Abstract:
AIM:To assess the predictive and prognostic value of textural parameters in locally advanced breast cancer (LABC) obtained by 18F-FDG PET/CT. METHODS:Prospective study including 68 patients with LABC, neoadjuvant chemotherapy (NC) indication and a baseline 18F-FDG PET/CT. Breast specimens were grouped into molecular phenotypes and classified as responders or non-responders after completion of NC. Patients underwent standard follow-up to obtain the disease-free survival (DFS) and overall survival (OS). After breast tumor segmentation, three-dimensional (3D) textural measures were computed based on run-length matrices (RLM) and co-occurrence matrices (CM). Relations between textural features with risk categories attending to molecular phenotypes were explored. Kaplan-Meier analysis and univariate and multivariate Cox proportional hazard analysis were used to study the potential of textural variables, molecular phenotypes and histologic response to predict DFS and OS. Receiver operating characteristic (ROC) analysis was used to obtain the best cut-off value, the area under the curve (AUC) and sensitivity and specificity considering OS and DFS. RESULTS:Eighteen patients were classified as responders. Mean ± SD of DFS and OS was 70.87 ± 21.85 and 76.77 ± 18.80 months, respectively. Long run emphasis (LRE) and long run high gray-level emphasis (LRHGE) showed a relation with risk categories. Low gray-level run emphasis (LGRE), LRHGE and run-length non-uniformity (RLNU) showed association with the NC response. Textural variables were significantly associated with OS and DFS in univariate analysis. Regarding the multivariate Cox regression analysis, PET stage with short run high gray-level emphasis (SRHGE) was significantly associated with OS, and PET stage and high gray-level run emphasis (HGRE) with DFS. CONCLUSION:Textural variables obtained with 18F-FDG PET/CT were predictors of neoadjuvant chemotherapy response and prognosis, being as relevant as PET stage at diagnosis for OS and DFS prediction.
journal_name
Ann Nucl Medjournal_title
Annals of nuclear medicineauthors
Molina-García D,García-Vicente AM,Pérez-Beteta J,Amo-Salas M,Martínez-González A,Tello-Galán MJ,Soriano-Castrejón Á,Pérez-García VMdoi
10.1007/s12149-018-1253-0subject
Has Abstractpub_date
2018-07-01 00:00:00pages
379-388issue
6eissn
0914-7187issn
1864-6433pii
10.1007/s12149-018-1253-0journal_volume
32pub_type
杂志文章abstract::A 62-year-old woman experienced headache and rapidly progressive left hemiparesis over 2 weeks. Diffusion-weighted and fluid-attenuated inversion recovery MR images of the head showed increased signal intensity in the right basal ganglia, periventricular white matter and the brain stem. Enhancement was not observed on...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03027408
更新日期:2005-07-01 00:00:00
abstract::The purpose of this study was to examine the normal distribution patterns of 99mTc-HMPAO (HMPAO) in young and aged normal individuals and to clarify differences between the distribution patterns of the two groups by means of an anatomical standardization technique. The tracer distribution was measured with HMPAO and S...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164922
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To determine the optimal accumulation time for three-dimensional positron emission tomography (3D-PET) with (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) to detect the brain uptake pattern typical of Alzheimer's disease (AD). METHODS:Patients with mild AD or amnestic mild cognitive impairment (MCI) and normal...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,多中心研究
doi:10.1007/s12149-013-0704-x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Image segmentation is an essential step in quantifying the extent of reduced or absent lung function. The aim of this study is to develop and validate a new tool for automatic segmentation of lungs in ventilation and perfusion SPECT images and compare automatic and manual SPECT lung segmentations with referen...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-017-1223-y
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. METHODS:Forty-seve...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-007-0179-8
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:Dementia with Lewy bodies (DLB) is generally characterized by a decrease in regional cerebral blood flow (rCBF) in the occipital lobe. However, not all patients with DLB have this feature. We explored characteristics of rCBF pattern changes to improve the identification of DLB, in addition to occipital hypope...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-008-0193-5
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To design, build, and evaluate an animal PET scanner, which can be used with non-human primates under conscious condition, incorporating flat-panel position-sensitive photomultiplier tubes (PS-PMTs). METHODS:The system contains 30 detector modules, each having two PS-PMTs and 16×18 lutetium–yttrium oxyortho-...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0772-y
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Single-photon emission computed tomography (SPECT) using gallium (Ga) has been frequently used for diagnosing head and neck tumors in patients. Although the usefulness of Ga-SPECT is well known, the degree of the increase in diagnostic ability with Ga-SPECT for head and neck tumors has not been reported. We c...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-007-0116-x
更新日期:2008-05-01 00:00:00
abstract::By means of Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy, an established method for assessing renal cortical damage, we evaluated the pick-up rate for renal defects (scars) by single photon computed tomography (SPECT) and planar images of 10 normal volunteers, and 58 patients (70 scintigrams) with upper urinary ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164610
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:Pyothorax-associated lymphoma (PAL) is a rare form of lymphoma and its management on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined computed tomography (CT) has not been well reported. The purpose of this study was to evaluate the usefulness of FDG PET/CT in patients with PAL. MAT...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-010-0408-4
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:In this study, the feasibility and kinetic characteristics of the (68)Ga-NOTA-RGD, a recently developed RGD peptide agent, were investigated for atherosclerosis imaging in comparison with (18)FDG. METHODS:ApoE(-/-) mice were fed a high-fat diet for more than 20 weeks. To evaluate the feasibility, tissue upta...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-013-0757-x
更新日期:2013-11-01 00:00:00
abstract::67Ga-citrate and 99mTc(V)-DMSA images were obtained in a patient with recurrent extraabdominal fibromatosis of the left calf. The 67Ga-citrate image showed abnormal uptake in the left calf lesion and right calf, which was considered due to probable myositis caused by overexertion. On the other hand, the 99mTc(V)-DMSA ...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164850
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To clarify the difference of (18)F-FDG uptake kinetics between FDG-avid metastatic lymph nodes (LNs) in patients with non-small-cell lung cancer (NSCLC) and FDG-avid benign LNs associated with various etiologies on dual-time point PET/CT scan, and to determine the optimal parameter for differentiation. METHO...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-009-0268-y
更新日期:2009-08-01 00:00:00
abstract::Positron emission tomography (PET) with C-11 palmitate has been used in estimating the myocardial utilization of free fatty acid. To assess the metabolic reserve in normal subjects, a PET study was performed at control and during dobutamine infusion at 2 hour intervals in 5 normal subjects. Following monoexponential c...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164614
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:Respiratory motion causes loss of image quality and inaccuracy of quantification in oncologic positron emission tomography (PET) imaging. This study introduces a bioimpedance-based gating method for compensation of respiratory motion artefacts. METHODS:The bioimpedance-based respiratory gating method was stu...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-015-0953-y
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the diagnostic performance of postoperative fluorine-18 fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) as a surveillance modality for advanced gastric cancer patients who were asymptomatic and negative by conventional...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0871-4
更新日期:2014-10-01 00:00:00
abstract::We reviewed the findings of adrenocortical scintigraphy with 131I-6-beta-iodomethyl-19-norcholesterol (NCL-6-131I) of 39 patients to clarify its role in the evaluation of unilateral adrenal or juxtaadrenal masses incidentally discovered by CT, ultrasonography or plain radiography. Twenty-seven benign adrenal masses sh...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164960
更新日期:1993-08-01 00:00:00
abstract::Myocardial normal databases for stress myocardial perfusion study have been created by the Japanese Society of Nuclear Medicine Working Group. The databases comprised gender-, camera rotation range- and radiopharmaceutical-specific data-sets from multiple institutions, and normal database files were created for instal...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-009-0337-2
更新日期:2010-04-01 00:00:00
abstract::In order to investigate whether or not transferrin is involved in the uptake of 67Ga by inflamed liver (acute inflammatory tissues) the uptake of 67Ga by the liver of mice treated with carbon tetrachloride (CCl4) was studied. The serum GPT value reached its maximum on the 1st day after the CCl4 treatment. The uptake o...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164602
更新日期:1990-11-01 00:00:00
abstract::Osmotic demyelination syndrome can result from the rapid correction of hyponatremia, and is categorized by central pontine myelinolysis and extrapontine myelinolysis (EPM). Magnetic resonance imaging (MRI) is currently the most useful modality for visualizing EPM lesions. However, MRI is unable to delineate the severi...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-009-0244-6
更新日期:2009-06-01 00:00:00
abstract::To design a mathematical model for quantifying cerebral blood flow using 99mTc-hexamethyl-propyleneamine oxime (HM-PAO), basic studies were performed in animals and human volunteers. Microautoradiography revealed that HM-PAO crossed the blood-brain barrier. Thin layer chromatographic studies demonstrated the rapid dis...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03164581
更新日期:1988-05-01 00:00:00
abstract::In a 43-year-old woman with fibrous dysplasia of the ribs and facial bone and in a 40-year-old man with fibrous dysplasia of the facial bone, there were considerable increases in the uptake of Tc-99m methylenediphosphonate (Tc-99m MDP) and Gallium-67 citrate. Fibrous dysplasia should be added to differential diagnosis...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03165658
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:To assess the role of serial FLT-PET scans during early neoadjuvant treatment as a prognostic marker of response to treatment and survival. METHODS:This study is a prospective cohort study which draws from a larger original study which examined the utility of FLT-PET imaging across multiple cancers. Our coho...
journal_title:Annals of nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s12149-019-01345-w
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the value of breast-specific gamma imaging (BSGI) as compared with mammography (MMG) and ultrasonography (US). METHODS:This study retrospectively enrolled 121 women with breast cancer (45.0 ± 8.1 years) and dense breasts (breast density >50 %). All patients underwent pre...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-012-0649-5
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Because of the urinary excretion of fluorine-18 fluorodeoxyglucose ((18)F-FDG), FDG-PET or PET/CT is thought of little value in patients with bladder cancer. The purpose of our study was to investigate the value of (18)F-FDG PET/CT with additional pelvic images in detection of recurrent bladder cancers. METH...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-012-0614-3
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine changes in FDG-PET/CT after pleurodesis with OK-432 and to investigate differences in the changes between non-malignant and malignant lesions. METHODS:Study participants were 17 patients with a history of malignant chest disease who underwent FDG-PET/CT after pleurodesis using O...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01508-0
更新日期:2020-10-01 00:00:00
abstract::To systematically review published data on the role of positron emission tomography (PET) or PET/computed tomography (PET/CT) using either Carbon-11 ((11)C) or Fluorine-18 ((18)F) choline tracer in tumors other than prostatic cancer. A comprehensive literature search of studies published in PubMed/MEDLINE and Embase d...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章,评审
doi:10.1007/s12149-012-0602-7
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The liver itself regenerates after hepatectomy but little is known about how much hepatic function recovers during the regeneration. The liver uptake value (LUV), calculated from Tc-99m-labeled galactosyl-human-serum-albumin ((99m)Tc-GSA) SPECT/CT fused images, is reliable and useful for evaluating hepatic f...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-014-0872-3
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:Our purpose was to explore the clinical significance of unexpected osseous foci on 18F-FDG-PET without correlative CT abnormalities (FWCT) in patients referred for oncologic evaluation. The significance of FDG-avid foci without correlative CT abnormalities has been previously explored in tissues such as breast,...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/s12149-020-01572-6
更新日期:2021-01-13 00:00:00
abstract:OBJECTIVES:To compare L-3-[18F]-fluoro-a-methyltyrosine (FMT)-positron emission tomography (PET) and 2-[18F]-fluoro-2-deoxy-D-glucose (FDG)-PET in the differential diagnosis of maxillofacial tumors. METHODS:This study included 36 patients (16 males, 20 females; 31-90 years old) with untreated malignant tumors (34 squa...
journal_title:Annals of nuclear medicine
pub_type: 杂志文章
doi:10.1007/BF03033991
更新日期:2007-02-01 00:00:00