Abstract:
OBJECTIVE:Bone-seeking radiopharmaceuticals have the main role in the treatment of painful bone metastases. The aim of this study was to dosimetrically compare radiopharmaceuticals in use for bone pain palliation therapy and bone scan. METHODS:The MCNPX code was used to simulate the radiation transport in a vertebral phantom. Absorbed fractions were calculated for monoenergetic electrons, photons and alpha particles. S values were obtained for radionuclides 32P, 33P, 89Sr, 90Y, 99mTc, 117mSn, 153Sm, 166Ho, 169Er, 177Lu, 186Re, 188Re, 223Ra, 224Ra and their progenies for target regions including the active marrow and the bone endosteum. RESULTS:The results demonstrated the dependence of dosimetric parameters on the source or target size, particle energy and location of the source. The electron emitters including 33P, 117mSn, 169Er and 177Lu and 223Ra as an α-emitter gave the lower absorbed dose to the active marrow. These radionuclides gave the highest values of the Relative Advantage Factor (RAF). CONCLUSIONS:According to the results, 33P, 117mSn, 169Er, 177Lu and 223Ra have fewer side effects on the active marrow than other investigated radionuclides. Therefore, these radionuclides may be a better choice for use in palliative radiotherapy.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Sadremomtaz A,Masoumi Mdoi
10.1007/s12149-019-01329-wsubject
Has Abstractpub_date
2019-04-01 00:00:00pages
252-264issue
4eissn
0914-7187issn
1864-6433pii
10.1007/s12149-019-01329-wjournal_volume
33pub_type
杂志文章abstract:BACKGROUND:Despite recent technological advances allowing for quantitative single-photon emission computed tomography (SPECT), quantitative SPECT has not been widely used in the clinical practice of osteoporosis. The aim of this study is to evaluate the feasibility of quantitative bone SPECT/CT for measuring lumbar sta...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01425-x
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to elucidate the causes of false-negative cases of technetium-99 m methoxyisobutylisonitrile scintigraphy (MIBI) for hyperparathyroidism. METHODS:Consecutive MIBI examinations performed in 154 patients between April 2011 and March 2017 were retrospectively reviewed. Sensitivities of...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01520-4
更新日期:2020-12-01 00:00:00
abstract::We conducted a study of rCBF in the primary visual cortex of visually impaired subjects who have not been subjected to external stimulation for a long period, by means of 123I-IMP SPECT and MRI. The four subjects had lost their sight due to brain tumors (n = 2), glaucoma (n = 1) and trauma (n = 1). 123I-IMP SPECT show...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164976
更新日期:1995-05-01 00:00:00
abstract::We are proposing a new method for correcting of scattered photons in technetium-99m (99mTc) imaging by means of photopeak dual-energy window acquisition. This method consists of the simultaneous acquisition of two images and estimation of a scatter image included in the symmetric energy window (SW) image by the differ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03178307
更新日期:1992-08-01 00:00:00
abstract::Filtered back projection (FBP) method, maximum likelihood-expectation maximization(ML-EM) method, and ordered subsets-expectation maximization (OS-EM) method are currently used for reconstruction of SPECT images in clinical studies. In the ML-EM method, images of good quality can be reconstructed even with a small sam...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03006664
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determine...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0917-7
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To investigate the potential role of Tc-99m depreotide (Tc-DEPR) in the preoperative lymph node (N) staging of non-small-cell lung cancer (NSCLC). METHODS:Sixty-one patients with NSCLC at the potentially operable stage were enrolled and underwent scintigraphy before surgery (n=56) or mediastinoscopy (n=5). I...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0839-4
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the usefulness of a breath-holding (BH) (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography ((18)F-FDG-PET) technique for PET/computed tomography (CT) scanning of pulmonary lesions near the diaphragm, where image quality is influenced by respiratory motion. METHODS:In a basic study, sim...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0206-4
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:We investigated the changes in 125I-iomazenil (125I-IMZ) benzodiazepine receptor (BZR) binding with psychological stress in a rat model. METHODS:Six male Wistar rats were placed under psychological stress for 1 hour by using a communication box. No physical stress was not received. 1.85 MBq of 125I-IMZ was i...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02996307
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to investigate whether total lesion glycolysis (TLG) and metabolic tumor volume (MTV) measured by ¹⁸F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) could predict the aggressiveness and lymph node metastasis (LNM) in patients with incid...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-0994-2
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Radioiodide is commonly used to diagnose and treat hyperthyroidism and thyroid carcinoma. However, we could not find any experimental data that strictly compared the biodistribution and thyroid uptake of radioactive iodide between the oral and intravenous (iv) routes with time. This prompted us to compare (12...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0909-7
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:In clinical practice, measurement of the rCBF has mainly been conducted by I-123-N-isopropyl-p-iodoamphetamine ((123)I-IMP) SPECT using the microsphere (MS) method, with continuous arterial blood sampling. While several non-invasive (123)I-IMP quantification methods have been developed, their accuracy has bee...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1053-8
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:This study aims to clarify the effect of renal function on 2-[(18)F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) imaging and determine the clinical significance of renal function in this setting. We compared FDG distribution between normal volunteers and patients with suspected renal failu...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0012-4
更新日期:2007-06-01 00:00:00
abstract:AIM:The purpose of the study was to determine the lung toxicity caused by amiodarone (AD) and bleomycin (BLM) in rats, by means of Tc-99m HMPAO lung scintigraphy. METHODS:Thirty albino rats were randomly divided into five groups. After AD or BLM was dissolved with isotonic saline (SF), a 0.5 ml solution was applied to...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0722-8
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:In mCRPC patients treated with 223Ra, a major issue is the validation of reliable prognostic and predictive biomarkers to maximize clinical benefit and minimize toxicities and costs. Bearing in mind how changes in tALP did not meet statistical requirements as surrogate marker for survival, aim of this single-...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1228-6
更新日期:2018-02-01 00:00:00
abstract:UNLABELLED:We studied the causative mechanism of ampulla (Takotsubo) cardiomyopathy. METHODS:We examined 7 patients with ampulla cardiomyopathy by means of coronary angiography, two-dimensional echocardiography and 99Tc-tetrofosmin myocardial SPECT at the time of emergency admission (acute phase), at 3 to 5 days after...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988242
更新日期:2001-08-01 00:00:00
abstract::HIV infection results in profound alterations of immunologic function that render the patient severely immunocompromised, and susceptible to malignancies and opportunistic infections. Three AIDS-defining malignancies include Kaposi's sarcoma (KS), non-Hodgkin's lymphoma (NHL) and invasive cervical cancer. In AIDS pati...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-011-0506-y
更新日期:2011-10-01 00:00:00
abstract:AIM:To investigate the diagnostic performance of early acquisition compared to late imaging for the detection of local recurrence of prostate cancer by means of ¹⁸F-FCH PET/CT. MATERIALS AND METHODS:99 patients with radical prostatectomy (mean PSA 3.9 ± 5.03) were subjected to early dynamic PET/CT acquisition of the p...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-1015-1
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Variable uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has been noticed in positron emission tomography (PET) studies of gastric carcinoma patients, with low uptake occurring especially in some particular histological subtypes and early carcinomas. But this phenomenon has not been adequately explained. The ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984657
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:A positron emission tomography (PET) scanner using a silicon photomultiplier (SiPM PET) in place of a photomultiplier tube significantly improves the spatial and time resolution. It may also improve the evaluation of smaller lesions compared to conventional (non-SiPM) PET scanners. We compared the maximum sta...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01489-0
更新日期:2020-09-01 00:00:00
abstract:UNLABELLED:The purpose of this study was to validate a double-injection (DI) method with N-isopropyl-[123I]p-iodoamphetamine (IMP) to measure regional cerebral blood flow (rCBF) twice in a single session of dynamic SPECT and to elucidate a possible role of this method to identify patients with occlusive disease of majo...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02987833
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To investigate the utility of 13N-ammonia PET/CT imaging in the differential diagnosis of gliomas and brain inflammations. METHODS:13N-ammonia PET/CT imaging data of 77 patients with gliomas and 34 patients with brain inflammations were retrospectively analyzed. No patients received any treatment before 13N-...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1308-2
更新日期:2019-01-01 00:00:00
abstract::F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging is a useful modality in the detection of various tumors, including colon cancer and gastric cancer. We evaluated a patient with duodenal cancer with multiple metastases including brain metastases using FDG-PET imaging. It revealed multiple tumor up...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984475
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess I-131 biokinetics in thyroid cancer and remnant tissue in patients with differentiated thyroid cancer using whole-body scan (WBS) and SPECT images acquired after I-131 therapy. The influence of thyroid stimulating hormone (TSH) stimulation method on the kinetics was also ev...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1188-x
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The potential of positron emission tomography/computed tomography using 62Cu-diacetyl-bis (N4-methylthiosemicarbazone) (62Cu-ATSM PET/CT), which was originally developed as a hypoxic tracer, to predict therapeutic resistance and prognosis has been reported in various cancers. Our purpose was to investigate pr...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-018-1241-4
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:The physiology of gastrointestinal transfer function after proximal gastrectomy with bypass-tract reconstruction is not well understood. We applied a simultaneous dual-radionuclide method with a hepatobiliary imaging and gastric emptying study to evaluate physiologic alterations occurring after surgery. METH...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02984603
更新日期:2005-05-01 00:00:00
abstract::A rare case of inferior vena cava (IVC) thrombosis and pulmonary embolism secondary to acute exacerbation of chronic pancreatitis was reported. Radionuclide venography and lung perfusion scintigraphy were performed on a 46-year-old male with acute exacerbation of chronic pancreatitis who complained of mild swelling of...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02993720
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. METHODS:Forty-seve...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-007-0179-8
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:An anthropomorphic pelvis phantom was made by the modification of a National Electrical Manufacturers Association (NEMA) phantom, currently the most popular one, and its clinical usefulness was evaluated. METHODS:The NEMA plus bone phantom was made by placing the pelvic bone model in the NEMA phantom. The NE...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-009-0229-5
更新日期:2009-05-01 00:00:00
abstract:RATIONALE:Myocardial perfusion SPECT is a commonly performed, well established, clinically useful procedure for the management of patients with coronary artery disease. However, the attenuation of photons from myocardium impacts the quantification of infarct sizes. CT-Attenuation Correction (AC) potentially resolves th...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1211-2
更新日期:2017-12-01 00:00:00