Paradigm shift in theranostics of neuroendocrine tumors: conceptual horizons of nanotechnology in nuclear medicine.

abstract：UNLABELLED:The purpose of this study is to determine the subcellular distribution of thallium (SDTl) by electron microscopy and a newly designed fixation method that makes insoluble grains of Tl visible. METHODS:To obtain the high dose necessary for electron microscopic visualization, we employed TlCl instead of 201Tl...

journal_title：Annals of nuclear medicine

authors： Fukumoto M,Yoshida D,Yoshida S

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:Because thickening of the gallbladder wall is observed not only in patients with gallbladder cancer but also in those with benign diseases such as chronic cholecystitis and gallbladder adenomyosis, it is difficult to distinguish between benign and malignant gallbladder wall thickening by conventional techniqu...

journal_title：Annals of nuclear medicine

authors： Oe A,Kawabe J,Torii K,Kawamura E,Higashiyama S,Kotani J,Hayashi T,Kurooka H,Tsumoto C,Kubo S,Shiomi S

更新日期：2006-12-01 00:00:00

abstract：:Tl-201 SPECT and Tc-99m-Human serum albumin (HSA) multigated radionuclide ventriculography were performed on 11 patients with progressive muscular dystrophy (Becker type 2, Fukuyama type 2, Limb-girdle type 7) to evaluate myocardial involvement. Hypoperfusion was detected in 8 patients on Tl-201 SPECT. Decreases in bo...

journal_title：Annals of nuclear medicine

authors： Nagamachi S,Inoue K,Jinnouchi S,Hoshi H,Ono S,Ohnishi T,Futami S,Watanabe K,Hayashi T

更新日期：1994-02-01 00:00:00

abstract：:Whole body imaging with radioiodine can detect functioning metastases, which can often be effectively treated with appropriate amounts of radioiodine. Non-physiologic I-131 uptake detected on images is usually interpreted as suggesting functioning thyroid metastases. However, extra-thyroidal I-131 accumulation does no...

journal_title：Annals of nuclear medicine

authors： Ozguven M,Ilgan S,Arslan N,Karacalioglu AO,Yuksel D,Dundar S

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:To compare L-3-[18F]-fluoro-a-methyltyrosine (FMT)-positron emission tomography (PET) and 2-[18F]-fluoro-2-deoxy-D-glucose (FDG)-PET in the differential diagnosis of maxillofacial tumors. METHODS:This study included 36 patients (16 males, 20 females; 31-90 years old) with untreated malignant tumors (34 squa...

journal_title：Annals of nuclear medicine

authors： Miyakubo M,Oriuchi N,Tsushima Y,Higuchi T,Koyama K,Arai K,Paudyal B,Iida Y,Hanaoka H,Ishikita T,Nakasone Y,Negishi A,Mogi K,Endo K

更新日期：2007-02-01 00:00:00

abstract：:Technetium-99m tetrofosmin and thallium-201 lung SPECT imaging were performed in a patient with adenocarcinoma of the lung. Significant activities in the lung lesion were clearly depicted on both technetium-99m tetrofosmin and thallium-201 SPECT imaging. The early uptake, delayed uptake ratios and retention indices of...

journal_title：Annals of nuclear medicine

authors： Matsunari I,Kinuya S,Nishikawa T,Matoba M,Murakita K,Ohguchi M,Ichiyanagi K,Taki J,Tonami N,Hisada K

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determine...

journal_title：Annals of nuclear medicine

authors： Shanehsazzadeh S,Yousefnia H,Lahooti A,Zolghadri S,Jalilian AR,Afarideh H

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:One of the major causes of diabetes and obesity is abnormality in glucose metabolism and glucose uptake in the muscle and adipose tissue based on an insufficient action of insulin. Therefore, many of the drug discovery programs are based on the concept of stimulating glucose uptake in these tissues. Improveme...

journal_title：Annals of nuclear medicine

authors： Ishino S,Sugita T,Kondo Y,Okai M,Tsuchimori K,Watanabe M,Mori I,Hosoya M,Horiguchi T,Kamiguchi H

更新日期：2017-06-01 00:00:00

abstract：:We studied the cerebral muscarinic acetylcholinergic receptor (mACh-R) by means of 11C-N-methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET) in Alzheimer's disease (AD) cases, and the findings were compared with the cerebral blood flow (CBF) and the glucose metabolism (CMRGlc) to evaluate th...

journal_title：Annals of nuclear medicine

authors： Yoshida T,Kuwabara Y,Ichiya Y,Sasaki M,Fukumura T,Ichimiya A,Takita M,Ogomori K,Masuda K

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Variable uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has been noticed in positron emission tomography (PET) studies of gastric carcinoma patients, with low uptake occurring especially in some particular histological subtypes and early carcinomas. But this phenomenon has not been adequately explained. The ...

journal_title：Annals of nuclear medicine

authors： Yamada A,Oguchi K,Fukushima M,Imai Y,Kadoya M

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to assess the value of CT and bone scintigraphic findings for grading of rib chondrosarcoma. METHODS:Included in this study were six cases of histologically proven chondrosarcoma of the rib, in which bone scintigraphy and/or CT was performed. Correlation of histologic grade (I-...

journal_title：Annals of nuclear medicine

authors： Ehara S,Nakayama T,Nishida J,Shiraishi H,Yoshioka H,Aoki J

更新日期：2004-10-01 00:00:00

abstract：UNLABELLED:We evaluated a new semiquantitative procedure to more easily and objectively estimate the striatal uptake of 123I-FP-CIT in patients with Parkinsonian syndrome (PS) and essential tremor (ET), using an anatomical standardization method, the Neurostat. METHODS:Eleven patients with PS and 8 with ET were examin...

journal_title：Annals of nuclear medicine

authors： Takada S,Yoshimura M,Shindo H,Saito K,Koizumi K,Utsumi H,Abe K

更新日期：2006-08-01 00:00:00

abstract：:Positron emission tomography (PET) using pyruvate-1-11C was carried out to investigate the in vivo metabolism of pyruvate in the brains of patients with mitochondrial encephalomyopathy and Leigh's disease. Two epileptic patients were studied as control subjects. Radioactivity was eliminated from the brain tissue of th...

journal_title：Annals of nuclear medicine

authors： Toyoda M,Sakuragawa N,Arai Y,Yoshikawa H,Sugai K,Arima M,Hara T,Iio M,Satoyoshi E

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:Epidermal growth factor receptor tyrosine kinase (EGFR-TK) represents an attractive target for tumor diagnosis agents. Previously, radioiodinated 4-(3-iodophenoxy)-6,7-diethoxyquinazoline (PHY) was reported to possess good characteristics as a tumor imaging agent. We have explored the feasibility of developin...

journal_title：Annals of nuclear medicine

authors： Hirata M,Kanai Y,Naka S,Yoshimoto M,Kagawa S,Matsumuro K,Katsuma H,Yamaguchi H,Magata Y,Ohmomo Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Rest thallium-201 (201Tl) myocardial perfusion imaging has been widely used for evaluation of myocardial ischemia/viability after myocardial infarction, but the ideal timing for imaging after injection to maximally estimate viability is not well established. METHODS:Thirty-six patients with myocardial infar...

journal_title：Annals of nuclear medicine

authors： Yang XJ,He YM,Zhang B,Wu YW,Hui J,Jiang TB,Song JP,Liu ZH,Jiang WP

更新日期：2006-01-01 00:00:00

abstract：:This study evaluates the regional cerebral blood flow (CBF) with H2(15)O-PET and the distribution of central benzodiazepine receptor (BZR) with C-11 flumazenil (FMZ) by PET and I-123 iomazenil (IMZ) by SPECT in Alzheimer's disease (AD). In AD, whereas the CBF was diminished in the frontal, temporal, parietal, and occi...

journal_title：Annals of nuclear medicine

authors： Ohyama M,Senda M,Ishiwata K,Kitamura S,Mishina M,Ishii K,Toyama H,Oda K,Katayama Y

更新日期：1999-10-01 00:00:00

abstract：:We report a functional neuroimaging study of a patient clinically diagnosed with Korsakoff syndrome. Positron emission tomography (PET) with the 15O inhalation method showed decreased regional cerebral blood flow (rCBF) and decreased regional cerebral metabolic ratio for oxygen (rCMRO2) in the bilateral fronto-tempora...

journal_title：Annals of nuclear medicine

authors： Matsuda K,Yamaji S,Ishii K,Sasaki M,Sakamoto S,Kitagaki H,Imamura T,Mori E

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to perform a systematic review of the prognostic value of texture parameters derived by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with lung cancer. METHODS:PubMed and EMBASE databases were searched up to March 12, 2018, for original articles invol...

journal_title：Annals of nuclear medicine

authors： Han S,Woo S,Suh CH,Kim YJ,Oh JS,Lee JJ

更新日期：2018-11-01 00:00:00

abstract：:We present a case of inferior vena cava (IVC) tumor thrombus detected by fluorine- 18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET). A man underwent operations for the treatment of sigmoid colon cancer at the age of 63. Because tumor markers [carcinoembryonic antigen (CEA) and CA19-9] were increased at...

journal_title：Annals of nuclear medicine

authors： Kaida H,Ishibashi M,Kurata S,Uchida M,Hayabuchi N

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to establish the optimal regions of interest (ROIs) in anatomically normalized I-123 FP-CIT SPECT images for the quantification of dopamine transporter binding. METHODS:The subjects comprised 16 normal controls and 14 Parkinsonian patients. All of the normal control subjects underwen...

journal_title：Annals of nuclear medicine

authors： Nonokuma M,Kuwabara Y,Hida K,Tani T,Takano K,Yoshimitsu K

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Image segmentation is an essential step in quantifying the extent of reduced or absent lung function. The aim of this study is to develop and validate a new tool for automatic segmentation of lungs in ventilation and perfusion SPECT images and compare automatic and manual SPECT lung segmentations with referen...

journal_title：Annals of nuclear medicine

authors： Cheimariotis GA,Al-Mashat M,Haris K,Aletras AH,Jögi J,Bajc M,Maglaveras N,Heiberg E

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:The relationships among regional diastolic impairment, the elongation of global time to peak filling rate (g-TPF), and global diastolic function were examined by a novel program using electrocardiography-gated myocardial perfusion single-photon emission computed tomography (SPECT) (GMPS) in heart failure (HF)...

journal_title：Annals of nuclear medicine

authors： Yamamoto A,Takahashi N,Munakata K,Abe K,Kobayashi Y,Tamai J,Shiiba M,Okuyama T,Kaneshiro T,Tsuruta H,Takama T,Satou M

更新日期：2007-10-01 00:00:00

abstract：:We report a patient with DTPA and DMSA uptake on unsuspected bone metastases. He had severe pain due to grade 3 hydronephrosis of his left kidney. When Tc-99m DTPA and DMSA renal scanning were performed for preoperative evaluation, abnormal radiopharmaceutical uptake on the iliac area was noted. Pancreatic adenocarcin...

journal_title：Annals of nuclear medicine

authors： Balci TA,Ciftci I,Karaoglu A

更新日期：2006-06-01 00:00:00

abstract：:Identification and treatment of hibernating myocardium (HM) lead to improvement in LV function and prognosis in patients with post-ischemic heart failure. Different techniques are used to diagnose HM: echocardiography, MRI, SPECT and PET and, in patients with moderate LV impairment, their predictive values are similar...

journal_title：Annals of nuclear medicine

authors： Camici PG,Rimoldi OE

更新日期：2003-07-01 00:00:00

abstract：:Attenuation correction is very important for quantitative SPECT imaging. We designed an uncollimated non-uniform line array source (non-uniform LAS) for attenuation correction based on transmission computed tomography (TCT) using Tc-99m and compared its performance with an uncollimated uniform line array source (unifo...

journal_title：Annals of nuclear medicine

authors： Kojima A,Kawanaka K,Nakaura T,Shiraishi S,Utsunomiya D,Katsuda N,Tomiguchi S,Yamashita Y,Matsumoto M,Motomura N,Ichihara T

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:Uptake value in quantitative PET imaging is biased due to the presence of CT contrast agents when using CT-based attenuation correction. Our aim was to examine spectral CT imaging to suppress inaccuracy of 511 keV attenuation map in the presence of multiple nanoparticulate contrast agents. METHODS:Using a si...

journal_title：Annals of nuclear medicine

authors： Ghadiri H,Shiran MB,Soltanian-Zadeh H,Rahmim A,Zaidi H,Ay MR

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:We examined the cardiac function of patients who underwent Tc-99m sestamibi quantitative gated myocardial single photon emission computed tomography with 16-framing data acquisition between January 1, 2004 and March 31, 2006 for an evaluation of suspected or known heart disease in our hospital. METHODS:In 19...

journal_title：Annals of nuclear medicine

authors： Nakae I,Matsuo S,Tsutamoto T,Matsumoto T,Mitsunami K,Horie M

更新日期：2007-08-01 00:00:00

abstract：:Iodine-131 metaiodobenzylguanidine ((131)I-MIBG) therapy is an effective treatment for patients with malignant paraganglioma for which surgical resection is not indicated. We performed high-dose (131)I-MIBG therapy on two patients with malignant paraganglioma and multiple bone metastases. The bone metastases were diag...

journal_title：Annals of nuclear medicine

authors： Inoue T,Yoshinaga K,Morita K,Shiga T,Kanegae K,Hirata K,Okamoto S,Tamaki N

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:The Response Evaluation Criteria In Solid Tumors (RECIST) is the most used radiological method for evaluating response after peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumors. This method may give too positive estimates of response in slow growing tumors as it allows a substa...

journal_title：Annals of nuclear medicine

authors： Løitegård T,Berntzen DT,Thiis-Evensen E

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To determine the optimal accumulation time for three-dimensional positron emission tomography (3D-PET) with (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) to detect the brain uptake pattern typical of Alzheimer's disease (AD). METHODS:Patients with mild AD or amnestic mild cognitive impairment (MCI) and normal...

journal_title：Annals of nuclear medicine

authors： Takahashi R,Ishii K,Senda M,Ito K,Ishii K,Kato T,Makishi Y,Nishio T,Ikari Y,Iwatsubo T,Japanese Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2013-06-01 00:00:00