A new method for apparent diffusion coefficient measurement using sequential (18)F-FDG PET and MRI: correlation with histological grade of invasive ductal carcinoma of the breast.

Abstract:

OBJECTIVE:The aim of this study was to measure the apparent diffusion coefficient (ADC) value at the region with the highest FDG uptake using sequential (18)F-FDG PET and MRI, and to correlate it with the histological grade of invasive ductal carcinoma (IDC) of the breast. METHODS:A retrospective study was conducted on 75 untreated patients with IDC. First, a PET/CT scan and subsequent breast MRI were done and the SUVmax of the each breast tumor was recorded. Then, a PET image and ADC map were co-registered. On the axial slice containing the pixel with SUVmax, we drew multiple circular ROIs within the tumor and measured the mean ADC value of each ROI. The average (ADC-mean) and minimum (ADC-min) of the mean ADC values for all ROIs within the tumor were calculated, respectively. Then, a circular ROI was placed at the corresponding location to the pixel with the highest SUV and the mean ADC value of the ROI was denoted as ADC-PET. We compared the averages of the ADC parameters and assessed the correlations among SUVmax and ADC parameters. ROC curve and logistic regression analyses were performed to assess the utility of ADC and SUVmax for detecting histological grade 3. RESULTS:ADC-min was significantly lower than the ADC-mean or ADC-PET. All of the ADC parameters showed a negative correlation with SUVmax. The area under the ROC curve for identifying histological grade 3 using ADC-PET, ADC-min, ADC-mean and SUVmax was 0.684, 0.660, 0.633 and 0.639, respectively. By multivariate analysis, ADC-PET was a significant, independent predictor of histological grade 3 (p = 0.004). CONCLUSIONS:We estimated the ADC value at the breast tumor region with the highest FDG uptake using sequential (18)F-FDG PET and MRI. This new ADC parameter distinguished high-grade IDC, supporting the feasibility of the combined PET-MRI system in patients with breast cancer.

journal_name

Ann Nucl Med

authors

Byun BH,Noh WC,Lim I,Lee SS,Cho AR,Park JA,Kim KM,Kim HA,Kim EK,Kim BI,Choi CW,Lim SM

doi

10.1007/s12149-013-0737-1

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

720-8

issue

8

eissn

0914-7187

issn

1864-6433

journal_volume

27

pub_type

杂志文章
  • Unusual patterns of I-131 contamination.

    abstract::Whole body imaging with radioiodine can detect functioning metastases, which can often be effectively treated with appropriate amounts of radioiodine. Non-physiologic I-131 uptake detected on images is usually interpreted as suggesting functioning thyroid metastases. However, extra-thyroidal I-131 accumulation does no...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02985010

    authors: Ozguven M,Ilgan S,Arslan N,Karacalioglu AO,Yuksel D,Dundar S

    更新日期:2004-05-01 00:00:00

  • Performance assessment of the ALBIRA II pre-clinical SPECT S102 system for 99mTc imaging.

    abstract:OBJECTIVE:The performance characteristics of the SPECT sub-system S102 of the ALBIRA II PET/SPECT/CT are analyzed for the 80 mm field of view (FOV) to evaluate the potential in-vivo imaging in rats, based on measurements of the system response for the commonly used Technetium-99 m (99mTc) in small animal imaging. METH...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01547-7

    authors: Attarwala AA,Hardiansyah D,Romanó C,Jiménez-Franco LD,Roscher M,Wängler B,Glatting G

    更新日期:2021-01-01 00:00:00

  • Water-pipe smoking effects on pulmonary permeability using technetium-99m DTPA inhalation scintigraphy.

    abstract:OBJECTIVE:Although extensive work has been done on cigarette smoking and its effects on pulmonary function, there are limited number of studies on water-pipe smoking. The effects of water-pipe smoking on health are not widely investigated. The aim of this study was to determine the effects of water-pipe smoking on pulm...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02984465

    authors: Aydin A,Kiter G,Durak H,Ucan ES,Kaya GC,Ceylan E

    更新日期:2004-06-01 00:00:00

  • Animal studies on the reduction and/or dilution of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) activity in the urinary system.

    abstract::To evaluate two methods for decreasing and/or diluting the FDG activity in the urinary system, five rats were intraperitoneally given 1,000 micrograms/g of L-lysine 4 times, starting from 60 minutes before iv injection of FDG, and then at 30-minute intervals for 90 minutes. Five rats were used as controls. In a furose...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164766

    authors: Kosuda S,Fisher S,Wahl RL

    更新日期:1997-08-01 00:00:00

  • A trial for the quantification of regional myocardial blood flow with continuous infusion of Tc-99m MIBI and dynamic SPECT.

    abstract:UNLABELLED:We propose a new method to quantify regional myocardial blood flow (rMBF) by continuous infusion of Tc-99m MIBI and dynamic SPECT. METHODS:Five patients with old myocardial infarction were studied. During continuous infusion of MIBI (approximately 740 MBq) with a syringe pump in 10 min, dynamic SPECT scan w...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03165431

    authors: Tsuchida T,Yonekura Y,Takahashi N,Nakano A,Lee JD,Sadato N,Yamamoto K,Waki A,Sugimoto K,Hayashi N,Ishii Y

    更新日期:1999-02-01 00:00:00

  • Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study.

    abstract:OBJECTIVE:To examine the patterns of longitudinal tau accumulation and cortical atrophy and their association in subjects with mild cognitive impairment (MCI). METHODS:We collected 23 participants (60-89 years old, 11 males/12 females) with MCI from the Alzheimer's Disease Neuroimaging Initiative database. All partici...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01506-2

    authors: Xu G,Zheng S,Zhu Z,Yu X,Jiang J,Jiang J,Chu Z,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2020-11-01 00:00:00

  • Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma.

    abstract::We present an interesting case with a central mediastinal pheochromocytoma showing intense F-18 fluorodeoxyglucose (FDG) uptake in tumor and systemic brown adipose tissue (BAT) mimicking metastases. The findings of hypertension and high plasma catecholamine concentration suggested the presence of pheochromocytoma. Med...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0096-x

    authors: Kuji I,Imabayashi E,Minagawa A,Matsuda H,Miyauchi T

    更新日期:2008-04-01 00:00:00

  • Radioactive synthesis of tau PET imaging agent 18F-AV-1451 and its role in monitoring the progression of Alzheimer's disease and supporting differential diagnosis.

    abstract::Alzheimer's disease (AD) is on the rise all over the world, and brings with it great challenges to medical care and heavy burdens to family and society. Accurate diagnosis and differential diagnosis are of great importance. Tau positron emission tomography (PET) might offer novel insights and be of great assistance in...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-020-01566-4

    authors: Zhang W,Xu S,Yu H,Li X,Jin Z,Li Y,He Z

    更新日期:2021-01-18 00:00:00

  • A comparison of Tc-99m HMPAO brain SPECT images of young and aged normal individuals.

    abstract::The purpose of this study was to examine the normal distribution patterns of 99mTc-HMPAO (HMPAO) in young and aged normal individuals and to clarify differences between the distribution patterns of the two groups by means of an anatomical standardization technique. The tracer distribution was measured with HMPAO and S...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164922

    authors: Goto R,Kawashima R,Ito H,Koyama M,Sato K,Ono S,Yoshioka S,Fukuda H

    更新日期:1998-12-01 00:00:00

  • Esophageal transit study using a sliding sum image: application to patients with probable and definite systemic sclerosis.

    abstract:PURPOSE:Esophageal complication is common in systemic sclerosis (SSc), but scintigraphic transit patterns based on each subtype have not been understood well. The aim of this study was to develop a new algorithm for integrating a dynamic esophageal transit study and to apply the method to patients with SSc. METHODS:A ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-011-0465-3

    authors: Nakajima K,Hasegawa M,Inaki A,Wakabayashi H,Hosoya T,Takehara K,Kinuya S

    更新日期:2011-06-01 00:00:00

  • FDG-PET imaging in duodenal cancer.

    abstract::F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging is a useful modality in the detection of various tumors, including colon cancer and gastric cancer. We evaluated a patient with duodenal cancer with multiple metastases including brain metastases using FDG-PET imaging. It revealed multiple tumor up...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02984475

    authors: Watanabe N,Hayashi S,Kato H,Shimizu M,Kamisaki Y,Noguchi K,Kishida M,Matsunari I,Hisada K,Seto H

    更新日期:2004-06-01 00:00:00

  • Assessment of cardiac function in patients with heart disease by quantitative gated myocardial perfusion SPECT.

    abstract:OBJECTIVE:We examined the cardiac function of patients who underwent Tc-99m sestamibi quantitative gated myocardial single photon emission computed tomography with 16-framing data acquisition between January 1, 2004 and March 31, 2006 for an evaluation of suspected or known heart disease in our hospital. METHODS:In 19...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0032-0

    authors: Nakae I,Matsuo S,Tsutamoto T,Matsumoto T,Mitsunami K,Horie M

    更新日期:2007-08-01 00:00:00

  • Discontinuation of metformin to prevent metformin-induced high colonic FDG uptake: is 48 h sufficient?

    abstract:OBJECTIVE:In this retrospective, single-center observational study, we investigated whether discontinuing metformin for at least 48 h prevents metformin-induced [18F]fluorodeoxyglucose (FDG) uptake in all segments of the colon. METHODS:Patients with type 2 diabetes who were using metformin before undergoing an FDG PET...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01509-z

    authors: Schreuder N,Klarenbeek H,Vendel BN,Jager PL,Kosterink JGW,van Puijenbroek EP

    更新日期:2020-11-01 00:00:00

  • The role of adrenocortical scintigraphy in the evaluation of unilateral incidentally discovered adrenal and juxtaadrenal masses.

    abstract::We reviewed the findings of adrenocortical scintigraphy with 131I-6-beta-iodomethyl-19-norcholesterol (NCL-6-131I) of 39 patients to clarify its role in the evaluation of unilateral adrenal or juxtaadrenal masses incidentally discovered by CT, ultrasonography or plain radiography. Twenty-seven benign adrenal masses sh...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164960

    authors: Nakajo M,Nakabeppu Y,Yonekura R,Iwashita S,Goto T

    更新日期:1993-08-01 00:00:00

  • Assessment of anatomic relation between pulmonary perfusion and morphology in pulmonary emphysema with breath-hold SPECT-CT fusion images.

    abstract:OBJECTIVE:Anatomic relation between pulmonary perfusion and morphology in pulmonary emphysema was assessed on deep-inspiratory breath-hold (DIBrH) perfusion single-photon emission computed tomography (SPECT)-CT fusion images. METHODS:Subjects were 38 patients with pulmonary emphysema and 11 non-smoker controls, who su...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0137-5

    authors: Suga K,Kawakami Y,Iwanaga H,Hayashi N,Seto A,Matsunaga N

    更新日期:2008-06-01 00:00:00

  • Peritoneal tuberculosis with elevated serum CA125 mimicking peritoneal carcinomatosis on F-18 FDG-PET/CT.

    abstract::18F-fluorodeoxyglucose positron emission tomography (F-18 FDG-PET) plays an important role in differentiating benign from malignant tumors. However, some false-positive findings, such as tuberculosis, may occur. We report a case referred for F-18 FDG whole-body PET computed tomography (PET/CT) scan owing to an elevate...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-008-0139-y

    authors: Chen CJ,Yao WJ,Chou CY,Chiu NT,Lee BF,Wu PS

    更新日期:2008-07-01 00:00:00

  • Does lung perfusion scintigraphy continue to have a role in the clinical management of patients suspected of pulmonary embolism in the CT pulmonary angiography era?

    abstract:OBJECTIVE:Acute pulmonary embolism (PE) is a life-threatening disorder with high mortality. A prompt diagnosis and treatment is essential for reducing the mortality rate. The purpose of the study is to evaluate if lung perfusion scintigraphy (LPS) continues to have a role in the clinical management of patients suspecte...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1295-3

    authors: Koukouraki SI,Hatzidakis AA,Mitrouska I,Stathaki MI,Perisinakis K

    更新日期:2018-12-01 00:00:00

  • Clinical usefulness of positron emission tomography with fluorine-18-fluorodeoxyglucose in the diagnosis of liver tumors.

    abstract::We studied various liver tumors by positron emission tomography with fluorine-18 fluorodeoxyglucose (FDG-PET) to examine the diagnostic usefulness of this technique. We also examined the relation between findings on FDG-PET and the characteristics of hepatocellular carcinoma. FDG-PET was performed in 78 patients with ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988591

    authors: Iwata Y,Shiomi S,Sasaki N,Jomura H,Nishiguchi S,Seki S,Kawabe J,Ochi H

    更新日期:2000-04-01 00:00:00

  • F-18 fluorodeoxyglucose PET angiography of the abdominal arteries: evaluation of image quality and comparison with contrast-enhanced CT.

    abstract:OBJECTIVE:Positron emission tomography (PET) angiography utilizes early dynamic PET acquisitions for depiction of the arterial vasculature. The aim of this study was to assess image quality and to evaluate feasibility of F-18 FDG PET angiography of the abdominal arteries. METHODS:Twenty-seven patients were included in...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0930-x

    authors: Drescher R,Freesmeyer M

    更新日期:2015-02-01 00:00:00

  • Clinical significance of diastolic function as an indicator of myocardial ischemia assessed by 16-frame gated myocardial perfusion SPECT.

    abstract:OBJECTIVE:Studies have suggested that ischemia-induced diastolic dysfunction persists longer than systolic dysfunction. We examined whether global left ventricular (LV) diastolic function during stress testing assessed by 16-frame gated myocardial perfusion single-photon emission computed tomography (SPECT) is useful a...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-008-0174-8

    authors: Nakae I,Matsuo S,Matsumoto T,Mitsunami K,Horie M

    更新日期:2008-10-01 00:00:00

  • Prediction of response to revascularization in patients with renal artery stenosis by Tc-99m-ethylenedicysteine captopril scintigraphy.

    abstract::The aim of the present study was to assess the predictive value of captopril scintigraphy with the new renal agent 99mTc-ethylenedicysteine (99mTc-EC) for post-interventional improvement in blood pressure. Twelve patients who had persistently high blood pressure with previous demonstration of various degrees of renal ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164881

    authors: Uğur O,Serdengeçti M,Karacalioğlu O,Ergün EL,Peksoy I,Cekirge S

    更新日期:1999-04-01 00:00:00

  • Phase I clinical trial of 99mTc-etarfolatide, an imaging agent for folate receptor in healthy Japanese adults.

    abstract:OBJECTIVE:Technetium etarfolatide ((99m)Tc-EF) is a radioactive diagnostic imaging agent that was developed to assess the expression of folate receptors in tumors. Administering folic acid prior to the administration of (99m)Tc-EF has been shown to improve SPECT images. Here, we conducted a phase I clinical trial to as...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-015-1006-2

    authors: Yamada Y,Nakatani H,Yanaihara H,Omote M

    更新日期:2015-11-01 00:00:00

  • Performance of (18)F-FDG PET/CT as a postoperative surveillance imaging modality for asymptomatic advanced gastric cancer patients.

    abstract:OBJECTIVE:The purpose of this study was to investigate the diagnostic performance of postoperative fluorine-18 fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) as a surveillance modality for advanced gastric cancer patients who were asymptomatic and negative by conventional...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0871-4

    authors: Lee DY,Lee CH,Seo MJ,Lee SH,Ryu JS,Lee JJ

    更新日期:2014-10-01 00:00:00

  • A comparative study of breast-specific gamma imaging with the conventional imaging modality in breast cancer patients with dense breasts.

    abstract:OBJECTIVE:The aim of this study was to evaluate the value of breast-specific gamma imaging (BSGI) as compared with mammography (MMG) and ultrasonography (US). METHODS:This study retrospectively enrolled 121 women with breast cancer (45.0 ± 8.1 years) and dense breasts (breast density >50 %). All patients underwent pre...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-012-0649-5

    authors: Kim BS,Moon BI,Cha ES

    更新日期:2012-12-01 00:00:00

  • The utility of FDG-PET/CT as an effective tool for detecting recurrent colorectal cancer regardless of serum CEA levels.

    abstract:PURPOSE:Tumor recurrence of colorectal cancers (CRC) is generally followed up by analyses of the serum carcinoembryonic antigen (CEA) levels. However, recent evidence suggests that tumor recurrence can also be visualized by 18F-fluoro-deoxyglucose emission tomography/computed tomography (FDG-PET/CT) in patients with no...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-012-0609-0

    authors: Sanli Y,Kuyumcu S,Ozkan ZG,Kilic L,Balik E,Turkmen C,Has D,Isik G,Asoglu O,Kapran Y,Adalet I

    更新日期:2012-08-01 00:00:00

  • Do short-time SPECT images of bone scintigraphy improve the diagnostic value in the evaluation of solitary lesions in the thoracic spine in patients with extraskeletal malignancies?

    abstract:OBJECTIVE:Single photon emission computed tomography (SPECT) images provide many details of the anatomical structure. Also about bone scintigraphy, there are many reports of the improvement of diagnosis by SPECT images. Although SPECT is useful, it requires much time. So to perform SPECT for all cases is difficult in t...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02985048

    authors: Kobayashi K,Okuyama C,Kubota T,Nakai T,Ushijima Y,Nishimura T

    更新日期:2005-10-01 00:00:00

  • Attenuation correction using combination of a parallel hole collimator and an uncollimated non-uniform line array source.

    abstract::Attenuation correction is very important for quantitative SPECT imaging. We designed an uncollimated non-uniform line array source (non-uniform LAS) for attenuation correction based on transmission computed tomography (TCT) using Tc-99m and compared its performance with an uncollimated uniform line array source (unifo...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02984481

    authors: Kojima A,Kawanaka K,Nakaura T,Shiraishi S,Utsunomiya D,Katsuda N,Tomiguchi S,Yamashita Y,Matsumoto M,Motomura N,Ichihara T

    更新日期:2004-07-01 00:00:00

  • Gallium-67 uptake in fibrous dysplasia of the bone.

    abstract::In a 43-year-old woman with fibrous dysplasia of the ribs and facial bone and in a 40-year-old man with fibrous dysplasia of the facial bone, there were considerable increases in the uptake of Tc-99m methylenediphosphonate (Tc-99m MDP) and Gallium-67 citrate. Fibrous dysplasia should be added to differential diagnosis...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03165658

    authors: Hoshi H,Futami S,Ohnishi T,Nagamachi S,Jinnouchi S,Murai N,Watanabe K

    更新日期:1990-03-01 00:00:00

  • Estimation of 99mTc-MAG3 clearance by single-sample methods and camera-based methods.

    abstract::We compared single-sample methods, proposed by Russell et al. and Bubeck et al., and camera-based methods in calculating 99mTc-MAG3 clearance, and determined camera-based methods that provide estimates comparable to those measured by the Russell method. Twenty-one patients underwent 99mTc-MAG3 renal scintigraphy, and ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988691

    authors: Inoue Y,Yoshikawa K,Yokoyama I,Ohtomo K

    更新日期:2000-10-01 00:00:00

  • Thallium-201 brain SPECT to diagnose aggressiveness of meningiomas.

    abstract::This investigation was conducted to determine the ability of 201Tl brain SPECT with respect to preoperative prediction of lesional aggressiveness of meningioma. Fifty-nine lesions in 42 patients were examined. Early (15 min) and late (3 h) SPECT were obtained. Early uptake ratio (ER; lesion to normal brain average cou...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03006435

    authors: Kinuya K,Ohashi M,Itoh S,Sakai S,Yamamoto K,Kakuda K,Nobata K,Terahata S,Taki S,Kinuya S

    更新日期:2003-09-01 00:00:00