A hand-held beta imaging probe for FDG.

Abstract:

OBJECTIVES:Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as (18)FDG, (131)I and (32)P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. METHODS:We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of (18)FDG-avid primary tumors and metastases in an animal model. RESULTS:We have demonstrated a device which can generate beta images from (18)FDG avid lesions in an animal model. CONCLUSIONS:It is feasible to image beta irradiation in animal models of cancer given (18)FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.

journal_name

Ann Nucl Med

authors

Singh B,Stack BC Jr,Thacker S,Gaysinskiy V,Bartel T,Lowe V,Cool S,Entine G,Nagarkar V

doi

10.1007/s12149-012-0672-6

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

203-8

issue

3

eissn

0914-7187

issn

1864-6433

journal_volume

27

pub_type

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