Abstract:
:Current medical treatment of type 2 diabetes mellitus (T2DM) requires special attention to different comorbidities that often are associated with hyperglycemia, such as overweight or obesity, dyslipidemia, hypertension, microvascular or macrovascular complications, etc. .. The control of these factors risk to health is as important as the glucose control in diabetes type 2, it is essential for the antidiabetes drugs consider these risk factors. The consensus statement published by the ADA/EASD and AACE emphasizes that the potential effects of antidiabetes medications on CV risk factors besides hyperglycemia (ie, overweight/obesity, hypertension, and dyslipidemia) should be considered in pharmacotherapy selection. Since T2DM is a progressive disease with worsening HbA1C values over time, monotherapy, even with different agents, will eventually fail to maintain the glycemic target. Because insulin resistance occurs in a variety of organs and tissues, many patients may achieve fasting glycemic control but develop postprandial hyperglycemia. Other issues include the risk for hypoglycaemia or weight gain with traditional glucose-lowering medications. The AACE/ACE algorithm for glycemic control is structured according to categories of HbA1C and suggests an HbA1C goal of =6.5%, although that may not be appropriate for all patients.42 The algorithm recommends monotherapy, dual therapy, or triple therapy based on initial HbA1C level of 6.5% to 7.5%, 7.6% to 9%, and >9% and reserves initiation of insulin therapy until treatment with oral or other injectable agents has failed. GLP-1 receptor agonists and DPP-4 inhibitors are novel options to improve glycemic control and reduce the incidence of weight gain. Combination therapy with newer and traditional agents improves glycemic control with a low incidence of hypoglycemia. :El tratamiento médico actual de la diabetes mellitus tipo 2 (DMT2) requiere una especial atención a las distintas comorbilidades que a menudo aparecen asociados a la hiperglucemia, como por ejemplo el sobrepeso u obesidad, la dislipidemia, la hipertensión, las complicaciones microvasculares o macrovasculares, etc.. El control de estos factores de riesgo para la salud es tan importante como el control de la glucosa en la diabetes tipo 2, por lo que es fundamental que los medicamentos contra la diabetes tengan en cuenta estos factores de riesgo. La declaración de consenso publicado por la ADA (American Diabetes Association) / EASD (European Association for the Study of Diabetes) y la AACE (American Association of Clinical Endocrinologists) hace hincapié en que los efectos potenciales de los medicamentos antidiabéticos sobre los factores de riesgo cardiovascular, el sobrepeso/obesidad, hipertensión y dislipidemia, deben ser considerados en la selección del tratamiento farmacológico. Dado que la DM2 es una enfermedad progresiva con empeoramiento de los valores de HbA1c en el tiempo, la monoterapia, aunque sea con diferentes medicamentos antidiabéticos, a largo plazo será incapaz de mantener el objetivo glucémico. Debido a que la resistencia a la insulina se produce en una gran variedad de órganos y tejidos, muchos pacientes pueden conseguir el control glucémico en ayunas pero desarrollar hiperglucemia postprandial. Además, algunos fármacos llevan asociados riesgos adicionales como hipoglucemia o aumento de peso. La AACE/ACE han establecido un algoritmo para el control glucémico que se estructura de acuerdo a los niveles de HbA1C y sugiere un objetivo para los valores de HbA1C =?de 6,5%, a pesar de que puede no ser apropiado para todos los pacientes. El algoritmo recomienda monoterapia, terapia doble, o triple terapia basada en el nivel inicial de HbA1C de 6,5% a 7,5%, 7,6% a 9%, y > 9% y se reserva el inicio de la terapia con insulina hasta que el tratamiento con agentes orales u otros agentes inyectables no sea efectivo. Los agonistas del receptor de GLP-1 e inhibidores de la DPP-4 son nuevas opciones para mejorar el control glucémico y reducir la incidencia de aumento de peso. La terapia combinada con agentes nuevos y tradicionales mejora el control glucémico con una baja incidencia de hipoglucemia.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
Carrera Boada CA,Martínez-Moreno JMdoi
10.3305/nh.2013.28.sup2.6707subject
Has Abstractpub_date
2013-03-01 00:00:00pages
3-13eissn
0212-1611issn
1699-5198journal_volume
28 Suppl 2pub_type
杂志文章abstract:INTRODUCTION:Stature is an important variable in several indices of nutritional status that are applicable to elderly persons. However, stature is difficult or impossible to measure in elderly because they are often unable to maintain the standing position. A alternative is the use of estimated height from measurements...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.2.7618
更新日期:2014-10-16 00:00:00
abstract::Diet is an important factor related to the development of numerous diseases. In developing countries like Ecuador, this aspect is not considered as priority however, the study of the incidence of certain diet-related diseases could help to assess consumption habits of a country from a Public Health perspective and sup...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.5.6755
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Health inequality is the difference in incidence, prevalence, mortality, volume of diseases and other adverse sanitary conditions that exist between groups of specific populations. OBJECTIVES:To analyze the possible nutritional inequalities between two educational centers of Madrid to promote healthy habi...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.29.1.6778
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:there is a lack of consensus on the benefits of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementations on cognition in dementia and/or Alzheimer's disease (AD) elderly. OBJECTIVE:this study presents a systematic review of the results of randomized clinical trials about this topic. The...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.3305/nh.2015.32.2.9111
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:to compare the DSM Nutritional distributed in three states: normal, overweight and obese. SUBJECTS AND METHODS:test DSM "TEPSI" 58 children (intentional sample) from a total of 150, 4 to 4.5 years, which were divided into 3 groups was applied: normal weight (n = 28); overweight (n = 18) and obese (n = 12). W...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.1.9060
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Protein-energy wasting (PEW), defined as the body loss of muscle mass and fat, is an important cardiovascular risk factor in dialysis patients. Diagnosing this condition requires the presence of three characteristics: biochemical (low albumine, prealbumine or cholesterol), body mass reduction (body mass inde...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.30.4.7730
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The origin of most non-communicable diseases (NCDs) is in early life. Consequently obtaining information on risk factors for NCDs is important for preventive purposes. However, there is no information available on the prevalence of obesity, metabolic syndrome (MS) and insulin resistance (IR) in Chilean child...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nutr hosp.v28in06.6770
更新日期:2013-11-01 00:00:00
abstract:Introduction:Introduction: in Mexico the main problem in public health is obesity and other diseases that are associated whit this condition, including oral health. Objective: to evaluate the effect of metformin treatment in patients with class I obese on the activity of metalloproteinases present in periodontium with ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.02602
更新日期:2019-10-17 00:00:00
abstract::Chagasic megaesophagus is a chronic disease that courses with progressive dysphagia, regurgitation and protein-calorie malnutrition. Advanced or recurrent megaesophagus can be treated with Serra Dória's operation (cardioplasty, partial gastrectomy and gastrojejunal Roux-en-Y anastomosis). A nutritional evaluation was ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract:Introduction:Background and objectives: the aim of the present investigation was to describe the association of this single nucleotide polymorphism (SNP) with fasting glucose levels, serum adipokine levels and diabetes mellitus. Methods: the study involved a population of 1,002 adult obese subjects. Measurements of ant...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.2013
更新日期:2019-03-07 00:00:00
abstract:UNLABELLED:Obesity is associated with increased inflammation. C-reactive protein (CRP) is a proinflammatory molecule, and alpha1-antitrypsin is an inflammation-sensitive plasma protein. Proinflammatory process may be influenced by postprandial hyperglycemia. OBJECTIVE:The aim of the present study was to evaluate the r...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:to identify what effect causes enteral nutrition on nutritional status of cancer. METHOD:a search was performed using the keywords "Cancer" AND "Enteral Nutrition" AND "Supplementation" in four document databases: Pubmed, EBSCO, ProQuest, and Web of Science. INCLUSION CRITERIA:age of the sample, major than ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.3305/nh.2015.32.4.9227
更新日期:2015-10-01 00:00:00
abstract:Introduction:Aim and background: the incidence of obesity has increased among children, and obesity has been considered an independent risk factor for chronic kidney disease. We aimed to determine the degree of kidney function impairment by evaluating urine neutrophil gelatinase-associated lipocalin (NGAL) and kidney i...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.02651
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Although changes in eating patterns may occur during gestation, predictors of these changes have not been explored. This study aimed to identify predictors of adherence to the Mediterranean diet (MD) from the first to second trimester of pregnancy. METHODS:A prospective study was conducted with 102 pregnant...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.3.8158
更新日期:2014-10-04 00:00:00
abstract::Introducción: el trastorno por atracón o "Binge Eating Disorders" (BED) se caracteriza por el consumo de grandes cantidades de comida en un breve periodo de tiempo acompañado de una sensación de falta de control sobre la ingesta. El BED se relaciona con una alimentación poco equilibrada, contribuyendo a la aparición d...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.799
更新日期:2016-11-29 00:00:00
abstract::According to the scientific literature, alcohol effects on health are dose-dependent, since beneficial effects have been observed when consumed at moderate level compared to abstinence or excessive consumption, in both observational and interventional studies. There are specifically two components in fermented beverag...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.20960/nh.2286
更新日期:2018-09-07 00:00:00
abstract:INTRODUCTION:Cardiovascular diseases are the leading cause of death in women after menopause, since after this stage there are profound metabolic and hormonal changes which favor the development of metabolic syndrome. An increase in the percentage of visceral fat may be related to the onset of this syndrome. OBJECTIVE...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1085
更新日期:2017-07-28 00:00:00
abstract::The importance of the treatment of diabetes mellitus in the diet, is well known. Given that the glycemic response of the foods can not be predicted simply based on their chemical composition, prior to advising diabetics, one must have comparative data on the physiologic effects of the different foods. In this work we ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:the aging population has been accompanied by epidemiological changes of the Brazilian population, with the highlight being the continued growth of the prevalence of non-communicable chronic diseases especially cardiovascular or artery-coronary, resulting from changes in the lipid profile of the elderly. OBJ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.2.8875
更新日期:2015-08-01 00:00:00
abstract::Continuous physical exercise leads the athlete to maintain an unstable balance between dietary intake, energy expenditure and the additional demands of a high amount of physical activity. Thus, an accurate assessment of nutritional status is essential to optimize the performance, since it affects health, body composit...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2015.31.sup3.8770
更新日期:2015-02-26 00:00:00
abstract:INTRODUCTION:Evidences suggest that fat intake, visceral obesity and intracellular lipids are related to insulin impairment. OBJECTIVE:The objective of the present paper was correlate visceral obesity and metabolic alterations in control (CTR) and hyperlipidic cafeteria diet (CFT) fed animals. METHODS:After 6 months ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.2.6181
更新日期:2013-03-01 00:00:00
abstract::If sepsis due to a catheter is suspected in a patient receiving parenteral nutrition, the doctor responsible for the patient usually withdraws the catheter and sends the point to the bacteriological laboratory for examination. This operation is usually accompanied by the extraction of several blood samples for haemocu...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:Introduction:For centuries the traditional ingredients of food patterns in Basque Country were millet, chestnuts, cabbage, beans, lentils, fish, pork and beef especially, as well as a variety of fruits such as apples, pears and grapes. Later, the potato replaced chestnuts, corn replaced millet and beans replaced broad ...
journal_title:Nutricion hospitalaria
pub_type: 历史文章,杂志文章
doi:10.20960/nh.02689
更新日期:2019-07-02 00:00:00
abstract:INTRODUCTION:in relation to the student population, their class schedules, hours of study, budget shortages, among others, do not allow them to have good eating habits and sedentary ago. Within this context are the sports teams, which must deal with the above. OBJECTIVE:knowing the nutritional status of a group of col...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.6.9877
更新日期:2015-12-01 00:00:00
abstract:OBJETIVE:to determine food patterns and its association with the consumption of various foods with nutritional status of Chilean university students of Nutrition and Dietetics. MATERIAL AND METHODS:cross-sectional study, 634 students were evaluated Nutrition and Dietetics at the Universidad San Sebastián, of Santiago,...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.4.9515
更新日期:2015-10-01 00:00:00
abstract::Resection of long segments of the small bowel may cause variable degrees of malabsorption. Therefore, the results of the resection will depend on the length and location of the resected segment, and on the age of the patient and the underlying disease that motivated the resection. The implementation of Nutritional Sup...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2006-09-01 00:00:00
abstract:UNLABELLED:Introducción y objetivos: las enfermedades cardiovasculares (ECV) son la principal causa de muerte mundial, por ello el objetivo de este estudio es analizar los factores de riesgo de ECV en los trabajadores de la Universidad de Alicante.Material y métodos: estudio transversal descriptivo. Muestra aleatoria (...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.273
更新日期:2016-06-30 00:00:00
abstract:INTRODUCTION:apart from the known effects of vitamin D on phospho-calcium homeostasis, in recent years there is great interest in its extrabone effects. OBJECTIVES:to know the concentration of 25-hydroxyvitamin D (25[OH] D) in newly diagnosed patients of cancer and to verify if there are differences between the differ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1675
更新日期:2018-04-05 00:00:00
abstract::At our hospital, there is an At-Home Enteral Nutrition programme (NED in its Spanish acronym) with participation of the Clinical Nutrition Unit and the Pharmacy Service. The products and all necessary material are dispensed directly to the patient's home and nutritional follow-up is carried out. As a lack of informati...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To assess the nutritional status of orthopaedic patients. DESIGN:Prospective observation study. SETTING:Tertiary hospital, Clinical Nutrition Unit. PATIENTS:107 patients (56.1% women, 43.9% men, 62.1 +/- 20.4 years) are studied at admission to the orthopaedic unit and it is observed the evolution of orthop...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00