[New reliable methods for the diagnose of protein-energy wasting in hemodialysis patients].

Abstract:

BACKGROUND:Protein-energy wasting (PEW), defined as the body loss of muscle mass and fat, is an important cardiovascular risk factor in dialysis patients. Diagnosing this condition requires the presence of three characteristics: biochemical (low albumine, prealbumine or cholesterol), body mass reduction (body mass index, weight loss or fat loss) and muscle mass reduction (measured by means of creatinine or arm muscle area). This study aimed at demonstrating that the lean tissue index (LTI) calculated by spectroscopic bioimpedance (SBI) is a valid parameter for the diagnostic of protein-energy wasting. METHODS:Cross-sectional study including 1369 patients with two BCM measurements on a six-month delay, analyzing analytic and spectroscopic bioimpedance parameters. RESULTS:The lean tissue index from the BCM (Body Composition Monitor) quantifies the patient's lean mass and it is matched against traditional parameters (plasma albumine) and non-traditional parameters (IRE and PCR) for protein-energy wasting with no alterations from the patient's hydration level. CONCLUSIONS:LTI is an easy to obtain parameter of lean mass which can be followed and monitored in order to diagnose risk situations of our patients as it is the protein- energy wasting. :Introducción: La depleción proteico-calórica (protein- energy wasting, PEW) definida como pérdida de masa muscular y grasa del organismo, supone un importante factor de riesgo cardiovascular en los pacientes en diálisis. Para su diagnóstico se requiere de la presencia de tres características: bioquímicas (albúmina, prealbúmina o colesterol bajos), descenso de masa corporal (índice de masa corporal, pérdida de peso o de grasa) y reducción de masa muscular (evaluada mediante creatinina o área muscular del brazo). El Objetivo del presente estudio es demostrar que el índice de tejido magro (LTI) obtenido por bioimpedancia espectroscópica (BIS) es un parámetro válido para el diagnóstico de depleción proteico- calórica. Métodos: Estudio transversal de 1369 pacientes con dos mediciones de BCM entre las que transcurren seis meses, en los que analizamos parámetros analíticos y de bioimpedancia espectroscópica . Resultados: El índice de tejido magro aportado por el BCM (Body Composition Monitor) cuantifica la masa magra del paciente y se correlaciona con parámetros tradicionales (albúmina plasmática) y no-tradicionales (IRE y PCR) de depleción proteico-calórica sin verse alterado por la situación hídrica del paciente. Conclusiones: El LTI es un parámetro de masa magra fácil de obtener cuyo seguimiento y monitorización nos puede ayudar a diagnosticar situaciones de riesgo para nuestros pacientes como la depleción proteico-calórica.

journal_name

Nutr Hosp

journal_title

Nutricion hospitalaria

authors

Castellano-Gasch S,Palomares-Sancho I,Molina-Núñez M,Ramos-Sánchez R,Merello-Godino JI,Maduell F

doi

10.3305/nh.2014.30.4.7730

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

905-10

issue

4

eissn

0212-1611

issn

1699-5198

journal_volume

30

pub_type

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