Abstract:
OBJECTIVE:The aim of this study was to assess I-131 biokinetics in thyroid cancer and remnant tissue in patients with differentiated thyroid cancer using whole-body scan (WBS) and SPECT images acquired after I-131 therapy. The influence of thyroid stimulating hormone (TSH) stimulation method on the kinetics was also evaluated. METHODS:A total of 57 patients who received I-131 therapy (2.96-7.4 GBq) were retrospectively included. TSH stimulation was achieved by recombinant human thyrotropin (rhTSH) or by thyroid hormone withdrawal (THW). Each patient received three sequential WBSs on days 1, 2, and 4 (or 5) after I-131 administration. All lesions were classified either as thyroid remnant (ThyR) or as metastatic lymph nodes (mLN) after considering the SPECT/CT images acquired during the last WBS. The lesion-based retention rate and absorbed dose of ThyR and mLN were calculated using a commercial dosimetric toolkit combined with the OLINDA software. RESULTS:The retention rate and the effective half-time of mLN were lower than that of ThyR (p < 0.001, p = 0.003). In addition, the retention rate and the effective half-time of ThyR in the rhTSH group were higher than those in the THW group (p < 0.001, p < 0.001). The differences in the retention rate and the effective half-time of mLN were not statistically significant between the THW group and rhTSH group (p = 0.549, p = 0.571). CONCLUSIONS:Radioiodine therapy using rhTSH delivered an at least similar radiation dose to target lesions compared to using THW in thyroid remnants and metastatic lymph nodes.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Hong CM,Kim CY,Son SH,Jung JH,Lee CH,Jeong JH,Jeong SY,Lee SW,Lee J,Ahn BCdoi
10.1007/s12149-017-1188-xsubject
Has Abstractpub_date
2017-10-01 00:00:00pages
582-589issue
8eissn
0914-7187issn
1864-6433pii
10.1007/s12149-017-1188-xjournal_volume
31pub_type
杂志文章abstract:OBJECTIVES:Cardiac resynchronization therapy (CRT) is the established treatment for patients with chronic and severe heart failure, and it has been reported that the presence of left ventricular (LV) dyssynchrony is one of the most important factors which predict positive response of this therapy. In the present study,...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-011-0525-8
更新日期:2011-12-01 00:00:00
abstract:UNLABELLED:We propose a new method to quantify regional myocardial blood flow (rMBF) by continuous infusion of Tc-99m MIBI and dynamic SPECT. METHODS:Five patients with old myocardial infarction were studied. During continuous infusion of MIBI (approximately 740 MBq) with a syringe pump in 10 min, dynamic SPECT scan w...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF03165431
更新日期:1999-02-01 00:00:00
abstract::Bone scintigraphy is often performed to assess the response to systemic therapy of bone metastasis from prostate cancer. We examined the changes in bone scintigraphic findings and the agreement with AIP, AcP, or other tumor markers measured in the follow-up of patients with known bone metastasis after hormonal therapy...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF03165024
更新日期:1994-11-01 00:00:00
abstract::HIV infection results in profound alterations of immunologic function that render the patient severely immunocompromised, and susceptible to malignancies and opportunistic infections. Three AIDS-defining malignancies include Kaposi's sarcoma (KS), non-Hodgkin's lymphoma (NHL) and invasive cervical cancer. In AIDS pati...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-011-0506-y
更新日期:2011-10-01 00:00:00
abstract:AIM:The purpose of the study was to determine the lung toxicity caused by amiodarone (AD) and bleomycin (BLM) in rats, by means of Tc-99m HMPAO lung scintigraphy. METHODS:Thirty albino rats were randomly divided into five groups. After AD or BLM was dissolved with isotonic saline (SF), a 0.5 ml solution was applied to...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0722-8
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:This study was designed to investigate the efficacy of 99mtechnetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ([99mTc]3PRGD2) in the evaluation of patients with esophageal cancer. METHODS:Twenty-nine patients with a suspected esophageal lesion and for whom definite pathological diagn...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-018-1315-3
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:The potential of positron emission tomography/computed tomography using 62Cu-diacetyl-bis (N4-methylthiosemicarbazone) (62Cu-ATSM PET/CT), which was originally developed as a hypoxic tracer, to predict therapeutic resistance and prognosis has been reported in various cancers. Our purpose was to investigate pr...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-018-1241-4
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Vesicoureteral reflux (VUR) is a major risk factor for recurrent symptomatic urinary tract infection (UTI) in pediatric patients. In addition, dimercaptosuccinic acid renal scintigraphy (DMSA) is an important diagnostic modality of VUR. However, the value of DMSA for predicting recurrent pediatric UTI has not...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01379-0
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To assess the diagnostic value of fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) using standard uptake values (SUV) in the differential diagnoses of indeterminate pulmonary nodules. Specifically, we assessed the probability of malignancy for various SUV ranges, and compared the di...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0112-1
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To compare histological findings of FDG-PET false-positive and true-negative hilar and mediastinal lymph nodes. METHODS:Sixty-seven lymphnode areas in 11 patients who were diagnosed to have N3 lymph nodes by FDG-PET and underwent surgery were histologically examined, and the histopathological findings in fal...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02985610
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:Image segmentation is an essential step in quantifying the extent of reduced or absent lung function. The aim of this study is to develop and validate a new tool for automatic segmentation of lungs in ventilation and perfusion SPECT images and compare automatic and manual SPECT lung segmentations with referen...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1223-y
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:The main aim of this work is to build a robust Convolutional Neural Network (CNN) algorithm that efficiently and quickly classifies bone scintigraphy images, by determining the presence or absence of prostate cancer metastasis. METHODS:CNN, widely applied in medical image classification, was used for bone sc...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01510-6
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:Lung clearance rates of inhaled (99m)Tc-DTPA aerosols constitute a sensitive index to evaluate the permeability changes characteristic of airway epithelial damage. It was thought that edema of the airway wall which is reported in asthma could be relieved with a diuretic like furosemide, helping to relieve the...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-009-0275-z
更新日期:2009-08-01 00:00:00
abstract::In a 43-year-old woman with fibrous dysplasia of the ribs and facial bone and in a 40-year-old man with fibrous dysplasia of the facial bone, there were considerable increases in the uptake of Tc-99m methylenediphosphonate (Tc-99m MDP) and Gallium-67 citrate. Fibrous dysplasia should be added to differential diagnosis...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03165658
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:4-Benzyl-1-(3-iodobenzylsulfonyl)piperidine, 4-B-IBSP, has shown high-binding affinity to both sigma (σ) receptors in our previous work. In current study, radiolabeling and preclinical evaluation of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl)piperidine, 4-B-[125I]IBSP, in human ductal breast carcinoma (T47D) cel...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1161-8
更新日期:2017-05-01 00:00:00
abstract::Evaluation of viral myocarditis is essential for the clinician to assess the prognosis. In this study, Tl-201 myocardial scintigraphy and Tc-99m gated cardiac blood pool scan were performed in 16 patients with myocarditis diagnosed by clinical symptoms and laboratory findings and these nuclear medicine techniques were...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164597
更新日期:1990-07-01 00:00:00
abstract::The author reports CT of the abdomen and quantitative analysis of renal scintigraphy that was spuriously assessed due to unwanted extrarenal uptake. The patient had a retroperitoneal abscess that was related to fistula from the right kidney. Renal scintigraphy was performed to assess split renal function as a preopera...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164784
更新日期:1998-06-01 00:00:00
abstract::In this review I summarize observations of PET and SPECT studies about cerebral blood flow and metabolic abnormalities in Alzheimer's disease. In very early AD flow or metabolism reduces first in the posterior cingulate gyrus and precuneus. This reduction may arise from functional deafferentation caused by primary neu...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/BF02988596
更新日期:2001-04-01 00:00:00
abstract::We report FDG PET of two cases of cold abscess due to Mycobacterium tuberculosis. Case 1 had colon cancer; FDG PET showed high FDG uptake in the colon lesion and low uptake in the inguinal lesion. The latter was a tuberculous cold abscess confirmed by CT/MRI and biopsy. Case 2 received radiotherapy for lung cancer and...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02985581
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The liver itself regenerates after hepatectomy but little is known about how much hepatic function recovers during the regeneration. The liver uptake value (LUV), calculated from Tc-99m-labeled galactosyl-human-serum-albumin ((99m)Tc-GSA) SPECT/CT fused images, is reliable and useful for evaluating hepatic f...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0872-3
更新日期:2014-10-01 00:00:00
abstract::18F-fluorodeoxyglucose positron emission tomography (F-18 FDG-PET) plays an important role in differentiating benign from malignant tumors. However, some false-positive findings, such as tuberculosis, may occur. We report a case referred for F-18 FDG whole-body PET computed tomography (PET/CT) scan owing to an elevate...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0139-y
更新日期:2008-07-01 00:00:00
abstract:AIM:18F-Choline (FCH) uptake parameters are strong indicators of aggressive disease in prostate cancer. Functional parameters derived by magnetic resonance imaging (MRI) are also correlated to aggressive disease. The aim of this work was to evaluate the relationship between metabolic parameters derived by FCH PET/CT an...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1302-8
更新日期:2019-01-01 00:00:00
abstract::A method has been described to optimize the cutoff frequency of the Butterworth filter for brain SPECT imaging. Since a computer simulation study has demonstrated that separation between an object signal and the random noise in projection images in a spatial-frequency domain is influenced by the total number of counts...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164571
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:A complication after spinal fusion surgery is pseudarthrosis, but its radiological diagnosis is of limited value. (18)F-fluoride PET with its ability to assess bone metabolism activity could be of value. The goal of this study was to assess the clinical feasibility of calculating the static standardized uptak...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1008-0
更新日期:2015-11-01 00:00:00
abstract::We report a functional neuroimaging study of a patient clinically diagnosed with Korsakoff syndrome. Positron emission tomography (PET) with the 15O inhalation method showed decreased regional cerebral blood flow (rCBF) and decreased regional cerebral metabolic ratio for oxygen (rCMRO2) in the bilateral fronto-tempora...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164755
更新日期:1997-02-01 00:00:00
abstract::Whole-body positron emission tomography/computed tomography (PET/CT) with [(11)C]- and [(18)F]-labeled choline derivates has emerged as a promising molecular imaging modality for the evaluation of prostate cancer. (11)C- and (18)F-choline PET/CT are used successfully for restaging prostate cancer in patients with bioc...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-013-0731-7
更新日期:2013-08-01 00:00:00
abstract::The aim of this study was to evaluate the washout rate of Tc-99m tetrofosmin in asymmetric septal hypertrophy (ASH). As Tc-99m tetrofosmin accumulation and retention depend on sarcolemmal and/or mitochondrial function, the presence or absence of abnormalities in the washout rate of Tc-99m tetrofosmin could provide inf...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02986332
更新日期:2005-02-01 00:00:00
abstract::Portal-systemic shunting was studied in 54 portal hypertensive rats both in vivo and in vitro using radioactive microspheres. The animals underwent partial portal vein ligation around needles of varying diameter to produce a wide range of shunting. Two to four weeks later, quantitative lung-liver scintigraphic and who...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164656
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:Mantle cell lymphoma (MCL) is an aggressive lymphoma sub-type with poor prognosis and high 18F-FDG avidity at PET/CT; nowadays, no validated criteria for PET/CT in treatment response evaluation and prediction of outcome are present. The aim of study was to investigate whether the metabolic PET/CT features may...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01354-9
更新日期:2019-07-01 00:00:00
abstract::99mTc-tetrofosmin, Thallium-201-chloride (201Tl) and 99mTc-MIBI imagings were performed in a patient with malignant thymoma. Tracer uptake in the primary tumor was demonstrated. The tumor-to-background ratios of planar and SPECT imagings were 1.60 and 1.98 for 99mTc-tetrofosmin, 1.12 and 2.09 for 201Tl, and 1.19 and 1...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988212
更新日期:2000-08-01 00:00:00