Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study.


OBJECTIVE:To determine the optimal accumulation time for three-dimensional positron emission tomography (3D-PET) with (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) to detect the brain uptake pattern typical of Alzheimer's disease (AD). METHODS:Patients with mild AD or amnestic mild cognitive impairment (MCI) and normal control subjects were recruited in the Japanese Alzheimer's disease neuroimaging initiative and examined with a PET scan during the 30-60 min after FDG injection. Three independent blinded experts interpreted the 30- to 60-min sum images, and images of patients with AD and MCI presenting AD patterns and normal subjects presenting normal patterns were used in the analysis. Early-scan (ES) and late-scan (LS) images were obtained from the data acquired at 30-35 min and 55-60 min after the injection, respectively. Separate target regions of interest (ROI) for ES and LS were defined as areas of significant reductions in the posterior cingulate and parietotemporal lobe in both hemispheres from the results of an initial cohort with 21 patients (AD 16, MCI 5) and 19 controls. A subsequent sample of 36 (AD 9, MCI 27) patients and 38 controls were used to compare the diagnostic capability of ES and LS using Z scores within the target ROI in individual statistical parametric mapping analysis. RESULTS:Compared to LS, ES showed lower activity in the frontal lobes and higher activity in the venous sinus than LS; however, the diagnostic capability of ES and LS did not significantly differ (sensitivity 0.97 and 0.97, specificity 0.82 and 0.84, area under the receiver-operating characteristic curve 0.96 and 0.97, respectively). CONCLUSIONS:For a qualitative diagnosis of the AD pattern in 3D FDG-PET, results of ES were equivalent to those of LS. ES may be an option to shorten the entire PET procedure time, particularly in diagnosing early stages of AD.


Ann Nucl Med


Takahashi R,Ishii K,Senda M,Ito K,Ishii K,Kato T,Makishi Y,Nishio T,Ikari Y,Iwatsubo T,Japanese Alzheimer’s Disease Neuroimaging Initiative.




Has Abstract


2013-06-01 00:00:00












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    abstract:PURPOSE:Tumor recurrence of colorectal cancers (CRC) is generally followed up by analyses of the serum carcinoembryonic antigen (CEA) levels. However, recent evidence suggests that tumor recurrence can also be visualized by 18F-fluoro-deoxyglucose emission tomography/computed tomography (FDG-PET/CT) in patients with no...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Sanli Y,Kuyumcu S,Ozkan ZG,Kilic L,Balik E,Turkmen C,Has D,Isik G,Asoglu O,Kapran Y,Adalet I

    更新日期:2012-08-01 00:00:00

  • Relationship between bone scintigraphy and tumor markers in patients with breast cancer.

    abstract:PURPOSE:The aim of this study is to specify the precise role of bone scintigraphy and serum CEA and CA 15-3 assays in the monitoring of breast cancers in order to optimize their use and to determine whether it is possible to guide the prescription of bone scan by the use of CEA and CA 15-3 assays in the monitoring of b...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Yildiz M,Oral B,Bozkurt M,Cobaner A

    更新日期:2004-09-01 00:00:00

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    abstract::Written by associate editors of the Annals of Nuclear Medicine, this invited review article is intended to offer our readers a condensed global view on the high-quality research work that has been published in Europe last year. We have divided this article into five sections. The first three sections from the oncology...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审


    authors: Inubushi M,Tatsumi M,Yamamoto Y,Kato K,Tsujikawa T,Nishii R

    更新日期:2018-11-01 00:00:00

  • Usefulness of the Chang attenuation correction method with use of a CT-based μ map by FBP reconstruction in (201)Tl SPECT-MPI.

    abstract:OBJECTIVE:Attenuation correction (AC) on nuclear images of non-uniform domains is generally performed by a change of the computed tomography (CT) values to μ values, which are then inserted as components into the detection probability of iterative reconstruction techniques (OS-EM Iterative AC). We established an AC tec...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Nakamura Y,Tomiguchi S

    更新日期:2015-06-01 00:00:00

  • Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study.

    abstract:OBJECTIVE:To examine the patterns of longitudinal tau accumulation and cortical atrophy and their association in subjects with mild cognitive impairment (MCI). METHODS:We collected 23 participants (60-89 years old, 11 males/12 females) with MCI from the Alzheimer's Disease Neuroimaging Initiative database. All partici...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Xu G,Zheng S,Zhu Z,Yu X,Jiang J,Jiang J,Chu Z,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2020-11-01 00:00:00

  • Evaluation of a direct 4D reconstruction method using generalised linear least squares for estimating nonlinear micro-parametric maps.

    abstract:OBJECTIVE:Estimation of nonlinear micro-parameters is a computationally demanding and fairly challenging process, since it involves the use of rather slow iterative nonlinear fitting algorithms and it often results in very noisy voxel-wise parametric maps. Direct reconstruction algorithms can provide parametric maps wi...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Angelis GI,Matthews JC,Kotasidis FA,Markiewicz PJ,Lionheart WR,Reader AJ

    更新日期:2014-11-01 00:00:00

  • Optimization of Butterworth filter for brain SPECT imaging.

    abstract::A method has been described to optimize the cutoff frequency of the Butterworth filter for brain SPECT imaging. Since a computer simulation study has demonstrated that separation between an object signal and the random noise in projection images in a spatial-frequency domain is influenced by the total number of counts...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Minoshima S,Maruno H,Yui N,Togawa T,Kinoshita F,Kubota M,Berger KL,Uchida Y,Uno K,Arimizu N

    更新日期:1993-05-01 00:00:00

  • Optimal ROI setting on the anatomically normalized I-123 FP-CIT images using high-resolution SPECT.

    abstract:OBJECTIVE:The aim of this study is to establish the optimal regions of interest (ROIs) in anatomically normalized I-123 FP-CIT SPECT images for the quantification of dopamine transporter binding. METHODS:The subjects comprised 16 normal controls and 14 Parkinsonian patients. All of the normal control subjects underwen...

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    pub_type: 杂志文章


    authors: Nonokuma M,Kuwabara Y,Hida K,Tani T,Takano K,Yoshimitsu K

    更新日期:2016-11-01 00:00:00

  • Performance of beta- and high-energy gamma probes for the detection of cancer tissue in experimental surgical resection beds.

    abstract:OBJECTIVE:While high-energy gamma and beta probes have gained considerable attention due to their ability to detect cancerous lesions using (18)F-FDG in humans intraoperatively, it is unknown whether the sensitivity of such probes would allow the detection of remaining tumor tissue in the resection bed after removal of...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Garcia-Parra R,Clinthorne N,Wang L,Picchio M,Piert M

    更新日期:2011-08-01 00:00:00

  • Omission of [(15)O]CO scan for PET CMRO(2) examination using (15)O-labelled compounds.

    abstract:OBJECTIVE:CBF, OEF and CMRO(2) provide us important clinical indices and are used for assessing ischemic degree in cerebrovascular disorders. These quantitative images can be measured by PET using (15)O-labelled tracers such as C(15)O, C(15)O(2) and (15)O(2). To reduce the time of scan, one possibility is to omit the u...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Sasakawa Y,Kudomi N,Yamamoto Y,Monden T,Kawai N,Nishiyama Y

    更新日期:2011-04-01 00:00:00

  • A 18F-FDG-positive, 67Ga-negative, and transferrin receptor expression-negative patient with diffuse large B-cell lymphoma.

    abstract::We recently experienced a case with uveitis suffering from fever of unknown origin suspected of being caused by sarcoidosis. Chest computed tomography showed right supraclavicular, bilateral mediastinal, and right hilar lymphadenopathy, and intensive abnormal uptake of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) was obs...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Tsujikawa T,Okazawa H,Tsuchida T,Demura Y,Imamura Y,Fujibayashi Y

    更新日期:2007-08-01 00:00:00

  • In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [11C]PK-11195 and animal PET following ethanol injury in rat striatum.

    abstract:OBJECTIVE:To investigate whether [(11)C]PK-11195, a specific peripheral benzodiazepine receptors (PBRs) ligand for positron emission tomography (PET), can show activated microglia in a rat brain injury model. METHODS:On day 1, ethanol was injected into the rat's right striatum (ST) using a stereotaxic operative proced...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Toyama H,Hatano K,Suzuki H,Ichise M,Momosaki S,Kudo G,Ito F,Kato T,Yamaguchi H,Katada K,Sawada M,Ito K

    更新日期:2008-06-01 00:00:00

  • Validation of the 3-variable prognostic score (3-PS) in mCRPC patients treated with 223Radium-dichloride: a national multicenter study.

    abstract:OBJECTIVE:Radium-223 (223Ra) has been approved for treatment in patients with metastatic castration-resistant prostatic cancer (mCRPC) and bone metastasis. This α-emitting radionuclide has a beneficial effect on pain and is also capable to increase overall survival (OS). Several studies evaluated the prognostic value o...

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    pub_type: 杂志文章


    authors: Frantellizzi V,Monari F,Mascia M,Costa R,Rubini G,Spanu A,Di Rocco A,Lodi Rizzini E,Cindolo L,Licari M,Lavelli V,Nuvoli S,De Angelis C,Dionisi V,Ferrari C,De Vincentis G

    更新日期:2020-10-01 00:00:00

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    abstract:OBJECTIVE:Exact classifying between malignant and benign tumors in the parotid gland is important because the cancer has relatively poor prognosis. There have been several studies that F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) can differentiate between malignant and benign parotid gland tumors. H...

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    pub_type: 杂志文章


    authors: Kim BS,Kim SJ,Pak K

    更新日期:2016-06-01 00:00:00

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    abstract:OBJECTIVE:123I-beta-methyl iodophenyl pentadecanoic acid (BMIPP) can visualize myocardial fatty acid metabolism and has extensive potential for diagnosing cardiac diseases such as acute coronary syndrome in the clinical setting. Increased BMIPP uptake with decreased perfusion occasionally occurs under acute reperfusion...

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    pub_type: 杂志文章


    authors: Fukushima K,Momose M,Kondo C,Hagiwara N,Sakai S

    更新日期:2011-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Goto R,Kawashima R,Ito H,Koyama M,Sato K,Ono S,Yoshioka S,Fukuda H

    更新日期:1998-12-01 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Kusuoka H,Nishimura S,Yamashina A,Nakajima K,Nishimura T

    更新日期:2006-04-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2020-12-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2000-10-01 00:00:00

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    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Büyükdereli G,Kanadasi M,Kibar M

    更新日期:2005-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Ghadiri H,Shiran MB,Soltanian-Zadeh H,Rahmim A,Zaidi H,Ay MR

    更新日期:2014-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Fukumitsu N,Tsuchida D,Ogi S,Uchiyama M,Mori Y

    更新日期:2002-05-01 00:00:00

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    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Yoshida T,Kuwabara Y,Ichiya Y,Sasaki M,Fukumura T,Ichimiya A,Takita M,Ogomori K,Masuda K

    更新日期:1998-02-01 00:00:00

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    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


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    更新日期:2003-09-01 00:00:00

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    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Blokland KJ,de Vos tot Nederveen Cappel WH,van Eck-Smit BL,Pauwels EK

    更新日期:2003-12-01 00:00:00

  • Assessment of hepatic functional regeneration after hepatectomy using (99m)Tc-GSA SPECT/CT fused imaging.

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    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Yoshida M,Shiraishi S,Sakamoto F,Beppu T,Utsunomiya D,Okabe H,Tomiguchi S,Baba H,Yamashita Y

    更新日期:2014-10-01 00:00:00

  • Risk stratification and prognostic assessment by myocardial perfusion-gated SPECT in patients with left bundle-branch block and low-intermediate cardiac risk.

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    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Fovino LN,Saladini G,Mormino GP,Saladini F,Razzolini R,Evangelista L

    更新日期:2012-08-01 00:00:00

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    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章


    authors: Oku S,Nakagawa K,Momose T,Kumakura Y,Abe A,Watanabe T,Ohtomo K

    更新日期:2002-09-01 00:00:00

  • Impaired coronary microvascular function in diabetics.

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    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章


    authors: Tsujimoto G

    更新日期:2000-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Choi HJ,Jacene H,Kim CK

    更新日期:2019-10-01 00:00:00