Abstract:
:To systematically review published data on the role of positron emission tomography (PET) or PET/computed tomography (PET/CT) using either Carbon-11 ((11)C) or Fluorine-18 ((18)F) choline tracer in tumors other than prostatic cancer. A comprehensive literature search of studies published in PubMed/MEDLINE and Embase databases through January 2012 and regarding (11)C-choline or (18)F-choline PET or PET/CT in patients with tumors other than prostatic cancer was carried out. Fifty-two studies comprising 1800 patients were included and discussed. Brain tumors were evaluated in 15 articles, head and neck tumors in 6, thoracic tumors (including lung and mediastinal neoplasms) in 14, liver tumors (including hepatocellular carcinoma) in 5, gynecologic malignancies (including breast tumors) in 5, bladder and upper urinary tract tumors in 5, and musculoskeletal tumors in 7. Radiolabeled choline PET or PET/CT is useful to differentiate high-grade from low-grade gliomas and malignant from benign brain lesions, to early detect brain tumor recurrences and to guide the stereotactic biopsy sampling. The diagnostic accuracy of radiolabeled choline PET is superior compared to Fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET in this setting. Radiolabeled choline PET or PET/CT seems to be accurate in differential diagnosis between malignant and benign thoracic lesions and in staging lung tumors; nevertheless, a superiority of radiolabeled choline compared to (18)F-FDG has not been demonstrated in this setting, except for the detection of brain metastases. Few but significant studies on radiolabeled choline PET and PET/CT in patients with hepatocellular carcinoma (HCC) and musculoskeletal tumors are reported in the literature. The combination of radiolabeled choline and (18)F-FDG PET increases the detection rate of HCC. The diagnostic accuracy of radiolabeled choline PET or PET/CT seems to be superior compared to (18)F-FDG PET or PET/CT and conventional imaging methods in patients with bone and soft tissue tumors. Limited experience exists about the role of radiolabeled choline PET and PET/CT in patients with head and neck tumors, bladder cancer and gynecologic malignancies including breast cancer.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Treglia G,Giovannini E,Di Franco D,Calcagni ML,Rufini V,Picchio M,Giordano Adoi
10.1007/s12149-012-0602-7subject
Has Abstractpub_date
2012-07-01 00:00:00pages
451-61issue
6eissn
0914-7187issn
1864-6433journal_volume
26pub_type
杂志文章,评审abstract:PURPOSE:The aim of this study was to elucidate the regional differences between brain perfusion single photon emission computed tomography (SPECT) images reconstructed with a uniform attenuation correction using Chang's method (AC-Chang) and a non-uniform attenuation correction with CT using SPECT/CT (AC-CT). METHODS:...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0567-y
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Primary brain lymphoma is an aggressive extranodal non-Hodgkin lymphoma with poor prognosis. Many possible prognostic factors are investigated with controversial results, but possible prognostic role of 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) features re...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1274-8
更新日期:2018-10-01 00:00:00
abstract:UNLABELLED:We evaluated a new semiquantitative procedure to more easily and objectively estimate the striatal uptake of 123I-FP-CIT in patients with Parkinsonian syndrome (PS) and essential tremor (ET), using an anatomical standardization method, the Neurostat. METHODS:Eleven patients with PS and 8 with ET were examin...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02987257
更新日期:2006-08-01 00:00:00
abstract::The increasing life expectancy in our society results in a continuously growing number of patients suffering from neurodegenerative disorders, particularly Alzheimer's disease (AD). Apart from the deleterious consequences for patients and their relatives, this issue has also alarming effects on our social systems. The...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-009-0330-9
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:This study aims to determine whether a (131)I double-phase whole body scan (WBS) and SPECT-CT images have added value over a single-phase WBS image in identifying benign and malignant lesions in patients with well-differentiated thyroid cancer (DTC) at their first radioactive iodine (RAI) treatment. METHODS:...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0513-z
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:In clinical practice, measurement of the rCBF has mainly been conducted by I-123-N-isopropyl-p-iodoamphetamine ((123)I-IMP) SPECT using the microsphere (MS) method, with continuous arterial blood sampling. While several non-invasive (123)I-IMP quantification methods have been developed, their accuracy has bee...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1053-8
更新日期:2016-04-01 00:00:00
abstract::Scintigraphy with 99mTc-diethylenetriamine pentaacetic acid galactosyl human serum albumin (99mTc-GSA) was performed on 102 patients, then the hepatic extraction fraction (HEF), the rate constant for liver uptake of the tracer from the blood (K1) and the hepatic blood flow index (HBFI) were determined by spectral anal...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988293
更新日期:2000-12-01 00:00:00
abstract::F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging is a useful modality in the detection of various tumors, including colon cancer and gastric cancer. We evaluated a patient with duodenal cancer with multiple metastases including brain metastases using FDG-PET imaging. It revealed multiple tumor up...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984475
更新日期:2004-06-01 00:00:00
abstract:UNLABELLED:In the management of rectal cancer after the combined therapy of the radiation and surgical operation, the evaluation of the prognosis is important. Although fluoro- 18-deoxyglucose positron emission tomography (FDG-PET) is considered as a useful tool for evaluation of therapeutic effect of this cancer as we...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02990079
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:Variable uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has been noticed in positron emission tomography (PET) studies of gastric carcinoma patients, with low uptake occurring especially in some particular histological subtypes and early carcinomas. But this phenomenon has not been adequately explained. The ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984657
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate the outcomes and prognostic factors of high-dose 131I-metaiodobenzylguanidine (131I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan. METHODS:We retrospectively analyzed 20 patients with refractory or relapsed high-risk NBL who underwe...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01460-z
更新日期:2020-06-01 00:00:00
abstract:AIM:Computer-aided diagnosis (CAD) software for bone scintigrams have recently been introduced as a clinical quality assurance tool. The purpose of this study was to compare the diagnostic accuracy of two CAD systems, one based on a European and one on a Japanese training database, in a group of bone scans from Japanes...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-012-0620-5
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:A complication after spinal fusion surgery is pseudarthrosis, but its radiological diagnosis is of limited value. (18)F-fluoride PET with its ability to assess bone metabolism activity could be of value. The goal of this study was to assess the clinical feasibility of calculating the static standardized uptak...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1008-0
更新日期:2015-11-01 00:00:00
abstract::We report a functional neuroimaging study of a patient clinically diagnosed with Korsakoff syndrome. Positron emission tomography (PET) with the 15O inhalation method showed decreased regional cerebral blood flow (rCBF) and decreased regional cerebral metabolic ratio for oxygen (rCMRO2) in the bilateral fronto-tempora...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164755
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:In mCRPC patients treated with 223Ra, a major issue is the validation of reliable prognostic and predictive biomarkers to maximize clinical benefit and minimize toxicities and costs. Bearing in mind how changes in tALP did not meet statistical requirements as surrogate marker for survival, aim of this single-...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1228-6
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Lutetium oxyorthosilicate (LSO) contains natural radioactivity that emits beta particles and three gamma photons simultaneously. These beta particles and gamma photons increase the single and random rates in a positron emission tomography (PET) system while a beta particle and gamma photon produced in the sam...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03027389
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:The presence of central lymph node (LN) metastasis increases the risk of cervical LN recurrence or distant metastasis in patients with papillary thyroid microcarcinoma (PTMC). We investigated the value of preoperative (18)F-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG PET)-computerized tomography ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-012-0594-3
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:123I-beta-methyl iodophenyl pentadecanoic acid (BMIPP) can visualize myocardial fatty acid metabolism and has extensive potential for diagnosing cardiac diseases such as acute coronary syndrome in the clinical setting. Increased BMIPP uptake with decreased perfusion occasionally occurs under acute reperfusion...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0510-2
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. METHODS:Forty-seve...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-007-0179-8
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The FDG uptake in lung cancer is considered to reflect the degree of malignancy, while alterations of some tumor suppressor genes are considered to be related to the malignant biological behavior of tumors. The aim of this study is to examine the relationship between FDG-PET and alterations in the tumor suppr...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02990021
更新日期:2003-05-01 00:00:00
abstract:UNLABELLED:Poor and variable spatial resolution of the gamma camera, the movement of the heart and, above all, the inclusion of scattered photons in the acquisition data contribute to the deterioration of image contrast in 201Tl myocardium perfusion studies. Scatter correction algorithms may correct for the latter fact...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02984983
更新日期:2003-12-01 00:00:00
abstract:PURPOSE:The objectives of this study were to (1) elucidate the relationship between the mean CBF in the whole brain (Av.mCBF) before rehabilitation of CVD patients and the BI score before and after rehabilitation, (2) determine whether the efficacy of rehabilitation can be predicted by measurement of the Av.mCBF, and (...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02990478
更新日期:2000-02-01 00:00:00
abstract::Fine 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) powder was obtained by adding diethyl ether into a methyl alcohol solution of 18FDG and other sugar as seed. When micronized particles of sodium N-acetyl-neuraminate (Neu5Ac-Na) were used as seed crystals, particles containing 18FDG were obtained and 80% of them were smalle...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03178301
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:This study aims to clarify the effect of renal function on 2-[(18)F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) imaging and determine the clinical significance of renal function in this setting. We compared FDG distribution between normal volunteers and patients with suspected renal failu...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0012-4
更新日期:2007-06-01 00:00:00
abstract::An early image of intra-tumor distribution of 14C-labeled fluorodeoxy glucose (14C-FDG) was compared with a late image of 18F-labeled FDG (18F-FDG) using mouse fibrosarcoma. Heterogeneous intra-tumor distribution of 14C-FDG was observed 1 minute post injection of the tracer, whereas relatively homogeneous distribution...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02985113
更新日期:2005-12-01 00:00:00
abstract::16alpha-[(18)F]Fluoro-17beta-estradiol (FES) is an estrogen receptor (ER) ligand used for the detection of ER-positive malignant tumors such as breast cancer. We recently reported the feasibility of combined FES-and 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) scans for the differential d...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0075-2
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:ECG-gated myocardial perfusion SPECT is widely applied to diagnose ischemic heart disease, and such findings are useful to predict patient prognosis. However, Japan does not have a database that correlates SPECT image findings with the prognosis of patients who have ischemic heart disease. METHODS:A large-s...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,多中心研究
doi:10.1007/BF03027430
更新日期:2006-04-01 00:00:00
abstract:AIM:The motion of the head during brain positron emission tomography (PET) acquisitions has been identified as a source of artifact in the reconstructed image. In this study, a method is described to develop an image-based motion correction technique for correcting the post-acquisition data without using external optic...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0532-9
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To clarify the difference of (18)F-FDG uptake kinetics between FDG-avid metastatic lymph nodes (LNs) in patients with non-small-cell lung cancer (NSCLC) and FDG-avid benign LNs associated with various etiologies on dual-time point PET/CT scan, and to determine the optimal parameter for differentiation. METHO...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-009-0268-y
更新日期:2009-08-01 00:00:00
abstract::Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein highly expressed by prostate cancer cells. PSMA-based radioligand therapy (RLT) emerged as a promising therapeutic option for prostate cancer in the early 2000s, and has been clinically validated with great enthusiasm during these past two decad...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-020-01549-5
更新日期:2020-12-01 00:00:00