Assessment of human effective absorbed dose of 67 Ga-ECC based on biodistribution rat data.

Abstract:

OBJECTIVE:In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determined by using distribution data for rats. METHODS:For biodistribution data, the animals were sacrificed by CO2 asphyxiation at selected times after injection (0.5, 2 and 48 h, n = 3 for each time interval), then the tissue (blood, heart, lung, brain, intestine, feces, skin, stomach, kidneys, liver, muscle and bone) were removed. The absorbed dose was determined by Medical Internal Radiation Dose (MIRD) method after calculating cumulated activities in each organ. RESULTS:Our prediction shows that a 185-MBq injection of (67)Ga-ECC into the humans might result in an estimated absorbed dose of 0.029 mGy in the whole body. The highest absorbed doses are observed in the spleen and liver with 33.766 and 16.847 mGy, respectively. CONCLUSION:The results show that this radiopharmaceutical can be a good SPECT tracer since it can be produced easily and also the absorbed dose in each organ is less than permitted absorbed dose.

journal_name

Ann Nucl Med

authors

Shanehsazzadeh S,Yousefnia H,Lahooti A,Zolghadri S,Jalilian AR,Afarideh H

doi

10.1007/s12149-014-0917-7

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

118-24

issue

2

eissn

0914-7187

issn

1864-6433

journal_volume

29

pub_type

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