modality in breast cancer patients with dense breasts.

    abstract:OBJECTIVE:The aim of this study was to evaluate the value of breast-specific gamma imaging (BSGI) as compared with mammography (MMG) and ultrasonography (US). METHODS:This study retrospectively enrolled 121 women with breast cancer (45.0 ± 8.1 years) and dense breasts (breast density >50 %). All patients underwent pre...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Kim BS,Moon BI,Cha ES

    更新日期:2012-12-01 00:00:00

  • Evaluation of pleural lesions after pleurodesis with OK-432 by fluorodeoxyglucose-positron emission tomography/CT.

    abstract:OBJECTIVE:This study aimed to determine changes in FDG-PET/CT after pleurodesis with OK-432 and to investigate differences in the changes between non-malignant and malignant lesions. METHODS:Study participants were 17 patients with a history of malignant chest disease who underwent FDG-PET/CT after pleurodesis using O...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Nishimori M,Yoshimatsu R,Iwasa H,Miyatake K,Nitta N,Anayama T,Yamagami T

    更新日期:2020-10-01 00:00:00

  • Comparison of (99m)Tc-labeled PR81 and its F(ab')₂ fragments as radioimmunoscintigraphy agents for breast cancer imaging.

    abstract:OBJECTIVE:We digested anti-MUC1 monoclonal antibody PR81 to produce F(ab')₂ fragments. A comparison was performed between the two radiolabeled PR81 and F(ab')₂ fragments for breast tumor imaging in a mouse model. METHODS:The optimum conditions for pepsin digestion of PR81 were investigated in terms of enzymes: antibod...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Salouti M,Babaei MH,Rajabi H,Foroutan H,Rasaee MJ,Rajabi AB,Mohammadnejad J,Shafiee M,Mazidi M,Daha FJ

    更新日期:2011-02-01 00:00:00

  • Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF.

    abstract::This study evaluates the regional cerebral blood flow (CBF) with H2(15)O-PET and the distribution of central benzodiazepine receptor (BZR) with C-11 flumazenil (FMZ) by PET and I-123 iomazenil (IMZ) by SPECT in Alzheimer's disease (AD). In AD, whereas the CBF was diminished in the frontal, temporal, parietal, and occi...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Ohyama M,Senda M,Ishiwata K,Kitamura S,Mishina M,Ishii K,Toyama H,Oda K,Katayama Y

    更新日期:1999-10-01 00:00:00

  • Intravascular large B-cell lymphoma with diffuse FDG uptake in the lung by 18FDG-PET/CT without chest CT findings.

    abstract::We report a rare case of intravascular large B-cell lymphoma (IVLBCL) with diffuse fluorodeoxyglucose (FDG) uptake in the lung by (18)FDG-positron emission tomography/computed tomography (PET/CT). CT showed nodular shadow, whereas diffuse FDG uptake in PET/CT suggested IVLBCL in the lung. A random skin biopsy provided...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Yamashita H,Suzuki A,Takahashi Y,Kubota K,Kano T,Mimori A

    更新日期:2012-07-01 00:00:00

  • A 18F-FDG-positive, 67Ga-negative, and transferrin receptor expression-negative patient with diffuse large B-cell lymphoma.

    abstract::We recently experienced a case with uveitis suffering from fever of unknown origin suspected of being caused by sarcoidosis. Chest computed tomography showed right supraclavicular, bilateral mediastinal, and right hilar lymphadenopathy, and intensive abnormal uptake of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) was obs...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Tsujikawa T,Okazawa H,Tsuchida T,Demura Y,Imamura Y,Fujibayashi Y

    更新日期:2007-08-01 00:00:00

  • Transient seizure activity demonstrated by Tc-99m HMPAO SPECT and diffusion-weighted MR imaging.

    abstract::Cerebral perfusion single photon emission computed tomography (SPECT) has been used to confirm the localization of the epileptic focus and the evaluation of seizure. Recently, diffusion-weighted MR imaging (DWI) has been recognized for evaluation of seizure activity. We describe a case of transient seizure activity de...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Sagiuchi T,Ishii K,Asano Y,Aoki Y,Woodhams R,Yanaihara H,Kan S,Hayakawa K

    更新日期:2001-06-01 00:00:00

  • Left ventricular systolic/diastolic function evaluated by quantitative ECG-gated SPECT: comparison with echocardiography and plasma BNP analysis.

    abstract:OBJECTIVE:The aim of this study was to evaluate the left ventricular (LV) functional parameters calculated using quantitative electrocardiography (ECG)-gated myocardial perfusion single photon emission computed tomography (QGS). In addition to LV systolic parameters, diastolic parameters were compared with those by ult...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Nakae I,Matsuo S,Koh T,Mitsunami K,Horie M

    更新日期:2005-09-01 00:00:00

  • High metabolic tumor volume and total lesion glycolysis are associated with lateral lymph node metastasis in patients with incidentally detected thyroid carcinoma.

    abstract:OBJECTIVE:The objective of this study was to investigate whether total lesion glycolysis (TLG) and metabolic tumor volume (MTV) measured by ¹⁸F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) could predict the aggressiveness and lymph node metastasis (LNM) in patients with incid...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Kim BH,Kim SJ,Kim K,Kim H,Kim SJ,Kim WJ,Jeon YK,Kim SS,Kim YK,Kim IJ

    更新日期:2015-10-01 00:00:00

  • Cost-effective initial assessment strategies for thyroid nodules in iodine-adequate areas.

    abstract:OBJECTIVE:In the initial assessment of thyroid nodules, thyrotropin (TSH) has very low sensitivity for assessing functional thyroid nodules (FTNs). The false negativity in FTNs and the false positivity in non-FTNs misinterpreted by TSH will raise unnecessary assessment costs. Therefore, the aim of this study is to expl...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Cai H,Qiao Y,Huang X,Sun M,Luo Q,Yuan X,Yang Y,Mao W,Lv Z

    更新日期:2017-01-01 00:00:00

  • In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [11C]PK-11195 and animal PET following ethanol injury in rat striatum.

    abstract:OBJECTIVE:To investigate whether [(11)C]PK-11195, a specific peripheral benzodiazepine receptors (PBRs) ligand for positron emission tomography (PET), can show activated microglia in a rat brain injury model. METHODS:On day 1, ethanol was injected into the rat's right striatum (ST) using a stereotaxic operative proced...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Toyama H,Hatano K,Suzuki H,Ichise M,Momosaki S,Kudo G,Ito F,Kato T,Yamaguchi H,Katada K,Sawada M,Ito K

    更新日期:2008-06-01 00:00:00

  • Quantification of human splenic blood flow (quantitative measurement of splenic blood flow with H2(15)O and a dynamic state method: 1).

    abstract::Positron emission tomography (PET) by means of a dynamic state method and H2(15)O was performed to quantify splenic blood flow in 20 patients who had no hepatic functional disorders. Non-linear regression analysis was applied to determine splenic blood flow. In calculating arterial input function for the spleen, our o...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Oguro A,Taniguchi H,Koyama H,Tanaka H,Miyata K,Takeuchi K,Inaba T,Nakahashi H,Takahashi T

    更新日期:1993-11-01 00:00:00

  • Alterations of tumor suppressor genes (Rb, p16, p27 and p53) and an increased FDG uptake in lung cancer.

    abstract:OBJECTIVE:The FDG uptake in lung cancer is considered to reflect the degree of malignancy, while alterations of some tumor suppressor genes are considered to be related to the malignant biological behavior of tumors. The aim of this study is to examine the relationship between FDG-PET and alterations in the tumor suppr...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Sasaki M,Sugio K,Kuwabara Y,Koga H,Nakagawa M,Chen T,Kaneko K,Hayashi K,Shioyama Y,Sakai S,Honda H

    更新日期:2003-05-01 00:00:00

  • Assessment of myocardial viability in patients with myocardial infarction using twenty-four hour thallium-201 late redistribution imaging.

    abstract:BACKGROUND:Rest thallium-201 (201Tl) myocardial perfusion imaging has been widely used for evaluation of myocardial ischemia/viability after myocardial infarction, but the ideal timing for imaging after injection to maximally estimate viability is not well established. METHODS:Thirty-six patients with myocardial infar...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Yang XJ,He YM,Zhang B,Wu YW,Hui J,Jiang TB,Song JP,Liu ZH,Jiang WP

    更新日期:2006-01-01 00:00:00

  • Amyloid-plaque imaging in early and differential diagnosis of dementia.

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    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审


    authors: Drzezga A

    更新日期:2010-02-01 00:00:00

  • Efficacy of conventional whole-body ¹⁸F-FDG PET/CT in the incidental findings of parotid masses.

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    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Wang HC,Zuo CT,Hua FC,Huang ZM,Tan HB,Zhao J,Guan YH

    更新日期:2010-10-01 00:00:00

  • Luxury perfusion phenomenon in acute herpes simplex virus encephalitis.

    abstract::In a patient with acute herpes simplex virus (HSV) encephalitis, positron emission tomography (PET) demonstrated increased cerebral blood flow in the affected temporal lobe accompanied by reduction in the cerebral oxygen extraction fraction and the cerebral metabolic rate of oxygen, i.e., luxury perfusion. Follow-up P...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Tanaka M,Uesugi M,Igeta Y,Kondo S,Sun X,Hirai S

    更新日期:1995-02-01 00:00:00

  • Radioiodination and preclinical evaluation of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl)piperidine as a breast tumor imaging tracer in mouse.

    abstract:OBJECTIVE:4-Benzyl-1-(3-iodobenzylsulfonyl)piperidine, 4-B-IBSP, has shown high-binding affinity to both sigma (σ) receptors in our previous work. In current study, radiolabeling and preclinical evaluation of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl)piperidine, 4-B-[125I]IBSP, in human ductal breast carcinoma (T47D) cel...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Sadeghzadeh M,Alirezapour B,Charkhlooie GA,Baghery MK,Khorouti A

    更新日期:2017-05-01 00:00:00

  • Regional differences in distribution volume of I-123 IMP in the human brain: effect on CBF calculated by ARG method.

    abstract:OBJECTIVE:Two methods of quantitating cerebral blood flow (CBF) with iodine-123-labeled N-isopropyl-p-iodoamphetamine (I-123 IMP) and a two-compartment model had been proposed; one is the table look-up (TLU) method and the other is the autoradiographic (ARG) method. The TLU method provides values of the cerebral blood ...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Inoue K,Ito H,Nakagawa M,Goto R,Yamazaki T,Fukuda H

    更新日期:2002-07-01 00:00:00

  • Prognostic role of pretreatment 18F-FDG PET/CT in primary brain lymphoma.

    abstract:OBJECTIVE:Primary brain lymphoma is an aggressive extranodal non-Hodgkin lymphoma with poor prognosis. Many possible prognostic factors are investigated with controversial results, but possible prognostic role of 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) features re...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Albano D,Bertoli M,Battistotti M,Rodella C,Statuto M,Giubbini R,Bertagna F

    更新日期:2018-10-01 00:00:00

  • Development of Convolutional Neural Networks to identify bone metastasis for prostate cancer patients in bone scintigraphy.

    abstract:OBJECTIVE:The main aim of this work is to build a robust Convolutional Neural Network (CNN) algorithm that efficiently and quickly classifies bone scintigraphy images, by determining the presence or absence of prostate cancer metastasis. METHODS:CNN, widely applied in medical image classification, was used for bone sc...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Papandrianos N,Papageorgiou EI,Anagnostis A

    更新日期:2020-11-01 00:00:00