Abstract:
OBJECTIVE:Lung clearance rates of inhaled (99m)Tc-DTPA aerosols constitute a sensitive index to evaluate the permeability changes characteristic of airway epithelial damage. It was thought that edema of the airway wall which is reported in asthma could be relieved with a diuretic like furosemide, helping to relieve the symptoms. We intended to study the effect of inhaled furosemide on lung epithelial permeability in asthmatics and smokers with the help of (99m)Tc-DTPA lung clearance test (LCT). METHODS:The study included three groups (n = 15), viz. normal healthy controls, asymptomatic chronic smokers, and chronic persistent asthmatics. Each subject underwent the LCT twice, baseline and post-furosemide (Lasix) study, within a week's interval. The post-furosemide study was carried out 15 min after inhalation of 10 mg of lasix. Lung epithelial permeability was determined in terms of clearance half-life (T (1/2)). RESULTS:The baseline mean T (1/2) values for controls, smokers, and asthmatics were 50.95 +/- 16.58, 20.81 +/- 5.47, 24.06 +/- 6.19 min, respectively. Post-lasix T (1/2) values were 50.83 +/- 15.84, 20.70 +/- 5.65, 41.27 +/- 15.07 min, respectively. There was a significant difference (P < 0.001) in baseline and post-lasix clearance values in asthmatics only. CONCLUSION:Baseline lung epithelial permeability was altered in smokers and asthmatics compared to the controls. Furosemide was effective only in asthmatics in reverting the permeability almost back to the normal range. Inhaled furosemide was effective even in moderate and severe asthmatics. Furosemide has multiple mechanisms of action. It possibly acts at bronchial level in view of the pathology in asthmatics lying in the airways.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Bhure UN,Bhure SU,Bhatt BM,Mistry S,Pednekar SJ,Chari VV,Desai SA,Joshi JM,Paidhungat AJdoi
10.1007/s12149-009-0275-zsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
549-57issue
6eissn
0914-7187issn
1864-6433journal_volume
23pub_type
临床试验,杂志文章abstract:UNLABELLED:We evaluated a new semiquantitative procedure to more easily and objectively estimate the striatal uptake of 123I-FP-CIT in patients with Parkinsonian syndrome (PS) and essential tremor (ET), using an anatomical standardization method, the Neurostat. METHODS:Eleven patients with PS and 8 with ET were examin...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02987257
更新日期:2006-08-01 00:00:00
abstract::Positron emission tomography (PET) using pyruvate-1-11C was carried out to investigate the in vivo metabolism of pyruvate in the brains of patients with mitochondrial encephalomyopathy and Leigh's disease. Two epileptic patients were studied as control subjects. Radioactivity was eliminated from the brain tissue of th...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164593
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:To investigate the genotoxic effects of (90)Y and (186)Re in patients with hemophilia who were undergoing radionuclide synovectomy (RS) procedure in the last 3 years. METHODS:Nineteen patients were enrolled in the study. Most of the patients (n = 17) were hemophilia-A (mean age 20.6 ± 10.5 years) and 18 pati...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0540-9
更新日期:2012-01-01 00:00:00
abstract::Bone scintigraphy is often performed to assess the response to systemic therapy of bone metastasis from prostate cancer. We examined the changes in bone scintigraphic findings and the agreement with AIP, AcP, or other tumor markers measured in the follow-up of patients with known bone metastasis after hormonal therapy...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF03165024
更新日期:1994-11-01 00:00:00
abstract::Nuclear Medicine is the specialty of medical imaging, which utilizes a variety of radionuclides incorporated into specific compounds for diagnostic imaging and therapeutic applications. During recent years, research efforts in this discipline have concentrated on the decay characteristics of particular radionuclides a...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/BF03164930
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess I-131 biokinetics in thyroid cancer and remnant tissue in patients with differentiated thyroid cancer using whole-body scan (WBS) and SPECT images acquired after I-131 therapy. The influence of thyroid stimulating hormone (TSH) stimulation method on the kinetics was also ev...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1188-x
更新日期:2017-10-01 00:00:00
abstract::Tl-201 SPECT and Tc-99m-Human serum albumin (HSA) multigated radionuclide ventriculography were performed on 11 patients with progressive muscular dystrophy (Becker type 2, Fukuyama type 2, Limb-girdle type 7) to evaluate myocardial involvement. Hypoperfusion was detected in 8 patients on Tl-201 SPECT. Decreases in bo...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164989
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the lesion detectability of a gamma camera based coincidence detector system (c-PET system) in comparison to the dedicated PET system (d-PET system), and thereby clarify the feasibility of the clinical application of this system and also describe any factors influencin...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02985103
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To determine the optimal accumulation time for three-dimensional positron emission tomography (3D-PET) with (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) to detect the brain uptake pattern typical of Alzheimer's disease (AD). METHODS:Patients with mild AD or amnestic mild cognitive impairment (MCI) and normal...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,多中心研究
doi:10.1007/s12149-013-0704-x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Attenuation correction (AC) on nuclear images of non-uniform domains is generally performed by a change of the computed tomography (CT) values to μ values, which are then inserted as components into the detection probability of iterative reconstruction techniques (OS-EM Iterative AC). We established an AC tec...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-0972-8
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether [(11)C]PK-11195, a specific peripheral benzodiazepine receptors (PBRs) ligand for positron emission tomography (PET), can show activated microglia in a rat brain injury model. METHODS:On day 1, ethanol was injected into the rat's right striatum (ST) using a stereotaxic operative proced...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0136-1
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:The variability of physiologic 18F-FDG uptake in the myocardium has hampered the accurate evaluation of cardiac glucose metabolism. We investigated the effects of multiple factors, including fasting duration and physical activity, on the physiologic uptake of 18F-FDG by the myocardium in healthy participants....
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01551-x
更新日期:2021-01-02 00:00:00
abstract:PURPOSE:The aim of this study was to elucidate the regional differences between brain perfusion single photon emission computed tomography (SPECT) images reconstructed with a uniform attenuation correction using Chang's method (AC-Chang) and a non-uniform attenuation correction with CT using SPECT/CT (AC-CT). METHODS:...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0567-y
更新日期:2012-04-01 00:00:00
abstract::A method has been described to optimize the cutoff frequency of the Butterworth filter for brain SPECT imaging. Since a computer simulation study has demonstrated that separation between an object signal and the random noise in projection images in a spatial-frequency domain is influenced by the total number of counts...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164571
更新日期:1993-05-01 00:00:00
abstract::We present an interesting case with a central mediastinal pheochromocytoma showing intense F-18 fluorodeoxyglucose (FDG) uptake in tumor and systemic brown adipose tissue (BAT) mimicking metastases. The findings of hypertension and high plasma catecholamine concentration suggested the presence of pheochromocytoma. Med...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0096-x
更新日期:2008-04-01 00:00:00
abstract::Most of the acute ischemic events, such as acute coronary syndromes and stroke, are attributed to vulnerable plaques. These lesions have common histological and pathophysiological features, including inflammatory cell infiltration, neo-angiogenesis, remodelling, haemorrhage predisposition, thin fibrous cap, large lipi...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-020-01458-7
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:Nitrate administration has been proposed to enhance the detection of myocardial viability when performing myocardial perfusion imaging. In this study, we aimed to compare Tl-201 exercise-rest-reinjection protocol with rest isosorbide dinitrate (ISDN)-Tc99m MIBI study in the same population examined for the myoc...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-009-0256-2
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:The quality of images reconstructed by means of the maximum likelihood-expectation maximization (ML-EM) and ordered subset (OS)-EM algorithms, was examined with parameters such as the number of iterations and subsets, then compared with the quality of images reconstructed by the filtered back projection method....
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988506
更新日期:2001-12-01 00:00:00
abstract::We conducted a study of rCBF in the primary visual cortex of visually impaired subjects who have not been subjected to external stimulation for a long period, by means of 123I-IMP SPECT and MRI. The four subjects had lost their sight due to brain tumors (n = 2), glaucoma (n = 1) and trauma (n = 1). 123I-IMP SPECT show...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164976
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVES:This study investigated the prognostic value of preoperative breast-specific gamma imaging (BSGI) uptake measured by a semi-quantitative method in invasive ductal carcinoma (IDC). METHODS:One hundred and sixty-two women with IDC who underwent preoperative BSGI were retrospectively enrolled. The tumor-to-nor...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-0977-3
更新日期:2015-08-01 00:00:00
abstract:AIM:To investigate the diagnostic performance of early acquisition compared to late imaging for the detection of local recurrence of prostate cancer by means of ¹⁸F-FCH PET/CT. MATERIALS AND METHODS:99 patients with radical prostatectomy (mean PSA 3.9 ± 5.03) were subjected to early dynamic PET/CT acquisition of the p...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1015-1
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Pre-clinical studies with gallium-68 zoledronate ([68Ga]Ga-DOTAZOL) have proposed it to be a potent bisphosphonate for PET/CT diagnosis of bone diseases and diagnostic counterpart to [177Lu]Lu-DOTAZOL and [225Ac]Ac-DOTAZOL. This study aims to be the first human biodistribution and dosimetric analysis of [68Ga...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01348-7
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The main aim of this work is to build a robust Convolutional Neural Network (CNN) algorithm that efficiently and quickly classifies bone scintigraphy images, by determining the presence or absence of prostate cancer metastasis. METHODS:CNN, widely applied in medical image classification, was used for bone sc...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01510-6
更新日期:2020-11-01 00:00:00
abstract::Evaluation of viral myocarditis is essential for the clinician to assess the prognosis. In this study, Tl-201 myocardial scintigraphy and Tc-99m gated cardiac blood pool scan were performed in 16 patients with myocarditis diagnosed by clinical symptoms and laboratory findings and these nuclear medicine techniques were...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164597
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:To examine the patterns of longitudinal tau accumulation and cortical atrophy and their association in subjects with mild cognitive impairment (MCI). METHODS:We collected 23 participants (60-89 years old, 11 males/12 females) with MCI from the Alzheimer's Disease Neuroimaging Initiative database. All partici...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01506-2
更新日期:2020-11-01 00:00:00
abstract::Pulmonary emphysema can be diagnosed easily by X-ray CT (CT) as a low attenuation area. Recently Tc-99m-Technegas (Technegas) has been used for ventilation scintigraphy. The present study was undertaken to assess the usefulness of planar and SPECT images by using Technegas scintigraphy in patients with pulmonary emphy...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164818
更新日期:1997-05-01 00:00:00
abstract::Bone imaging is commonly used as a sensitive indicator of metastatic bone diseases or other bone pathology. Furthermore, it is now generally known that technetium-99m (99mTc) phosphonates tend to concentrate in various tissues other than bones. Ultrasonography is also widely used for the evaluation of pelvic masses. U...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164568
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:The performance characteristics of the SPECT sub-system S102 of the ALBIRA II PET/SPECT/CT are analyzed for the 80 mm field of view (FOV) to evaluate the potential in-vivo imaging in rats, based on measurements of the system response for the commonly used Technetium-99 m (99mTc) in small animal imaging. METH...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01547-7
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:CBF, OEF and CMRO(2) provide us important clinical indices and are used for assessing ischemic degree in cerebrovascular disorders. These quantitative images can be measured by PET using (15)O-labelled tracers such as C(15)O, C(15)O(2) and (15)O(2). To reduce the time of scan, one possibility is to omit the u...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-010-0438-y
更新日期:2011-04-01 00:00:00
abstract::Eight patients were inadvertently administered, and imaged with, 99mTc-labeled MDP which was 45 months expired. Two cases are presented. All patients were subsequently imaged with normal MDP. The images obtained with expired MDP were clinically acceptable. No differences in scan abnormalities were observed compared wi...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164879
更新日期:1999-10-01 00:00:00