Comparison of integrated whole-body PET/MR and PET/CT: Is PET/MR alternative to PET/CT in routine clinical oncology?

Abstract:

PURPOSE:To compare the diagnostic accuracy of whole-body PET/CT and integrated PET/MR in relation to the total scan time durations. METHODS:One hundred and twenty-three (123) patients (40 males and 83 females; mean age 59.6 years; range 20-83 years) with confirmed primary cancer and clinical suspicion of metastatic disease underwent whole-body 18F-FDG-PET/CT and 18F-FDG-PET/MR. Data acquisition was done after intravenous administration of 110-301 MBq radioactivity of 18F-FDG, and PET/MR data were acquired after the PET/CT data acquisition. The mean uptake times for PET/CT and PET/MR acquisition were 68.0 ± 8.0 and 98.0 ± 14 min, respectively. Total scan time was 20.0 and 25.0 min for whole-body PET/CT and PET/MR imaging. RESULTS:The reconstructed PET/CT and PET/MR data detected 333/355 (93.8 %) common lesions in 111/123 (90.2 %) patients. PET/CT and PET/MR alone detected 348/355 and 340/355 lesions, respectively. No significant (p = 0.08) difference was observed for the overall detection efficiency between the two techniques. On the other hand, a significant difference was observed between the two techniques for the detection of lung (p = 0.003) and cerebrospinal (p = 0.007) lesions. The 15 lesions identified by PET/CT only included 8 lung, 3 lymph nodes, 2 bone, and 1 each of peritoneal and adrenal gland lesions. On the other hand, 7 (6 brain metastatic lesions and 1 bone lesion) were identified by PET/MR only. CONCLUSION:Integrated PET/MR is a feasible whole-body imaging modality and may score better than PET/CT for the detection of brain metastases. To further prove diagnostic utility, this technique requires further clinical validation.

journal_name

Ann Nucl Med

authors

Ishii S,Shimao D,Hara T,Miyajima M,Kikuchi K,Takawa M,Kumamoto K,Ito H,Shishido F

doi

10.1007/s12149-015-1050-y

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

225-33

issue

3

eissn

0914-7187

issn

1864-6433

pii

10.1007/s12149-015-1050-y

journal_volume

30

pub_type

杂志文章
  • Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang's

    abstract:OBJECTIVE:We examined the diagnostic value of brain perfusion single-photon emission computed tomography (SPECT) using voxel-based statistical analysis with CT-based attenuation correction (CT-AC) by comparing it to that with Chang's AC in mild cognitive impairment (MCI) patients and attempted to locate brain areas tha...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01477-4

    authors: Sohara K,Kiriyama T,Mizumura S,Ishiwata A,Yamazaki M,Kimura K,Kumita SI

    更新日期:2020-07-01 00:00:00

  • Assessment of cardiac function in patients with heart disease by quantitative gated myocardial perfusion SPECT.

    abstract:OBJECTIVE:We examined the cardiac function of patients who underwent Tc-99m sestamibi quantitative gated myocardial single photon emission computed tomography with 16-framing data acquisition between January 1, 2004 and March 31, 2006 for an evaluation of suspected or known heart disease in our hospital. METHODS:In 19...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0032-0

    authors: Nakae I,Matsuo S,Tsutamoto T,Matsumoto T,Mitsunami K,Horie M

    更新日期:2007-08-01 00:00:00

  • Prognosis of hypertrophic cardiomyopathy: assessment by 123I-BMIPP (beta-methyl-p-(123I)iodophenyl pentadecanoic acid) myocardial single photon emission computed tomography.

    abstract::123I-BMIPP (beta-methyl-iodophenyl pentadecanoic acid) has shown unique properties for potential use in assessing myocardial metabolism. Previous basic and clinical studies demonstrated that the disturbances of myocardial metabolism precede the occurrence of myocardial perfusion abnormalities by using 201Tl in hypertr...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03165056

    authors: Nishimura T,Nagata S,Uehara T,Morozumi T,Ishida Y,Nakata T,Iimura O,Kurata C,Wakabayashi Y,Sugihara H,Otsuki K,Wada T,Koga Y

    更新日期:1996-02-01 00:00:00

  • Transient seizure activity demonstrated by Tc-99m HMPAO SPECT and diffusion-weighted MR imaging.

    abstract::Cerebral perfusion single photon emission computed tomography (SPECT) has been used to confirm the localization of the epileptic focus and the evaluation of seizure. Recently, diffusion-weighted MR imaging (DWI) has been recognized for evaluation of seizure activity. We describe a case of transient seizure activity de...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02987844

    authors: Sagiuchi T,Ishii K,Asano Y,Aoki Y,Woodhams R,Yanaihara H,Kan S,Hayakawa K

    更新日期:2001-06-01 00:00:00

  • FDG-PET of patients with suspected renal failure: standardized uptake values in normal tissues.

    abstract:OBJECTIVE:This study aims to clarify the effect of renal function on 2-[(18)F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) imaging and determine the clinical significance of renal function in this setting. We compared FDG distribution between normal volunteers and patients with suspected renal failu...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0012-4

    authors: Minamimoto R,Takahashi N,Inoue T

    更新日期:2007-06-01 00:00:00

  • A case of recurrent cholangitis after bile duct injury during laparoscopic cholecystectomy: value of scintigraphy with Tc-99m GSA and hepatobiliary scintigraphy for indication of lobectomy.

    abstract::A 39-year-old woman with acute cholecystitis and gallstones underwent laparoscopic cholecystectomy. She suffered from recurrent episodes of cholangitis due to injury of the major bile ducts during laparoscopic cholecystectomy. Hepatobiliary scintigraphy with Tc-99m Sn-N-pyridoxyl-5-methyltryptophan was performed. Alth...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988702

    authors: Nishiguchi S,Shiomi S,Sasaki N,Iwata Y,Tanaka H,Kubo S,Hirohashi K,Ochi H

    更新日期:2000-10-01 00:00:00

  • A case of lung cancer associated with pneumoconiosis diagnosed by fluorine-18 fluorodeoxyglucose positron emission tomography.

    abstract::We report a case of lung cancer arising from progressive massive fibrosis (PMF) associated with pneumoconiosis. In this case, fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) was able to clearly distinguish the lung cancer from PMF, suggesting a potential usefulness of FDG-PET in cancer screening ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03006674

    authors: Bandoh S,Fujita J,Yamamoto Y,Nishiyama Y,Ueda Y,Tojo Y,Ishii T,Kubo A,Ishida T

    更新日期:2003-10-01 00:00:00

  • Lack of correlation between Tc-99m-sestaMIBI uptake and cadherin expression in infiltrating ductal breast carcinoma as prognostic indicators.

    abstract::Despite using various kinds of prognostic indicators, it is still not possible to predict the biological behavior of breast cancer in all patients. Tc-99m-sestaMIBI (MIBI) uptake determined by breast scintigraphy and cadherin expression of tumor tissue revealed by immunohistochemistry are suggested as potential agents...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988522

    authors: Uğur Y,Sari O,Uğur O,Korkusuz P,Varoğlu E,Arslan N,Gürcan N,Yildirim M,Sökmensüer C,Aşan E,Aras T

    更新日期:2003-06-01 00:00:00

  • Evaluation of a short dynamic 18F-fluoride PET/CT scanning method to assess bone metabolic activity in spinal orthopedics.

    abstract:OBJECTIVE:A complication after spinal fusion surgery is pseudarthrosis, but its radiological diagnosis is of limited value. (18)F-fluoride PET with its ability to assess bone metabolism activity could be of value. The goal of this study was to assess the clinical feasibility of calculating the static standardized uptak...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-015-1008-0

    authors: Peters MJ,Wierts R,Jutten EM,Halders SG,Willems PC,Brans B

    更新日期:2015-11-01 00:00:00

  • Metastatic calcification: accumulation of a bone tracer during dynamic data acquisition.

    abstract::Metastatic calcification is often detected by bone scintigraphy. We recently saw metastatic calcification in the stomach and kidneys of a patient on continuous ambulatory peritoneal dialysis. Tc-99m HMDP accumulation into both organs was noted even in the first frame of dynamic data acquisition of 4 min/frame, suggest...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164806

    authors: Kinuya S,Taki J,Fujioka M,Michigishi T,Tonami N

    更新日期:1996-11-01 00:00:00

  • Washout rates of Tc-99m tetrofosmin in asymmetric septal hypertrophy.

    abstract::The aim of this study was to evaluate the washout rate of Tc-99m tetrofosmin in asymmetric septal hypertrophy (ASH). As Tc-99m tetrofosmin accumulation and retention depend on sarcolemmal and/or mitochondrial function, the presence or absence of abnormalities in the washout rate of Tc-99m tetrofosmin could provide inf...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02986332

    authors: Büyükdereli G,Kanadasi M,Kibar M

    更新日期:2005-02-01 00:00:00

  • Assessment of absolute Tc-99m tetrofosmin retention in the myocardium as an index of myocardial blood flow and coronary flow reserve by gated-SPECT/CT: a feasibility study.

    abstract:OBJECTIVE:Estimation of myocardial blood flow (MBF) and coronary flow reserve (CFR) by SPECT myocardial perfusion imaging (MPI) remains challenging. Our aim was to approximate MBF and CFR by quantifying the absolute Tc-99m tetrofosmin retention in the myocardium via gated-SPECT/CT MPI. METHODS:Tracer retention was cal...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12149-015-0982-6

    authors: Apostolopoulos DJ,Kaspiri A,Spyridonidis T,Patsouras N,Savvopoulos CA,Davlouros P,Vassilakos PJ,Alexopoulos D

    更新日期:2015-08-01 00:00:00

  • Potential utility of bone scan in cranial bone flap osteomyelitis.

    abstract:OBJECTIVE:Currently, the diagnosis of bone flap osteomyelitis (BFO) remains a challenge for medical imaging. The present study aimed to identify predictive scintigraphic patterns of BFO. METHODS:This retrospective study reviewed planar bone scan of patients with suspected BFO between 2010, and 2016. A total of 15 pati...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-019-01351-y

    authors: Bani Sadr A,Gregoire B,Tordo J,Guyotat J,Boibieux A,Janier M

    更新日期:2019-06-01 00:00:00

  • Comparison of choline influx from dynamic 18F-Choline PET/CT and clinicopathological parameters in prostate cancer initial assessment.

    abstract:AIM:The aim of the study was to compare the kinetic analysis of 18F-labeled choline (FCH) uptake with static analysis and clinicopathological parameters in patients with newly diagnosed prostate cancer (PC). MATERIALS AND METHODS:Sixty-one patients were included. PSA was performed few days before FCH PET/CT. Gleason s...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1246-z

    authors: Palard-Novello X,Blin AL,Bourhis D,Garin E,Salaün PY,Devillers A,Querellou S,Bourguet P,Le Jeune F,Saint-Jalmes H

    更新日期:2018-05-01 00:00:00

  • Morphine-augmented cholescintigraphy enhances duodenogastric reflux.

    abstract::Morphine intervention in cholescintigraphy decreases imaging time to diagnose acute cholecystitis. Not infrequently we observe duodenogastric reflux during scintigraphy with and without morphine intervention. To evaluate occurrence of duodenogastric reflux related to morphine, we reviewed 55 patients who underwent cho...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03168405

    authors: Shih WJ,Lee JK,Magoun S,Wierzbinski B,Ryo UY

    更新日期:1995-11-01 00:00:00

  • The utility of FDG-PET/CT as an effective tool for detecting recurrent colorectal cancer regardless of serum CEA levels.

    abstract:PURPOSE:Tumor recurrence of colorectal cancers (CRC) is generally followed up by analyses of the serum carcinoembryonic antigen (CEA) levels. However, recent evidence suggests that tumor recurrence can also be visualized by 18F-fluoro-deoxyglucose emission tomography/computed tomography (FDG-PET/CT) in patients with no...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-012-0609-0

    authors: Sanli Y,Kuyumcu S,Ozkan ZG,Kilic L,Balik E,Turkmen C,Has D,Isik G,Asoglu O,Kapran Y,Adalet I

    更新日期:2012-08-01 00:00:00

  • Maximal safe dose of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma.

    abstract:OBJECTIVE:The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. METHODS:Forty-seve...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12149-007-0179-8

    authors: Lee JJ,Chung JK,Kim SE,Kang WJ,Park DJ,Lee DS,Cho BY,Lee MC

    更新日期:2008-11-01 00:00:00

  • Prognostic value of semi-quantitative tumor uptake on Tc-99m sestamibi breast-specific gamma imaging in invasive ductal breast cancer.

    abstract:OBJECTIVES:This study investigated the prognostic value of preoperative breast-specific gamma imaging (BSGI) uptake measured by a semi-quantitative method in invasive ductal carcinoma (IDC). METHODS:One hundred and sixty-two women with IDC who underwent preoperative BSGI were retrospectively enrolled. The tumor-to-nor...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-015-0977-3

    authors: Yoon HJ,Kim Y,Chang KT,Kim BS

    更新日期:2015-08-01 00:00:00

  • Water-pipe smoking effects on pulmonary permeability using technetium-99m DTPA inhalation scintigraphy.

    abstract:OBJECTIVE:Although extensive work has been done on cigarette smoking and its effects on pulmonary function, there are limited number of studies on water-pipe smoking. The effects of water-pipe smoking on health are not widely investigated. The aim of this study was to determine the effects of water-pipe smoking on pulm...

    journal_title:Annals of nuclear medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02984465

    authors: Aydin A,Kiter G,Durak H,Ucan ES,Kaya GC,Ceylan E

    更新日期:2004-06-01 00:00:00

  • Amyloid-plaque imaging in early and differential diagnosis of dementia.

    abstract::The increasing life expectancy in our society results in a continuously growing number of patients suffering from neurodegenerative disorders, particularly Alzheimer's disease (AD). Apart from the deleterious consequences for patients and their relatives, this issue has also alarming effects on our social systems. The...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-009-0330-9

    authors: Drzezga A

    更新日期:2010-02-01 00:00:00

  • Usefulness of 67Ga SPECT and integrated low-dose CT scanning (SPECT/CT) in the diagnosis of cardiac sarcoidosis.

    abstract:OBJECTIVE:We performed 67Gallium (Ga) single-photon emission computed tomography (SPECT) with integrated low-dose computed tomography (CT) for the interpretation of myocardial outline to investigate the value of co-registered fusion imaging using a hybrid system (SPECT/CT) in patients with cardiac sarcoidosis. METHODS...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0064-5

    authors: Momose M,Kadoya M,Koshikawa M,Matsushita T,Yamada A

    更新日期:2007-12-01 00:00:00

  • FDG PET in solitary metastastic/secondary tumor of the kidney: a report of three cases and a review of the relevant literature.

    abstract::Metastatic tumors or secondary lymphoma of the kidney are rare and can often be missed on conventional computed tomography (CT) imaging. On the other hand, many types of metastatic tumor or lymphoma can be detected clearly as hotspots of elevated uptake on FDG PET. However, excreted FDG present in the urinary tract mi...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/BF02985596

    authors: Kaneta T,Hakamatsuka T,Yamada T,Takase K,Sato A,Higano S,Kinomura S,Fukuda H,Takahashi S,Yamada S

    更新日期:2006-01-01 00:00:00

  • Tc-99m MIBI SPECT in prediction of prognosis in patients with small cell lung cancer.

    abstract:PURPOSE:The purpose of this study was to evaluate whether the degree of technetium-99m methoxyisobutylisonitrile (MIBI) uptake and its retention in delayed imaging in small cell lung cancer (SCLC) was correlated with the response to multiagent chemotherapy and to investigate if there was a relationship between the surv...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02984643

    authors: Akgun A,Cok G,Karapolat I,Goksel T,Burak Z

    更新日期:2006-05-01 00:00:00

  • Normal uptake of F-18 FDG in the testis as assessed by PET/CT in a pediatric study population.

    abstract:OBJECTIVE:To investigate the correlation between the F-18 FDG uptake in the normal testis as assessed by PET-CT and patient age in a pediatric study population. METHODS:The study population consisted of 22 subjects aged between 9 and 17 years. For these subjects 42 PET-CT scans were available for analysis. The testis ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-009-0308-7

    authors: Goethals I,De Vriendt C,Hoste P,Smeets P,Ham H

    更新日期:2009-11-01 00:00:00

  • I-131 biokinetics of remnant normal thyroid tissue and residual thyroid cancer in patients with differentiated thyroid cancer: comparison between recombinant human TSH administration and thyroid hormone withdrawal.

    abstract:OBJECTIVE:The aim of this study was to assess I-131 biokinetics in thyroid cancer and remnant tissue in patients with differentiated thyroid cancer using whole-body scan (WBS) and SPECT images acquired after I-131 therapy. The influence of thyroid stimulating hormone (TSH) stimulation method on the kinetics was also ev...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-017-1188-x

    authors: Hong CM,Kim CY,Son SH,Jung JH,Lee CH,Jeong JH,Jeong SY,Lee SW,Lee J,Ahn BC

    更新日期:2017-10-01 00:00:00

  • Visual and semi-quantitative analyses of dual-phase breast-specific gamma imaging with Tc-99m-sestamibi in detecting primary breast cancer.

    abstract:OBJECTIVES:Breast cancer is the most common malignancy for females worldwide. This study was to evaluate the application of dual-phase breast-specific gamma imaging (BSGI) in detecting primary breast cancer. METHODS:Seventy-six patients with indeterminate breast lesions that underwent dual-phase BSGI enrolled in this ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-013-0776-7

    authors: Tan H,Jiang L,Gu Y,Xiu Y,Han L,Wu P,Zhang H,Shi H

    更新日期:2014-01-01 00:00:00

  • A novel respiratory gating method for oncologic positron emission tomography based on bioimpedance approach.

    abstract:OBJECTIVE:Respiratory motion causes loss of image quality and inaccuracy of quantification in oncologic positron emission tomography (PET) imaging. This study introduces a bioimpedance-based gating method for compensation of respiratory motion artefacts. METHODS:The bioimpedance-based respiratory gating method was stu...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-015-0953-y

    authors: Koivumäki T,Teuho J,Teräs M,Vauhkonen M,Hakulinen MA

    更新日期:2015-05-01 00:00:00

  • Oncologic significance of unexpected osseous foci on FDG-PET without correlative CT abnormalities.

    abstract:PURPOSE:Our purpose was to explore the clinical significance of unexpected osseous foci on 18F-FDG-PET without correlative CT abnormalities (FWCT) in patients referred for oncologic evaluation. The significance of FDG-avid foci without correlative CT abnormalities has been previously explored in tissues such as breast,...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01572-6

    authors: Zamora E,Valdivia AY

    更新日期:2021-01-13 00:00:00

  • Usefulness of the Chang attenuation correction method with use of a CT-based μ map by FBP reconstruction in (201)Tl SPECT-MPI.

    abstract:OBJECTIVE:Attenuation correction (AC) on nuclear images of non-uniform domains is generally performed by a change of the computed tomography (CT) values to μ values, which are then inserted as components into the detection probability of iterative reconstruction techniques (OS-EM Iterative AC). We established an AC tec...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-015-0972-8

    authors: Nakamura Y,Tomiguchi S

    更新日期:2015-06-01 00:00:00

  • Pathophysiology and diagnosis of hibernating myocardium in patients with post-ischemic heart failure: the contribution of PET.

    abstract::Identification and treatment of hibernating myocardium (HM) lead to improvement in LV function and prognosis in patients with post-ischemic heart failure. Different techniques are used to diagnose HM: echocardiography, MRI, SPECT and PET and, in patients with moderate LV impairment, their predictive values are similar...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/BF03006599

    authors: Camici PG,Rimoldi OE

    更新日期:2003-07-01 00:00:00