Abstract：
:Photodynamic therapy (PDT) with topical application of delta-aminolevulinic acid (ALA) followed by irradiation with visible light (ALA-PDT) is a relatively new and promising experimental treatment of superficial premalignant and malignant skin neoplasms. The purpose of this study was to determine whether ALA-PDT can prevent photocarcinogenesis in hairless mice exposed to solar UV. A total of 140 mice was divided into seven groups of 20 mice each. Group 1: solar-UV exposure. Group 2: solar UV and a cream base+visible light once a week. Group 3: solar UV and ALA-PDT once a week. Group 4: solar UV and ALA-PDT once every second week. Group 5: solar UV and ALA-PDT every fourth week. Group 6: ALA-PDT once a week. Group 7: no treatment. The time to first and to second tumor > or = 1 mm was registered. Predefined endpoints, such as one tumor > or = 4 mm or an area of small confluent tumors on the back of the mice were criteria for withdrawal from the experiment. The time to first and to second tumor was significantly longer in the ALA-PDT-treated mice than in mice only exposed to solar UV and solar-UV/cream base-visible light (P < 0.005). However, we observed an increased death and accident rate in the ALA-PDT-treated groups compared to the groups not treated with ALA-PDT (chi-square test, P = 0.0250). Significantly more ALA-PDT-treated mice were withdrawn because of a tumor > or = 4 mm (P = 0.0005). The UV unexposed mice developed no tumors. Repetitive treatments with ALA-PDT delay photoinduced carcinogenesis in mice.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Stender IM,Bech-Thomsen N,Poulsen T,Wulf HCdoi
10.1111/j.1751-1097.1997.tb03178.xsubject
Has Abstractpub_date
1997-10-01 00:00:00pages
493-6issue
4eissn
0031-8655issn
1751-1097journal_volume
66pub_type
杂志文章abstract：:An ongoing study in our laboratories is to examine the relationship of DNA repair defects to human cancer. Our underlying hypothesis has been that human tumors may arise that lack interesting DNA repair pathways if these pathways are important in preventing cancer. In this study, we found that the UV-irradiated adenov...
journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：:The photochemistry of Ru(bpy)(3)+2 in the presence of amines was investigated in water by laser flash photolysis. N,N'-Dimethylaniline and p-phenylenediamine quench the luminescent metal to ligand charge transfer (MLCT) excited state of the complex by an electron transfer reaction that produces the semireduced form Ru...
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pub_type： 杂志文章
doi：10.1562/2005-05-31-RA-558
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pub_type： 杂志文章
doi：10.1562/0031-8655(2003)078<0603:SCFBSU>2.0.CO;2
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journal_title：Photochemistry and photobiology
pub_type： 评论,杂志文章
doi：10.1111/php.13102
更新日期：2019-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1751-1097.2008.00481.x
更新日期：2009-05-01 00:00:00
abstract：:Spatio-temporal patterns in sun exposure underlie variations in skin cancer incidence and vitamin D deficiency, indicate effectiveness of sun protection programs and provide insights into future health risks. From 558 adults across four regions of Australia (Brisbane (27°S), Newcastle (33°S), Geelong and the Western D...
journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/php.12044
更新日期：2013-05-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章,评审
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更新日期：2009-03-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.1989.tb02907.x
更新日期：1989-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.2012.01231.x
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章,评审
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更新日期：2017-03-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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更新日期：2001-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1751-1097.2007.00079.x
更新日期：2007-09-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1751-1097.1996.tb03130.x
更新日期：1996-10-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.1989.tb09188.x
更新日期：1989-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1562/0031-8655(2002)075<0249:ssapos>2.0.co;2
更新日期：2002-03-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.1991.tb08470.x
更新日期：1991-01-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1989-09-01 00:00:00
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doi：10.1111/j.1751-1097.1995.tb02348.x
更新日期：1995-05-01 00:00:00
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更新日期：2006-07-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：
更新日期：1981-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-01-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1562/2005-07-11-RA-608
更新日期：2006-01-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
abstract：:As our understanding of the role of UV in causing skin cancer continues to expand, researchers and clinicians must continue to remain up to date on the various means by which UV exposure can be quantified. The purpose of this article was to review the current methods used to measure lifetime exposure to UV and to summ...
journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.2008.00367.x
更新日期：2008-11-01 00:00:00
