当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > Relationship between age and likelihood of lymph node metastases in patients with intermediate thickness melanoma (1.01-4.00 mm): A National Cancer Database study.

Relationship between age and likelihood of lymph node metastases in patients with intermediate thickness melanoma (1.01-4.00 mm): A National Cancer Database study.

Abstract：

BACKGROUND:There is large variability in the risk of sentinel lymph node (SLN) positivity among patients with intermediate thickness melanoma (ITM), with a subgroup of patients exhibiting a low risk of nodal disease. OBJECTIVE:To identify a group of patients with ITM for whom the risk of nodal disease is low. METHODS:A retrospective cohort of patients with ITM who underwent wide excision and nodal evaluation from 2010 to 2013 was identified by using the National Cancer Database and analyzed for the presence of nodal disease. Classification and regression tree analysis identified the most important factors used in a model to identify groups at low risk of SLN positivity. RESULTS:Of 23,440 patients, 14.7% were found to have nodal metastasis. On classification and regression tree analysis, patients older than 55 years without lymphovascular invasion and with a lesion thickness less than 1.7 mm had an SLN positivity rate of 4.9%. A model using age and thickness in nonulcerated patients identified a low-risk subgroup with a corresponding SLN positivity rate of 4.7%. LIMITATIONS:This was a retrospective study, and the model developed requires prospective validation. CONCLUSIONS:Patient age is an important factor in estimating risk of SLN in patients with ITM and may help identify patients without ulceration who may be safely spared an SLN biopsy.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Hanna AN,Sinnamon AJ,Roses RE,Kelz RR,Elder DE,Xu X,Pockaj BA,Zager JS,Fraker DL,Karakousis GC

doi

10.1016/j.jaad.2018.08.022

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

433-440

issue

2

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(18)32476-9

journal_volume

80

pub_type

杂志文章

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