Abstract:
OBJECTIVE:While high-energy gamma and beta probes have gained considerable attention due to their ability to detect cancerous lesions using (18)F-FDG in humans intraoperatively, it is unknown whether the sensitivity of such probes would allow the detection of remaining tumor tissue in the resection bed after removal of macroscopically evident disease. METHODS:9L tumors (13 primaries, 17 lymph node metastases) were generated at the upper thigh of Fisher 344 rats. After approximately 2 weeks, microPET was performed to verify increased (18)F-FDG tumor uptake. Tumors were surgically exposed and probe readings of tumor and background tissues were performed in triplicate. To evaluate the ability to detect tiny tumor lesions, 12 tumor fragments (range 0.001-0.032 g) were placed into the resection bed and measured to obtain a tumor-to-muscle ratio (TMR). Lesions were classified as positive if count rates were above 2.5 SD of muscle background. All tumor and muscle tissues were weighed and counted to obtain the "true" tumor-to-muscle background ratio (TMR(counter)) for reference. The presence or absence of tumor tissue was verified by histology. RESULTS:In the presence of background gamma radiation, the beta probe detected all tumor lesions with TMR greater than 2.5 SD of muscle background (TMR range 1.24-3.9 for all 41 lesions). Despite suitable shielding, lesion identification by the gamma probe was clearly limited by the presence of background radioactivity. As a result, only 11/13 primary tumors, 6/17 lymph nodes and 1/11 tumor fragments were identified above 2.5 SD of muscle background (TMR range 0.64-3.59 for all lesions). CONCLUSION:Under experimental conditions, the beta probe was capable to detect minute amounts of tumor tissue at the surface of resection beds. While clinical application of the current beta probe design may depend on the particular intraoperative circumstances including time requirements for surface scanning of resection beds, the data indicate clinical potential for novel designs of hand-held beta probes.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Garcia-Parra R,Clinthorne N,Wang L,Picchio M,Piert Mdoi
10.1007/s12149-011-0492-0subject
Has Abstractpub_date
2011-08-01 00:00:00pages
486-93issue
7eissn
0914-7187issn
1864-6433journal_volume
25pub_type
杂志文章abstract::We report a functional neuroimaging study of a 43-year-old woman with Nasu-Hakola disease (NHD). Regional cerebral blood flow (rCBF) images were measured with technetium-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT). rCBF was decreased in the bilateral frontal lobes and thalamus. This f...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984623
更新日期:2005-06-01 00:00:00
abstract::To evaluate two methods for decreasing and/or diluting the FDG activity in the urinary system, five rats were intraperitoneally given 1,000 micrograms/g of L-lysine 4 times, starting from 60 minutes before iv injection of FDG, and then at 30-minute intervals for 90 minutes. Five rats were used as controls. In a furose...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164766
更新日期:1997-08-01 00:00:00
abstract::Nuclear Medicine is the specialty of medical imaging, which utilizes a variety of radionuclides incorporated into specific compounds for diagnostic imaging and therapeutic applications. During recent years, research efforts in this discipline have concentrated on the decay characteristics of particular radionuclides a...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/BF03164930
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVES:Breast cancer is the most common malignancy for females worldwide. This study was to evaluate the application of dual-phase breast-specific gamma imaging (BSGI) in detecting primary breast cancer. METHODS:Seventy-six patients with indeterminate breast lesions that underwent dual-phase BSGI enrolled in this ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0776-7
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Aortic knob width on chest radiography represents the extent of aortic dialation and tortuosity of the aortic arch. We tested the hypothesis that aortic knob width reflected left ventricular (LV) diastolic function assessed by gated myocardial perfusion single photon emission computed tomography (SPECT) in p...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1150-y
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Radium-223 (223Ra) has been approved for treatment in patients with metastatic castration-resistant prostatic cancer (mCRPC) and bone metastasis. This α-emitting radionuclide has a beneficial effect on pain and is also capable to increase overall survival (OS). Several studies evaluated the prognostic value o...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01501-7
更新日期:2020-10-01 00:00:00
abstract::67Ga-citrate and 99mTc(V)-DMSA images were obtained in a patient with recurrent extraabdominal fibromatosis of the left calf. The 67Ga-citrate image showed abnormal uptake in the left calf lesion and right calf, which was considered due to probable myositis caused by overexertion. On the other hand, the 99mTc(V)-DMSA ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164850
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determine...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0917-7
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:Nowadays, the number of primary studies on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been increasing rapidly. Thus, we updated meta-analysis to evaluate the test performance of FDG PET/CT for nodal staging in non-small cell lung cancer (NSCLC) including the most r...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,meta分析
doi:10.1007/s12149-015-0958-6
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:On hepatobiliary scintigraphy, "preferential gallbladder (GB) filling without tracer excretion into the small bowel (SB) [p-GB-no-SB]" is occasionally seen on images obtained up to an hour. In such cases, many practitioners administer cholecystokinin (CCK) (even when the measurement of GB ejection fraction is...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01384-3
更新日期:2019-10-01 00:00:00
abstract::Positron emission tomography (PET) by means of a dynamic state method and H2(15)O was performed to quantify splenic blood flow in 20 patients who had no hepatic functional disorders. Non-linear regression analysis was applied to determine splenic blood flow. In calculating arterial input function for the spleen, our o...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164705
更新日期:1993-11-01 00:00:00
abstract::In a 43-year-old woman with fibrous dysplasia of the ribs and facial bone and in a 40-year-old man with fibrous dysplasia of the facial bone, there were considerable increases in the uptake of Tc-99m methylenediphosphonate (Tc-99m MDP) and Gallium-67 citrate. Fibrous dysplasia should be added to differential diagnosis...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03165658
更新日期:1990-03-01 00:00:00
abstract:PURPOSE:Our purpose was to explore the clinical significance of unexpected osseous foci on 18F-FDG-PET without correlative CT abnormalities (FWCT) in patients referred for oncologic evaluation. The significance of FDG-avid foci without correlative CT abnormalities has been previously explored in tissues such as breast,...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01572-6
更新日期:2021-01-13 00:00:00
abstract:PURPOSE:To compare the diagnostic accuracy of whole-body PET/CT and integrated PET/MR in relation to the total scan time durations. METHODS:One hundred and twenty-three (123) patients (40 males and 83 females; mean age 59.6 years; range 20-83 years) with confirmed primary cancer and clinical suspicion of metastatic di...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1050-y
更新日期:2016-04-01 00:00:00
abstract:UNLABELLED:To determine the utility of the myocardial tracer Tc-99m-tetrofosmin in the examination of patients with left bundle branch block (LBBB) and to investigate Tc-99m-tetrofosmin uptake and retention in the myocardium, early and delayed Tc-99m-tetrofosmin SPECT was performed in 10 patients having LBBB without co...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164914
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the diagnostic performance of postoperative fluorine-18 fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) as a surveillance modality for advanced gastric cancer patients who were asymptomatic and negative by conventional...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0871-4
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Pyothorax-associated lymphoma (PAL) is a rare form of lymphoma and its management on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined computed tomography (CT) has not been well reported. The purpose of this study was to evaluate the usefulness of FDG PET/CT in patients with PAL. MAT...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-010-0408-4
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:In clinical practice, measurement of the rCBF has mainly been conducted by I-123-N-isopropyl-p-iodoamphetamine ((123)I-IMP) SPECT using the microsphere (MS) method, with continuous arterial blood sampling. While several non-invasive (123)I-IMP quantification methods have been developed, their accuracy has bee...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1053-8
更新日期:2016-04-01 00:00:00
abstract:AIM:The motion of the head during brain positron emission tomography (PET) acquisitions has been identified as a source of artifact in the reconstructed image. In this study, a method is described to develop an image-based motion correction technique for correcting the post-acquisition data without using external optic...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0532-9
更新日期:2012-01-01 00:00:00
abstract::We compared single-sample methods, proposed by Russell et al. and Bubeck et al., and camera-based methods in calculating 99mTc-MAG3 clearance, and determined camera-based methods that provide estimates comparable to those measured by the Russell method. Twenty-one patients underwent 99mTc-MAG3 renal scintigraphy, and ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988691
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:Lymphoscintigraphy and sentinel node biopsy are used for the detection of axillary lymph node metastasis in breast cancer patients. However, currently there is no standardized technique. For the detection of axillary lymph node metastasis by lymphoscintigraphy and sentinel node biopsy, in patients with breast...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-009-0259-z
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:Chemobrain is a recently proposed pathological entity. 18F-FDG PET/CT can show objective abnormalities to explain brain disorders caused by chemotherapy, although no study has investigated these phenomena in children to date. The main objective of the present study was to examine quantitatively the effects of...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01363-8
更新日期:2019-08-01 00:00:00
abstract::In this review I summarize observations of PET and SPECT studies about cerebral blood flow and metabolic abnormalities in Alzheimer's disease. In very early AD flow or metabolism reduces first in the posterior cingulate gyrus and precuneus. This reduction may arise from functional deafferentation caused by primary neu...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/BF02988596
更新日期:2001-04-01 00:00:00
abstract::We studied various liver tumors by positron emission tomography with fluorine-18 fluorodeoxyglucose (FDG-PET) to examine the diagnostic usefulness of this technique. We also examined the relation between findings on FDG-PET and the characteristics of hepatocellular carcinoma. FDG-PET was performed in 78 patients with ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988591
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Dopamine transporter imaging with SPECT is a valuable tool for both clinical routine and research studies. Semi-quantitative analysis plays a key role in interpreting the scans, but is dependent on numerous factors, rotational radius being one of them. This study systematically evaluates the potential influen...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0789-2
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:Currently, the diagnosis of bone flap osteomyelitis (BFO) remains a challenge for medical imaging. The present study aimed to identify predictive scintigraphic patterns of BFO. METHODS:This retrospective study reviewed planar bone scan of patients with suspected BFO between 2010, and 2016. A total of 15 pati...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01351-y
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The physiology of gastrointestinal transfer function after proximal gastrectomy with bypass-tract reconstruction is not well understood. We applied a simultaneous dual-radionuclide method with a hepatobiliary imaging and gastric emptying study to evaluate physiologic alterations occurring after surgery. METH...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02984603
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To demonstrate the effect of clinicopathological factors on 68Ga-PSMA-11 PET/CT positivity at the time of biochemical recurrence (BCR) of localized prostate cancer (PCa) following definitive therapy. METHODS:We retrospectively reviewed our institutional database for PCa patients who had BCR and subsequently ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01340-1
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Bone-seeking radiopharmaceuticals have the main role in the treatment of painful bone metastases. The aim of this study was to dosimetrically compare radiopharmaceuticals in use for bone pain palliation therapy and bone scan. METHODS:The MCNPX code was used to simulate the radiation transport in a vertebral ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01329-w
更新日期:2019-04-01 00:00:00
abstract::18F-fluorodeoxyglucose positron emission tomography (F-18 FDG-PET) plays an important role in differentiating benign from malignant tumors. However, some false-positive findings, such as tuberculosis, may occur. We report a case referred for F-18 FDG whole-body PET computed tomography (PET/CT) scan owing to an elevate...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0139-y
更新日期:2008-07-01 00:00:00