Abstract:
OBJECTIVE:On hepatobiliary scintigraphy, "preferential gallbladder (GB) filling without tracer excretion into the small bowel (SB) [p-GB-no-SB]" is occasionally seen on images obtained up to an hour. In such cases, many practitioners administer cholecystokinin (CCK) (even when the measurement of GB ejection fraction is not indicated) or obtain delayed images (DI) to exclude common bile duct (CBD) obstruction. We aimed (1) to assess the prevalence of clinically relevant CBD obstruction found by CCK administration or DI in this circumstance and (2) to find imaging findings and/or parameters that can be used to triage patients who do or do not need such maneuvers. METHODS:Of 1244 scans reviewed, 1089 were excluded because of one or more of the following reasons: SB visualized within 60 min, GB not visualized within 60 min, severely decreased hepatic function, and less than 1 month of clinical follow-up after scanning. The remaining 155 showed p-GB-no-SB with clinical follow-up available for ≥ 1 month. For the 155 scans, clearance of liver parenchymal activity was assessed. RESULTS:Of the 155 scans, 142 showed visually prompt clearance of liver parenchymal activity (group A), while 13 scans showed mild to moderately delayed clearance of liver parenchymal activity with or without initial decreased hepatic uptake (group B). 134 of 142 in group A had additional imaging (99 CCK or 35 DI); all 134 showed SB visualization. Eight remaining scans were terminated without additional imaging. None of the 142 had any event attributable to CBD obstruction on follow-up. All 13 in group B had additional imaging (9 CCK, 4 DI); SB visualized in 11, but not in two; clinical follow-up revealed no CBD obstruction in 11. ERCP revealed CBD obstruction in the latter two. CONCLUSIONS:When a HIDA scan shows p-GB-no-SB, the probability of identifying clinically relevant CBD obstruction by additional imaging with CCK or DI is virtually zero in an acute clinical setting if clearance of liver parenchymal activity is prompt. Additional imaging with CCK or DI can be reserved for only those showing abnormal clearance of liver parenchymal activity.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Choi HJ,Jacene H,Kim CKdoi
10.1007/s12149-019-01384-3subject
Has Abstractpub_date
2019-10-01 00:00:00pages
740-745issue
10eissn
0914-7187issn
1864-6433pii
10.1007/s12149-019-01384-3journal_volume
33pub_type
杂志文章abstract::In order to quantitatively assess the extent and severity of myocardial ischemia by Tc-99m sestamibi exercise myocardial scintigraphy, we developed a new method of change rate (CR) mapping and examined its efficiency. CR was calculated to divide the counts per pixel in the stress polar map by that in the rest polar ma...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03165306
更新日期:1997-11-01 00:00:00
abstract:AIM:18F-Choline (FCH) uptake parameters are strong indicators of aggressive disease in prostate cancer. Functional parameters derived by magnetic resonance imaging (MRI) are also correlated to aggressive disease. The aim of this work was to evaluate the relationship between metabolic parameters derived by FCH PET/CT an...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1302-8
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Technetium etarfolatide ((99m)Tc-EF) is a radioactive diagnostic imaging agent that was developed to assess the expression of folate receptors in tumors. Administering folic acid prior to the administration of (99m)Tc-EF has been shown to improve SPECT images. Here, we conducted a phase I clinical trial to as...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1006-2
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:In this study, the feasibility and kinetic characteristics of the (68)Ga-NOTA-RGD, a recently developed RGD peptide agent, were investigated for atherosclerosis imaging in comparison with (18)FDG. METHODS:ApoE(-/-) mice were fed a high-fat diet for more than 20 weeks. To evaluate the feasibility, tissue upta...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0757-x
更新日期:2013-11-01 00:00:00
abstract::Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein highly expressed by prostate cancer cells. PSMA-based radioligand therapy (RLT) emerged as a promising therapeutic option for prostate cancer in the early 2000s, and has been clinically validated with great enthusiasm during these past two decad...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-020-01549-5
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Radioiodide is commonly used to diagnose and treat hyperthyroidism and thyroid carcinoma. However, we could not find any experimental data that strictly compared the biodistribution and thyroid uptake of radioactive iodide between the oral and intravenous (iv) routes with time. This prompted us to compare (12...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0909-7
更新日期:2014-12-01 00:00:00
abstract::Pulmonary involvement secondary to Waldenstrom's macroglobulinemia (WMG) is described in a 40-year-old male by incidental findings on a bone scan. He was examined for right leg pain, and bone scan revealed unexpected pulmonary uptake of Tc-99m MDP. CT scan of the thorax revealed pleural effusion and slightly dissemina...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988647
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:The performance characteristics of the SPECT sub-system S102 of the ALBIRA II PET/SPECT/CT are analyzed for the 80 mm field of view (FOV) to evaluate the potential in-vivo imaging in rats, based on measurements of the system response for the commonly used Technetium-99 m (99mTc) in small animal imaging. METH...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01547-7
更新日期:2021-01-01 00:00:00
abstract::Most of the acute ischemic events, such as acute coronary syndromes and stroke, are attributed to vulnerable plaques. These lesions have common histological and pathophysiological features, including inflammatory cell infiltration, neo-angiogenesis, remodelling, haemorrhage predisposition, thin fibrous cap, large lipi...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-020-01458-7
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:The utility of 18F-FDG PET/CT in the assessment of thyroid nodules is unclear as there are several conflicting reports on the usefulness of SUV as an indicator to distinguish benign from malignant thyroid lesions. This study incorporated an additional parameter, namely dual time point imaging, to determine the ...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-010-0357-y
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To clarify the difference of (18)F-FDG uptake kinetics between FDG-avid metastatic lymph nodes (LNs) in patients with non-small-cell lung cancer (NSCLC) and FDG-avid benign LNs associated with various etiologies on dual-time point PET/CT scan, and to determine the optimal parameter for differentiation. METHO...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-009-0268-y
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the usefulness of a breath-holding (BH) (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography ((18)F-FDG-PET) technique for PET/computed tomography (CT) scanning of pulmonary lesions near the diaphragm, where image quality is influenced by respiratory motion. METHODS:In a basic study, sim...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0206-4
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Primary brain lymphoma is an aggressive extranodal non-Hodgkin lymphoma with poor prognosis. Many possible prognostic factors are investigated with controversial results, but possible prognostic role of 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) features re...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1274-8
更新日期:2018-10-01 00:00:00
abstract::Using the fuzzy set theory, a method was developed for analyzing the extent and severity of ischemia by comparing the exercise and delayed SPECT images with Thallium-201. For each short axial image (slice) for exercise and delayed study, a defect probability matrix (DPM) is created so that it shows the severity of isc...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164947
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the left ventricular (LV) functional parameters calculated using quantitative electrocardiography (ECG)-gated myocardial perfusion single photon emission computed tomography (QGS). In addition to LV systolic parameters, diastolic parameters were compared with those by ult...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02985571
更新日期:2005-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to elucidate the regional differences between brain perfusion single photon emission computed tomography (SPECT) images reconstructed with a uniform attenuation correction using Chang's method (AC-Chang) and a non-uniform attenuation correction with CT using SPECT/CT (AC-CT). METHODS:...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0567-y
更新日期:2012-04-01 00:00:00
abstract::A 62-year-old woman experienced headache and rapidly progressive left hemiparesis over 2 weeks. Diffusion-weighted and fluid-attenuated inversion recovery MR images of the head showed increased signal intensity in the right basal ganglia, periventricular white matter and the brain stem. Enhancement was not observed on...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03027408
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to establish the optimal regions of interest (ROIs) in anatomically normalized I-123 FP-CIT SPECT images for the quantification of dopamine transporter binding. METHODS:The subjects comprised 16 normal controls and 14 Parkinsonian patients. All of the normal control subjects underwen...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-016-1107-6
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:The variability of physiologic 18F-FDG uptake in the myocardium has hampered the accurate evaluation of cardiac glucose metabolism. We investigated the effects of multiple factors, including fasting duration and physical activity, on the physiologic uptake of 18F-FDG by the myocardium in healthy participants....
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01551-x
更新日期:2021-01-02 00:00:00
abstract:OBJECTIVE:To investigate the genotoxic effects of (90)Y and (186)Re in patients with hemophilia who were undergoing radionuclide synovectomy (RS) procedure in the last 3 years. METHODS:Nineteen patients were enrolled in the study. Most of the patients (n = 17) were hemophilia-A (mean age 20.6 ± 10.5 years) and 18 pati...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0540-9
更新日期:2012-01-01 00:00:00
abstract::Radionuclides of rare earth elements are gaining importance as emerging therapeutic agents in nuclear medicine. β(-)-particle emitter 142Pr [T (1/2) = 19.12 h, E(-)β = 2.162 MeV (96.3%), Eγ = 1575 keV (3.7%)] is one of the praseodymium-141 (100% abundant) radioisotopes. Production routes and therapy aspects of 142Pr w...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-011-0505-z
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Rest thallium-201 (201Tl) myocardial perfusion imaging has been widely used for evaluation of myocardial ischemia/viability after myocardial infarction, but the ideal timing for imaging after injection to maximally estimate viability is not well established. METHODS:Thirty-six patients with myocardial infar...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02985586
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Epidermal growth factor receptor tyrosine kinase (EGFR-TK) represents an attractive target for tumor diagnosis agents. Previously, the radioiodinated 4-(3-iodoanilino)-6,7-diethoxyquinazoline ([(125)I]m-IPQ) has been reported to possess good characteristics as a tumor imaging agent; however, it was also found...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-012-0583-6
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:The deep-inspiration breath-hold PET/CT (DIBH PET/CT) technique improves the limitations of diagnosing a lesion located in an area influenced by respiratory motion that results in spatial misregistrations caused by respiration between PET and CT. However, its reproducibility with regard to calculating the ma...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-010-0352-3
更新日期:2010-04-01 00:00:00
abstract::Physiological functions (e.g., cerebral blood flow, glucose metabolism, and neuroreceptor binding) can be investigated as parameters estimated by kinetic modeling using dynamic positron emission tomography (PET) images. Imaging of these physiological parameters, called parametric imaging, can locate the regional distr...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-007-0044-9
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To investigate the potential role of Tc-99m depreotide (Tc-DEPR) in the preoperative lymph node (N) staging of non-small-cell lung cancer (NSCLC). METHODS:Sixty-one patients with NSCLC at the potentially operable stage were enrolled and underwent scintigraphy before surgery (n=56) or mediastinoscopy (n=5). I...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0839-4
更新日期:2014-06-01 00:00:00
abstract::Alzheimer's disease (AD) is on the rise all over the world, and brings with it great challenges to medical care and heavy burdens to family and society. Accurate diagnosis and differential diagnosis are of great importance. Tau positron emission tomography (PET) might offer novel insights and be of great assistance in...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-020-01566-4
更新日期:2021-01-18 00:00:00
abstract::Portal-systemic shunting was studied in 54 portal hypertensive rats both in vivo and in vitro using radioactive microspheres. The animals underwent partial portal vein ligation around needles of varying diameter to produce a wide range of shunting. Two to four weeks later, quantitative lung-liver scintigraphic and who...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164656
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:In clinical practice, measurement of the rCBF has mainly been conducted by I-123-N-isopropyl-p-iodoamphetamine ((123)I-IMP) SPECT using the microsphere (MS) method, with continuous arterial blood sampling. While several non-invasive (123)I-IMP quantification methods have been developed, their accuracy has bee...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1053-8
更新日期:2016-04-01 00:00:00
abstract::We report a functional neuroimaging study of a patient clinically diagnosed with Korsakoff syndrome. Positron emission tomography (PET) with the 15O inhalation method showed decreased regional cerebral blood flow (rCBF) and decreased regional cerebral metabolic ratio for oxygen (rCMRO2) in the bilateral fronto-tempora...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164755
更新日期:1997-02-01 00:00:00