Abstract:
:Dacarbazine (DTIC-Dome) is a widely used chemotherapeutic agent employed in the therapy of malignant melanoma. In this communication, we present two patients who developed photosensitivity skin reactions immediately after its administration. Physicians using dacarbazine should be aware of this side effect and should instruct patients to avoid solar exposure following infusions of this drug.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Yung CW,Winston EM,Lorincz ALdoi
10.1016/s0190-9622(81)70053-7subject
Has Abstractpub_date
1981-05-01 00:00:00pages
541-3issue
5eissn
0190-9622issn
1097-6787pii
S0190-9622(81)70053-7journal_volume
4pub_type
杂志文章abstract::We present the case of two patients with an unusual form of discoid lupus erythematosus that was confined almost exclusively to the palms and soles. In both patients this form of discoid lupus erythematosus did not respond to conventional therapies, which included topical steroids, intralesional steroids, prednisone, ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(88)70259-5
更新日期:1988-11-01 00:00:00
abstract::Diagnosis and classification of cutaneous lymphoid infiltrates are often hampered by lack of frozen tissue to allow detailed immunophenotyping. Therefore antibodies that recognize antigens resistant to routine tissue processing would be of value. In this study we present a detailed analysis of two such antibodies agai...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(89)70155-9
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Surgical procedures used to remove genital warts (cryotherapy, electrodesiccation) are painful. Attempts to reduce the discomfort of surgery by prior lidocaine infiltration anesthesia are compromised by the pain of the infiltration. OBJECTIVE:Our purpose was to determine the efficacy of topically applied li...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0190-9622(97)70218-4
更新日期:1997-07-01 00:00:00
abstract::Scleromyxedema is a rare cutaneous disease with occasional systemic involvement and characteristic poor response to treatment. A case of scleromyxedema associated with renal scleroderma and acute psychosis is presented, along with a review of treatment and associated internal disorders. ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(86)70104-7
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:Some clinicians perform cutaneous laser treatments through transparent membranes to protect themselves and the surroundings from contamination by ejected tissue particles. Transmissibility of these membranes influences the tissue irradiance. OBJECTIVE:We compared the optical transmissibility of 8 membranes....
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1067/mjd.2001.116221
更新日期:2001-12-01 00:00:00
abstract::A recent study demonstrated that hirsute women with irregular menses had higher levels of serum androgens that hirsute women with regular menses. To investigate this finding, we measured total testosterone, biologically active testosterone, free testosterone, androstenedione, dehydroepiandrosterone, and dehydroepiandr...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(91)70064-9
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Appropriate primary end points in randomized controlled trials (RCTs) improve the quality of the measurement and enable comparison of the findings with those of other trials. OBJECTIVE:To assess the quality of reporting primary end points in RCTs recently published in dermatology journals. METHODS:We ident...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2020.04.067
更新日期:2020-04-22 00:00:00
abstract:BACKGROUND:The association of human herpesvirus 6 (HHV-6) and HHV-7 with pityriasis rosea suggests that systemic drugs directed against HHV may hasten recovery of patients with pityriasis rosea. OBJECTIVE:The purpose of this study was to verify the efficacy of oral acyclovir in the treatment of pityriasis rosea. METH...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2005.06.042
更新日期:2006-01-01 00:00:00
abstract::A clinical syndrome, consisting of eruptive linear seborrheic keratoses associated with adenomatous colonic polyps (malignant but without invasion of the stalk) and/or frankly invasive colonic adenocarcinomas, is described in five patients. Partial to almost complete regression of the cutaneous lesions over the succee...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(88)70141-3
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:The Food and Drug Administration (FDA) has received reports of depression and suicide in patients treated with isotretinoin. OBJECTIVE:Our purpose was to provide the number and describe the cases of depression and suicide reported to the FDA in US patients treated with isotretinoin and to consider the natur...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1067/mjd.2001.117730
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Diet is a modulator of inflammation that might impact inflammatory skin diseases. OBJECTIVE:To assess the relationship between pro-inflammatory dietary patterns and incident psoriasis, psoriatic arthritis (PsA), and atopic dermatitis (AD). METHODS:We conducted cohort studies among women in the Nurses' Heal...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2019.02.038
更新日期:2019-06-01 00:00:00
abstract::Infantile perineal protrusion, a relatively newly recognized condition, is underreported in both the dermatologic and pediatric literature. The name "infantile perineal protrusion" has evolved based on the typical anatomic location, morphologic features, and prevalence in prepubertal children. It occurs in 3 settings:...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2006.02.029
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Cholinergic urticaria is primarily seen in young adults, but little is known about its prevalence. OBJECTIVE:A prospective study was designed to investigate the frequency and severity of cholinergic urticaria in this age group. METHODS:Four hundred ninety-three high school and university students (15 to 35...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(94)70267-5
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:While scalp alopecia represents a distinctive feature of chronic graft-versus-host disease (cGVHD), little is known about the clinical and histologic presentation of hair loss. OBJECTIVES:We sought to classify the clinical presentations and histologic findings of chronic hair loss in patients with cutaneous...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2019.03.031
更新日期:2019-11-01 00:00:00
abstract::The acute complications that may result in failure of the surgical procedure are discussed. These include bleeding, hematoma, infection, dehiscence, and necrosis. The background of each is covered in detail and an attempt is made to show the interrelationships among them. The purpose of this communication is to aid in...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(86)70288-0
更新日期:1986-12-01 00:00:00
abstract::As summarized in the first article in this continuing medical education series, the currently available epidemiologic data suggest that psoriasis may be a risk factor for cardiometabolic disease. Emerging data also suggest associations between psoriasis and other comorbidities beyond psoriatic arthritis, including chr...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2016.07.065
更新日期:2017-03-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs have been shown to inhibit inflammation, an integral part of the wound-healing process. Compromised wound repair has been demonstrated in laboratory animals administered high-dose nonsteroidal anti-inflammatory drugs, a phenomenon we speculate could occur in humans undergoing surge...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(88)70119-x
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Access to dermatologists is low among Medicaid-insured patients. Higher clinic nonattendance among Medicaid-insured patients might affect provider decisions to accept these patients. OBJECTIVE:To determine the effect of different scheduling policies on the attendance among children seen at a pediatric derma...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2019.02.018
更新日期:2019-08-01 00:00:00
abstract::Epithelioid hemangioendothelioma (EHE) is a unique tumor, mainly of adults, which is characterized by epithelioid or histiocytoid endothelial cells. It is a low-grade malignant vascular tumor first described as a distinctive entity in 1982 by Weiss and Enzinger. An 8-year-old girl presented with an approximately 3-yea...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(00)90267-6
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:The epidemiology of pediatric melanoma is distinct from that seen in adults. This is more distinguishable when pediatric patients are separated into prepubertal and adolescent groups. OBJECTIVE:In this study, we compared epidemiologic, clinical, histologic, and molecular characteristics of pediatric superfi...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2017.05.051
更新日期:2017-11-01 00:00:00
abstract::Three siblings with infantile-onset biotin-responsive multiple carboxylase deficiency are described. Recognition of the characteristic dermatologic manifestations, alopecia and periorificial dermatitis, should result in early diagnosis and institution of potentially lifesaving therapy with biotin. Other metabolic diso...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(83)70113-1
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:For persons of childbearing potential prescribed isotretinoin, the iPLEDGE program requires use of 2 simultaneous methods of contraception or commitment to abstinence. OBJECTIVE:To model the relative effectiveness of a variety of contraception strategies for patients taking isotretinoin, including those tha...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2020.02.022
更新日期:2020-07-01 00:00:00
abstract::Fifteen patients with toxic epidermal necrolysis (TEN) were studied. In all of them the TEN was related to drug ingestion and believed to be drug-induced. The drugs implicated include pyrazolone derivatives, allopurinol, barbiturates, tetracycline, phenytoin, and penicillamine. Possible etiologic co-factors are infect...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(84)80317-5
更新日期:1984-06-01 00:00:00
abstract:BACKGROUND:The mature psoriatic lesion does not necessarily demonstrate changes relevant to early phases of the lesion. OBJECTIVE:In a model for relapsing psoriasis we examined the epidermal phenotype by means of a panel of immunohistochemical parameters: keratins 14 and 16, epidermal growth factor receptor (EGFR), Ki...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(99)70077-0
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Basaloid squamous cell carcinoma (BSCC), an aggressive tumor of the aerodigestive tract, was described over 20 years ago, and its defining histologic parameters remain largely unchanged. While rare reports have noted cutaneous metastatic deposition, primary tumors have not been previously described. OBJECTI...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2010.02.051
更新日期:2011-01-01 00:00:00
abstract::We review experimental studies that address age-related changes in cutaneous barrier function and dermal blood vessel function. These differences have important implications in the understanding of age-related changes in the inflammatory process and topical drug delivery systems. ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(94)70273-x
更新日期:1994-12-01 00:00:00
abstract:UNLABELLED:Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA), a medication used to treat psoriasis in the 1970s until side effects and the concern of carcinogenesis led to its discontinuation. The prodrug, MMF, emerged decades later in the transplant field. Dermatologists have since used MMF off-lab...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2008.08.049
更新日期:2009-02-01 00:00:00
abstract::We report a detailed clinical, histopathologic, and photobiologic study of 16 Dutch patients with actinic reticuloid. All were middle-aged or elderly men who had persistent plaques on light-exposed skin only (two patients), extension of lesions to nonexposed areas (four patients), or prolonged or persistent episodes o...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::The terminology of the specific dermatoses of pregnancy has become increasingly confusing, with several names in use for identical clinical disorders. On the basis of our own study of sixty-four patients and a review of the literature, we propose a simplified classification: (1) herpes gestationis (pemphigoid gestatio...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(83)70046-0
更新日期:1983-03-01 00:00:00
abstract::A 46-year-old albino woman is described with a melanoma on the leg from which a punch biopsy specimen was inadvertently taken. In the reexcision specimen, two biopsy wounds were recognized that were filled with tumor. The initial level III lesion had to be subsequently reported as a deep level IV amelanotic melanoma w...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(85)70238-1
更新日期:1985-11-01 00:00:00