125I-iomazenil-benzodiazepine receptor binding during psychological stress in rats.

Abstract:

OBJECTIVE:We investigated the changes in 125I-iomazenil (125I-IMZ) benzodiazepine receptor (BZR) binding with psychological stress in a rat model. METHODS:Six male Wistar rats were placed under psychological stress for 1 hour by using a communication box. No physical stress was not received. 1.85 MBq of 125I-IMZ was injected into the lateral tail vein and the rat was killed 3 hours later. Twenty-micrometer-thick sections of the brain were collected and % injected dose per body weight (%ID/BW) of eleven regions (frontal, parietal, temporal, occipital cortices, caudate putamen, accumubens nuclei, globus pallidus, amygdala, thalamus, hippocampus and hypothalamus) were calculated by autoradiography. The %ID/BW of rats which were placed under psychological stress was compared with that of 6 control rats. RESULTS:The %ID/BW of rats which were placed under psychological stress diffusely tended to show a reduction in 125I-IMZ-BZR binding. A significant decrease in BZR binding was observed in the hippocampus of the rats which were placed under psychological stress. CONCLUSION:125I-IMZ-BZR binding tended to decrease throughout the brain.

journal_name

Ann Nucl Med

authors

Fukumitsu N,Tsuchida D,Ogi S,Uchiyama M,Mori Y

doi

10.1007/BF02996307

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

231-5

issue

3

eissn

0914-7187

issn

1864-6433

journal_volume

16

pub_type

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