Radioactive synthesis of tau PET imaging agent 18F-AV-1451 and its role in monitoring the progression of Alzheimer's disease and supporting differential diagnosis.

Abstract:

:Alzheimer's disease (AD) is on the rise all over the world, and brings with it great challenges to medical care and heavy burdens to family and society. Accurate diagnosis and differential diagnosis are of great importance. Tau positron emission tomography (PET) might offer novel insights and be of great assistance in monitoring disease progression and supporting the differential diagnosis. 18F-AV-1451, as the first Tau PET imaging agent approved by the Food and Drug Administration (FDA), has been of great potential in clinical trials. Here, we reviewed the synthesis and characteristics of 18F-AV-1451 and its role in monitoring AD progression and supporting the differential diagnosis.

journal_name

Ann Nucl Med

authors

Zhang W,Xu S,Yu H,Li X,Jin Z,Li Y,He Z

doi

10.1007/s12149-020-01566-4

subject

Has Abstract

pub_date

2021-01-18 00:00:00

eissn

0914-7187

issn

1864-6433

pii

10.1007/s12149-020-01566-4

pub_type

杂志文章,评审
  • The prognostic role of end-of-treatment FDG-PET/CT in diffuse large B cell lymphoma: a pilot study application of neural networks to predict time-to-event.

    abstract:PURPOSE:To evaluate the prognostic role of end-of-treatment (EoT) FDG-PET/CT parameters in diffuse large B cell lymphoma (DLBCL), and then to explore a pilot application of Neural Networks (NN) in predicting time-to-relapse. METHODS:For conventional survival analysis, parameters as Deauville score (DS) and quantitativ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01542-y

    authors: Annunziata S,Pelliccioni A,Hohaus S,Maiolo E,Cuccaro A,Giordano A

    更新日期:2021-01-01 00:00:00

  • Characteristics of single- and dual-photopeak energy window acquisitions with thallium-201 IQ-SPECT/CT system.

    abstract:OBJECTIVES:Although dual-energy (DE) acquisition with conventional 201Tl myocardial perfusion SPECT has several advantages such as improved attenuation of the inferior wall and increased acquisition counts, the characteristics of IQ-SPECT have not been fully evaluated. We evaluate the difference of characteristics betw...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-017-1177-0

    authors: Shibutani T,Onoguchi M,Yoneyama H,Konishi T,Matsuo S,Nakajima K,Kinuya S

    更新日期:2017-08-01 00:00:00

  • FDG-PET of patients with suspected renal failure: standardized uptake values in normal tissues.

    abstract:OBJECTIVE:This study aims to clarify the effect of renal function on 2-[(18)F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) imaging and determine the clinical significance of renal function in this setting. We compared FDG distribution between normal volunteers and patients with suspected renal failu...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0012-4

    authors: Minamimoto R,Takahashi N,Inoue T

    更新日期:2007-06-01 00:00:00

  • Unintentional human skeletal imaging with 99mTc-methylene diphosphonate 45 months beyond expiration.

    abstract::Eight patients were inadvertently administered, and imaged with, 99mTc-labeled MDP which was 45 months expired. Two cases are presented. All patients were subsequently imaged with normal MDP. The images obtained with expired MDP were clinically acceptable. No differences in scan abnormalities were observed compared wi...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164879

    authors: Riveros EG

    更新日期:1999-10-01 00:00:00

  • Assessment of human effective absorbed dose of 67 Ga-ECC based on biodistribution rat data.

    abstract:OBJECTIVE:In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determine...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0917-7

    authors: Shanehsazzadeh S,Yousefnia H,Lahooti A,Zolghadri S,Jalilian AR,Afarideh H

    更新日期:2015-02-01 00:00:00

  • Potential utility of bone scan in cranial bone flap osteomyelitis.

    abstract:OBJECTIVE:Currently, the diagnosis of bone flap osteomyelitis (BFO) remains a challenge for medical imaging. The present study aimed to identify predictive scintigraphic patterns of BFO. METHODS:This retrospective study reviewed planar bone scan of patients with suspected BFO between 2010, and 2016. A total of 15 pati...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-019-01351-y

    authors: Bani Sadr A,Gregoire B,Tordo J,Guyotat J,Boibieux A,Janier M

    更新日期:2019-06-01 00:00:00

  • Causes of false negatives in technetium-99 m methoxyisobutylisonitrile scintigraphy for hyperparathyroidism: influence of size and cysts in parathyroid lesions.

    abstract:OBJECTIVE:The aim of this study was to elucidate the causes of false-negative cases of technetium-99 m methoxyisobutylisonitrile scintigraphy (MIBI) for hyperparathyroidism. METHODS:Consecutive MIBI examinations performed in 154 patients between April 2011 and March 2017 were retrospectively reviewed. Sensitivities of...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01520-4

    authors: Ishii S,Sugawara S,Yaginuma Y,Kobiyama H,Hiruta M,Watanabe H,Yamakuni R,Hakozaki M,Fujimaki H,Ito H

    更新日期:2020-12-01 00:00:00

  • Development of Convolutional Neural Networks to identify bone metastasis for prostate cancer patients in bone scintigraphy.

    abstract:OBJECTIVE:The main aim of this work is to build a robust Convolutional Neural Network (CNN) algorithm that efficiently and quickly classifies bone scintigraphy images, by determining the presence or absence of prostate cancer metastasis. METHODS:CNN, widely applied in medical image classification, was used for bone sc...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01510-6

    authors: Papandrianos N,Papageorgiou EI,Anagnostis A

    更新日期:2020-11-01 00:00:00

  • Tc-99m depreotide SPECT/CT for lymph node staging of non-small-cell lung cancer.

    abstract:OBJECTIVE:To investigate the potential role of Tc-99m depreotide (Tc-DEPR) in the preoperative lymph node (N) staging of non-small-cell lung cancer (NSCLC). METHODS:Sixty-one patients with NSCLC at the potentially operable stage were enrolled and underwent scintigraphy before surgery (n=56) or mediastinoscopy (n=5). I...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0839-4

    authors: Apostolopoulos DJ,Koletsis EN,Spyridonidis T,Paschali A,Papandrianos N,Stamou E,Vassilakos PJ,Dougenis D

    更新日期:2014-06-01 00:00:00

  • Myocardial glucose metabolism in patients with hypertrophic cardiomyopathy: assessment by F-18-FDG PET study.

    abstract::In an investigation of myocardial metabolic abnormalities in hypertrophic myocardium, the myocardial glucose metabolism was evaluated with F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in 32 patients with hypertrophic cardiomyopathy, and the results were compared with those in 9 patients with hypert...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164836

    authors: Uehara T,Ishida Y,Hayashida K,Shimonagata T,Miyake Y,Sago M,Oka H,Nagata S,Miyatake K,Nishimura T

    更新日期:1998-04-01 00:00:00

  • Correction of scattered photons in Tc-99m imaging by means of a photopeak dual-energy window acquisition.

    abstract::We are proposing a new method for correcting of scattered photons in technetium-99m (99mTc) imaging by means of photopeak dual-energy window acquisition. This method consists of the simultaneous acquisition of two images and estimation of a scatter image included in the symmetric energy window (SW) image by the differ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03178307

    authors: Kojima A,Tsuji A,Takaki Y,Tomiguchi S,Hara M,Matsumoto M,Takahashi M

    更新日期:1992-08-01 00:00:00

  • Can (18)F-FDG-PET/CT be generally recommended in patients with differentiated thyroid carcinoma and elevated thyroglobulin levels but negative I-131 whole body scan?

    abstract:BACKGROUND:Exact localization of recurrent iodine-negative thyroid cancer is mandatory, since surgery is the only curative therapy option in patients with iodine-negative tumor tissue. The aim of this study was to evaluate the impact of (18)F-FDG-PET/CT as a routine diagnostic tool on clinical management in patients wi...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-011-0545-4

    authors: Bannas P,Derlin T,Groth M,Apostolova I,Adam G,Mester J,Klutmann S

    更新日期:2012-01-01 00:00:00

  • Present diagnostic strategies for acute pulmonary thromboembolism; results of a questionnaire in a retrospective trial conducted by the Respiratory Nuclear Medicine Working Group of the Japanese Society of Nuclear Medicine.

    abstract::The aim of this study is to re-evaluate and clarify the diagnostic role of ventilation/perfusion lung scintigraphy in Japan, now that single-detector-row helical CT and multidetector-row CT are available in clinical practice. The Respiratory Nuclear Medicine Working Group of the Japanese Society of Nuclear Medicine di...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988632

    authors: Kawamoro M,Ogura Y,Honda N,Satoh K,Suga K,Mori Y,Imai T,Inoue T,Narabayashi I

    更新日期:2002-12-01 00:00:00

  • Comparison of choline influx from dynamic 18F-Choline PET/CT and clinicopathological parameters in prostate cancer initial assessment.

    abstract:AIM:The aim of the study was to compare the kinetic analysis of 18F-labeled choline (FCH) uptake with static analysis and clinicopathological parameters in patients with newly diagnosed prostate cancer (PC). MATERIALS AND METHODS:Sixty-one patients were included. PSA was performed few days before FCH PET/CT. Gleason s...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1246-z

    authors: Palard-Novello X,Blin AL,Bourhis D,Garin E,Salaün PY,Devillers A,Querellou S,Bourguet P,Le Jeune F,Saint-Jalmes H

    更新日期:2018-05-01 00:00:00

  • Study on the primary visual cortex of visually impaired subjects by means of 123I-IMP SPECT and MRI.

    abstract::We conducted a study of rCBF in the primary visual cortex of visually impaired subjects who have not been subjected to external stimulation for a long period, by means of 123I-IMP SPECT and MRI. The four subjects had lost their sight due to brain tumors (n = 2), glaucoma (n = 1) and trauma (n = 1). 123I-IMP SPECT show...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164976

    authors: Ishikawa N,Nishijo K,Satou M,Takeda T,Itai Y

    更新日期:1995-05-01 00:00:00

  • Optimal ROI setting on the anatomically normalized I-123 FP-CIT images using high-resolution SPECT.

    abstract:OBJECTIVE:The aim of this study is to establish the optimal regions of interest (ROIs) in anatomically normalized I-123 FP-CIT SPECT images for the quantification of dopamine transporter binding. METHODS:The subjects comprised 16 normal controls and 14 Parkinsonian patients. All of the normal control subjects underwen...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-016-1107-6

    authors: Nonokuma M,Kuwabara Y,Hida K,Tani T,Takano K,Yoshimitsu K

    更新日期:2016-11-01 00:00:00

  • The role of positron emission tomography using carbon-11 and fluorine-18 choline in tumors other than prostate cancer: a systematic review.

    abstract::To systematically review published data on the role of positron emission tomography (PET) or PET/computed tomography (PET/CT) using either Carbon-11 ((11)C) or Fluorine-18 ((18)F) choline tracer in tumors other than prostatic cancer. A comprehensive literature search of studies published in PubMed/MEDLINE and Embase d...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-012-0602-7

    authors: Treglia G,Giovannini E,Di Franco D,Calcagni ML,Rufini V,Picchio M,Giordano A

    更新日期:2012-07-01 00:00:00

  • Quantification of human splenic blood flow (quantitative measurement of splenic blood flow with H2(15)O and a dynamic state method: 1).

    abstract::Positron emission tomography (PET) by means of a dynamic state method and H2(15)O was performed to quantify splenic blood flow in 20 patients who had no hepatic functional disorders. Non-linear regression analysis was applied to determine splenic blood flow. In calculating arterial input function for the spleen, our o...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164705

    authors: Oguro A,Taniguchi H,Koyama H,Tanaka H,Miyata K,Takeuchi K,Inaba T,Nakahashi H,Takahashi T

    更新日期:1993-11-01 00:00:00

  • Positron emission tomography using pyruvate-1-11C in two cases of mitochondrial encephalomyopathy.

    abstract::Positron emission tomography (PET) using pyruvate-1-11C was carried out to investigate the in vivo metabolism of pyruvate in the brains of patients with mitochondrial encephalomyopathy and Leigh's disease. Two epileptic patients were studied as control subjects. Radioactivity was eliminated from the brain tissue of th...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164593

    authors: Toyoda M,Sakuragawa N,Arai Y,Yoshikawa H,Sugai K,Arima M,Hara T,Iio M,Satoyoshi E

    更新日期:1989-07-01 00:00:00

  • The use of 3'-deoxy-3'-18F-fluorothymidine (FLT) PET in the assessment of long-term survival in breast cancer patients treated with neoadjuvant chemotherapy.

    abstract:OBJECTIVE:To assess the role of serial FLT-PET scans during early neoadjuvant treatment as a prognostic marker of response to treatment and survival. METHODS:This study is a prospective cohort study which draws from a larger original study which examined the utility of FLT-PET imaging across multiple cancers. Our coho...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12149-019-01345-w

    authors: Ueberroth BE,Lawhorn-Crews JM,Heilbrun LK,Smith DW,Akoury J,Ali-Fehmi R,Eiseler NT,Shields AF

    更新日期:2019-06-01 00:00:00

  • Characteristics and trends of research on positron emission tomography: a bibliometric analysis, 2002-2012.

    abstract:OBJECTIVE:We performed a bibliometric analysis of scientific publications focused on positron emission tomography (PET) over a 10-year period. METHODS:The MEDLINE and ISI Web of Knowledge databases were searched for English language original articles focused on PET in SCI/SCIE-indexed journals in 2002, 2007, and 2012....

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0836-7

    authors: Baek S,Yoon DY,Min KJ,Lim KJ,Seo YL,Yun EJ

    更新日期:2014-06-01 00:00:00

  • Peritoneal tuberculosis with elevated serum CA125 mimicking peritoneal carcinomatosis on F-18 FDG-PET/CT.

    abstract::18F-fluorodeoxyglucose positron emission tomography (F-18 FDG-PET) plays an important role in differentiating benign from malignant tumors. However, some false-positive findings, such as tuberculosis, may occur. We report a case referred for F-18 FDG whole-body PET computed tomography (PET/CT) scan owing to an elevate...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-008-0139-y

    authors: Chen CJ,Yao WJ,Chou CY,Chiu NT,Lee BF,Wu PS

    更新日期:2008-07-01 00:00:00

  • Radius dependence of FP-CIT quantification: a Monte Carlo-based simulation study.

    abstract:OBJECTIVE:Dopamine transporter imaging with SPECT is a valuable tool for both clinical routine and research studies. Semi-quantitative analysis plays a key role in interpreting the scans, but is dependent on numerous factors, rotational radius being one of them. This study systematically evaluates the potential influen...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-013-0789-2

    authors: Koch W,Bartenstein P,la Fougère C

    更新日期:2014-02-01 00:00:00

  • Micronucleus evaluation for determining the chromosomal breakages after radionuclide synovectomy in patients with hemophilia.

    abstract:OBJECTIVE:To investigate the genotoxic effects of (90)Y and (186)Re in patients with hemophilia who were undergoing radionuclide synovectomy (RS) procedure in the last 3 years. METHODS:Nineteen patients were enrolled in the study. Most of the patients (n = 17) were hemophilia-A (mean age 20.6 ± 10.5 years) and 18 pati...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-011-0540-9

    authors: Kavakli K,Cogulu O,Karaca E,Durmaz B,Ozkinay F,Aydogdu S,Ozkilic H,Balkan C,Karapinar D,Ay Y

    更新日期:2012-01-01 00:00:00

  • A large renal pelvic diverticulum, presenting incomplete excretion during tc-99m MAG-3 scintigraphy and tracer accumulation on tc-99m DMSA scintigraphy; a case report.

    abstract::This case report illustrates the dynamic and static renal scintigraphic images of a patient with an unusual large diverticulum of the renal pelvis. The initial diagnosis by intravenous pyelography (IVP) and ultrasonographic (US) examination was a renal pelvic diverticulum of the left kidney, and the patient was referr...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02985963

    authors: Turgut B,Erselcan T,Ozdemir S,Hasbek Z,Tosun HB,Topaktas S

    更新日期:2004-12-01 00:00:00

  • The RECIST criteria compared to conventional response evaluation after peptide receptor radionuclide therapy in patients with neuroendocrine neoplasms.

    abstract:OBJECTIVE:The Response Evaluation Criteria In Solid Tumors (RECIST) is the most used radiological method for evaluating response after peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumors. This method may give too positive estimates of response in slow growing tumors as it allows a substa...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1316-2

    authors: Løitegård T,Berntzen DT,Thiis-Evensen E

    更新日期:2019-03-01 00:00:00

  • Abnormal retention of 99mTc-TF in a hamster model of cardiomyopathy analyzed by 99mTc-TF and 125I-BMIPP autoradiography.

    abstract:OBJECTIVE:Enhanced washout of 99mTc-tetrofosmin (TF) has been reported in patients with hypertrophic cardiomyopathy (HCM). Here, using quantitative dual-autoradiography, the relationship between TF retention abnormality and metabolism depicted by 125I-BMIPP uptake was investigated quantitatively in a hamster model of c...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02985000

    authors: Thet-Thet-Lwin,Takeda T,Wu J,Tsuchiya Y,Itai Y

    更新日期:2004-05-01 00:00:00

  • Water-pipe smoking effects on pulmonary permeability using technetium-99m DTPA inhalation scintigraphy.

    abstract:OBJECTIVE:Although extensive work has been done on cigarette smoking and its effects on pulmonary function, there are limited number of studies on water-pipe smoking. The effects of water-pipe smoking on health are not widely investigated. The aim of this study was to determine the effects of water-pipe smoking on pulm...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02984465

    authors: Aydin A,Kiter G,Durak H,Ucan ES,Kaya GC,Ceylan E

    更新日期:2004-06-01 00:00:00

  • Washout rates of Tc-99m tetrofosmin in asymmetric septal hypertrophy.

    abstract::The aim of this study was to evaluate the washout rate of Tc-99m tetrofosmin in asymmetric septal hypertrophy (ASH). As Tc-99m tetrofosmin accumulation and retention depend on sarcolemmal and/or mitochondrial function, the presence or absence of abnormalities in the washout rate of Tc-99m tetrofosmin could provide inf...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02986332

    authors: Büyükdereli G,Kanadasi M,Kibar M

    更新日期:2005-02-01 00:00:00

  • Fluorine-18-fluorodeoxyglucose positron emission tomography for assessment of patients with unresectable recurrent or metastatic lung cancers after CT-guided radiofrequency ablation: preliminary results.

    abstract:OBJECTIVES:We compared the diagnostic value of fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) with that of computed tomography (CT) following radiofrequency ablation (RFA) of inoperable recurrent or metastatic cancers in the lung. METHODS:Twelve patients (9 males and 3 females; 5 had recurrent l...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02985623

    authors: Okuma T,Okamura T,Matsuoka T,Yamamoto A,Oyama Y,Toyoshima M,Koyama K,Inoue K,Nakamura K,Inoue Y

    更新日期:2006-02-01 00:00:00