Abstract:
BACKGROUND:ECG-gated myocardial perfusion SPECT is widely applied to diagnose ischemic heart disease, and such findings are useful to predict patient prognosis. However, Japan does not have a database that correlates SPECT image findings with the prognosis of patients who have ischemic heart disease. METHODS:A large-scale clinical study involving 117 medical facilities throughout Japan was established to survey the clinical background and image findings of patients who have undergone ECG-gated stress perfusion SPECT. These patients were followed up for three years to investigate the occurrence of cardiac events. RESULTS:The 4,629 registered patients comprised 2,989 males (age 64.9 +/- 10.3 y, mean +/- SD) and 1,640 females (age 67.2 +/- 9.7 y). The most frequent complication was hypertension (54.5%), followed by hyperlipidemia (47.2%) and diabetes (29.4%). Percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) was conducted on 1,925 of the patients. SPECT examinations were ordered for further examination of chest pain (32.8%), periodic follow-up after coronary artery intervention (24.2%), screening for coronary artery disease (15.1%), follow-up of old myocardial infarction (14.9%), more detailed investigation of ECG or echocardiographic abnormalities (13.1%), etiological assessment of heart failure (1.6%), and further inspection for acute coronary syndrome (0.3%). The method of inducing stress was most often exercise loading at 68.8%, and infusion of either dipyridamole (14.6%) or adenosine triphosphate (ATP, 13.8%). The most frequently applied amount of 99mTc-tetrofosmin was an initial dose of 200 to 300 MBq combined with a second dose of 700 to 800 MBq (37.7%). The mean doses were 305 +/- 81 at the initial and 709 +/- 132 MBq at the second administration. A history of angina pectoris (41.2%) was the most frequent, followed by myocardial infarction (29.5%). CONCLUSIONS:During the two years of follow-up after registration, 46 of the 4,629 subjects have discontinued or dropped out, 134 have died, and 4,449 (97.8%) continue to undergo follow-up investigations. A complete report will be presented when the follow-up data for 3 years have been compiled and analyzed.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Kusuoka H,Nishimura S,Yamashina A,Nakajima K,Nishimura Tdoi
10.1007/BF03027430subject
Has Abstractpub_date
2006-04-01 00:00:00pages
195-202issue
3eissn
0914-7187issn
1864-6433journal_volume
20pub_type
杂志文章,多中心研究abstract:OBJECTIVE:We digested anti-MUC1 monoclonal antibody PR81 to produce F(ab')₂ fragments. A comparison was performed between the two radiolabeled PR81 and F(ab')₂ fragments for breast tumor imaging in a mouse model. METHODS:The optimum conditions for pepsin digestion of PR81 were investigated in terms of enzymes: antibod...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-010-0434-2
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVES:We compared the diagnostic value of fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) with that of computed tomography (CT) following radiofrequency ablation (RFA) of inoperable recurrent or metastatic cancers in the lung. METHODS:Twelve patients (9 males and 3 females; 5 had recurrent l...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02985623
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:This study aims to clarify the effect of renal function on 2-[(18)F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) imaging and determine the clinical significance of renal function in this setting. We compared FDG distribution between normal volunteers and patients with suspected renal failu...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0012-4
更新日期:2007-06-01 00:00:00
abstract::Identification and treatment of hibernating myocardium (HM) lead to improvement in LV function and prognosis in patients with post-ischemic heart failure. Different techniques are used to diagnose HM: echocardiography, MRI, SPECT and PET and, in patients with moderate LV impairment, their predictive values are similar...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/BF03006599
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the usefulness of a breath-holding (BH) (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography ((18)F-FDG-PET) technique for PET/computed tomography (CT) scanning of pulmonary lesions near the diaphragm, where image quality is influenced by respiratory motion. METHODS:In a basic study, sim...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0206-4
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Aortic knob width on chest radiography represents the extent of aortic dialation and tortuosity of the aortic arch. We tested the hypothesis that aortic knob width reflected left ventricular (LV) diastolic function assessed by gated myocardial perfusion single photon emission computed tomography (SPECT) in p...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1150-y
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Image segmentation is an essential step in quantifying the extent of reduced or absent lung function. The aim of this study is to develop and validate a new tool for automatic segmentation of lungs in ventilation and perfusion SPECT images and compare automatic and manual SPECT lung segmentations with referen...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1223-y
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine whether (11)C-hydroxyephedrine ((11)C-HED) can predict adverse events including all-cause death in Japanese patients with left ventricular (LV) dysfunction. BACKGROUND:Although (11)C-HED PET has been used to assess cardiac sympathetic innervation in various disease con...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-016-1081-z
更新日期:2016-08-01 00:00:00
abstract::Radium-223 dichloride (Ra-223) is the first targeted alpha therapy approved for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone metastasis. Ra-223 improved overall survival in the international Phase III ALSYMPCA (ALpharadin in SYMPtomatic Prostate Cancer) study. Ra-223 was also de...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1317-1
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to perform a systematic review of the prognostic value of texture parameters derived by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with lung cancer. METHODS:PubMed and EMBASE databases were searched up to March 12, 2018, for original articles invol...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12149-018-1281-9
更新日期:2018-11-01 00:00:00
abstract::Myocardial normal databases for stress myocardial perfusion study have been created by the Japanese Society of Nuclear Medicine Working Group. The databases comprised gender-, camera rotation range- and radiopharmaceutical-specific data-sets from multiple institutions, and normal database files were created for instal...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-009-0337-2
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:Treatment effect of radiofrequency ablation (RFA) is traditionally accomplished with MRI and/or CT. The aim of the study was to assess the role of FDG-PET in post RFA hepatic tumor evaluation, in comparison with MRI and CT. MATERIALS AND METHODS:28 patients (33 hepatic RFA lesions) who had post RFA FDG-PET wit...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-012-0656-6
更新日期:2013-01-01 00:00:00
abstract::In order to investigate whether or not transferrin is involved in the uptake of 67Ga by inflamed liver (acute inflammatory tissues) the uptake of 67Ga by the liver of mice treated with carbon tetrachloride (CCl4) was studied. The serum GPT value reached its maximum on the 1st day after the CCl4 treatment. The uptake o...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164602
更新日期:1990-11-01 00:00:00
abstract::We present a rare case of occult low-grade myofibroblastic sarcoma (LGMFS) detected by marked 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) uptake on positron emission tomography (PET). A 46-year-old woman presented with abnormal FDG uptake in her back when FDG-PET was performed for cancer screening. The maximum stan...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0194-4
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The Response Evaluation Criteria In Solid Tumors (RECIST) is the most used radiological method for evaluating response after peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumors. This method may give too positive estimates of response in slow growing tumors as it allows a substa...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1316-2
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To investigate the genotoxic effects of (90)Y and (186)Re in patients with hemophilia who were undergoing radionuclide synovectomy (RS) procedure in the last 3 years. METHODS:Nineteen patients were enrolled in the study. Most of the patients (n = 17) were hemophilia-A (mean age 20.6 ± 10.5 years) and 18 pati...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0540-9
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Estimation of myocardial blood flow (MBF) and coronary flow reserve (CFR) by SPECT myocardial perfusion imaging (MPI) remains challenging. Our aim was to approximate MBF and CFR by quantifying the absolute Tc-99m tetrofosmin retention in the myocardium via gated-SPECT/CT MPI. METHODS:Tracer retention was cal...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-015-0982-6
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:The deep-inspiration breath-hold PET/CT (DIBH PET/CT) technique improves the limitations of diagnosing a lesion located in an area influenced by respiratory motion that results in spatial misregistrations caused by respiration between PET and CT. However, its reproducibility with regard to calculating the ma...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-010-0352-3
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:The aim of this study is to specify the precise role of bone scintigraphy and serum CEA and CA 15-3 assays in the monitoring of breast cancers in order to optimize their use and to determine whether it is possible to guide the prescription of bone scan by the use of CEA and CA 15-3 assays in the monitoring of b...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984567
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:This study aims to determine whether a (131)I double-phase whole body scan (WBS) and SPECT-CT images have added value over a single-phase WBS image in identifying benign and malignant lesions in patients with well-differentiated thyroid cancer (DTC) at their first radioactive iodine (RAI) treatment. METHODS:...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0513-z
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to assess the value of CT and bone scintigraphic findings for grading of rib chondrosarcoma. METHODS:Included in this study were six cases of histologically proven chondrosarcoma of the rib, in which bone scintigraphy and/or CT was performed. Correlation of histologic grade (I-...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984588
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:The main aim of this work is to build a robust Convolutional Neural Network (CNN) algorithm that efficiently and quickly classifies bone scintigraphy images, by determining the presence or absence of prostate cancer metastasis. METHODS:CNN, widely applied in medical image classification, was used for bone sc...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01510-6
更新日期:2020-11-01 00:00:00
abstract::Nuclear Medicine is the specialty of medical imaging, which utilizes a variety of radionuclides incorporated into specific compounds for diagnostic imaging and therapeutic applications. During recent years, research efforts in this discipline have concentrated on the decay characteristics of particular radionuclides a...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/BF03164930
更新日期:1999-12-01 00:00:00
abstract:AIM:18F-Choline (FCH) uptake parameters are strong indicators of aggressive disease in prostate cancer. Functional parameters derived by magnetic resonance imaging (MRI) are also correlated to aggressive disease. The aim of this work was to evaluate the relationship between metabolic parameters derived by FCH PET/CT an...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1302-8
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Breast cancer is the most common malignancy for females worldwide. This study was to evaluate the application of dual-phase breast-specific gamma imaging (BSGI) in detecting primary breast cancer. METHODS:Seventy-six patients with indeterminate breast lesions that underwent dual-phase BSGI enrolled in this ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0776-7
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Accurate and validated methods for estimating regional PET image noise are helpful for optimizing image processing. The bootstrap is a data-based simulation method for statistical inference, which can be used to estimate the PET image noise without repeated measurements. The aim of this study was to experimen...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0782-9
更新日期:2014-02-01 00:00:00
abstract::This investigation was conducted to determine the ability of 201Tl brain SPECT with respect to preoperative prediction of lesional aggressiveness of meningioma. Fifty-nine lesions in 42 patients were examined. Early (15 min) and late (3 h) SPECT were obtained. Early uptake ratio (ER; lesion to normal brain average cou...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF03006435
更新日期:2003-09-01 00:00:00
abstract::Scintigraphy with 99mTc-diethylenetriamine pentaacetic acid galactosyl human serum albumin (99mTc-GSA) was performed on 102 patients, then the hepatic extraction fraction (HEF), the rate constant for liver uptake of the tracer from the blood (K1) and the hepatic blood flow index (HBFI) were determined by spectral anal...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988293
更新日期:2000-12-01 00:00:00
abstract::Reported here is a case of an inferior mesenteric varix demonstrated by 99mTc-red blood cell (RBC) scintigraphy performed for gastrointestinal bleeding in a 47-year-old man. It was shaped like a question mark ranging from the left upper abdomen to the pelvis. This is the first report of scintigraphic recognition of an...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164828
更新日期:1997-05-01 00:00:00
abstract::A case of calcifying soft tissue malignant fibrous histiocytoma (MFH) which showed a concentration of Tc-99m MDP and Ga-67 citrate, is presented. Tc-99m MDP and Ga-67 citrate scintigraphies of the thigh mass were correlated with conventional radiography, computed tomography (CT) and angiography. ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164794
更新日期:1993-02-01 00:00:00