Abstract:
OBJECTIVE:The aim of this study was to elucidate the causes of false-negative cases of technetium-99 m methoxyisobutylisonitrile scintigraphy (MIBI) for hyperparathyroidism. METHODS:Consecutive MIBI examinations performed in 154 patients between April 2011 and March 2017 were retrospectively reviewed. Sensitivities of MIBI, CT and US were calculated. The effects of serum calcium, phosphorus, PTH, weight of parathyroid lesions, use of NSAIDs and Ca-channel blocker (CCB), presence of cyst in parathyroid lesions, and a number of lesions observed by MIBI were investigated. RESULTS:Seventy-nine patients (21 men and 58 women), ranging from 18 to 88 years of age (mean ± SD: 57.6 ± 15.3 years), who underwent parathyroidectomy, were included. MIBI and preoperative US were performed in the 79 patients and single-phase parenchymal contrast-enhanced CT (CE-CT) was performed in 55 patients. A total of 120 parathyroid proliferative nodules were detected by MIBI and US, and 92 lesions were detected by CE-CT. In the lesion base, MIBI detected 82 out of the 120 lesions (sensitivity = 68.3%), US detected 103 out of the 120 lesions (sensitivity = 85.8%), CE-CT detected 63 out of the 92 lesions (sensitivity = 68.5%), and MIBI plus CE-CT detected 72 of the 92 lesions (sensitivity = 78.3%). A significant difference in the sensitivity was found between US and MIBI (P < 0.01), and between US and CT (P < 0.01). In the patient base, MIBI detected 67 out of the 79 patients (sensitivity = 84.8%), US detected 74 out of the 79 patients (sensitivity = 93.7%), CE-CT detected 45 out of the 55 patients (sensitivity = 81.8%), and MIBI plus CE-CT detected 52 out of the 55 patients (sensitivity = 94.5%). No significant difference was observed in any of the comparisons. A significant difference was observed in lesion weight (P < 0.01), single or multiple lesions (P = 0.02), and presence of cyst (P < 0.01) between the MIBI false-negative (n = 38) and the true-positive groups (n = 82). CONCLUSION:The presence of cyst in parathyroid proliferative lesions as well as small size and multiple number of parathyroid lesions contribute to false negative in parathyroid MIBI scan.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Ishii S,Sugawara S,Yaginuma Y,Kobiyama H,Hiruta M,Watanabe H,Yamakuni R,Hakozaki M,Fujimaki H,Ito Hdoi
10.1007/s12149-020-01520-4subject
Has Abstractpub_date
2020-12-01 00:00:00pages
892-898issue
12eissn
0914-7187issn
1864-6433pii
10.1007/s12149-020-01520-4journal_volume
34pub_type
杂志文章abstract:BACKGROUND:The deep-inspiration breath-hold PET/CT (DIBH PET/CT) technique improves the limitations of diagnosing a lesion located in an area influenced by respiratory motion that results in spatial misregistrations caused by respiration between PET and CT. However, its reproducibility with regard to calculating the ma...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-010-0352-3
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To determine the optimal accumulation time for three-dimensional positron emission tomography (3D-PET) with (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) to detect the brain uptake pattern typical of Alzheimer's disease (AD). METHODS:Patients with mild AD or amnestic mild cognitive impairment (MCI) and normal...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,多中心研究
doi:10.1007/s12149-013-0704-x
更新日期:2013-06-01 00:00:00
abstract::The aim of the present study was to assess the predictive value of captopril scintigraphy with the new renal agent 99mTc-ethylenedicysteine (99mTc-EC) for post-interventional improvement in blood pressure. Twelve patients who had persistently high blood pressure with previous demonstration of various degrees of renal ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164881
更新日期:1999-04-01 00:00:00
abstract::Bone imaging is commonly used as a sensitive indicator of metastatic bone diseases or other bone pathology. Furthermore, it is now generally known that technetium-99m (99mTc) phosphonates tend to concentrate in various tissues other than bones. Ultrasonography is also widely used for the evaluation of pelvic masses. U...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164568
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:Dementia with Lewy bodies (DLB) is generally characterized by a decrease in regional cerebral blood flow (rCBF) in the occipital lobe. However, not all patients with DLB have this feature. We explored characteristics of rCBF pattern changes to improve the identification of DLB, in addition to occipital hypope...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0193-5
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:The potential of positron emission tomography/computed tomography using 62Cu-diacetyl-bis (N4-methylthiosemicarbazone) (62Cu-ATSM PET/CT), which was originally developed as a hypoxic tracer, to predict therapeutic resistance and prognosis has been reported in various cancers. Our purpose was to investigate pr...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-018-1241-4
更新日期:2018-05-01 00:00:00
abstract::Reinjection images were obtained in 23 patients with myocardial infarction by the additional injection of 37 MBq of thallium-201 after obtaining 4 hour delayed images on exercise thallium-201 SPECT (TSPECT). A redistribution index (RI) was derived of the changes in perfusion defects between immediate and 4 hour delaye...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164630
更新日期:1991-11-01 00:00:00
abstract:AIM:18F-Choline (FCH) uptake parameters are strong indicators of aggressive disease in prostate cancer. Functional parameters derived by magnetic resonance imaging (MRI) are also correlated to aggressive disease. The aim of this work was to evaluate the relationship between metabolic parameters derived by FCH PET/CT an...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1302-8
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Single photon emission computed tomography (SPECT) images provide many details of the anatomical structure. Also about bone scintigraphy, there are many reports of the improvement of diagnosis by SPECT images. Although SPECT is useful, it requires much time. So to perform SPECT for all cases is difficult in t...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02985048
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:To evaluate the prognostic role of end-of-treatment (EoT) FDG-PET/CT parameters in diffuse large B cell lymphoma (DLBCL), and then to explore a pilot application of Neural Networks (NN) in predicting time-to-relapse. METHODS:For conventional survival analysis, parameters as Deauville score (DS) and quantitativ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01542-y
更新日期:2021-01-01 00:00:00
abstract:UNLABELLED:We evaluated a new semiquantitative procedure to more easily and objectively estimate the striatal uptake of 123I-FP-CIT in patients with Parkinsonian syndrome (PS) and essential tremor (ET), using an anatomical standardization method, the Neurostat. METHODS:Eleven patients with PS and 8 with ET were examin...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02987257
更新日期:2006-08-01 00:00:00
abstract:PURPOSE:Several studies have reported significant renal toxicity after the use of a high dose of 90Y-DOTATOC. Thus, renal protection is necessary in treatments with 90Y-DOTA Tyr3-octreotide (DOTATOC). The infusion of certain positively charged amino acids has been shown to effectively reduce renal uptake of DOTATOC. In...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03034003
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Despite recent technological advances allowing for quantitative single-photon emission computed tomography (SPECT), quantitative SPECT has not been widely used in the clinical practice of osteoporosis. The aim of this study is to evaluate the feasibility of quantitative bone SPECT/CT for measuring lumbar sta...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01425-x
更新日期:2020-02-01 00:00:00
abstract::Eight patients were inadvertently administered, and imaged with, 99mTc-labeled MDP which was 45 months expired. Two cases are presented. All patients were subsequently imaged with normal MDP. The images obtained with expired MDP were clinically acceptable. No differences in scan abnormalities were observed compared wi...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164879
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate if increased serum thyroglobulin (Tg) levels after radioactive iodine (RAI) showed more therapeutic effects in patients with differentiated thyroid cancer (DTC). METHODS:Data of 65 patients with DTC who underwent RAI from June 2014 to September 2016 were reviewed. Ser...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1313-5
更新日期:2019-02-01 00:00:00
abstract::(-)-O-Methylvesamicol ((-)-OMV) exhibited in vitro a high affinity for vesicular acetylcholine transporter (VAChT) (Ki, 6.7 nM) and a relatively low affinity for sigmal receptor (Ki, 33.7 nM). We prepared (-)-[11C]OMV by a palladium-promoted cross-coupling reaction using [11C]methyl iodide, in a radiochemical yield of...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03027377
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:This study was designed to investigate the efficacy of 99mtechnetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ([99mTc]3PRGD2) in the evaluation of patients with esophageal cancer. METHODS:Twenty-nine patients with a suspected esophageal lesion and for whom definite pathological diagn...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-018-1315-3
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Rest thallium-201 (201Tl) myocardial perfusion imaging has been widely used for evaluation of myocardial ischemia/viability after myocardial infarction, but the ideal timing for imaging after injection to maximally estimate viability is not well established. METHODS:Thirty-six patients with myocardial infar...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02985586
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Epidermal growth factor receptor tyrosine kinase (EGFR-TK) represents an attractive target for tumor diagnosis agents. Previously, radioiodinated 4-(3-iodophenoxy)-6,7-diethoxyquinazoline (PHY) was reported to possess good characteristics as a tumor imaging agent. We have explored the feasibility of developin...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0703-y
更新日期:2013-06-01 00:00:00
abstract::We report a patient with DTPA and DMSA uptake on unsuspected bone metastases. He had severe pain due to grade 3 hydronephrosis of his left kidney. When Tc-99m DTPA and DMSA renal scanning were performed for preoperative evaluation, abnormal radiopharmaceutical uptake on the iliac area was noted. Pancreatic adenocarcin...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02987249
更新日期:2006-06-01 00:00:00
abstract::Tuberculosis peritonitis is a rare manifestation of extrapulmonary tuberculosis. The results of gallium-67 scintigraphy of three patients with tuberculosis peritonitis were reviewed to assess its usefulness in the diagnosis of this condition. Tuberculosis peritonitis was associated with diffuse or focal abdominal loca...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164860
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine changes in FDG-PET/CT after pleurodesis with OK-432 and to investigate differences in the changes between non-malignant and malignant lesions. METHODS:Study participants were 17 patients with a history of malignant chest disease who underwent FDG-PET/CT after pleurodesis using O...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01508-0
更新日期:2020-10-01 00:00:00
abstract::123I-BMIPP (beta-methyl-iodophenyl pentadecanoic acid) has shown unique properties for potential use in assessing myocardial metabolism. Previous basic and clinical studies demonstrated that the disturbances of myocardial metabolism precede the occurrence of myocardial perfusion abnormalities by using 201Tl in hypertr...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03165056
更新日期:1996-02-01 00:00:00
abstract::Tl-201 SPECT and Tc-99m-Human serum albumin (HSA) multigated radionuclide ventriculography were performed on 11 patients with progressive muscular dystrophy (Becker type 2, Fukuyama type 2, Limb-girdle type 7) to evaluate myocardial involvement. Hypoperfusion was detected in 8 patients on Tl-201 SPECT. Decreases in bo...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164989
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:Metabolic tumor burden (MTB) incorporates the advantages of the existing indices: the metabolic volume of the lesion calculated by size-dependent thresholding on positron emission tomography-computed tomography (PET-CT) along with its aggressiveness as determined by standardized uptake value (SUV). This study...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0539-2
更新日期:2012-01-01 00:00:00
abstract::Nerve growth factor (NGF) exerts various actions on neuronal and non-neuronal tissues and has potential therapeutic utility, but difficulties in using the whole protein have stimulated interest in small NGF fragments. We radioiodinated a small cyclic peptide derived from NGF using the Bolton-Hunter method [125I-C(92-9...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03026817
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess I-131 biokinetics in thyroid cancer and remnant tissue in patients with differentiated thyroid cancer using whole-body scan (WBS) and SPECT images acquired after I-131 therapy. The influence of thyroid stimulating hormone (TSH) stimulation method on the kinetics was also ev...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1188-x
更新日期:2017-10-01 00:00:00
abstract::Using the fuzzy set theory, a method was developed for analyzing the extent and severity of ischemia by comparing the exercise and delayed SPECT images with Thallium-201. For each short axial image (slice) for exercise and delayed study, a defect probability matrix (DPM) is created so that it shows the severity of isc...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164947
更新日期:1988-11-01 00:00:00
abstract::By means of Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy, an established method for assessing renal cortical damage, we evaluated the pick-up rate for renal defects (scars) by single photon computed tomography (SPECT) and planar images of 10 normal volunteers, and 58 patients (70 scintigrams) with upper urinary ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164610
更新日期:1991-03-01 00:00:00
abstract:UNLABELLED:To determine the utility of the myocardial tracer Tc-99m-tetrofosmin in the examination of patients with left bundle branch block (LBBB) and to investigate Tc-99m-tetrofosmin uptake and retention in the myocardium, early and delayed Tc-99m-tetrofosmin SPECT was performed in 10 patients having LBBB without co...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164914
更新日期:1998-10-01 00:00:00