Abstract:
OBJECTIVE:To investigate whether [(11)C]PK-11195, a specific peripheral benzodiazepine receptors (PBRs) ligand for positron emission tomography (PET), can show activated microglia in a rat brain injury model. METHODS:On day 1, ethanol was injected into the rat's right striatum (ST) using a stereotaxic operative procedure. On day 3, head magnetic resonance imaging (MRI) scans for surgically treated rats were performed to evaluate ethanol injury morphologically. On day 4, dynamic PET scans (17 injured rats and 7 non-injured controls) were performed for 60 min with an animal PET scanner under chloral hydrate anesthesia following a bolus injection of [(11)C]PK-11195 through tail vein. Because PBRs are present throughout the brain, there is no suitable receptor-free reference region. The reference tissue model may not be applicable because of low target to background ratio for low affinity of [(11)C]PK-11195 to PBRs. We evaluated the PBRs binding with regions of interest (ROIs)-based approach to estimate total distribution volume (V). We used an integral from 0 min to 60 min (V (60)) as an estimate of V. On the coronal PET image, ROIs were placed on bilateral ST. Differences in right/left ST V (60) ratios between lesioned and unlesioned control rats were compared using unpaired t tests. Immunohistochemical staining was performed for confirming the presence of activated microglia following decapitation on the PET experiment day. RESULTS:The right/left ST V (60) ratios in lesioned rats (1.07 +/- 0.08) were significantly higher than those in unlesioned control rats (1.00 +/- 0.06, P < 0.05). On immunohistochemical staining, activated microglia were exclusively observed in the injured right ST but not in the noninjured left ST of the injury rats and the bilateral ST of the non-injured control rats. CONCLUSIONS:These results suggest that [(11)C]PK-11195 PET imaging would be a useful tool for evaluating microglial activation in a rat brain injury model.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Toyama H,Hatano K,Suzuki H,Ichise M,Momosaki S,Kudo G,Ito F,Kato T,Yamaguchi H,Katada K,Sawada M,Ito Kdoi
10.1007/s12149-008-0136-1subject
Has Abstractpub_date
2008-06-01 00:00:00pages
417-24issue
5eissn
0914-7187issn
1864-6433journal_volume
22pub_type
杂志文章abstract:PURPOSE:The objectives of this study were to (1) elucidate the relationship between the mean CBF in the whole brain (Av.mCBF) before rehabilitation of CVD patients and the BI score before and after rehabilitation, (2) determine whether the efficacy of rehabilitation can be predicted by measurement of the Av.mCBF, and (...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02990478
更新日期:2000-02-01 00:00:00
abstract::Pyothorax-associated lymphoma (PAL) is a non-Hodgkin's lymphoma developing in the pleural cavity after a long-standing history of chronic pyothorax (CP). F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging is a useful modality for determination of disease extent of various malignant tumors, includin...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02985123
更新日期:2005-12-01 00:00:00
abstract::Nerve growth factor (NGF) exerts various actions on neuronal and non-neuronal tissues and has potential therapeutic utility, but difficulties in using the whole protein have stimulated interest in small NGF fragments. We radioiodinated a small cyclic peptide derived from NGF using the Bolton-Hunter method [125I-C(92-9...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03026817
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. METHODS:Forty-seve...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-007-0179-8
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:Accurate and validated methods for estimating regional PET image noise are helpful for optimizing image processing. The bootstrap is a data-based simulation method for statistical inference, which can be used to estimate the PET image noise without repeated measurements. The aim of this study was to experimen...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0782-9
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To compare histological findings of FDG-PET false-positive and true-negative hilar and mediastinal lymph nodes. METHODS:Sixty-seven lymphnode areas in 11 patients who were diagnosed to have N3 lymph nodes by FDG-PET and underwent surgery were histologically examined, and the histopathological findings in fal...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02985610
更新日期:2004-02-01 00:00:00
abstract::The aim of this study is to re-evaluate and clarify the diagnostic role of ventilation/perfusion lung scintigraphy in Japan, now that single-detector-row helical CT and multidetector-row CT are available in clinical practice. The Respiratory Nuclear Medicine Working Group of the Japanese Society of Nuclear Medicine di...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988632
更新日期:2002-12-01 00:00:00
abstract::We report a patient with DTPA and DMSA uptake on unsuspected bone metastases. He had severe pain due to grade 3 hydronephrosis of his left kidney. When Tc-99m DTPA and DMSA renal scanning were performed for preoperative evaluation, abnormal radiopharmaceutical uptake on the iliac area was noted. Pancreatic adenocarcin...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02987249
更新日期:2006-06-01 00:00:00
abstract::Scintigraphy with 99mTc-diethylenetriaminepentaacetate with galactosyl human serum albumin (99mTc-GSA) and per-rectal portal scintigraphy are useful for evaluating hepatic functional reserve and portal circulation, respectively. We did the procedures simultaneously in some patients to examine the relationship between ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164899
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determine...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0917-7
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate the outcomes and prognostic factors of high-dose 131I-metaiodobenzylguanidine (131I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan. METHODS:We retrospectively analyzed 20 patients with refractory or relapsed high-risk NBL who underwe...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01460-z
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Anatomic relation between pulmonary perfusion and morphology in pulmonary emphysema was assessed on deep-inspiratory breath-hold (DIBrH) perfusion single-photon emission computed tomography (SPECT)-CT fusion images. METHODS:Subjects were 38 patients with pulmonary emphysema and 11 non-smoker controls, who su...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0137-5
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:On hepatobiliary scintigraphy, "preferential gallbladder (GB) filling without tracer excretion into the small bowel (SB) [p-GB-no-SB]" is occasionally seen on images obtained up to an hour. In such cases, many practitioners administer cholecystokinin (CCK) (even when the measurement of GB ejection fraction is...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01384-3
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Respiratory motion causes loss of image quality and inaccuracy of quantification in oncologic positron emission tomography (PET) imaging. This study introduces a bioimpedance-based gating method for compensation of respiratory motion artefacts. METHODS:The bioimpedance-based respiratory gating method was stu...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-0953-y
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:We digested anti-MUC1 monoclonal antibody PR81 to produce F(ab')₂ fragments. A comparison was performed between the two radiolabeled PR81 and F(ab')₂ fragments for breast tumor imaging in a mouse model. METHODS:The optimum conditions for pepsin digestion of PR81 were investigated in terms of enzymes: antibod...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-010-0434-2
更新日期:2011-02-01 00:00:00
abstract::The aim of the present study was to assess the predictive value of captopril scintigraphy with the new renal agent 99mTc-ethylenedicysteine (99mTc-EC) for post-interventional improvement in blood pressure. Twelve patients who had persistently high blood pressure with previous demonstration of various degrees of renal ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164881
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:We evaluated the relationships between coronary flow reserve (CFR) and relative flow reserve (RFR) measured by N-13 ammonia positron emission tomography (PET) for characterization of epicardial coronary artery disease (CAD). METHODS:Sixty-nine consecutive stable angina patients underwent N-13 ammonia PET, co...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-016-1138-z
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:Bone-seeking radiopharmaceuticals have the main role in the treatment of painful bone metastases. The aim of this study was to dosimetrically compare radiopharmaceuticals in use for bone pain palliation therapy and bone scan. METHODS:The MCNPX code was used to simulate the radiation transport in a vertebral ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-019-01329-w
更新日期:2019-04-01 00:00:00
abstract::Radionuclides of rare earth elements are gaining importance as emerging therapeutic agents in nuclear medicine. β(-)-particle emitter 142Pr [T (1/2) = 19.12 h, E(-)β = 2.162 MeV (96.3%), Eγ = 1575 keV (3.7%)] is one of the praseodymium-141 (100% abundant) radioisotopes. Production routes and therapy aspects of 142Pr w...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-011-0505-z
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:Radium-223 (223Ra) is used in unsealed radionuclide therapy for metastatic bone tumors. The aim of this study is to apply a computational model observer to 223Ra planar images, and to assess the performance of collimators in 223Ra imaging. METHODS:The 223Ra planar images were created via an in-house Monte Ca...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-018-1286-4
更新日期:2018-12-01 00:00:00
abstract::Pulmonary involvement secondary to Waldenstrom's macroglobulinemia (WMG) is described in a 40-year-old male by incidental findings on a bone scan. He was examined for right leg pain, and bone scan revealed unexpected pulmonary uptake of Tc-99m MDP. CT scan of the thorax revealed pleural effusion and slightly dissemina...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02988647
更新日期:2002-11-01 00:00:00
abstract::The Logan plot is a widely used algorithm for the quantitative analysis of neuroreceptors using PET because it is easy to use and simple to implement. The Logan plot is also suitable for receptor imaging because its algorithm is fast. However, use of the Logan plot, and interpretation of the formed receptor images sho...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/BF03033993
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:This study was designed to investigate the efficacy of 99mtechnetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ([99mTc]3PRGD2) in the evaluation of patients with esophageal cancer. METHODS:Twenty-nine patients with a suspected esophageal lesion and for whom definite pathological diagn...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-018-1315-3
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:The aim of this study was to elucidate the regional differences between brain perfusion single photon emission computed tomography (SPECT) images reconstructed with a uniform attenuation correction using Chang's method (AC-Chang) and a non-uniform attenuation correction with CT using SPECT/CT (AC-CT). METHODS:...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-011-0567-y
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy is currently used to evaluate cardiac sympathetic nerve function, but MIBG also has the capacity to evaluate dilated cardiomyopathy (DCM) severity and therapeutic effectiveness. In this study, we administered beta-blockers to a DCM hamster model and ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02984974
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To assess the diagnostic value of fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) using standard uptake values (SUV) in the differential diagnoses of indeterminate pulmonary nodules. Specifically, we assessed the probability of malignancy for various SUV ranges, and compared the di...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0112-1
更新日期:2008-04-01 00:00:00
abstract::The aim of this study was to evaluate the washout rate of Tc-99m tetrofosmin in asymmetric septal hypertrophy (ASH). As Tc-99m tetrofosmin accumulation and retention depend on sarcolemmal and/or mitochondrial function, the presence or absence of abnormalities in the washout rate of Tc-99m tetrofosmin could provide inf...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/BF02986332
更新日期:2005-02-01 00:00:00
abstract::We report a case of an atypical bronchial carcinoid showing sestamibi uptake. A 27-year-old man with Kallmann's syndrome and hyperparathyroidism had parathyroid scintigraphy with 99mTc-sestamibi. A focal uptake was observed on the right perihilar region, and this right perihilar mass was demonstrated on computed tomog...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF02995293
更新日期:2002-02-01 00:00:00
abstract::We are proposing a new method for correcting of scattered photons in technetium-99m (99mTc) imaging by means of photopeak dual-energy window acquisition. This method consists of the simultaneous acquisition of two images and estimation of a scatter image included in the symmetric energy window (SW) image by the differ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03178307
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine changes in FDG-PET/CT after pleurodesis with OK-432 and to investigate differences in the changes between non-malignant and malignant lesions. METHODS:Study participants were 17 patients with a history of malignant chest disease who underwent FDG-PET/CT after pleurodesis using O...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01508-0
更新日期:2020-10-01 00:00:00