A brain uptake study of [1-(11)C]hexanoate in the mouse: the effect of hypoxia, starvation and substrate competition.

Abstract:

:We evaluated the potential of sodium [1-(11)C]hexanoate (11C-HA) as a radiopharmaceutical with which to assess oxidative metabolism of the brain by PET. 11C-HA, sodium [1-(14)C]acetate and [3H]deoxyglucose were simultaneously injected into mice under control, hypoxic and starving conditions. In the control, the brain uptake of 11C was maximal at 3 min (% ID/g = 2.2-2.5), being twice as high as that of 14C, followed by a gradual clearance. The time-radioactivity curve of 11C was similar to that of 14C. Hypoxia enhanced the brain uptake of 3H, but not of either 11C or 14C. Starvation enhanced the brain uptake of 3H and 11C. The clearance rate of 11C was not significantly affected by either condition. In the control brain at 3 min postinjection of HA, 65% of the total radioactivity was detected as labeled glutamate and glutamine, which was gradually decreased by 47% at 30 min. The brain to blood ratios of 11C-HA at 3 min were significantly reduced by butyrate, hexanoate and octanoate loading but not by that with other monocarboxylic acids or ketone bodies.

journal_name

Ann Nucl Med

authors

Ishiwata K,Ishii K,Ogawa K,Nozaki T,Senda M

doi

10.1007/BF03165404

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

265-70

issue

2

eissn

0914-7187

issn

1864-6433

journal_volume

10

pub_type

杂志文章
  • Usefulness of [18F]FDG-PET kinetic analysis in non-enhancing primary central nervous system lymphoma: case report.

    abstract::A 62-year-old woman experienced headache and rapidly progressive left hemiparesis over 2 weeks. Diffusion-weighted and fluid-attenuated inversion recovery MR images of the head showed increased signal intensity in the right basal ganglia, periventricular white matter and the brain stem. Enhancement was not observed on...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03027408

    authors: Kawai N,Kawanishi M,Tamiya T,Nagao S

    更新日期:2005-07-01 00:00:00

  • Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

    abstract:OBJECTIVE:One mechanism that may be responsible for drug resistance in epilepsy is the upregulation of P-glycoprotein (P-gp), a drug efflux pump, at the epileptogenic focus. In this study, we sought to evaluate the potential of a recently developed P-gp PET radiotracer, [(11)C]N-desmethyl-loperamide ([(11)C]dLop), for ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-013-0725-5

    authors: Farwell MD,Chong DJ,Iida Y,Bae SA,Easwaramoorthy B,Ichise M

    更新日期:2013-08-01 00:00:00

  • Improvement in automated quantitation of myocardial perfusion abnormality by using iterative reconstruction image in combination with resolution recovery, attenuation and scatter corrections for the detection of coronary artery disease.

    abstract:OBJECTIVE:An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-016-1146-z

    authors: Chono T,Onoguchi M,Shibutani T,Hashimoto A,Nakata T,Yama N,Tsuchihashi K,Hatakenaka M

    更新日期:2017-02-01 00:00:00

  • Paradigm shift in theranostics of neuroendocrine tumors: conceptual horizons of nanotechnology in nuclear medicine.

    abstract::We present a comprehensive review of Neuroendocrine Tumors (NET) and the current and developing imaging and therapeutic modalities for NET with emphasis on Nuclear Medicine modalities. Subsequently, nanotechnology and its emerging role in cancer management, especially NET, are discussed. The article is both educative ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-018-1235-2

    authors: Arora G,Bandopadhyaya G

    更新日期:2018-04-01 00:00:00

  • The role of adrenocortical scintigraphy in the evaluation of unilateral incidentally discovered adrenal and juxtaadrenal masses.

    abstract::We reviewed the findings of adrenocortical scintigraphy with 131I-6-beta-iodomethyl-19-norcholesterol (NCL-6-131I) of 39 patients to clarify its role in the evaluation of unilateral adrenal or juxtaadrenal masses incidentally discovered by CT, ultrasonography or plain radiography. Twenty-seven benign adrenal masses sh...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164960

    authors: Nakajo M,Nakabeppu Y,Yonekura R,Iwashita S,Goto T

    更新日期:1993-08-01 00:00:00

  • Static and moving phantom studies for radiation treatment planning in a positron emission tomography and computed tomography (PET/CT) system.

    abstract:OBJECTIVE:To determine an appropriate threshold value for delineation of the target in positron emission tomography (PET) and to investigate whether PET can delineate an internal target volume (ITV), a series of phantom studies were performed. METHODS:An ellipse phantom (background) was filled with 1028 Bq/ml of [(18)...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-008-0166-8

    authors: Okubo M,Nishimura Y,Nakamatsu K,Okumura M,Shibata T,Kanamori S,Hanaoka K,Hosono M

    更新日期:2008-08-01 00:00:00

  • Comparative evaluation of scintigraphy and upper gastrointestinal tract endoscopy for detection of duodenogastric reflux.

    abstract::Duodenogastric reflux, the reflux of duodenal bile into stomach, when suspected clinically requires an objective evaluation for proper management. In this study hepatobiliary scintigraphy in 91 patients of different clinical conditions was evaluated for presence of duodenogastric reflux. Upper gastrointestinal endosco...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03164995

    authors: Mittal BR,Ibrarullah M,Agarwal DK,Maini A,Ali W,Sikora SS,Das BK

    更新日期:1994-08-01 00:00:00

  • Lack of correlation between Tc-99m-sestaMIBI uptake and cadherin expression in infiltrating ductal breast carcinoma as prognostic indicators.

    abstract::Despite using various kinds of prognostic indicators, it is still not possible to predict the biological behavior of breast cancer in all patients. Tc-99m-sestaMIBI (MIBI) uptake determined by breast scintigraphy and cadherin expression of tumor tissue revealed by immunohistochemistry are suggested as potential agents...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988522

    authors: Uğur Y,Sari O,Uğur O,Korkusuz P,Varoğlu E,Arslan N,Gürcan N,Yildirim M,Sökmensüer C,Aşan E,Aras T

    更新日期:2003-06-01 00:00:00

  • Prognostic role of pretreatment 18F-FDG PET/CT in primary brain lymphoma.

    abstract:OBJECTIVE:Primary brain lymphoma is an aggressive extranodal non-Hodgkin lymphoma with poor prognosis. Many possible prognostic factors are investigated with controversial results, but possible prognostic role of 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) features re...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1274-8

    authors: Albano D,Bertoli M,Battistotti M,Rodella C,Statuto M,Giubbini R,Bertagna F

    更新日期:2018-10-01 00:00:00

  • Demonstrations of AIDS-associated malignancies and infections at FDG PET-CT.

    abstract::HIV infection results in profound alterations of immunologic function that render the patient severely immunocompromised, and susceptible to malignancies and opportunistic infections. Three AIDS-defining malignancies include Kaposi's sarcoma (KS), non-Hodgkin's lymphoma (NHL) and invasive cervical cancer. In AIDS pati...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-011-0506-y

    authors: Liu Y

    更新日期:2011-10-01 00:00:00

  • A case of recurrent cholangitis after bile duct injury during laparoscopic cholecystectomy: value of scintigraphy with Tc-99m GSA and hepatobiliary scintigraphy for indication of lobectomy.

    abstract::A 39-year-old woman with acute cholecystitis and gallstones underwent laparoscopic cholecystectomy. She suffered from recurrent episodes of cholangitis due to injury of the major bile ducts during laparoscopic cholecystectomy. Hepatobiliary scintigraphy with Tc-99m Sn-N-pyridoxyl-5-methyltryptophan was performed. Alth...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988702

    authors: Nishiguchi S,Shiomi S,Sasaki N,Iwata Y,Tanaka H,Kubo S,Hirohashi K,Ochi H

    更新日期:2000-10-01 00:00:00

  • Dilated cardiomyopathy relieved as a result of beta-blocker therapy: a case report--key points in assessment of prognosis based on MIBG myocardial scintigraphy and BNP levels.

    abstract::A 48-year-old male patient was admitted to our hospital with dyspnea accompanied by orthopnea. Chest x-rays showed a cardiothoracic ratio of 68% and pulmonary congestion. He was diagnosed with dilated cardiomyopathy. Beta-Blocker (carvedilol) therapy was initiated on Day 22 of the disease using a small initial dose. H...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02984613

    authors: Matsuo S,Nakae I,Masuda D,Matsumoto T,Horie M

    更新日期:2005-05-01 00:00:00

  • Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions.

    abstract:OBJECTIVE:(11)C-Methionine positron emission tomography (MET-PET) has been used to distinguish brain tumor recurrence from radiation necrosis. Because the spatial resolution of conventional PET scanners is low, partial volume effect (PVE) may decrease the detectability of small tumor recurrence. The aim of this study i...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-010-0450-2

    authors: Okamoto S,Shiga T,Hattori N,Kubo N,Takei T,Katoh N,Sawamura Y,Nishijima K,Kuge Y,Tamaki N

    更新日期:2011-04-01 00:00:00

  • The use of quantitative scintigraphy in the measurement of portal-systemic shunting in rats.

    abstract::Portal-systemic shunting was studied in 54 portal hypertensive rats both in vivo and in vitro using radioactive microspheres. The animals underwent partial portal vein ligation around needles of varying diameter to produce a wide range of shunting. Two to four weeks later, quantitative lung-liver scintigraphic and who...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164656

    authors: Stauber RE,Mochizuki T,Van Thiel DH,Tauxe WN

    更新日期:1992-11-01 00:00:00

  • Assessment of anatomic relation between pulmonary perfusion and morphology in pulmonary emphysema with breath-hold SPECT-CT fusion images.

    abstract:OBJECTIVE:Anatomic relation between pulmonary perfusion and morphology in pulmonary emphysema was assessed on deep-inspiratory breath-hold (DIBrH) perfusion single-photon emission computed tomography (SPECT)-CT fusion images. METHODS:Subjects were 38 patients with pulmonary emphysema and 11 non-smoker controls, who su...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0137-5

    authors: Suga K,Kawakami Y,Iwanaga H,Hayashi N,Seto A,Matsunaga N

    更新日期:2008-06-01 00:00:00

  • Correction of head movements in positron emission tomography using point source tracking system: a simulation study.

    abstract:AIM:The motion of the head during brain positron emission tomography (PET) acquisitions has been identified as a source of artifact in the reconstructed image. In this study, a method is described to develop an image-based motion correction technique for correcting the post-acquisition data without using external optic...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-011-0532-9

    authors: Nazarparvar B,Shamsaei M,Rajabi H

    更新日期:2012-01-01 00:00:00

  • Tumor thrombus in the inferior vena cava from colon cancer detected by 18F-FDG-PET.

    abstract::We present a case of inferior vena cava (IVC) tumor thrombus detected by fluorine- 18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET). A man underwent operations for the treatment of sigmoid colon cancer at the age of 63. Because tumor markers [carcinoembryonic antigen (CEA) and CA19-9] were increased at...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0003-5

    authors: Kaida H,Ishibashi M,Kurata S,Uchida M,Hayabuchi N

    更新日期:2007-06-01 00:00:00

  • Quantification evaluation of 99mTc-MDP concentration in the lumbar spine with SPECT/CT: compare with bone mineral density.

    abstract:BACKGROUND:Despite recent technological advances allowing for quantitative single-photon emission computed tomography (SPECT), quantitative SPECT has not been widely used in the clinical practice of osteoporosis. The aim of this study is to evaluate the feasibility of quantitative bone SPECT/CT for measuring lumbar sta...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-019-01425-x

    authors: Huang K,Feng Y,Liu D,Liang W,Li L

    更新日期:2020-02-01 00:00:00

  • (99m)Tc-TRODAT-1 and (123)I-IBZM SPECT studies in a patient with extrapontine myelinolysis with parkinsonian features.

    abstract::Osmotic demyelination syndrome can result from the rapid correction of hyponatremia, and is categorized by central pontine myelinolysis and extrapontine myelinolysis (EPM). Magnetic resonance imaging (MRI) is currently the most useful modality for visualizing EPM lesions. However, MRI is unable to delineate the severi...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-009-0244-6

    authors: Wu YC,Peng GS,Cheng CA,Lin CC,Huang WS,Hsueh CJ,Lee JT

    更新日期:2009-06-01 00:00:00

  • Abnormal retention of 99mTc-TF in a hamster model of cardiomyopathy analyzed by 99mTc-TF and 125I-BMIPP autoradiography.

    abstract:OBJECTIVE:Enhanced washout of 99mTc-tetrofosmin (TF) has been reported in patients with hypertrophic cardiomyopathy (HCM). Here, using quantitative dual-autoradiography, the relationship between TF retention abnormality and metabolism depicted by 125I-BMIPP uptake was investigated quantitatively in a hamster model of c...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02985000

    authors: Thet-Thet-Lwin,Takeda T,Wu J,Tsuchiya Y,Itai Y

    更新日期:2004-05-01 00:00:00

  • Assessment of collimators in radium-223 imaging with channelized Hotelling observer: a simulation study.

    abstract:OBJECTIVE:Radium-223 (223Ra) is used in unsealed radionuclide therapy for metastatic bone tumors. The aim of this study is to apply a computational model observer to 223Ra planar images, and to assess the performance of collimators in 223Ra imaging. METHODS:The 223Ra planar images were created via an in-house Monte Ca...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1286-4

    authors: Takahashi A,Baba S,Sasaki M

    更新日期:2018-12-01 00:00:00

  • Introduction of the targeted alpha therapy (with Radium-223) into clinical practice in Japan: learnings and implementation.

    abstract::Radium-223 dichloride (Ra-223) is the first targeted alpha therapy approved for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone metastasis. Ra-223 improved overall survival in the international Phase III ALSYMPCA (ALpharadin in SYMPtomatic Prostate Cancer) study. Ra-223 was also de...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1317-1

    authors: Hosono M,Ikebuchi H,Nakamura Y,Yanagida S,Kinuya S

    更新日期:2019-03-01 00:00:00

  • Performance of beta- and high-energy gamma probes for the detection of cancer tissue in experimental surgical resection beds.

    abstract:OBJECTIVE:While high-energy gamma and beta probes have gained considerable attention due to their ability to detect cancerous lesions using (18)F-FDG in humans intraoperatively, it is unknown whether the sensitivity of such probes would allow the detection of remaining tumor tissue in the resection bed after removal of...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-011-0492-0

    authors: Garcia-Parra R,Clinthorne N,Wang L,Picchio M,Piert M

    更新日期:2011-08-01 00:00:00

  • A trial for the quantification of regional myocardial blood flow with continuous infusion of Tc-99m MIBI and dynamic SPECT.

    abstract:UNLABELLED:We propose a new method to quantify regional myocardial blood flow (rMBF) by continuous infusion of Tc-99m MIBI and dynamic SPECT. METHODS:Five patients with old myocardial infarction were studied. During continuous infusion of MIBI (approximately 740 MBq) with a syringe pump in 10 min, dynamic SPECT scan w...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03165431

    authors: Tsuchida T,Yonekura Y,Takahashi N,Nakano A,Lee JD,Sadato N,Yamamoto K,Waki A,Sugimoto K,Hayashi N,Ishii Y

    更新日期:1999-02-01 00:00:00

  • Evaluation of treatment effects in brain abscess with positron emission tomography: comparison of fluorine-18-fluorodeoxyglucose and carbon-11-methionine.

    abstract::Positron emission tomography (PET) imaging is in common use preoperatively to clinically evaluate patients who present with central nervous system mass lesions. The usefulness of PET is also recognized as a method to detect intracranial tumorous lesions. A number of papers reportthat some inflammatory processes also s...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988258

    authors: Tsuyuguchi N,Sunada I,Ohata K,Takami T,Nishio A,Hara M,Kawabe J,Okamura T,Ochi H

    更新日期:2003-02-01 00:00:00

  • Development of visual scoring system with Tc-99m DMSA renal scintigraphy to predict the risk of recurrence of symptomatic urinary tract infections in pediatric patients.

    abstract:OBJECTIVE:Vesicoureteral reflux (VUR) is a major risk factor for recurrent symptomatic urinary tract infection (UTI) in pediatric patients. In addition, dimercaptosuccinic acid renal scintigraphy (DMSA) is an important diagnostic modality of VUR. However, the value of DMSA for predicting recurrent pediatric UTI has not...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-019-01379-0

    authors: Kim D,Yoon HJ,Woo SH,Lee WJ,Kim BS,Chung YA,Oh JK

    更新日期:2019-09-01 00:00:00

  • Fluoro-deoxy-glucose positron emission tomography for evaluation of indeterminate lung nodules: assigning a probability of malignancy may be preferable to binary readings.

    abstract:OBJECTIVE:To assess the diagnostic value of fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) using standard uptake values (SUV) in the differential diagnoses of indeterminate pulmonary nodules. Specifically, we assessed the probability of malignancy for various SUV ranges, and compared the di...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0112-1

    authors: Kim SC,Machac J,Krynyckyi BR,Knesaurek K,Krellenstein D,Schultz B,Gribetz A,DePalo L,Teirstein A,Kim CK

    更新日期:2008-04-01 00:00:00

  • Technetium-99m tetrofosmin uptake in lung cancer: comparison with thallium-201.

    abstract::Technetium-99m tetrofosmin and thallium-201 lung SPECT imaging were performed in a patient with adenocarcinoma of the lung. Significant activities in the lung lesion were clearly depicted on both technetium-99m tetrofosmin and thallium-201 SPECT imaging. The early uptake, delayed uptake ratios and retention indices of...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03165069

    authors: Matsunari I,Kinuya S,Nishikawa T,Matoba M,Murakita K,Ohguchi M,Ichiyanagi K,Taki J,Tonami N,Hisada K

    更新日期:1996-02-01 00:00:00

  • Comparison of FDG-PET, MRI and CT for post radiofrequency ablation evaluation of hepatic tumors.

    abstract:PURPOSE:Treatment effect of radiofrequency ablation (RFA) is traditionally accomplished with MRI and/or CT. The aim of the study was to assess the role of FDG-PET in post RFA hepatic tumor evaluation, in comparison with MRI and CT. MATERIALS AND METHODS:28 patients (33 hepatic RFA lesions) who had post RFA FDG-PET wit...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-012-0656-6

    authors: Chen W,Zhuang H,Cheng G,Torigian DA,Alavi A

    更新日期:2013-01-01 00:00:00

  • Unsuccessful tracer injection in radionuclide cisternography revisited.

    abstract::Since cerebrospinal fluid (CSF) leakage is highlighted as a cause of persistent headache, radionuclide cisternography has been increasingly performed in Japan to confirm the disorder, although the limited ability of the examination should be recognized. We present 3 cases in which failure of a tracer injection was str...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02984653

    authors: Horikoshi T,Asari Y,Watanabe A,Uchida M,Umeda T,Kolzumi H,Kinouchi H

    更新日期:2006-05-01 00:00:00