Positron emission tomography using pyruvate-1-11C in two cases of mitochondrial encephalomyopathy.

Abstract:

:Positron emission tomography (PET) using pyruvate-1-11C was carried out to investigate the in vivo metabolism of pyruvate in the brains of patients with mitochondrial encephalomyopathy and Leigh's disease. Two epileptic patients were studied as control subjects. Radioactivity was eliminated from the brain tissue of the epileptic patients soon after injection of pyruvate-1-11C. PET images of mitochondrial encephalomyopathy patients showed an increase in radioactivity in the cerebral cortex, basal ganglia and thalamus, with elimination of radioactivity being slower than that of epileptic patients. One patient with Leigh's disease showed similar PET images. PET using pyruvate-1-11C is useful for the evaluation of mitochondrial energy metabolism in the brain.

journal_name

Ann Nucl Med

authors

Toyoda M,Sakuragawa N,Arai Y,Yoshikawa H,Sugai K,Arima M,Hara T,Iio M,Satoyoshi E

doi

10.1007/BF03164593

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

103-9

issue

2

eissn

0914-7187

issn

1864-6433

journal_volume

3

pub_type

杂志文章
  • Assessment of collimators in radium-223 imaging with channelized Hotelling observer: a simulation study.

    abstract:OBJECTIVE:Radium-223 (223Ra) is used in unsealed radionuclide therapy for metastatic bone tumors. The aim of this study is to apply a computational model observer to 223Ra planar images, and to assess the performance of collimators in 223Ra imaging. METHODS:The 223Ra planar images were created via an in-house Monte Ca...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-018-1286-4

    authors: Takahashi A,Baba S,Sasaki M

    更新日期:2018-12-01 00:00:00

  • Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions.

    abstract:OBJECTIVE:(11)C-Methionine positron emission tomography (MET-PET) has been used to distinguish brain tumor recurrence from radiation necrosis. Because the spatial resolution of conventional PET scanners is low, partial volume effect (PVE) may decrease the detectability of small tumor recurrence. The aim of this study i...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-010-0450-2

    authors: Okamoto S,Shiga T,Hattori N,Kubo N,Takei T,Katoh N,Sawamura Y,Nishijima K,Kuge Y,Tamaki N

    更新日期:2011-04-01 00:00:00

  • Quantifying regional cerebral blood flow with N-isopropyl-p[123I]iodoamphetamine by ring-type single-photon emission computed tomography: validity of a method to estimate early reference value by means of regional brain time-activity curve.

    abstract::A more accurate quantitative method for the measurement of regional cerebral blood flow (rCBF) with the microsphere model and N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) and ring-type single-photon emission computed tomography (SPECT) was developed. Continuous withdrawal of arterial blood was carried out for 5 minu...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03165028

    authors: Takahashi N

    更新日期:1994-11-01 00:00:00

  • Tuberculosis peritonitis: gallium-67 scintigraphic appearance.

    abstract::Tuberculosis peritonitis is a rare manifestation of extrapulmonary tuberculosis. The results of gallium-67 scintigraphy of three patients with tuberculosis peritonitis were reviewed to assess its usefulness in the diagnosis of this condition. Tuberculosis peritonitis was associated with diffuse or focal abdominal loca...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164860

    authors: Sumi Y,Ozaki Y,Hasegawa H,Shindoh N,Katayama H,Tamamoto F

    更新日期:1999-06-01 00:00:00

  • Brain perfusion SPECT study with 99mTc-bicisate: clinical pitfalls and improved diagnostic accuracy with a combination of linearization and scatter-attenuation correction.

    abstract::To evaluate the usefulness of a combination of linearization and scatter-attenuation correction on 99mTc-bicisate (ECD)-single photon emission tomographic (SPECT) images, both cerebral blood flow (CBF)-positron emission tomographic (PET) images and ECD-SPECT images from fifteen patients with chronic cerebral infarctio...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988602

    authors: Kado H,Iida H,Kimura H,Ogawa T,Narita Y,Hatazawa J,Tsuchida T,Yonekura Y,Itoh H

    更新日期:2001-04-01 00:00:00

  • Development of Convolutional Neural Networks to identify bone metastasis for prostate cancer patients in bone scintigraphy.

    abstract:OBJECTIVE:The main aim of this work is to build a robust Convolutional Neural Network (CNN) algorithm that efficiently and quickly classifies bone scintigraphy images, by determining the presence or absence of prostate cancer metastasis. METHODS:CNN, widely applied in medical image classification, was used for bone sc...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01510-6

    authors: Papandrianos N,Papageorgiou EI,Anagnostis A

    更新日期:2020-11-01 00:00:00

  • High metabolic tumor volume and total lesion glycolysis are associated with lateral lymph node metastasis in patients with incidentally detected thyroid carcinoma.

    abstract:OBJECTIVE:The objective of this study was to investigate whether total lesion glycolysis (TLG) and metabolic tumor volume (MTV) measured by ¹⁸F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) could predict the aggressiveness and lymph node metastasis (LNM) in patients with incid...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-015-0994-2

    authors: Kim BH,Kim SJ,Kim K,Kim H,Kim SJ,Kim WJ,Jeon YK,Kim SS,Kim YK,Kim IJ

    更新日期:2015-10-01 00:00:00

  • Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study.

    abstract:OBJECTIVE:To examine the patterns of longitudinal tau accumulation and cortical atrophy and their association in subjects with mild cognitive impairment (MCI). METHODS:We collected 23 participants (60-89 years old, 11 males/12 females) with MCI from the Alzheimer's Disease Neuroimaging Initiative database. All partici...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01506-2

    authors: Xu G,Zheng S,Zhu Z,Yu X,Jiang J,Jiang J,Chu Z,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2020-11-01 00:00:00

  • Usefulness of reinjection image for evaluating viable myocardium in the infarcted zone on exercise thallium-201 SPECT.

    abstract::Reinjection images were obtained in 23 patients with myocardial infarction by the additional injection of 37 MBq of thallium-201 after obtaining 4 hour delayed images on exercise thallium-201 SPECT (TSPECT). A redistribution index (RI) was derived of the changes in perfusion defects between immediate and 4 hour delaye...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164630

    authors: Tomiguchi S,Takahashi M,Shimomura O,Kojima A,Hara M,Koga Y,Minoda K,Yasue H,Hayasaki K

    更新日期:1991-11-01 00:00:00

  • The value of Bayesian penalized likelihood reconstruction for improving lesion conspicuity of malignant lung tumors on 18F-FDG PET/CT: comparison with ordered subset expectation maximization reconstruction incorporating time-of-flight model and point spre

    abstract:OBJECTIVE:To evaluate the value of Bayesian penalized likelihood (BPL) reconstruction for improving lesion conspicuity of malignant lung tumors on 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography computed tomography (PET/CT) as compared with the ordered subset expectation maximization (OSEM) reconstructi...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01446-x

    authors: Kurita Y,Ichikawa Y,Nakanishi T,Tomita Y,Hasegawa D,Murashima S,Hirano T,Sakuma H

    更新日期:2020-04-01 00:00:00

  • Choline PET/CT for imaging prostate cancer: an update.

    abstract::Whole-body positron emission tomography/computed tomography (PET/CT) with [(11)C]- and [(18)F]-labeled choline derivates has emerged as a promising molecular imaging modality for the evaluation of prostate cancer. (11)C- and (18)F-choline PET/CT are used successfully for restaging prostate cancer in patients with bioc...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-013-0731-7

    authors: Kitajima K,Murphy RC,Nathan MA

    更新日期:2013-08-01 00:00:00

  • Visual and semi-quantitative analyses of dual-phase breast-specific gamma imaging with Tc-99m-sestamibi in detecting primary breast cancer.

    abstract:OBJECTIVES:Breast cancer is the most common malignancy for females worldwide. This study was to evaluate the application of dual-phase breast-specific gamma imaging (BSGI) in detecting primary breast cancer. METHODS:Seventy-six patients with indeterminate breast lesions that underwent dual-phase BSGI enrolled in this ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-013-0776-7

    authors: Tan H,Jiang L,Gu Y,Xiu Y,Han L,Wu P,Zhang H,Shi H

    更新日期:2014-01-01 00:00:00

  • The search for consistency in the manufacture of PET radiopharmaceuticals.

    abstract::Nuclear Medicine is the specialty of medical imaging, which utilizes a variety of radionuclides incorporated into specific compounds for diagnostic imaging and therapeutic applications. During recent years, research efforts in this discipline have concentrated on the decay characteristics of particular radionuclides a...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/BF03164930

    authors: Finn RD

    更新日期:1999-12-01 00:00:00

  • Occult myofibroblastic sarcoma detected on FDG-PET performed for cancer screening.

    abstract::We present a rare case of occult low-grade myofibroblastic sarcoma (LGMFS) detected by marked 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) uptake on positron emission tomography (PET). A 46-year-old woman presented with abnormal FDG uptake in her back when FDG-PET was performed for cancer screening. The maximum stan...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-008-0194-4

    authors: Morii T,Mochizuki K,Sano H,Fujino T,Harasawa A,Satomi K

    更新日期:2008-11-01 00:00:00

  • PET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging.

    abstract::Physiological functions (e.g., cerebral blood flow, glucose metabolism, and neuroreceptor binding) can be investigated as parameters estimated by kinetic modeling using dynamic positron emission tomography (PET) images. Imaging of these physiological parameters, called parametric imaging, can locate the regional distr...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-007-0044-9

    authors: Shidahara M,Ikoma Y,Kershaw J,Kimura Y,Naganawa M,Watabe H

    更新日期:2007-09-01 00:00:00

  • Development of visual scoring system with Tc-99m DMSA renal scintigraphy to predict the risk of recurrence of symptomatic urinary tract infections in pediatric patients.

    abstract:OBJECTIVE:Vesicoureteral reflux (VUR) is a major risk factor for recurrent symptomatic urinary tract infection (UTI) in pediatric patients. In addition, dimercaptosuccinic acid renal scintigraphy (DMSA) is an important diagnostic modality of VUR. However, the value of DMSA for predicting recurrent pediatric UTI has not...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-019-01379-0

    authors: Kim D,Yoon HJ,Woo SH,Lee WJ,Kim BS,Chung YA,Oh JK

    更新日期:2019-09-01 00:00:00

  • 99mTc(V)-DMSA and 67Ga-citrate images in a patient with recurrent extraabdominal fibromatosis.

    abstract::67Ga-citrate and 99mTc(V)-DMSA images were obtained in a patient with recurrent extraabdominal fibromatosis of the left calf. The 67Ga-citrate image showed abnormal uptake in the left calf lesion and right calf, which was considered due to probable myositis caused by overexertion. On the other hand, the 99mTc(V)-DMSA ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164850

    authors: Ohta H,Komibuchi T,Tomihara M,Watanabe H,Fujikawa S,Shintaku M

    更新日期:1998-08-01 00:00:00

  • F-18 fluorodeoxyglucose PET angiography of the abdominal arteries: evaluation of image quality and comparison with contrast-enhanced CT.

    abstract:OBJECTIVE:Positron emission tomography (PET) angiography utilizes early dynamic PET acquisitions for depiction of the arterial vasculature. The aim of this study was to assess image quality and to evaluate feasibility of F-18 FDG PET angiography of the abdominal arteries. METHODS:Twenty-seven patients were included in...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0930-x

    authors: Drescher R,Freesmeyer M

    更新日期:2015-02-01 00:00:00

  • Present diagnostic strategies for acute pulmonary thromboembolism; results of a questionnaire in a retrospective trial conducted by the Respiratory Nuclear Medicine Working Group of the Japanese Society of Nuclear Medicine.

    abstract::The aim of this study is to re-evaluate and clarify the diagnostic role of ventilation/perfusion lung scintigraphy in Japan, now that single-detector-row helical CT and multidetector-row CT are available in clinical practice. The Respiratory Nuclear Medicine Working Group of the Japanese Society of Nuclear Medicine di...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988632

    authors: Kawamoro M,Ogura Y,Honda N,Satoh K,Suga K,Mori Y,Imai T,Inoue T,Narabayashi I

    更新日期:2002-12-01 00:00:00

  • Current status of radioligand therapy and positron-emission tomography with prostate-specific membrane antigen.

    abstract::Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein highly expressed by prostate cancer cells. PSMA-based radioligand therapy (RLT) emerged as a promising therapeutic option for prostate cancer in the early 2000s, and has been clinically validated with great enthusiasm during these past two decad...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s12149-020-01549-5

    authors: Inubushi M,Miura H,Kuji I,Ito K,Minamimoto R

    更新日期:2020-12-01 00:00:00

  • Assessment of human effective absorbed dose of 67 Ga-ECC based on biodistribution rat data.

    abstract:OBJECTIVE:In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determine...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0917-7

    authors: Shanehsazzadeh S,Yousefnia H,Lahooti A,Zolghadri S,Jalilian AR,Afarideh H

    更新日期:2015-02-01 00:00:00

  • An assessment of bone-seeking radionuclides for palliation of metastatic bone pain in a vertebral model.

    abstract:OBJECTIVE:Bone-seeking radiopharmaceuticals have the main role in the treatment of painful bone metastases. The aim of this study was to dosimetrically compare radiopharmaceuticals in use for bone pain palliation therapy and bone scan. METHODS:The MCNPX code was used to simulate the radiation transport in a vertebral ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-019-01329-w

    authors: Sadremomtaz A,Masoumi M

    更新日期:2019-04-01 00:00:00

  • Receiver operating characteristic (ROC) analysis of images reconstructed with iterative expectation maximization algorithms.

    abstract:PURPOSE:The quality of images reconstructed by means of the maximum likelihood-expectation maximization (ML-EM) and ordered subset (OS)-EM algorithms, was examined with parameters such as the number of iterations and subsets, then compared with the quality of images reconstructed by the filtered back projection method....

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF02988506

    authors: Takahashi Y,Murase K,Higashino H,Sogabe I,Sakamoto K

    更新日期:2001-12-01 00:00:00

  • Normal uptake of F-18 FDG in the testis as assessed by PET/CT in a pediatric study population.

    abstract:OBJECTIVE:To investigate the correlation between the F-18 FDG uptake in the normal testis as assessed by PET-CT and patient age in a pediatric study population. METHODS:The study population consisted of 22 subjects aged between 9 and 17 years. For these subjects 42 PET-CT scans were available for analysis. The testis ...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-009-0308-7

    authors: Goethals I,De Vriendt C,Hoste P,Smeets P,Ham H

    更新日期:2009-11-01 00:00:00

  • Assessment of technetium-99m Technegas scintigraphy for ventilatory impairment in pulmonary emphysema: comparison of planar and SPECT images.

    abstract::Pulmonary emphysema can be diagnosed easily by X-ray CT (CT) as a low attenuation area. Recently Tc-99m-Technegas (Technegas) has been used for ventilation scintigraphy. The present study was undertaken to assess the usefulness of planar and SPECT images by using Technegas scintigraphy in patients with pulmonary emphy...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/BF03164818

    authors: Satoh K,Tanabe M,Takahashi K,Kobayashi T,Nishiyama Y,Yamamoto Y,Honjo N,Sasaki M,Ohkawa M,Fujita J,Okada H

    更新日期:1997-05-01 00:00:00

  • Potential utility of bone scan in cranial bone flap osteomyelitis.

    abstract:OBJECTIVE:Currently, the diagnosis of bone flap osteomyelitis (BFO) remains a challenge for medical imaging. The present study aimed to identify predictive scintigraphic patterns of BFO. METHODS:This retrospective study reviewed planar bone scan of patients with suspected BFO between 2010, and 2016. A total of 15 pati...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-019-01351-y

    authors: Bani Sadr A,Gregoire B,Tordo J,Guyotat J,Boibieux A,Janier M

    更新日期:2019-06-01 00:00:00

  • Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang's

    abstract:OBJECTIVE:We examined the diagnostic value of brain perfusion single-photon emission computed tomography (SPECT) using voxel-based statistical analysis with CT-based attenuation correction (CT-AC) by comparing it to that with Chang's AC in mild cognitive impairment (MCI) patients and attempted to locate brain areas tha...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-020-01477-4

    authors: Sohara K,Kiriyama T,Mizumura S,Ishiwata A,Yamazaki M,Kimura K,Kumita SI

    更新日期:2020-07-01 00:00:00

  • Fluoro-deoxy-glucose positron emission tomography for evaluation of indeterminate lung nodules: assigning a probability of malignancy may be preferable to binary readings.

    abstract:OBJECTIVE:To assess the diagnostic value of fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) using standard uptake values (SUV) in the differential diagnoses of indeterminate pulmonary nodules. Specifically, we assessed the probability of malignancy for various SUV ranges, and compared the di...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-007-0112-1

    authors: Kim SC,Machac J,Krynyckyi BR,Knesaurek K,Krellenstein D,Schultz B,Gribetz A,DePalo L,Teirstein A,Kim CK

    更新日期:2008-04-01 00:00:00

  • Diagnostic value of metabolic heterogeneity as a reliable parameter for differentiating malignant parotid gland tumors.

    abstract:OBJECTIVE:Exact classifying between malignant and benign tumors in the parotid gland is important because the cancer has relatively poor prognosis. There have been several studies that F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) can differentiate between malignant and benign parotid gland tumors. H...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-016-1068-9

    authors: Kim BS,Kim SJ,Pak K

    更新日期:2016-06-01 00:00:00

  • Comparison of radioactive iodide uptake in the rat thyroid between oral and intravenous bolus administration.

    abstract:OBJECTIVE:Radioiodide is commonly used to diagnose and treat hyperthyroidism and thyroid carcinoma. However, we could not find any experimental data that strictly compared the biodistribution and thyroid uptake of radioactive iodide between the oral and intravenous (iv) routes with time. This prompted us to compare (12...

    journal_title:Annals of nuclear medicine

    pub_type: 杂志文章

    doi:10.1007/s12149-014-0909-7

    authors: Kurosawa H,Sakurai K,Hasegawa H,Uchida K,Kasahara H,Minamizawa T,Nakajo M,Nakajo M

    更新日期:2014-12-01 00:00:00