Abstract：
BACKGROUND:Lack of agreement on how to accurately capture disease outcomes in localized scleroderma (LS) has hindered the development of efficacious treatment protocols. The LS Cutaneous Assessment Tool (LoSCAT), consisting of the modified LS Skin Severity Index (mLoSSI) and the LS Damage Index, has potential for use in clinical trials. OBJECTIVE:The goal of this article is to further evaluate the clinical responsiveness of the LoSCAT. Based on the modifiable nature of disease activity versus damage, we expected the mLoSSI to be responsive to change. METHODS:At 2 study visits, a physician completed the LoSCAT and Physician Global Assessment (PGA) of Disease Activity and of Disease Damage for 29 patients with LS. Spearman correlations were used to examine the relationships between the change in the LoSCAT and the PGA scores. To evaluate contrasted group validity, patients were grouped according to disease activity classification and change scores of groups were compared. Minimal clinically important differences were calculated and compared with the standard error of measurement. RESULTS:Change in the mLoSSI score correlated strongly with change in the PGA of Disease Activity score, whereas change in the LS Damage Index score correlated weakly with change in the PGA of Disease Damage score. The mLoSSI and PGA of Disease Activity exhibited contrasted group validity. Minimal clinically important differences for the activity measures were greater than the respective standard errors of measurement. LIMITATIONS:Only 2 study visits were included in analysis. CONCLUSION:This study gives further evidence that the LoSCAT, specifically the mLoSSI, is a responsive, valid measure of activity in LS and should be used in future treatment studies.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Kelsey CE,Torok KSdoi
10.1016/j.jaad.2013.02.007subject
Has Abstractpub_date
2013-08-01 00:00:00pages
214-20issue
2eissn
0190-9622issn
1097-6787pii
S0190-9622(13)00189-8journal_volume
69pub_type
杂志文章abstract：BACKGROUND:Topical corticosteroids alone or in combination with other therapies are widely used to treat mycosis fungoides (MF), but data on response rates to their use as monotherapy in MF are limited. OBJECTIVE:To evaluate the efficacy of topical corticosteroid monotherapy in MF; compare sex, age, stage distribution...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.05.043
更新日期：2020-05-16 00:00:00
abstract：:The presence of the discoid lupus erythematosus (DLE) skin lesion in a patient with systemic lupus erythematosus (SLE) has been suggested to be a marker of less frequent and less severe renal disease. The clinical and laboratory features of seventeen patients who were seen in a dermatology practice and who had DLE as ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)80036-0
更新日期：1985-02-01 00:00:00
abstract：:Tumid lupus erythematosus (LE) is a relatively rare and only recently recognized subset of chronic cutaneous lupus. We report a case occurring in a male with HIV infection whereby his rash was only unmasked by immune restoration following highly active antiretroviral therapy (HAART). The phenomenon of latent inflammat...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2004.04.020
更新日期：2004-11-01 00:00:00
abstract：:A 40-year-old man with severe psoriasis developed painless muscle stiffness coinciding with four successive courses of etretinate therapy. Peripheral nerve block extinguished the increased muscle tone. Our patient's symptoms resembled those of the stiff-man syndrome. Increased muscle tone is a potential side effect of...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70110-2
更新日期：1986-05-01 00:00:00
abstract：:The monoclonal gammopathies are characterized by clonal proliferation of plasma cells and other clonally related cells in the B-cell lineage. These disorders include monoclonal gammopathy of undetermined significance, multiple myeloma, Waldenström macroglobulinemia, heavy chain diseases, plasmacytoma, and primary amyl...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(99)70434-2
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Secukinumab is a first-in-class interleukin 17A monoclonal antibody that has demonstrated an excellent safety and efficacy profile in phase 3 studies. OBJECTIVE:To evaluate the effectiveness of secukinumab in daily clinical practice and to understand the clinical and epidemiologic characteristics of patient...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jaad.2019.02.062
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:The negative pigment network (NPN) is seen as a negative of the pigmented network and it is purported to be a melanoma-specific structure. OBJECTIVES:We sought to assess the frequency, sensitivity, specificity, and odds ratios (ORs) of NPN between melanoma cases and a group of control lesions. METHODS:Digi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2012.08.012
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Acral lentiginous melanomas compose a higher proportion of melanomas and have a higher mortality in ethnic minorities than in whites. Early detection by acral surface inspection during skin examinations may lead to improved acral lentiginous melanoma outcomes. OBJECTIVE:This study compared patient-reported ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2014.03.032
更新日期：2014-08-01 00:00:00
abstract：:Forty-seven patients with chronic venous leg ulcers were included in a randomized clinical trial to evaluate the efficacy of systemically administered antibiotics in healing with condition. One group was treated by means of elastic support bandages only, whereas the other one received the same local treatment plus sys...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0190-9622(86)70154-0
更新日期：1986-08-01 00:00:00
abstract：:To evaluate the sensitivity of histologic criteria 396 hematoxylin-eosin-stained step sections of 150 randomly sampled thin malignant melanomas (tumor thickness, less than or equal to 1.5 mm; level of invasion, I-III) were analyzed. The highest sensitivity was determined for nuclear atypia (84%), followed by the asymm...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(89)70143-2
更新日期：1989-06-01 00:00:00
abstract：:The case of a male diabetic patient with recurrent bullous lesions restricted to the hands is reported. Areas of spongiosis in the epidermis, as well as subepidermal blister formation, were observed in repeated biopsies. On electron microscopy, separation was seen at the level of the lamina lucida. No immunopathology ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：:We describe a 6-year-old boy with a granulomatous lesion on the upper aspect of his left arm. Fusarium solani infection was confirmed by biopsy studies and cultures. The biopsy specimen showed an unusually extensive dermal invasion with fungal hyphae. This is an uncommon clinical presentation for deep cutaneous infect...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2006.10.960
更新日期：2007-05-01 00:00:00
abstract：:Melanocytic nevi are commonly believed to undergo changes during pregnancy. This is probably related to hormonal influences; however, few studies have been able to prove it. We observed a case of a benign melanocytic nevus, which showed significant enlargement during pregnancy and immediate postpartum regression assoc...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(00)90277-9
更新日期：2000-05-01 00:00:00
abstract：:A 46-year-old albino woman is described with a melanoma on the leg from which a punch biopsy specimen was inadvertently taken. In the reexcision specimen, two biopsy wounds were recognized that were filled with tumor. The initial level III lesion had to be subsequently reported as a deep level IV amelanotic melanoma w...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)70238-1
更新日期：1985-11-01 00:00:00
abstract：BACKGROUND:Melanoma is the most lethal form of skin cancer. Diagnosis of amelanotic melanoma and detection of micrometastases in sentinel lymph nodes pose diagnostic and therapeutic dilemmas for the dermatopathologist and clinician. OBJECTIVE:The purpose of this article is to determine the utility of immunohistochemis...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.117526
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:The formulation of topical dermatologic products must take into account efficacy, safety, and patient compliance. OBJECTIVE:We describe how an aqueous gel containing adapalene, a novel naphthoic acid derivative was selected for the topical treatment of acne. METHODS AND RESULTS:Dose selection was made usin...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(97)70055-0
更新日期：1997-06-01 00:00:00
abstract：:A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4- 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocy...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(94)70157-1
更新日期：1994-08-01 00:00:00
abstract：:The PA Patch, a new multiple-antigen, predispensed patch testing device, was compared to the Finn Chamber in subjects with previous positive patch tests. After pressing the PA Patch well, the PA Patch performed as well as the Finn Chamber in nine subjects tested. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0190-9622(87)70121-2
更新日期：1987-05-01 00:00:00
abstract：:Novel tretinoin cream and gel formulations have been developed that incorporate polyolprepolymer-2, which is a material designed to help retain drug molecules in and on the skin when applied in topical vehicles. The results of preclinical and clinical investigations have confirmed the beneficial impact of such a vehic...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(98)70139-2
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Botulinum toxin type A (BTX-A) is widely used for facial esthetics but is incompletely studied. OBJECTIVE:This study was conducted to evaluate the efficacy and safety of BTX-A treatment of glabellar lines. METHODS:Patients with moderate to severe glabellar lines at maximum frown received intramuscular inje...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1067/mjd.2002.121356
更新日期：2002-06-01 00:00:00
abstract：:The treatment of hidradenitis suppurativa (HS) has remained challenging because of the many knowledge gaps regarding etiology. However, recent studies into the pathogenesis of HS have enabled the investigation of newer therapies. The second article in this continuing medical education series reviews the evidence for e...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2019.08.089
更新日期：2020-05-01 00:00:00
abstract：:Our case series report is the first documented depiction of the appearance of aphthous ulcers secondary to imiquimod application. This case series presentation discusses the underlying pathophysiology of aphthous ulcer development and imiquimod therapy in terms of the stimulation of proinflammatory cytokines, such as ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2004.06.045
更新日期：2005-02-01 00:00:00
abstract：:Papular mucinosis is a rare, idiopathic cutaneous mucinosis that is typically chronic and progressively severe. We present a case of a 59-year-old woman with a 6-month history of a dramatic papular eruption on her face and neck, with no associated internal organ involvement. A biopsy specimen demonstrated increased de...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(03)00790-4
更新日期：2004-01-01 00:00:00
abstract：:Cicatricial pemphigoid is an autoimmune bullous disease that has a predilection for mucous membranes and often results in scarring. We describe a case of cicatricial pemphigoid with severe involvement of the glans penis, which, despite systemic therapy, led to phimosis. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2002.107967
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Significant unmet need exists for long-term treatment of moderate to severe atopic dermatitis (AD). OBJECTIVE:To assess the long-term safety and efficacy of dupilumab in patients with AD. METHODS:This ongoing, multicenter, open-label extension study (NCT01949311) evaluated long-term dupilumab treatment in ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jaad.2019.07.074
更新日期：2020-02-01 00:00:00
abstract：:Sixteen patients with granular cell tumors were seen between 1964 and 1979. The medical data of these patients showed an average age incidence of 39 years and a greater frequency among Negroes (69%) and in female patients (62.5%). The most common sign (in 12 of 16 patients) was the presence of an asymptomatic mass. Th...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(81)70085-9
更新日期：1981-08-01 00:00:00
abstract：:We present the case of two patients with an unusual form of discoid lupus erythematosus that was confined almost exclusively to the palms and soles. In both patients this form of discoid lupus erythematosus did not respond to conventional therapies, which included topical steroids, intralesional steroids, prednisone, ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(88)70259-5
更新日期：1988-11-01 00:00:00
abstract：:Dacarbazine (DTIC-Dome) is a widely used chemotherapeutic agent employed in the therapy of malignant melanoma. In this communication, we present two patients who developed photosensitivity skin reactions immediately after its administration. Physicians using dacarbazine should be aware of this side effect and should i...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(81)70053-7
更新日期：1981-05-01 00:00:00
abstract：BACKGROUND:Intraoperative pain during Mohs micrographic surgery (MMS) has not been characterized. However, many patients report postoperative pain on the day of MMS. OBJECTIVE:We sought to determine if patients experience pain during their MMS visit. METHODS:In phase I of this study, patients were asked to report int...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2016.02.1230
更新日期：2016-09-01 00:00:00
abstract：:Linear IgA bullous dermatosis (LABD) is an autoimmune blistering skin disease characterized by circulating IgA antibodies binding the basement membrane zone. In most cases the origin is not clear, but in a minority of cases LABD is drug induced. We describe a patient in whom linear IgA disease developed shortly after ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.113462
更新日期：2001-04-01 00:00:00
