Distinctive FDG and FES accumulation pattern of two tamoxifen-treated patients with endometrial hyperplasia.

Abstract:

:16alpha-[(18)F]Fluoro-17beta-estradiol (FES) is an estrogen receptor (ER) ligand used for the detection of ER-positive malignant tumors such as breast cancer. We recently reported the feasibility of combined FES-and 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) scans for the differential diagnosis of endometrial tumors. ER expression measured by FES-PET was preserved in endometrial hyperplasia, whereas ERs were assumed to be reduced in endometrial carcinoma with accelerated glucose metabolism measured by FDG-PET. We report two postmenopausal patients under suspicion of endometrial carcinoma on the basis of cytology and/or magnetic resonance imaging (MRI), who were on tamoxifen treatment since undergoing surgery for breast cancer. Pelvic MRI suggested endometrial carcinomas, whereas FDG-and FES-PET showed no abnormal tracer accumulation. A postoperative histopathologic examination revealed that the lesions were endometrial hyperplasias with no malignant findings. FES-PET enables us to evaluate the ERalpha expression of endometrium noninvasively, whereas the evaluation of ER expression using FES-PET requires careful attention regarding the influence of hormonal therapy because tamoxifen greatly affects FES accumulation of even endometrial hyperplasia, which should be an FES-avid lesion.

journal_name

Ann Nucl Med

authors

Tsujikawa T,Okazawa H,Yoshida Y,Mori T,Kobayashi M,Tsuchida T,Fujibayashi Y

doi

10.1007/s12149-007-0075-2

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

73-7

issue

1

eissn

0914-7187

issn

1864-6433

journal_volume

22

pub_type

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