PET kinetic analysis --pitfalls and a solution for the Logan plot.

Abstract:

:The Logan plot is a widely used algorithm for the quantitative analysis of neuroreceptors using PET because it is easy to use and simple to implement. The Logan plot is also suitable for receptor imaging because its algorithm is fast. However, use of the Logan plot, and interpretation of the formed receptor images should be regarded with caution, because noise in PET data causes bias in the Logan plot estimates. In this paper, we describe the basic concept of the Logan plot in detail and introduce three algorithms for the Logan plot. By comparing these algorithms, we demonstrate the pitfalls of the Logan plot and discuss the solution.

journal_name

Ann Nucl Med

authors

Kimura Y,Naganawa M,Shidahara M,Ikoma Y,Watabe H

doi

10.1007/BF03033993

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

1-8

issue

1

eissn

0914-7187

issn

1864-6433

journal_volume

21

pub_type

杂志文章,评审
  • Extrarenal uptake of Tc-99m-DTPA in a case of retroperitoneal abscess causing spurious data in renal function assessment.

    abstract::The author reports CT of the abdomen and quantitative analysis of renal scintigraphy that was spuriously assessed due to unwanted extrarenal uptake. The patient had a retroperitoneal abscess that was related to fistula from the right kidney. Renal scintigraphy was performed to assess split renal function as a preopera...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164784

    authors: Choe W

    更新日期:1998-06-01 00:00:00

  • The prognostic role of end-of-treatment FDG-PET/CT in diffuse large B cell lymphoma: a pilot study application of neural networks to predict time-to-event.

    abstract:PURPOSE:To evaluate the prognostic role of end-of-treatment (EoT) FDG-PET/CT parameters in diffuse large B cell lymphoma (DLBCL), and then to explore a pilot application of Neural Networks (NN) in predicting time-to-relapse. METHODS:For conventional survival analysis, parameters as Deauville score (DS) and quantitativ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01542-y

    authors: Annunziata S,Pelliccioni A,Hohaus S,Maiolo E,Cuccaro A,Giordano A

    更新日期:2021-01-01 00:00:00

  • Amyloid-plaque imaging in early and differential diagnosis of dementia.

    abstract::The increasing life expectancy in our society results in a continuously growing number of patients suffering from neurodegenerative disorders, particularly Alzheimer's disease (AD). Apart from the deleterious consequences for patients and their relatives, this issue has also alarming effects on our social systems. The...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-009-0330-9

    authors: Drzezga A

    更新日期:2010-02-01 00:00:00

  • The role of adrenocortical scintigraphy in the evaluation of unilateral incidentally discovered adrenal and juxtaadrenal masses.

    abstract::We reviewed the findings of adrenocortical scintigraphy with 131I-6-beta-iodomethyl-19-norcholesterol (NCL-6-131I) of 39 patients to clarify its role in the evaluation of unilateral adrenal or juxtaadrenal masses incidentally discovered by CT, ultrasonography or plain radiography. Twenty-seven benign adrenal masses sh...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164960

    authors: Nakajo M,Nakabeppu Y,Yonekura R,Iwashita S,Goto T

    更新日期:1993-08-01 00:00:00

  • Evaluation of viral myocarditis in children by radionuclide method.

    abstract::Evaluation of viral myocarditis is essential for the clinician to assess the prognosis. In this study, Tl-201 myocardial scintigraphy and Tc-99m gated cardiac blood pool scan were performed in 16 patients with myocarditis diagnosed by clinical symptoms and laboratory findings and these nuclear medicine techniques were...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164597

    authors: Kawamura Y,Morishita T,Yamazaki J,Okuzumi I,Wakakura M,Muto T,Saji T,Matsuura H,Matsuo N,Yabe Y

    更新日期:1990-07-01 00:00:00

  • Unintentional human skeletal imaging with 99mTc-methylene diphosphonate 45 months beyond expiration.

    abstract::Eight patients were inadvertently administered, and imaged with, 99mTc-labeled MDP which was 45 months expired. Two cases are presented. All patients were subsequently imaged with normal MDP. The images obtained with expired MDP were clinically acceptable. No differences in scan abnormalities were observed compared wi...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164879

    authors: Riveros EG

    更新日期:1999-10-01 00:00:00

  • Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function.

    abstract::Myocardial normal databases for stress myocardial perfusion study have been created by the Japanese Society of Nuclear Medicine Working Group. The databases comprised gender-, camera rotation range- and radiopharmaceutical-specific data-sets from multiple institutions, and normal database files were created for instal...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-009-0337-2

    authors: Nakajima K

    更新日期:2010-04-01 00:00:00

  • The utility of FDG-PET/CT as an effective tool for detecting recurrent colorectal cancer regardless of serum CEA levels.

    abstract:PURPOSE:Tumor recurrence of colorectal cancers (CRC) is generally followed up by analyses of the serum carcinoembryonic antigen (CEA) levels. However, recent evidence suggests that tumor recurrence can also be visualized by 18F-fluoro-deoxyglucose emission tomography/computed tomography (FDG-PET/CT) in patients with no...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-012-0609-0

    authors: Sanli Y,Kuyumcu S,Ozkan ZG,Kilic L,Balik E,Turkmen C,Has D,Isik G,Asoglu O,Kapran Y,Adalet I

    更新日期:2012-08-01 00:00:00

  • Usefulness of [18F]FDG-PET kinetic analysis in non-enhancing primary central nervous system lymphoma: case report.

    abstract::A 62-year-old woman experienced headache and rapidly progressive left hemiparesis over 2 weeks. Diffusion-weighted and fluid-attenuated inversion recovery MR images of the head showed increased signal intensity in the right basal ganglia, periventricular white matter and the brain stem. Enhancement was not observed on...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03027408

    authors: Kawai N,Kawanishi M,Tamiya T,Nagao S

    更新日期:2005-07-01 00:00:00

  • Myocardial glucose metabolism in patients with hypertrophic cardiomyopathy: assessment by F-18-FDG PET study.

    abstract::In an investigation of myocardial metabolic abnormalities in hypertrophic myocardium, the myocardial glucose metabolism was evaluated with F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in 32 patients with hypertrophic cardiomyopathy, and the results were compared with those in 9 patients with hypert...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164836

    authors: Uehara T,Ishida Y,Hayashida K,Shimonagata T,Miyake Y,Sago M,Oka H,Nagata S,Miyatake K,Nishimura T

    更新日期:1998-04-01 00:00:00

  • Distinctive FDG and FES accumulation pattern of two tamoxifen-treated patients with endometrial hyperplasia.

    abstract::16alpha-[(18)F]Fluoro-17beta-estradiol (FES) is an estrogen receptor (ER) ligand used for the detection of ER-positive malignant tumors such as breast cancer. We recently reported the feasibility of combined FES-and 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) scans for the differential d...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0075-2

    authors: Tsujikawa T,Okazawa H,Yoshida Y,Mori T,Kobayashi M,Tsuchida T,Fujibayashi Y

    更新日期:2008-01-01 00:00:00

  • Oncologic significance of unexpected osseous foci on FDG-PET without correlative CT abnormalities.

    abstract:PURPOSE:Our purpose was to explore the clinical significance of unexpected osseous foci on 18F-FDG-PET without correlative CT abnormalities (FWCT) in patients referred for oncologic evaluation. The significance of FDG-avid foci without correlative CT abnormalities has been previously explored in tissues such as breast,...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01572-6

    authors: Zamora E,Valdivia AY

    更新日期:2021-01-13 00:00:00

  • Clinical usefulness of positron emission tomography with fluorine-18-fluorodeoxyglucose in the diagnosis of liver tumors.

    abstract::We studied various liver tumors by positron emission tomography with fluorine-18 fluorodeoxyglucose (FDG-PET) to examine the diagnostic usefulness of this technique. We also examined the relation between findings on FDG-PET and the characteristics of hepatocellular carcinoma. FDG-PET was performed in 78 patients with ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988591

    authors: Iwata Y,Shiomi S,Sasaki N,Jomura H,Nishiguchi S,Seki S,Kawabe J,Ochi H

    更新日期:2000-04-01 00:00:00

  • Usefulness of FDG-PET imaging for the radiotherapy treatment planning of pyothorax-associated lymphoma.

    abstract::Pyothorax-associated lymphoma (PAL) is a non-Hodgkin's lymphoma developing in the pleural cavity after a long-standing history of chronic pyothorax (CP). F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging is a useful modality for determination of disease extent of various malignant tumors, includin...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02985123

    authors: Asakura H,Togami T,Mitani M,Takashima H,Yokoe K,Yamamoto Y,Nishiyama Y,Monden T,Toyama Y,Ohkawa M

    更新日期:2005-12-01 00:00:00

  • Tc-99m RBC perfusion and blood-pool scintigraphy in the evaluation of vascular leiomyoma of the hand.

    abstract::A 62-year-old man with a soft, non-tender, movable mass 2.5 x 2.5-cm in diameter in the volar surface of the right index finger over the proximal phalanx underwent Tc-99m RBC perfusion and blood-pool scintigraphy to evaluate the vascular nature and extent of the mass. Highly increased activity on early and delayed blo...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03000110

    authors: Lim ST,Kim MW,Sohn MH

    更新日期:2002-06-01 00:00:00

  • Comparison of radioactive iodide uptake in the rat thyroid between oral and intravenous bolus administration.

    abstract:OBJECTIVE:Radioiodide is commonly used to diagnose and treat hyperthyroidism and thyroid carcinoma. However, we could not find any experimental data that strictly compared the biodistribution and thyroid uptake of radioactive iodide between the oral and intravenous (iv) routes with time. This prompted us to compare (12...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0909-7

    authors: Kurosawa H,Sakurai K,Hasegawa H,Uchida K,Kasahara H,Minamizawa T,Nakajo M,Nakajo M

    更新日期:2014-12-01 00:00:00

  • Internal radiotherapy techniques using radiolanthanide praseodymium-142: a review of production routes, brachytherapy, unsealed source therapy.

    abstract::Radionuclides of rare earth elements are gaining importance as emerging therapeutic agents in nuclear medicine. β(-)-particle emitter 142Pr [T (1/2) = 19.12 h, E(-)β = 2.162 MeV (96.3%), Eγ = 1575 keV (3.7%)] is one of the praseodymium-141 (100% abundant) radioisotopes. Production routes and therapy aspects of 142Pr w...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-011-0505-z

    authors: Bakht MK,Sadeghi M

    更新日期:2011-10-01 00:00:00

  • Improvement in automated quantitation of myocardial perfusion abnormality by using iterative reconstruction image in combination with resolution recovery, attenuation and scatter corrections for the detection of coronary artery disease.

    abstract:OBJECTIVE:An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-016-1146-z

    authors: Chono T,Onoguchi M,Shibutani T,Hashimoto A,Nakata T,Yama N,Tsuchihashi K,Hatakenaka M

    更新日期:2017-02-01 00:00:00

  • Risk stratification and prognostic assessment by myocardial perfusion-gated SPECT in patients with left bundle-branch block and low-intermediate cardiac risk.

    abstract:OBJECTIVE:In high-risk patients with left bundle-branch block (LBBB), functional but not perfusion parameters yield incremental prognostic information. The aim of our study was to evaluate the prognostic value of gated single photon emission computed tomography (SPECT) in low-intermediate risk LBBB patients. METHODS:O...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-012-0613-4

    authors: Fovino LN,Saladini G,Mormino GP,Saladini F,Razzolini R,Evangelista L

    更新日期:2012-08-01 00:00:00

  • Inferior mesenteric varix demonstrated by 99mTc-red blood cell gastrointestinal bleeding study.

    abstract::Reported here is a case of an inferior mesenteric varix demonstrated by 99mTc-red blood cell (RBC) scintigraphy performed for gastrointestinal bleeding in a 47-year-old man. It was shaped like a question mark ranging from the left upper abdomen to the pelvis. This is the first report of scintigraphic recognition of an...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164828

    authors: Yoshikai T,Yokomizo Y,Iwashita I,Okada Y,Koga H,Kudo S

    更新日期:1997-05-01 00:00:00

  • Development of a simple non-invasive microsphere quantification method for cerebral blood flow using I-123-IMP.

    abstract:OBJECTIVE:In clinical practice, measurement of the rCBF has mainly been conducted by I-123-N-isopropyl-p-iodoamphetamine ((123)I-IMP) SPECT using the microsphere (MS) method, with continuous arterial blood sampling. While several non-invasive (123)I-IMP quantification methods have been developed, their accuracy has bee...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-015-1053-8

    authors: Ofuji A,Mimura H,Yamashita K,Takaki A,Sone T,Ito S

    更新日期:2016-04-01 00:00:00

  • Comparison of integrated whole-body PET/MR and PET/CT: Is PET/MR alternative to PET/CT in routine clinical oncology?

    abstract:PURPOSE:To compare the diagnostic accuracy of whole-body PET/CT and integrated PET/MR in relation to the total scan time durations. METHODS:One hundred and twenty-three (123) patients (40 males and 83 females; mean age 59.6 years; range 20-83 years) with confirmed primary cancer and clinical suspicion of metastatic di...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-015-1050-y

    authors: Ishii S,Shimao D,Hara T,Miyajima M,Kikuchi K,Takawa M,Kumamoto K,Ito H,Shishido F

    更新日期:2016-04-01 00:00:00

  • (99m)Tc-DTPA dynamic SPECT and CT volumetry for measuring split renal function in live kidney donors.

    abstract:OBJECTIVES:Split renal function (SRF) estimated from the posterior view of (99m)Tc-diethylenetriaminepentaacetic acid planar scintigraphy (DTPA/P) is not sufficiently accurate even after correction for kidney depth by computed tomography (CT). To obtain more accurate SRF using (99m)Tc-DTPA, dynamic SPECT method was car...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-010-0349-y

    authors: Miyazaki C,Harada H,Shuke N,Okizaki A,Miura M,Hirano T

    更新日期:2010-04-01 00:00:00

  • Validation of the 3-variable prognostic score (3-PS) in mCRPC patients treated with 223Radium-dichloride: a national multicenter study.

    abstract:OBJECTIVE:Radium-223 (223Ra) has been approved for treatment in patients with metastatic castration-resistant prostatic cancer (mCRPC) and bone metastasis. This α-emitting radionuclide has a beneficial effect on pain and is also capable to increase overall survival (OS). Several studies evaluated the prognostic value o...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01501-7

    authors: Frantellizzi V,Monari F,Mascia M,Costa R,Rubini G,Spanu A,Di Rocco A,Lodi Rizzini E,Cindolo L,Licari M,Lavelli V,Nuvoli S,De Angelis C,Dionisi V,Ferrari C,De Vincentis G

    更新日期:2020-10-01 00:00:00

  • Update on nodal staging in non-small cell lung cancer with integrated positron emission tomography/computed tomography: a meta-analysis.

    abstract:OBJECTIVES:Nowadays, the number of primary studies on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been increasing rapidly. Thus, we updated meta-analysis to evaluate the test performance of FDG PET/CT for nodal staging in non-small cell lung cancer (NSCLC) including the most r...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12149-015-0958-6

    authors: Pak K,Park S,Cheon GJ,Kang KW,Kim IJ,Lee DS,Kim EE,Chung JK

    更新日期:2015-06-01 00:00:00

  • Pediatric lymphoma: metabolic tumor burden as a quantitative index for treatment response evaluation.

    abstract:OBJECTIVE:Metabolic tumor burden (MTB) incorporates the advantages of the existing indices: the metabolic volume of the lesion calculated by size-dependent thresholding on positron emission tomography-computed tomography (PET-CT) along with its aggressiveness as determined by standardized uptake value (SUV). This study...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-011-0539-2

    authors: Sharma P,Gupta A,Patel C,Bakhshi S,Malhotra A,Kumar R

    更新日期:2012-01-01 00:00:00

  • Demonstration of systemic lymphnodes by bone scintigraphy in amyloidosis.

    abstract::We report a case of primary amyloidosis with calcification of systemic lymphnodes which were demonstrated as positives by bone scintigraphy. Positive sites delineated by bone scintigraphy would seem likely to reflect avid calcification of amyloid deposits. The discovery of positive systemic lymphnodes by bone scintigr...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164649

    authors: Itoh K,Baba Y,Taneichi K

    更新日期:1992-05-01 00:00:00

  • Accelerated BMIPP uptake immediately after reperfused ischemia in the isolated rat heart model.

    abstract:OBJECTIVE:123I-beta-methyl iodophenyl pentadecanoic acid (BMIPP) can visualize myocardial fatty acid metabolism and has extensive potential for diagnosing cardiac diseases such as acute coronary syndrome in the clinical setting. Increased BMIPP uptake with decreased perfusion occasionally occurs under acute reperfusion...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-011-0510-2

    authors: Fukushima K,Momose M,Kondo C,Hagiwara N,Sakai S

    更新日期:2011-10-01 00:00:00

  • An animal PET scanner using flat-panel position-sensitive PMTs.

    abstract:OBJECTIVE:To design, build, and evaluate an animal PET scanner, which can be used with non-human primates under conscious condition, incorporating flat-panel position-sensitive photomultiplier tubes (PS-PMTs). METHODS:The system contains 30 detector modules, each having two PS-PMTs and 16×18 lutetium–yttrium oxyortho-...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-013-0772-y

    authors: Okamoto T,Ote K,Sakai K,Noda A,Shimizu K,Masuda K,Ohmura T,Watanabe M

    更新日期:2014-01-01 00:00:00

  • Measurement of cerebral blood flow by the autoradiographic method with N-isopropyl-4-[I-123] iodoamphetamine: comparison of radiopharmaceuticals marketed by different companies in Japan.

    abstract:OBJECTIVE:Iodine-123-labeled N-isopropyl-4-iodoamphetamine (IMP) is used as a tracer for the measurement of cerebral blood flow (CBF) by single-photon emission computed tomography (SPECT). Two IMP products, IMP(A) (Nihon Medi-Physics Co., Ltd.) and IMP(B) (FUJIFILM RI Pharma Co., Ltd.), produced by different radiopharm...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-009-0242-8

    authors: Ogura T,Ito H,Hida K,Masuzuka T,Fukuda H,Hatazawa J

    更新日期:2009-06-01 00:00:00