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Skin distribution and pharmaceutical aspects of adapalene gel.

Abstract：

BACKGROUND:The formulation of topical dermatologic products must take into account efficacy, safety, and patient compliance. OBJECTIVE:We describe how an aqueous gel containing adapalene, a novel naphthoic acid derivative was selected for the topical treatment of acne. METHODS AND RESULTS:Dose selection was made using established in vivo models. In the Rhino mouse the comedolytic effect of adapalene 0.1% gel was similar or superior to that of a reference formulation containing 0.025% tretinoin. Qualitative distribution of adapalene after topical application was assessed on cryosections of human skin. They showed rapid penetration of adapalene into the pilosebaceous unit. A liberation/penetration study demonstrated that significant quantities of adapalene were present in epidermis and dermis, but only 0.01% of the applied dose penetrated through the skin. CONCLUSION:This formulation should result in effective and well-tolerated treatment of acne vulgaris with good patient compliance.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Allec J,Chatelus A,Wagner N

doi

10.1016/s0190-9622(97)70055-0

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

S119-25

issue

6 Pt 2

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(97)70055-0

journal_volume

36

pub_type

杂志文章

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