Abstract:
AIM:To investigate the diagnostic performance of early acquisition compared to late imaging for the detection of local recurrence of prostate cancer by means of ¹⁸F-FCH PET/CT. MATERIALS AND METHODS:99 patients with radical prostatectomy (mean PSA 3.9 ± 5.03) were subjected to early dynamic PET/CT acquisition of the pelvis and a whole body PET/CT in the same exam session. None of the patients examined was subjected to radiotherapy for local or distant recurrence. All the subjects were taken off hormonal therapy. RESULTS:58 subjects did not show local recurrence in both early and late acquisition, 22 were positive in both modalities, 10 showed a positive early and a negative late acquisition while 9 showed a negative early and a positive late acquisition (Cohen's k = 0.558). When the results of imaging modalities were considered separately, sensitivity, specificity, positive predictive value and negative predictive value resulted: 78.9, 96.7, 93.8 and 88.1 % for early acquisition and 73.7, 95.1, 90.3 and 85.3 % for late acquisition, respectively. When the results of early and late acquisition were considered together, results were 97.4, 93.4, 90.2 and 98.3 %, respectively. CONCLUSIONS:The combination of early acquisition with late acquisition lead to an increase of the diagnostic accuracy of ¹⁸F-FCH PET/CT for the diagnosis of local recurrence in prostate cancer.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Di Biagio D,Chiaravalloti A,Tavolozza M,Abbatiello P,Schillaci Odoi
10.1007/s12149-015-1015-1subject
Has Abstractpub_date
2015-12-01 00:00:00pages
861-9issue
10eissn
0914-7187issn
1864-6433pii
10.1007/s12149-015-1015-1journal_volume
29pub_type
杂志文章abstract::In a patient with acute herpes simplex virus (HSV) encephalitis, positron emission tomography (PET) demonstrated increased cerebral blood flow in the affected temporal lobe accompanied by reduction in the cerebral oxygen extraction fraction and the cerebral metabolic rate of oxygen, i.e., luxury perfusion. Follow-up P...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03165008
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:The quality of images reconstructed by means of the maximum likelihood-expectation maximization (ML-EM) and ordered subset (OS)-EM algorithms, was examined with parameters such as the number of iterations and subsets, then compared with the quality of images reconstructed by the filtered back projection method....
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988506
更新日期:2001-12-01 00:00:00
abstract::A case of Plummer's disease that spontaneously progressed to hypothyroidism is presented. A 49-year-old female visited our hospital because of a 3 kg decrease in body weight during the previous month and a painless nodule in the right anterior area of her neck. A diagnosis of Plummer's disease was made based on the re...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164940
更新日期:1999-12-01 00:00:00
abstract::Attenuation correction is very important for quantitative SPECT imaging. We designed an uncollimated non-uniform line array source (non-uniform LAS) for attenuation correction based on transmission computed tomography (TCT) using Tc-99m and compared its performance with an uncollimated uniform line array source (unifo...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984481
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess I-131 biokinetics in thyroid cancer and remnant tissue in patients with differentiated thyroid cancer using whole-body scan (WBS) and SPECT images acquired after I-131 therapy. The influence of thyroid stimulating hormone (TSH) stimulation method on the kinetics was also ev...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1188-x
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Exact classifying between malignant and benign tumors in the parotid gland is important because the cancer has relatively poor prognosis. There have been several studies that F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) can differentiate between malignant and benign parotid gland tumors. H...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-016-1068-9
更新日期:2016-06-01 00:00:00
abstract::To systematically review published data on the role of positron emission tomography (PET) or PET/computed tomography (PET/CT) using either Carbon-11 ((11)C) or Fluorine-18 ((18)F) choline tracer in tumors other than prostatic cancer. A comprehensive literature search of studies published in PubMed/MEDLINE and Embase d...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-012-0602-7
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:In the initial assessment of thyroid nodules, thyrotropin (TSH) has very low sensitivity for assessing functional thyroid nodules (FTNs). The false negativity in FTNs and the false positivity in non-FTNs misinterpreted by TSH will raise unnecessary assessment costs. Therefore, the aim of this study is to expl...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-016-1124-5
更新日期:2017-01-01 00:00:00
abstract::The Logan plot is a widely used algorithm for the quantitative analysis of neuroreceptors using PET because it is easy to use and simple to implement. The Logan plot is also suitable for receptor imaging because its algorithm is fast. However, use of the Logan plot, and interpretation of the formed receptor images sho...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/BF03033993
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether [(11)C]PK-11195, a specific peripheral benzodiazepine receptors (PBRs) ligand for positron emission tomography (PET), can show activated microglia in a rat brain injury model. METHODS:On day 1, ethanol was injected into the rat's right striatum (ST) using a stereotaxic operative proced...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0136-1
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To investigate the potential role of Tc-99m depreotide (Tc-DEPR) in the preoperative lymph node (N) staging of non-small-cell lung cancer (NSCLC). METHODS:Sixty-one patients with NSCLC at the potentially operable stage were enrolled and underwent scintigraphy before surgery (n=56) or mediastinoscopy (n=5). I...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0839-4
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:This study aims to clarify the effect of renal function on 2-[(18)F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) imaging and determine the clinical significance of renal function in this setting. We compared FDG distribution between normal volunteers and patients with suspected renal failu...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0012-4
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To design, build, and evaluate an animal PET scanner, which can be used with non-human primates under conscious condition, incorporating flat-panel position-sensitive photomultiplier tubes (PS-PMTs). METHODS:The system contains 30 detector modules, each having two PS-PMTs and 16×18 lutetium–yttrium oxyortho-...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0772-y
更新日期:2014-01-01 00:00:00
abstract::We evaluated the potential of sodium [1-(11)C]hexanoate (11C-HA) as a radiopharmaceutical with which to assess oxidative metabolism of the brain by PET. 11C-HA, sodium [1-(14)C]acetate and [3H]deoxyglucose were simultaneously injected into mice under control, hypoxic and starving conditions. In the control, the brain ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03165404
更新日期:1996-05-01 00:00:00
abstract::We are proposing a new method for correcting of scattered photons in technetium-99m (99mTc) imaging by means of photopeak dual-energy window acquisition. This method consists of the simultaneous acquisition of two images and estimation of a scatter image included in the symmetric energy window (SW) image by the differ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03178307
更新日期:1992-08-01 00:00:00
abstract::Written by associate editors of the Annals of Nuclear Medicine, this invited review article is intended to offer our readers a condensed global view on the high-quality research work that has been published in Europe last year. We have divided this article into five sections. The first three sections from the oncology...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-018-1303-7
更新日期:2018-11-01 00:00:00
abstract::Myocardial normal databases for stress myocardial perfusion study have been created by the Japanese Society of Nuclear Medicine Working Group. The databases comprised gender-, camera rotation range- and radiopharmaceutical-specific data-sets from multiple institutions, and normal database files were created for instal...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-009-0337-2
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:Tumor recurrence of colorectal cancers (CRC) is generally followed up by analyses of the serum carcinoembryonic antigen (CEA) levels. However, recent evidence suggests that tumor recurrence can also be visualized by 18F-fluoro-deoxyglucose emission tomography/computed tomography (FDG-PET/CT) in patients with no...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-012-0609-0
更新日期:2012-08-01 00:00:00
abstract::Evaluation of viral myocarditis is essential for the clinician to assess the prognosis. In this study, Tl-201 myocardial scintigraphy and Tc-99m gated cardiac blood pool scan were performed in 16 patients with myocarditis diagnosed by clinical symptoms and laboratory findings and these nuclear medicine techniques were...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164597
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-016-1146-z
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the lesion detectability of a gamma camera based coincidence detector system (c-PET system) in comparison to the dedicated PET system (d-PET system), and thereby clarify the feasibility of the clinical application of this system and also describe any factors influencin...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02985103
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To investigate the correlation between the F-18 FDG uptake in the normal testis as assessed by PET-CT and patient age in a pediatric study population. METHODS:The study population consisted of 22 subjects aged between 9 and 17 years. For these subjects 42 PET-CT scans were available for analysis. The testis ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-009-0308-7
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:A complication after spinal fusion surgery is pseudarthrosis, but its radiological diagnosis is of limited value. (18)F-fluoride PET with its ability to assess bone metabolism activity could be of value. The goal of this study was to assess the clinical feasibility of calculating the static standardized uptak...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1008-0
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:Bone-seeking radiopharmaceuticals have the main role in the treatment of painful bone metastases. The aim of this study was to dosimetrically compare radiopharmaceuticals in use for bone pain palliation therapy and bone scan. METHODS:The MCNPX code was used to simulate the radiation transport in a vertebral ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01329-w
更新日期:2019-04-01 00:00:00
abstract::18F-fluorodeoxyglucose positron emission tomography (F-18 FDG-PET) plays an important role in differentiating benign from malignant tumors. However, some false-positive findings, such as tuberculosis, may occur. We report a case referred for F-18 FDG whole-body PET computed tomography (PET/CT) scan owing to an elevate...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0139-y
更新日期:2008-07-01 00:00:00
abstract:UNLABELLED:We studied the causative mechanism of ampulla (Takotsubo) cardiomyopathy. METHODS:We examined 7 patients with ampulla cardiomyopathy by means of coronary angiography, two-dimensional echocardiography and 99Tc-tetrofosmin myocardial SPECT at the time of emergency admission (acute phase), at 3 to 5 days after...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988242
更新日期:2001-08-01 00:00:00
abstract::We report here a patient with mucosa associated lymphoid tissue (MALT)-lymphoma of the breast complicated with Sjögren syndrome. It is speculated that Ga-67 could accumulate not only in lymphoma lesions but also in benign lymphoproliferative locations of Sjögren syndrome. Gallium-67 scintigraphy might be useful for th...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02987866
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:Radium-223 (223Ra) has been approved for treatment in patients with metastatic castration-resistant prostatic cancer (mCRPC) and bone metastasis. This α-emitting radionuclide has a beneficial effect on pain and is also capable to increase overall survival (OS). Several studies evaluated the prognostic value o...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01501-7
更新日期:2020-10-01 00:00:00
abstract::Whole body imaging with radioiodine can detect functioning metastases, which can often be effectively treated with appropriate amounts of radioiodine. Non-physiologic I-131 uptake detected on images is usually interpreted as suggesting functioning thyroid metastases. However, extra-thyroidal I-131 accumulation does no...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02985010
更新日期:2004-05-01 00:00:00
abstract::To design a mathematical model for quantifying cerebral blood flow using 99mTc-hexamethyl-propyleneamine oxime (HM-PAO), basic studies were performed in animals and human volunteers. Microautoradiography revealed that HM-PAO crossed the blood-brain barrier. Thin layer chromatographic studies demonstrated the rapid dis...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164581
更新日期:1988-05-01 00:00:00